Closed-Loop Recyclable Solid-State Polymer Electrolytes Enabled by Reversible Lithium Salt Catalysis.

The rapid expansion in lithium battery production and disposal presents considerable sustainability challenges, emphasizing the critical need for recycling. However, current methods predominantly focus on metals from cathodes, while electrolytes have rarely been recycled. Here, we propose an innovative closed-loop design for solid polymer electrolytes (SPEs), enabled by reversible catalysis of lithium bis(trifluoromethane) sulfonimide (LiTFSI) in both polymerization and depolymerization.

Acute abdominal pain as the initial presenting symptom of pediatric Burkitt lymphoma: A case report and literature review.

Rationale: Acute abdominal pain is a prevalent clinical symptom in pediatric patients, primarily attributed to pediatric acute abdomen. However, there are rare exceptional instances where neoplastic diseases may cause acute abdominal pain.

Patient Concerns: The present study encompasses a case of pediatric Burkitt lymphoma wherein acute abdominal pain manifested as the initial symptom, erroneously diagnosed as acute appendicitis.

Effect of surgery on overall survival and cancer-specific survival in patients with primary HCC: A study based on PSM in the SEER cohort.

This study was designed to assess the effects of surgery method on overall survival (OS) and cancer-specific survival (CSS) in patients with hepatocellular carcinoma (HCC). This is a retrospective study. Patients diagnosed with primary HCC (N = 10,174) were identified from the Surveillance, Epidemiology, and End Results Database from 2010 to 2017 and categorized into surgical (N = 4950) and nonsurgical (N = 5224) groups.

One-stage Surgery for Intracardiac Leiomyomatosis.

Introduction: Intracardiac leiomyomatosis is a rare, histologically benign, but biologically aggressive tumor developed from uterus. This study aimed to summarize our experience with one-stage surgery for intracardiac leiomyomatosis.

Methods: We retrospectively reviewed seven patients who underwent surgical treatment for intracardiac leiomyomatosis between May 2016 and November 2021.

Protective effect of Pinacidil on hypoxic-reoxygenated cardiomyocytes in vitro and in vivo via HIF-1α/HRE pathway.

Cardiomyocyte hypoxia-reoxygenation (HR) is considered as a major cause of heart failure. Pinacidil is a classic ATP sensitive potassium channel opener and plays a crucial role in cardiomyocyte HR injuries. However, the specific mechanism is poorly understood.

Optimization Strategies and Efficiency Prediction for Silicon Solar Cells with Hybrid Route of PERC and SHJ Passivation Contact.

PERC solar cell technology, which emerged in the 1980s, has garnered a substantial portion of the PV market over the past decade. However, the main factors limiting their further efficiency advancements and wider commercialization lie in metal contact recombination and the passivation properties of the functional layers. Despite heterojunction cells demonstrating remarkable efficiency, challenges persist in terms of cost reduction and stability enhancement.

Facile Synthesis of Polymeric Nanoprobes for Actively Targeted and High-Performance MR/CT Dual-Modal Imaging of Rheumatoid Arthritis.

This study reports a facile approach for the green synthesis of a high-performance magnetic resonance/computed tomography (MR/CT) dual-modal imaging nanoprobe. The probe, designated as NPs-TCZ, is synthesized via one-step self-assembly of two amphiphilic block copolymers, namely, PEG-DTIPA-TCZ and pal-GGGGHHHHD. The NPs-TCZ exhibits a high longitudinal relaxivity (9.

Photothermal-Therapy-Based Targeting Thrombolytic Therapy.

Thrombosis, a common underlying mechanism of myocardial infarction, ischemic stroke, and venous thromboembolism, is the leading cause of death in patients. Owing to their lack of targeting ability, short half-life, low utilization rate, and high risk of bleeding side effects, the current first-line thrombolytic drugs are unable to meet the requirements for effective treatment of thrombi. Photothermal therapy (PTT) represents a promising thrombolytic modality due to its precise spatiotemporal selectivity and minimal invasiveness.

Knocking out artificially selected gene GmAOC4 improves germination in soybean.

Seed germination is an essential stage in the life cycle of flowering plants, influencing the field emergence rates of seeds. Consequently, the role of GmAOC4 in soybean seed germination was investigated in the present study. Results suggested that the chloroplast-localized GmAOC4 exhibited high expression levels in the roots and young pods and during the seed germination stage in soybeans.

Development of [Ac]Ac‑LNC1011 for targeted alpha-radionuclide therapy of prostate cancer.

Purpose: Prostate-specific membrane antigen (PSMA) radioligand therapy (PRLT) has become a promising option for treating metastatic castration-resistant prostate cancer (mCRPC). Radioligands labelled with the Ga/Lu theranostic pair have been most widely used in the clinic for diagnosis and therapy, respectively. This study aims to develop a novel PSMA-targeted radioligand, LNC1011, radiolabeled with alpha-emitter Ac, to optimise pharmacokinetic properties and assess its potential for targeted alpha therapy (TAT) in prostate cancer treatment.

Carrier-Free Cisplatin-Dactolisib Nanoparticles for Enhanced Synergistic Antitumor Efficacy.

Cisplatin (CDDP) is one of the most commonly used chemotherapeutic agents for solid tumors and hematologic malignancy. However, its therapeutic outcomes have remained unsatisfactory due to severe side effects, a short elimination half-life, the emergence of drug resistance, and the induction of metastasis. Combination with other chemotherapeutic agents has been proposed as one strategy to address the drawbacks of CDDP-based therapy.

A phase I, single-center, randomized, open-label, three-period crossover study to evaluate the drug-drug interaction between ZSP1273 and oseltamivir in healthy Chinese subjects.

ZSP1273 is a novel small-molecule anti-influenza drug that targets the RNA polymerase PB2 subunit, while oseltamivir is the first-line medication that inhibits neuraminidase. ZSP1273 showed high efficacy against human influenza viruses both and , including oseltamivir-resistant strains . In future clinical applications, the combination of these two antiviral drugs with different mechanisms can reduce the potential for antiviral resistance that may arise from monotherapy.

"Food Is Medicine" Strategies for Respiratory Health: Evidence From NHANES 2005-2012.

Objective: Compared with other diseases with similar global burdens, little is known about how lifestyle factors other than smoking affect respiratory health, and few studies have systematically investigated the combined associations between diet and respiratory health. The aim of this research was to examine the Dietary Inflammation Index (DII), Healthy Eating Index (HEI)-2015, and individual food and nutrient associations with multiple respiratory outcomes.

Methods: This study combined a cross-sectional study with a prospective cohort study to systematically evaluate data from adults aged 40 years or older ( = 13,227) from 4 National Health and Nutrition Examination Survey cycles (2005-2006 through 2011-2012) with lung function measures in a subset ( = 6337).

Aberrant DNA Methylation in Esophageal Squamous Cell Carcinoma and its Clinical Implications in Systemic Chemotherapy.

Esophageal cancer is a significant global health concern, with esophageal squamous cell carcinoma being the predominant subtype in high-incidence regions like China. Despite advances in multidisciplinary treatments, the prognosis for ESCC remains poor, with systemic chemotherapy facing the challenge of drug resistance. Epigenetic alterations, particularly DNA methylation, play a crucial role in ESCC carcinogenesis and therapeutic response.

Extracts of and relieve ultraviolet B-induced skin injury in solar dermatitis mice via inhibiting IL-17/CCL2 pathway and oxidative stress.

Solar dermatitis, a condition triggered by excessive exposure to ultraviolet B (UVB) radiation, results in inflammatory skin damage marked by erythema, edema, and epidermal injury. Portulaca oleracea (PO) and Patrinia scabiosaefolia (PS) have been traditionally used in dermatological treatments, though their mechanistic pathways in UVB-induced skin injury are not fully understood. In this study, a mouse model of UVB-induced solar dermatitis was employed to evaluate the therapeutic potential of combined PO and PS (POPS) extracts.

Mechanistic link between long noncoding RNA and stability of oncogene reveals stemness and chemoresistance of hepatocellular carcinoma.

This letter comments on the recently published manuscript by Yu , in which the authors revealed a novel mechanism by which the m6A-modified long noncoding RNA kinesin family member 9-antisense RNA 1 promotes stemness and sorafenib resistance of hepatocellular carcinoma (HCC) through ubiquitin-specific peptidase 1-mediated deubiquitination of oncogene short stature homeobox 2. Given the high mortality rate and poor prognosis of HCC, the findings by Yu open a new avenue for overcoming HCC burden by focusing on kinesin family member 9-antisense RNA 1 and short stature homeobox 2 as prognostic markers and therapeutic targets.

Regenerative therapies for myocardial infarction: exploring the critical role of energy metabolism in achieving cardiac repair.

Cardiovascular diseases are the most lethal diseases worldwide, of which myocardial infarction is the leading cause of death. After myocardial infarction, in order to ensure normal blood supply to the heart, the remaining cardiomyocytes compensate for the loss of cardiomyocytes mainly by working at high capacity rather than by proliferating to produce new cardiomyocytes. This is partly due to the extremely limited ability of the adult heart to repair itself.

Integrative multi-omics and machine learning identify a robust signature for discriminating prognosis and therapeutic targets in bladder cancer.

Bladder cancer (BLCA) is a common malignant tumor whose pathogenesis has not yet been fully elucidated. This study analyzed prognostic genes in BLCA by integrating transcriptomics and proteomics data, and established prognostic models, aiming to offer novel insights for BLCA therapy. Transcriptomic, proteomic, and protein acetylation sequencing were conducted on six BLCA tumor tissues and six paraneoplastic tissue samples.

Piezoelectric biomaterials for providing electrical stimulation in bone tissue engineering: Barium titanate.

With the increasing clinical demand for orthopedic implants, bone tissue engineering based on a variety of bioactive materials has shown promising applications in bone repair. And various physiological cues, such as mechanical, electrical, and magnetic stimulation, can influence cell fate and participate in bone regeneration. Natural bone has a piezoelectric effect due to the non-centrosymmetric nature of collagen, which can aid in cell adhesion, proliferation and differentiation, and bone growth by converting mechanical stimuli into electrical stimuli.

Review of the clinical status of cardiotoxicity of HER-2 positive breast cancer targeted therapeutic drugs.

Breast cancer is a major health challenge for women worldwide, and human epidermal growth factor receptor 2 (HER-2)-positive breast cancers have a relatively high incidence and are highly aggressive. Targeted therapeutic agents, represented by trastuzumab, have been effective in improving the survival rate of HER-2-positive breast cancer patients. However, in clinical applications, this type of targeted drugs exhibits varying degrees of cardiotoxicity, and the mechanism of their cardiotoxicity is currently unclear.

C-reactive protein to serum calcium ratio as a novel biomarker for predicting severity in acute pancreatitis: a retrospective cross-sectional study.

Background: Acute pancreatitis (AP) is a prevalent gastrointestinal emergency with a wide spectrum of clinical outcomes, varying from mild cases to severe forms. The early identification of high-risk patients is essential for improving prognosis. However, the predictive and prognostic potential of the C-reactive protein to serum calcium ratio (CCR) in AP has not been investigated.

[Research Advances in the Roles of High-Altitude Hypoxic Stress in Hepatocellular Carcinoma].

Hepatocellular carcinoma (HCC), one of the most prevalent malignant tumors causing the highest mortality globally, imposes an especially heavy burden of disease in China. Individuals living in high-altitude areas have a lower incidence of and mortality resulting from HCC compared with those in low-altitude regions do, potentially due to adaptive evolution in responses to hypoxic stress. Notably, high-altitude hypoxic stress is associated with the development and progression of HCC.

[Research Progress on Drug Intervention to Inhibit Dental Plaque Biofilm Formation by Based on the Concept of Ecological Prevention of Dental Caries].

Dental caries is the local destruction of hard tooth tissue caused by acidic byproducts generated by cariogenic bacteria, primarily , which ferment free sugars in the presence of host factors, dietary components, and environmental conditions. A main feature of dental caries is the formation of dental plaque biofilm, which significantly improves the resistance of bacteria to drugs and host immunity. Traditional anti-caries drugs mainly exert anti-biofilm functions indirectly through antibacterial activities.

[Current Status and Prospects of Research on Altitude-Related Hypertension].

The high-altitude environment, an extreme kind of geographical environment characterized by low atmospheric pressure and oxygen levels, coupled with low temperatures, may significantly impact on the cardiovascular system and blood pressure regulation. Hypertension, a primary cardiovascular risk factor threatening human health, is influenced by a variety of genetic and environmental factors. A growing body of evidence suggests the prevalence of hypertension is higher in populations living in high-altitude regions than that in populations living at low altitudes.

PX-MDsim: a rapid and efficient platform for large-scale construction of polyamide membranes automated molecular dynamics simulations.

Polyamide (PA) membranes have attracted extensive attention due to their excellent separation performance in water treatment through reverse osmosis and nanofiltration processes. Although numerous molecular simulation studies attempt to explore their advantages from the microstructure, large-scale construction and simulation of PA membranes remain challenging, mainly due to the complexity and computational intensity of cross-linking reactions of polymers in molecular dynamics simulations. This paper introduces an automated platform called PX-MDsim for modeling and simulation of PA membranes.