Case Report: Superior Vena Cava Resection and Reconstruction for Invasive Thyroid Cancer: Report of Three Cases and Literature Review.

Thyroid cancer with massive invasion into the cervical and mediastinal great veins is extremely rare, and the surgical treatment is controversial, thus posing a great challenge for head and neck surgeons. Here, we report our successful experiences in reconstructing the superior vena cava (SVC) system to treat thyroid cancer with an extensive tumor thrombus growing intraluminally into the SVC. From September 2019 to September 2020, three patients with superior vena cava syndrome(SVCS) caused by tumor thrombus invasion from thyroid cancer were continuously included in this series.

Next generation sequencing in children with unexplained epilepsy: A retrospective cohort study.

Objective: To evaluate the clinical utility of next-generation sequencing (NGS) in unexplained pediatric epilepsy, and to identify the potential predictors associated with Mendelian genetic causes.

Methods: Two hundred and ten children with unexplained epilepsy, who underwent NGS test were included. We analyzed the demographic, clinical and genetic characteristics, and executed a Logistic regression analysis for identifying predictors for Mendelian genetic causes.

Plasma Epstein-Barr virus DNA and risk of nasopharyngeal carcinoma in a prospective seropositive population.

Objective: Plasma Epstein-Barr virus (EBV) DNA is considered a biomarker for nasopharyngeal carcinoma (NPC). However, its long-term role in NPC development is unclear.

Materials And Methods: A total of 1363 participants seropositive for EBV VCA-IgA and EBNA1-IgA in a community-based NPC screening program in southern China were tested for plasma EBV DNA levels by real-time qPCR between 2008 and 2015.

Comprehensive analysis of competitive endogenous RNA associated with immune infiltration in lung adenocarcinoma.

To identify the prognostic biomarker of the competitive endogenous RNA (ceRNA) and explore the tumor infiltrating immune cells (TIICs) which might be the potential prognostic factors in lung adenocarcinoma. In addition, we also try to explain the crosstalk between the ceRNA and TIICs to explore the molecular mechanisms involved in lung adenocarcinoma. The transcriptome data of lung adenocarcinoma were obtained from The Cancer Genome Atlas (TCGA) database, and the hypergeometric correlation of the differently expressed miRNA-lncRNA and miRNA-mRNA were analyzed based on the starBase.

Acupuncture Can Play an Antidepressant Role by Regulating the Intestinal Microbes and Neurotransmitters in a Rat Model of Depression.

BACKGROUND Acupuncture, which has many good effects and few adverse effects, is widely recognized as an alternative therapy for depression in clinical practice. This study aimed to explore the mechanism of acupuncture in antidepressant treatment. MATERIAL AND METHODS In this experiment, Sprague-Dawley rats were randomly divided into 4 groups: control, chronic unpredictable mild stress (CUMS), acupuncture, and fluoxetine groups.

Towards better flood risk management: Assessing flood risk and investigating the potential mechanism based on machine learning models.

Integrating powerful machine learning models with flood risk assessment and determining the potential mechanism between risk and the driving factors are crucial for improving flood management. In this study, six machine learning models were utilized for flood risk assessment of the Pearl River Delta, in which the Gradient Boosting Decision Tree (GBDT), eXtreme Gradient Boosting (XGBoost), and Convolutional Neural Network (CNN) models were firstly applied in this field. Twelve indices were chosen and 2000 sample points were created for model training and testing.

Downregulation of Ascl2 promotes cell apoptosis by enhancing autophagy in colorectal cancer cells.

Background: Colorectal cancer (CRC) is the third most common cancer, according to recently published literature. While the incidence and the mortality of CRC has decreased due to effective cancer screening measures, there has been an increase in the number of young patients diagnosed with colon cancer due to unclear reasons. As a target molecule of the Wnt signaling pathway, Ascl2 is an important marker of CRC stem cells and plays an important role in maintaining the nature of colon cancer stem/precursor cells.

LSD1-mediated demethylation of OCT4 safeguards pluripotent stem cells by maintaining the transcription of PORE-motif-containing genes.

Reversible lysine methylation is essential for regulating histones and emerges to critically regulate non-histone proteins as well. Here we show that the master transcription factor OCT4 in pluripotent stem cells (PSCs) was methylated at multiple lysine residues. LSD1 that is highly expressed in PSCs can directly interact with and demethylate OCT4 at lysine 222 (K222) in the flexible linker region.

Clinical application of a multi-groove silicone drain combined with unidirectional negative-pressure drainage system in single-operating-port video-assisted thoracoscopic lung cancer surgery: a comparison study.

Objective: To evaluate the effect of a new negative-pressure drainage system in thoracoscopic lung cancer surgery; thereby, providing a new option for postoperative drainage.

Methods: We retrospectively analyzed data for 200 patients who underwent thoracoscopic surgery between May 2018 and October 2019. According to the thoracic drainage method, the patients were divided into the thoracic tube group and the new system group.

Molecular Epidemiology of Hypervirulent Carbapenemase-Producing .

Objective: To investigate the overall distributions of key virulence genes in , especially the hypervirulent -positive (Hv-(+)-KP).

Methods: A total of 521 complete genomes of from GenBank were collected and analyzed. Multilocus sequence typing, molecular serotyping, antibiotic-resistance, virulence genes and plasmid replicon typing were investigated.

A novel MSC-based immune induction strategy for ABO-incompatible liver transplantation: a phase I/II randomized, open-label, controlled trial.

Background: ABO-incompatible liver transplantation (ABO-i LT) has become a rescue therapeutic option for patients with severe hepatic failure. Although the use of rituximab greatly reduces the morbidity of antibody-mediated rejection (AMR), severe adverse effects, such as infection and biliary complications, still seriously threaten the survival of transplant recipients. The aim of this study was to evaluate the safety and feasibility of using mesenchymal stem cells (MSCs) to replace rituximab in ABO-i LT.

Intrinsic in-plane nodal chain and generalized quaternion charge protected nodal link in photonics.

Nodal lines are degeneracies formed by crossing bands in three-dimensional momentum space. Interestingly, these degenerate lines can chain together via touching points and manifest as nodal chains. These nodal chains are usually embedded in two orthogonal planes and protected by the corresponding mirror symmetries.

Precise Transmission for COVID-19 Information: Based on China's Experience.

Information on coronavirus disease 2019 (COVID-19) has been a significant focus for the global public since the outbreak of the disease. In response, data visualization has become the main form of media used to inform the public about the global pandemic's progress. This paper studies the example of China, the main country affected by the virus in the early stage of the pandemic, to explain the problems regarding the differences in time, knowledge, and technology for information transmission.

Double-layer metalens with a reduced meta-atom aspect ratio.

A dielectric metalens usually has a rather high meta-atom aspect ratio, causing difficulty in fabrication. In this Letter, we develop a kind of metalens constituting two different materials, which can lead to a much lower meta-atom aspect ratio for a full 0-2 phase modulation. The designed metalens is composed of double-layer circular nanopillars, and the pillars are constructed by a polycrystalline silicon layer and a titanium dioxide () layer.

Identification of Contamination in a Ready-to-Eat Meat Processing Plant in China.

is the etiologic agent of listeriosis, which remains a significant public health concern in many countries due to its high case-fatality rate. The constant risk of transmission to consumers remains a central challenge in the food production industry. At present, there is very little known about contamination in ready-to-eat (RTE) processing plants in China.

Iron-based nanoparticles for MR imaging-guided ferroptosis in combination with photodynamic therapy to enhance cancer treatment.

Ferroptosis therapy, which applies ferroptotic inducers to produce lethal lipid peroxidation and induce the death of tumor cells, is regarded as a promising therapeutic strategy for cancer treatment. However, there is still a challenge regarding how to increase reactive oxygen species (ROS) accumulation in the tumor microenvironment (TME) to enhance antitumor efficacy. Herein, we designed a nanosystem coated with the FDA approved poly(lactic-co-glycolic acid) (PLGA) containing ferrous ferric oxide (Fe3O4) and chlorin E6 (Ce6) for synergistic ferroptosis-photodynamic anticancer therapy.

Effects of clinicopathological factors on prognosis of young patients with resected breast cancer.

This study aims to analyze the relationship between clinicopathological characteristics and survival in young patients (≤35 years old) with resected breast cancer.A total of 173 cases were included in this study. The clinicopathological factors potentially associated with prognosis were evaluated.

Lymph node metastasis between the sternocleidomastoid and sternohyoid muscle in papillary thyroid carcinoma patients: A prospective study at multiple centers.

Background: The lymph nodes between the sternocleidomastoid and sternohyoid muscle (LNSS) are not explicitly mentioned in the 2015 American Thyroid Association and 2008 American Head and Neck Society (AHNS) guidelines, but they are easily overlooked in papillary thyroid carcinoma (PTC). We prospectively evaluated the clinical significance of the LNSS in papillary thyroid carcinoma (PTC) patients.

Method: In five medical centers, two hundred and thirty-four PTC patients with lateral neck metastasis who underwent 264 neck dissection were enrolled in this study.

Enhanced treatment of shale gas fracturing waste fluid through plant-microbial synergism.

Cost-efficient and environmentally friendly treatment of hydraulic fracturing effluents is of great significance for the sustainable development of shale gas exploration. We investigated the synergistic effects of plant-microbial treatment of shale gas fracturing waste fluid. The results showed that illumination wavelength and temperature are direct drivers for microbial treatment effects of COD and BOD, while exhibit little effects on nitrogen compounds, TDS, EC, and SS removals as well as microbial species and composition.

Potential Interaction Between SARS-CoV-2 and Thyroid: A Review.

The novel coronavirus disease 2019 (COVID-19) produced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is sweeping the world in a very short time. Although much has been learned about the clinical course, prognostic inflammatory markers, and disease complications of COVID-19, the potential interaction between SARS-CoV-2 and the thyroid is poorly understood. In contrast to SARS-CoV-1, limited available evidence indicates there is no pathological evidence of thyroid injury caused by SARS-CoV-2.

Characterization of the complete chloroplast genome of .

is a kind of wild vegetable with high nutritional value and even a traditional Chinese medicine. Here, we reported the complete chloroplast genome sequence of . The size of the chloroplast genome is 153,376 bp in length, including a large single copy region (LSC) of 82,912 bp, a small single copy region (SSC) of 18,054 bp, and a pair of inverted repeated regions of 26,205 bp.

Idiopathic Hypoparathyroidism With Papillary Thyroid Carcinoma in a Young Male: A Rare Case Report.

Background: Idiopathic hypoparathyroidism (IHP) is a rare disorder that is diagnosed by excluding other possible etiologies. Thyroid surgery causes approximately 14-60% of all cases of hypoparathyroidism; of these, surgery for papillary thyroid carcinoma (PTC) is the most common reason. Here, we report an extremely rare case of IHP combined with PTC.

A Hyperspectral Image Classification Approach Based on Feature Fusion and Multi-Layered Gradient Boosting Decision Trees.

At present, many Deep Neural Network (DNN) methods have been widely used for hyperspectral image classification. Promising classification results have been obtained by utilizing such models. However, due to the complexity and depth of the model, increasing the number of model parameters may lead to an overfitting of the model, especially when training data are insufficient.

Characterization of the complete chloroplast genome of (Amaryllidaceae).

(Amaryllidaceae) is an important vegetable and/or condiment for Tibetans, Indians, and Nepalese in the highlands of the Himalayas. Here, we reported the complete chloroplast genome of using the next-generation sequencing method. The size of the chloroplast genome is 153,509 bp in length, including a large single copy region (LSC) of 82,302 bp, a small single copy region (SSC) of 17,717 bp, and a pair of inverted repeat (IR) regions with 26,745 bp.

Prospective assessment of a nasopharyngeal carcinoma risk score in a population undergoing screening.

Despite evidence suggesting the utility of Epstein-Barr virus (EBV) markers to stratify individuals with respect to nasopharyngeal carcinoma (NPC) risk in NPC high-risk regions, no validated NPC risk prediction model exists. We aimed to validate an EBV-based NPC risk score in an endemic population undergoing screening for NPC. This prospective study was embedded within an ongoing NPC screening trial in southern China initiated in 2008, with 51 235 adult participants.