Publications by authors named "Chen Wanpei"
We explored physiological effects of the sodium-glucose co-transporter-2 inhibitor empagliflozin on intact experimentally hypertrophic murine hearts following transverse aortic constriction (TAC). Postoperative drug (2-6 weeks) challenge resulted in reduced late Na currents, and increased phosphorylated (p-)CaMK-II and Nav1.5 but not total (t)-CaMK-II, and Na/Ca exchanger expression, confirming previous cardiomyocyte-level reports.
View Article and Find Full Text PDFMetabolism is one of the vital functions of cells and living organisms, and the systems to sense and respond to the metabolic alterations play pivotal roles in a plethora of biological processes, including cell proliferative activities, immune cell functions, aging processes, and neuronal functions. Recently, we have reported that a transcriptional cofactor, C-terminal binding protein 2 (CtBP2), serves as a critical metabolite sensor in this context. CtBP2 has a structural pocket called Rossmann fold to accommodate metabolites, and it has been reported to be activated upon binding to NADH/NAD.
View Article and Find Full Text PDFArticle Synopsis
- In the early stages of obesity, insulin secretion increases as a protective measure to keep glucose levels stable, but this can’t last forever, leading to the failure of β cells and the onset of diabetes.
- The protein CtBP2 plays a vital role in regulating insulin gene expression in β cells by interacting with another factor, NEUROD1, which helps to open up chromatin at the insulin gene promoter.
- Reduced levels of CtBP2 in pancreatic islets are observed in both mouse models and humans with obesity, and mice lacking CtBP2 specifically in β cells show glucose intolerance and impaired insulin secretion, indicating its importance in maintaining β cell health and offering potential targets for obesity-related treatments.
Article Synopsis
- Maintaining the balance of metabolism is really important, but too much food can mess it up, especially in obesity.
- Researchers found out how two important proteins, PPARα and CtBP2, interact in a way that can slow down fat processing when there's extra fat in the body.
- In obese people, this interaction gets stronger, making it harder for the body to break down fat, which could lead to new treatments for obesity-related diseases.
Anti-PD-L1 therapy exhibits durable efficacy, but only in a small fraction of cancer patients. The immunosuppressive tumor microenvironment (TME) is a crucial obstacle that impedes cancer immunotherapy. Here, we found that anti-PD-L1 therapy coupled with CD4 T cell depletion induced colorectal tumor regression and vascular normalization, while monotherapy only retarded tumor growth without affecting the tumor vasculature.
View Article and Find Full Text PDFBackground: Dexmedetomidine is a widely used anaesthetic adjuvant for cancer resection surgeries. However, recent reports suggest that it may promote tumour growth or metastasis, so it is essential to clarify its tumour-related effects.
Methods: Seven syngeneic murine tumour models were used to assess the impact of dexmedetomidine on primary tumour growth, spontaneous tumour metastasis, and surgical resection-associated metastasis.