Effects of exercise on sleep quality in women - A systematic review and meta-analysis.

Objectives: Insomnia affects at least one-third of the global population and is more common in women. Exercise has been reported to improve sleep quality and subsequent use of hypnotics. Therefore, we performed a meta-analysis to assess the effect of exercise on sleep quality in adult women.

Osmotic demyelination syndrome: Case report and literature retrospect.

Rationale: Osmotic demyelination syndrome (ODS) is a noninflammatory demyelinating disorder involving the pontis and other regions of the central nervous system. This article tries to enhance the understanding of ODS. Combined with clinical features, we use laboratory/imaging examination and literature review.

Comparison of surgical results and technical performance between robotic and laparoscopic approaches for Kasai portoenterostomy in biliary atresia: a multicenter retrospective study.

Background: Many variables, including age at surgery, disease type, surgical approaches and perioperative management factors have been demonstrated to influence efficacy in BA infants, however, the effect of surgical performance remains unclear. The objective of this retrospective study was to compare the postoperative efficacy and surgical performance of robotic (RKPE) versus laparoscopic Kasai portoenterostomy (LKPE) for BA.

Methods: Between October 2018 and June 2023, 158 type III BA patients undergoing minimally invasive surgery (RKPE = 66, LKPE = 92) were included in this multicenter retrospective study.

Comparison of efficacy and safety between gonioscopy-assisted transluminal trabeculotomy and trabeculectomy for primary open-angle glaucoma treatment: a retrospective cohort study.

Background: Trabeculectomy (TRAB) traditionally has been the gold-standard surgical treatment for primary open-angle glaucoma (POAG), while gonioscopy-assisted transluminal trabeculotomy (GATT) is an emerging minimally invasive surgery used for the treatment of various open-angle glaucoma (OAG) types. In this study, we aimed to compare the efficacy and safety between GATT and TRAB for the treatment of POAG.

Methods: This cohort study included eyes with POAG that underwent a single GATT (30 eyes) or TRAB (34 eyes).

[Research progress and prediction of quality markers of Menispermi Rhizoma].

Menispermi Rhizoma, the dried rhizome of Menispermum dauricum, has anti-tumor, anti-inflammatory, anti-arrhythmic, anti-myocardial ischemia, and anti-cerebral ischemia activities. The primary constituents of this herbal medicine include alkaloids, polysaccharides, and fatty oils. This study predicts and evaluates the quality markers(Q-markers) of Menispermi Rhizoma by considering the phylogenetic relationship of the plant, chemical composition, conventional effects, component measurability, blood constituents, and network pharmacology.

Seasonal hydrological variation impacts nitrogen speciation and enhances bioavailability in plateau lake sediments.

Global warming has intensified the distinction between dry and wet seasons in monsoonal climates. The synergistic effect of high temperatures and rainfall during the wet season promotes the release of endogenous nitrogen (N) and eutrophication within lake ecosystems. However, the seasonal variations in sediments N speciation and bioavailability, and their intrinsic connection to release potential, remain unclear.

A novel dicyanoisophorone-based fluorescent probe for rapid detection of acetylcholinesterase in biological systems.

Acetylcholinesterase (AChE) plays a vital role in various neurological diseases including brain disorders, neurotransmission alterations, and cancer. Developing effective methods to image AChE in biological samples is essential for understanding its mechanisms in biosystems. Here, we introduce a novel fluorescent probe CNA, that enables detection of AChE at 520 nm with rapid response time of 60 s and a detection limit of 0.

aPKC/Par3/Par6 polarity complexes regulate podocyte motility and crescent formation in the progression of ANCA-associated vasculitis.

Objectives: Podocyte bridging may be a key initial event occurring early in crescent formation. This study aims to probe the underlying mechanism of atypical protein kinase C (aPKC)/protease-activated receptor 3(Par3)/Par6 polarity complexes on podocyte motility and crescent formation during the progression of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).

Methods: The effects of anti-TNF-α monoclonal antibody (mAb) on the crescent formation, localization and expression of aPKC/Par3/Par6 polarity complexes, and activities of small GTPases (Rho/Rac1/Cdc42) were explored in an AAV mouse model.

Examining the relationship between weekend catch-up sleep and phenotypic age acceleration: Insights from a cross-sectional study.

Background: Phenotypic age acceleration (PhenoAgeAccel) is a potential aging biomarker. While weekend catch-up sleep (WCS) is commonly practiced to compensate for weekday sleep deficits, its relationship with PhenoAgeAccel remains unclear.

Methods: In this cross-sectional study, we analyzed data from 7,683 participants in the National Health and Nutrition Examination Survey (NHANES).

Development of a machine learning model in prediction of the rapid progression of interstitial lung disease in patients with idiopathic inflammatory myopathy.

Background: Rapidly progressive interstitial lung disease (RP-ILD) significantly impacts the prognosis of patients with idiopathic inflammatory myopathies (IIM). High-resolution computed tomography (HRCT) is a crucial noninvasive technique for evaluating interstitial lung disease (ILD). Utilizing quantitative computed tomography (QCT) enables accurate quantification of disease severity and evaluation of prognosis, thereby serving as a crucial computer-aided diagnostic method.

Study on the mechanism of lactic acid bacteria and their fermentation broth in alleviating hyperuricemia based on metabolomics and gut microbiota.

Introduction: Hyperuricemia (HUA) is a metabolic disease caused by purine metabolism disorders in the body. Lactic acid bacteria (LAB) and their fermentation broth have the potential to alleviate hyperuricemia, but the potential mechanism of action is still unclear.

Methods: The LAB with high inhibitory activity against xanthine oxidase (XOD) were screened out.

Japanese encephalitis virus NS3 captures the protein translation element by interacting with HNRNPH1 to promote viral replication.

Japanese encephalitis caused by Japanese encephalitis virus (JEV) infection leads to the central nervous system disorder in human and swine. Viruses utilize the host protein synthesis mechanisms to efficiently translate their RNAs. Herein, we demonstrated that the host transcription factor SOX10 downregulated an RNA-binding protein heterogeneous nuclear ribonucleoprotein H (HNRNPH1) during JEV infection.

The transcription factor OsNAC25 regulates potassium homeostasis in rice.

Over-application of potassium (K) fertilizer in fields has a negative impact on the environment. Developing rice varieties with high KUE will reduce fertilizer for sustainable agriculture. However, the genetic basis of KUE in a more diverse and inclusive population remains largely unexplored.

Associations of sociodemographic and smoking characteristics with intention to quit among Chinese adults aged 20-69 years who smoke: Findings from nationwide China Health Literacy Survey during 2018-19.

Objective: To identify factors influencing the intention to quit (ItQ) among Chinese who smoke, focusing on 10th Revision of the International Classification of Diseases (ICD-10) Nicotine dependence. Additionally, to estimate the number of individuals with ItQ, supporting optimal allocation of cessation resources.

Methods: This study used data from the 2018 China Health Literacy Survey, a nationally representative cross-sectional study with 20,288 participants who smoke currently aged 20-69 years.

Efficacy of forefoot scrubbing with bristled brush during foot and ankle surgery.

Background: The utility of forefoot cleaning using bristled brush has been proposed by previous studies but has not been tested in any study. The aim of the current study is to investigate the antiseptic efficacy of additional forefoot scrubbing with bristled brush after a standard 2-step preparation with alcohol and chlorhexidine in foot and ankle surgery.

Methods: One hundred patients underwent foot and ankle surgery by one orthopedic surgeon were included and categorized into one of two groups of different skin preparation procedure before surgery.

Modelling indoor radical chemistry during the HOMEChem campaign.

In the indoor environment, occupants are exposed to air pollutants originating from continuous indoor sources and exchange with the outdoor air, with the highest concentration episodes dominated by activities performed indoors such as cooking and cleaning. Here we use the INdoor CHEMical model in Python (INCHEM-Py) constrained by measurements from the House Observations of Microbial and Environmental Chemistry (HOMEChem) campaign, to investigate the impact of a bleach cleaning event and cooking on indoor air chemistry. Measurements of the concentrations of longer-lived organic and inorganic compounds, as well as measured photolysis rates, have been used as input for the model, and the modelled hydroxyl (OH) radicals, hydroperoxyl radicals, and nitrous acid (HONO) concentrations compared to the measured values.

Gut-Microbiota-Derived Butyric Acid Overload Contributes to Ileal Mucosal Barrier Damage in Late Phase of Chronic Unpredictable Mild Stress Mice.

Intestinal mucosal barrier damage is regarded as the critical factor through which chronic unpredictable mild stress (CUMS) leads to a variety of physical and mental health problems. However, the exact mechanism by which CUMS induces intestinal mucosal barrier damage is unclear. In this study, 14, 28, and 42 d CUMS model mice were established.

Comparative Dosing of Adjunctive Corticosteroids Therapy for Pneumonia with ARDS in Non-HIV Immunocompromised Patients.

Background: Adjuvant corticosteroids are effective in patients with human immunodeficiency virus (HIV)-associated pneumonia (PCP) patients, but the effectiveness of adjuvant corticosteroids in non-HIV PCP remained controversial. This study aimed to evaluate the effectiveness of standard-dose compared with low-dose steroids in non-HIV PCP patients with acute respiratory distress syndrome (ARDS).

Methods: This retrospective observational study included non-HIV PCP patients with ARDS admitted to the respiratory intensive care unit (RICU) of Beijing Chao-Yang Hospital from 2015 to 2022.

Bioinformatics analysis reveals potential crosstalk genes and molecular mechanisms between ulcerative colitis and psoriasis.

Ulcerative colitis (UC) and psoriasis are highly correlated clinically; however, it is unclear whether they have a common pathophysiological mechanism. The purpose of this study is to investigate the important molecules and pathways that mediate the coexistence of UC and psoriasis through quantitative bioinformatics analysis of public RNA-sequencing databases. The UC (GSE38713) and psoriasis (GSE30999) datasets were downloaded from the Gene Expression Omnibus database.

Study on the piezoresistivity of Cr-doped VO thin film for MEMS sensor applications.

Cr-doped VO thin film shows a huge resistivity change with controlled epitaxial strain at room temperature as a result of a gradual Mott metal-insulator phase transition with strain. This novel piezoresistive transduction principle makes Cr-doped VO thin film an appealing piezoresistive material. To investigate the piezoresistivity of Cr-doped VO thin film for implementation in MEMS sensor applications, the resistance change of differently orientated Cr-doped VO thin film piezoresistors with external strain change was measured.

Carboxyl-functionalized multifunctional red-emitting carbon quantum dots as an ideal biomaterial.

Carbon quantum dots (CQDs) have been developed into a popular nanomaterial due to their abundant surface state, good biocompatibility, and excellent antimicrobial properties. However, CQDs which combine multiple functions such as red emission, good antibacterial, and excellent pH-sensitive have been rarely reported. In this work, a carboxyl-functionalized red fluorescent CQDS (R-CQDs) with maximum peak at 664 nm and an absolute photoluminescence quantum yield (PLQY) of 28.

Design, synthesis and biological evaluation of new SIRT3 activators for the treatment of triple-negative breast cancer.

Triple-negative breast cancer (TNBC) represents a highly malignant subtype of breast cancer with limited therapeutic options. In this study, we designed and synthesized a series of 1,4-DHP derivatives by structure-based strategy, 43 was documented to be a potent SIRT3 activator and exhibited profound anti-proliferative activity in BT-549 and MDA-MB-231 cells with low toxicity over normal cells. Additionally, 43 displayed the ability of direct binding to SIRT3 with a K value of 51.

One-shot pre-equalization scheme based on frequency pilot tones for bandwidth-limited IM/DD DCI transmission.

O-band intensity modulation and direct detection (IM/DD) transmission offers a promising solution for high-speed data center interconnects (DCIs). Additionally, the introduction of bismuth-doped fiber amplifiers (BDFAs) results in less nonlinear impact and a higher link budget compared with semiconductor optical amplifiers (SOAs). However, with these key issues resolved, the system bandwidth limitation emerges as the next critical bottleneck for high-speed O-band DCI transmission that limits overall performance.