Sequence polymorphisms provide a common consensus sequence for GPR41 and GPR42.

GPR41 and GPR42 are two closely related genes that are part of a cluster of four adjacent G protein-coupled receptors (GPCRs) (GPR40, 41, 42, and 43) localized on human chromosome 19. There are only six nucleotide and amino acid differences between GPR41 and GPR42. High sequence homology between these two genes suggests that they are the result of a recent duplication event.