Publications by authors named "Chen Sichang"

Background: Stereoelectroencephalography (SEEG), as a minimally invasive method that can stably collect intracranial electroencephalographic information over long periods, has increasingly been applied in the diagnosis and treatment of intractable epilepsy in recent years. Over the past 20 years, with the advancement of materials science and computer science, the application scenarios of SEEG have greatly expanded. Bibliometrics, as a method of scientifically analyzing published literature, can summarize the evolutionary process in the SEEG field and offer insights into its future development prospects.

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Objective: Recurrent high-grade gliomas are complicated cancers that require additional treatment options. Magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) is a safe method for treating recurrent high-grade glioma; however, its use in China has not been reported. In this study, we aimed to investigate the safety and efficacy of an MRgLITT system (SinoVision™) developed in China for treating recurrent high-grade glioma.

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Article Synopsis
  • The study aimed to explore abnormalities in the mesial temporal lobe of patients with mesial temporal lobe epilepsy (MTLE) by analyzing seizure-onset patterns identified through stereotactic electroencephalography (SEEG).
  • Fifty-one MTLE patients were divided into two groups (hypersynchronous (HYP) and low-voltage fast (LVF)) and their brain structures were compared to a control group using MRI and F-FDG-PET imaging.
  • Results showed distinct brain changes—LVF patients had amygdala enlargement and contralateral hippocampus hypermetabolism, while HYP patients showed significant hippocampal atrophy linked to worse outcomes; identifying these abnormalities could enhance diagnosis and treatment planning for MTLE
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Article Synopsis
  • The study investigates mesial temporal lobe epilepsy (mTLE) as a complex disorder that disrupts structural connectivity in the brain, using a new method called individual structural covariance network (IDSCN) to analyze these changes.
  • Researchers found significant abnormalities in specific brain regions (like the hippocampus and precentral gyrus) in mTLE patients compared to healthy individuals, with these abnormalities linked to gray matter atrophy.
  • The findings emphasize the importance of the hippo-thalamic-basal-cortical circuits in understanding the changes in brain structure and their relationship with clinical outcomes in mTLE.
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  • Thyroid hormones are vital for the development and functioning of the central nervous system, and there is a need for research on their potential role in epilepsy, a common neurological disorder.
  • A comprehensive analysis using GWAS data from two major consortia assessed the relationship between various thyroid functions and ten types of epilepsy through Mendelian randomization.
  • The results showed no significant causal link between thyroid hormone abnormalities and epilepsy types, as all findings did not pass the statistical significance threshold after correction.
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Rasmussen encephalitis is a rare and unexplained chronic brain hemispheric inflammatory disease. We report a case of epilepsy in which magnetoencephalography showed dipoles localized only in the operculum. Because the patient's clinical presentation and examination findings did not meet the diagnostic criteria for Rasmussen encephalitis, he underwent cortical electroencephalogram (ECoG) record and limited resection surgery.

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Introduction: This study was performed to examine whether there is a link between the application of three types of robot-guided stereotactic biopsy techniques and the diagnostic rate of intracranial lesion biopsy.

Methods: The study involved 407 patients who underwent robot-guided stereotactic intracranial lesion biopsy at Xuanwu Hospital of Capital Medical University from January 2019 to December 2021. Age, sex, lesion characteristics, lesion distribution, surgical method, and target path depth were assessed for their impact on the biopsy diagnostic rate.

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Deep brain regions such as hippocampus, insula, and amygdala are involved in neuropsychiatric disorders, including chronic insomnia and depression. Our recent reports showed that transcranial alternating current stimulation (tACS) with a current of 15 mA and a frequency of 77.5 Hz, delivered through a montage of the forehead and both mastoids was safe and effective in intervening chronic insomnia and depression over 8 weeks.

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Article Synopsis
  • Hypothalamic hamartoma (HH) is a rare brain disorder known for causing gelastic seizures and precocious puberty, with significant changes in diagnosis and treatment over the last 30 years.
  • A bibliometric analysis of 667 documents on HH showed a consistent increase in research, particularly from American institutions like the Barrow Neurological Institute; articles and reviews were the most common types of publications.
  • Research focus has shifted from conditions like Pallister-Hall syndrome to epilepsy and advanced treatment methods, indicating a growing interest and potential for future developments in HH research.
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Objective: To define the pattern of long-term clinical outcomes and prognostic factors in patients with spinal dural arteriovenous fistulas (SDAVFs).

Desgin: Prospective cohort study based on constantly recruiting patients with SDAVFs in two medical centres in China.

Setting: Patients with SDAVFs were recruited consecutively between March 2013 and December 2014 in two referral centres.

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Introduction: In this report, we aim to describe the design for the randomised controlled trial of Stereotactic electroencephalogram (EEG)-guided Radiofrequency Thermocoagulation versus Anterior Temporal Lobectomy for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis (STARTS). Mesial temporal lobe epilepsy (mTLE) is a classical subtype of temporal lobe epilepsy that often requires surgical intervention. Although anterior temporal lobectomy (ATL) remains the most popular treatment for mTLE, accumulating evidence has indicated that ATL can cause tetartanopia and memory impairments.

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Background: A frameless stereotactic robot-assisted system allows stereoelectroencephalography (SEEG) electrodes to span multiple lobes. As the angularity and length are increased, maintaining accuracy of the electrodes becomes more challenging. The goal of this study was to analyze the factors that influence the accuracy of multilobe-spanning SEEG electrodes inserted using a frameless stereotactic robot-assisted system.

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Background: Introducing multiple different stereoelectroencephalography electrodes in a three-dimensional (3D) network to create a 3D-lesioning field or stereo-crossed radiofrequency thermocoagulation (scRF-TC) might create larger lesioning size; however, this has not been quantified to date. This study aimed to quantify the configurations essential for scRF-TC.

Methods: By using polyacrylamide gel (PAG), we investigated the effect of electrode conformation (angled/parallel/multiple edges) and electrode distance of creating an electrode network.

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Study Design: A prospective cohort study.

Objective: We conducted a prospective cohort study to identify the association between steroids and clinical worsening and compare outcomes between patients with and without preoperative steroid administration.

Summary Of Background Data: Patients with spinal dural arteriovenous fistulas (SDAVFs) often were misdiagnosed and treated with steroids which led to acute worsening.

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Rasmussen's encephalitis (RE) is a rare pediatric neurological disorder, and the exact etiology is not clear. Viral infection may be involved in the pathogenesis of RE, but conflicting results have reported. In this study, we evaluated the expression of both Epstein-Barr virus (EBV) and human herpes virus (HHV) 6 antigens in brain sections from 30 patients with RE and 16 control individuals by immunohistochemistry.

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Background: Anatomic hemispherectomy is an effective surgical treatment for patients with hemispherical intractable epilepsy. Different degrees of brain shifting have been observed, but whether these shifts can predict motor function recovery is unknown. The aim of this study was to analyze the correlation between brain shift ratios of different brain areas and motor function before and after surgery.

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Objective: Hemispherectomy has been used successfully for patients with medically intractable epilepsy. However, it is difficult to predict postoperative motor function. The aim of the present study was to analyze whether the preoperative asymmetry of cerebral peduncles could be used to predict motor function restoration before hemispherectomy for young patients with medically intractable epilepsy.

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Background: The short-term outcomes and prognostic factors of patients with spinal dural arteriovenous fistulas (SDAVFs) have not been defined in large cohorts.

Objective: To define the short-term clinical outcomes and prognostic factors in patients with SDAVFs.

Methods: A prospective cohort of 112 patients with SDAVFs were included consecutively in this study.

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Background: Hemispherectomy is useful for treating patients with intractable epilepsy caused by diffuse unilateral hemispheric disease. Few patients develop recurrent seizures after hemispherectomy, but managing epilepsy by medical means alone is challenging for these patients, and it is also difficult to determine the treatment options and assess the need for reoperation.

Objective: To present the treatment strategies and outcomes of patients who developed recurrent intractable epilepsy after initial hemispherectomies that were performed at a single institution by a single surgeon between 2004 and 2014.

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Objective: To describe the surgery outcomes of RE patients in one centerto identify the indication for surgical treatment that results in the most favorable outcome.

Method: Forty-five RE patients from a single center were retrospectively reviewed. Preoperative evaluations included assessments of clinical manifestations, cognitive status, a physical examination, MRI, positron emission tomography (PET), electroencephalography (EEG), and magnetoencephalography (MEG).

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Rasmussen's encephalitis (RE) is a rare and severe progressive epileptic syndrome with unknown etiology. Infection by viruses, including human cytomegalovirus (HCMV), has been speculated to be a potential trigger for RE. However, no viral antigens have been detected in the brains of patients with RE; thus, a possible clinical linkage between viral infections and RE has not been firmly established.

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Spinal dural arterio-venous fistula (SDAVF) is a common type of spinal vascular malformation. Surgical obliteration of the fistula can cure SDAVF anatomically, but the functional outcome is unsatisfactory.The aim of the study was to evaluate the effect of hyperbaric oxygen therapy (HBOT) on the functional recovery of postoperative SDAVF patients.

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Objects: To investigate the expression of human papillomavirus (HPV)-specific antigen in the brain tissue of patients with Rasmussen's Encephalitis (RE) and its possible link to the clinical manifestation of RE.

Methods: The correlation between RE and HPV antigen expression in brain tissue sections was investigated using immunohistochemical (IHC) staining, pathological examination, MRI and clinical manifestations.

Results: HPV antigen expression was elevated in three out of four patients with RE, whereas there were no detectable HPV antigens in six control patients.

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Objectives: Severe symptomatic intracranial stenosis is an important cause of stroke. Intracranial stenting is alternatively applied to treat intracranial atherosclerotic disease. However, Stenting versus Aggressive Medical Therapy for Intracranial Arterial Stenosis trial (SAMMPRIS) and Vitesse Stent Ischemic Therapy trial (VISSIT) both demonstrated intracranial stenting were inferior to aggressive medical treatment.

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