Manganese Dioxides Induce the Transformation and Protection of Dissolved Organic Matter Simultaneously: A Significance of Crystallinity.

Interactions between manganese dioxides (MnO) and dissolved organic matter (DOM) have long been the subject of scientific inquiry. However, the effect of MnO crystallinity on the DOM fate remains unclear. Herein, we comprehensively investigate the adsorption, protection, and mineralization of DOM by MnO with various crystallinities (order of crystallinity: γ-30 < γ-90 < γ-120).

Magnetic field-oriented conductive decellularized extracellular matrix hydrogel synergizes with electrical stimulation to promote spinal cord injury repair and electrophysiological function restoration.

Spinal cord injury (SCI) results in electrophysiological and behavioral dysfunction. Electrical stimulation (ES) is considered to be an effective treatment for mild SCI; however, ES is not applicable to severe SCI due to the disruption of electrical conduction caused by tissue defects. Therefore, the use of conductive materials to fill the defects and restore electrical conduction in the spinal cord is a promising therapeutic strategy.

3D bioprinting of the airways and lungs for applications in tissue engineering and in vitro models.

Tissue engineering and in vitro modeling of the airways and lungs in the respiratory system are of substantial research and clinical importance. In vitro airway and lung models aim to improve treatment options for airway and lung repair and advance respiratory pathophysiological research. The construction of biomimetic native airways and lungs with tissue-specific biological, mechanical, and configurable features remains challenging.

High-Temperature Molecular Ferroelectric [CNH][SbI] with Narrow Bandgap and Switchable Photoelectric Response.

Organic-inorganic hybrid ferroelectrics have attracted considerable attention due to their outstanding piezoelectricity, mechanical flexibility, and robust nonlinear optical properties. But the species with above room-temperature (RT) ferroelectricity, visible-light bandgap, and high photoelectric performance are still scarce. Herein, a novel organic-inorganic hybrid ferroelectric [CNH][SbI] has been synthesized hydrothermally and employed as a light-absorbing layer in organic-inorganic hybrid solar cells.

Analysis of frequency changes in CD8 regulatory T cell subsets in peripheral blood of individuals with type 1 diabetes.

Background: This study aims to examine the alterations and clinical significance of CD8 regulatory T cell subsets in the peripheral blood of individuals with type 1 diabetes mellitus (T1DM).

Methods: From January 2020 to December 2023, a study was conducted involving 40 individuals with T1DM, who visited the Department of Endocrinology at the First Affiliated Hospital of Nanjing Medical University (T1DM group). For comparison, 40 healthy individuals who underwent routine physical examinations at the same hospital during this period were selected as the control group.

Locus-specific differential expression of human satellite sequences in the nuclei of cancer cells and heat-shocked cells.

Human satellitess(HSats) are pericentric, tandemly repeating satellite DNA sequences in the human genome. While silent in normal cells, a subset of HSat2 noncoding RNA is expressed and accumulates in the nucleus of cancer cells. We developed a FISH-based approach for identification of the distribution of three subfamilies of HSat2 (A1, A2, B) sequences on individual human chromosomes.

Interface Degradation of LaCl-Based Solid Electrolytes Coupled with Ultrahigh-Nickel Cathodes.

Despite competitive compatibility with high-nickel cathodes, chloride solid electrolytes (SEs) still experience inevitable side reactions at the cathode/SE interface, causing capacity decay in all-solid-state lithium batteries (ASSLBs) during cycling. Herein, a three-electrode ASSLB testing device is developed to comprehensively reveal the interface failure mechanisms of the ultrahigh-nickel LiNiCoMnO (NCM92) cathode paired with LaCl-based chloride SE LiLaZrTaCl (LLZTC). Distribution of relaxation time (DRT) analysis clearly shows the ASSLB degradation accompanied by a significant NCM92/LLZTC interface impedance increase, which becomes more pronounced at the higher cutoff charging voltage of 4.

Development of a Photoelectrochemical Microelectrode Using an Organic Probe for Monitoring Hydrogen Sulfide in Living Brains.

Hydrogen sulfide (HS) is an important bioactive molecule that plays a significant role in various functions, particularly in the living brain, where it is closely linked to cognition, memory, and several neurological diseases. Consequently, developing effective detection methods for HS is essential for studying brain functions and the underlying mechanisms of these diseases. This study aims to construct a novel photoelectrochemical (PEC) microelectrode Ti/TiO@HSP for the quantitative monitoring of HS levels in the living brain.

Multifunctional hydrogel electronics for closed-loop antiepileptic treatment.

Closed-loop strategies offer advanced therapeutic potential through intelligent disease management. Here, we develop a hydrogel-based, single-component, organic electronic device for closed-loop neurotherapy. Fabricated out of conductive hydrogels, the device consists of a flexible array of microneedle electrodes, each of which can be individually addressed to perform electrical recording and control chemical release with sophisticated spatiotemporal control, thus pioneering a smart antiseizure therapeutic system by combining electrical and pharmacological interventions.

Mendelian randomization analyses support causal relationships between gut microbiome and longevity.

Background: Gut microbiome plays a significant role in longevity, and dysbiosis is indeed one of the hallmarks of aging. However, the causal relationship between gut microbiota and human longevity or aging remains elusive.

Methods: Our study assessed the causal relationships between gut microbiome and longevity using Mendelian Randomization (MR).

Arsenic trioxide versus Realgar-Indigo naturalis formula in non-high-risk acute promyelocytic leukemia: a multicenter, randomized trial.

Realgar-Indigo Naturalis Formula (RIF) is an oral form of arsenic that is effective against acute promyelocytic leukemia (APL). This multicenter, randomized, controlled trial compared the efficacy of all-trans retinoic acid (ATRA) plus RIF with ATRA plus arsenic trioxide (ATO) in a simplified regimen for non-high-risk APL. Following induction therapy with ATRA and ATO, participants were randomly assigned to receive either ATRA plus ATO or ATRA plus RIF both in a 2-week on 2-week off schedule for consolidation therapy.

[Extracorporeal Membrane Oxygenation in Complex Tracheobronchial Surgery: A Series Case Reports and Systematic Review].

Airway management in complex tracheobronchial surgery (TBS) remains a challenge in thoracic surgery. The use of extracorporeal membrane pulmonary oxygenation (ECMO) in thoracic surgery is rather rare, except for lung transplantation. To report the safety and efficacy of ECMO in complex TBS, a total of 5 patients with tracheobronchial and bronchial reconstructive surgery supported by ECMO in the Department of Thoracic Surgery of Tangdu Hospital, Air Force Medical University from May 2019 to June 2024 were collected.

Vehicle effect on in-vitro and in-vivo performance of spray-dried dispersions.

In early drug development, amorphous spray-dried dispersions (SDDs) applied to enhance the bioavailability of poorly water-soluble compounds are typically administered to preclinical species via oral gavage in the form of suspensions. The liquid formulations are usually prepared on the same day of dosing to minimize the exposure of the amorphous material to the aqueous vehicle, thereby reducing the risk of crystallization. Dose-ability (e.

Characteristics, utilization of reproductive health services and AI prediction among Taiwanese adolescent mothers during the COVID-19 pandemic.

Background: Although adolescent birth rates have declined globally, the sexual and reproductive health of adolescent mothers remains an area of specific concern, and these were impacted by the COVID-19 pandemic. This study investigates characteristics, utilization of reproductive health services (RHS) and artificial intelligence (AI) prediction during the pandemic.

Methods: We conducted an exploratory study using data for 2020-2022 from the Taipei City Government Health Bureau.

PRODH Regulates Tamoxifen Resistance through Ferroptosis in Breast Cancer Cells.

Background: Estrogen receptor-positive breast cancer accounts for around 70% of all cases. Tamoxifen, an anti-estrogenic inhibitor, is the primary drug used for this type of breast cancer treatment. However, tamoxifen resistance is a major challenge in clinics.

A minimally invasive biomarker for sensitive and accurate diagnosis of Parkinson's disease.

Seeding activities of disease-associated α-synuclein aggregates (αSyn), a hallmark of Parkinson's disease (PD), are detectable by seed amplification assay (αSyn-SAA) and being developed as a diagnostic biomarker for PD. Sensitive and accurate αSyn-SAA for blood or saliva would greatly facilitate PD diagnosis. This prospective diagnostic study conducted αSyn-SAA analyses on serum and saliva samples collected from patients clinically diagnosed with PD or healthy controls (HC).

Switchable Photovoltaic Effect and Robust Nonlinear Optical Response in a High-Temperature Molecular Ferroelectric [CNH][PbI].

Hybrid organic-inorganic molecular ferroelectrics (HOIMFs) have garnered significant attention for their potential applications in nonvolatile memory and spintronic devices. However, few efforts have been devoted to the photoelectric properties of lead halide molecular ferroelectrics, despite the fact that robust ferroelectricity and flexibility are desirable for thin-film photoelectric devices. Herein, we present a novel lead halide molecular ferroelectric [CNH][PbI] () synthesized hydrothermally.