Pathway Elucidation and Key Enzymatic Processes in the Biodegradation of Difenoconazole by A-3.

The extensive agricultural use of the fungicide difenoconazole (DIF) and its associated toxicity increasingly damage ecosystems and human health. Thus, an urgent need is to develop environmentally friendly technological approaches capable of effectively removing DIF residues. In this study, strain A-3 was isolated for the first time which can degrade DIF efficiently.

Uncovering glycolysis-driven molecular subtypes in diabetic nephropathy: a WGCNA and machine learning approach for diagnostic precision.

Introduction: Diabetic nephropathy (DN) is a common diabetes-related complication with unclear underlying pathological mechanisms. Although recent studies have linked glycolysis to various pathological states, its role in DN remains largely underexplored.

Methods: In this study, the expression patterns of glycolysis-related genes (GRGs) were first analyzed using the GSE30122, GSE30528, and GSE96804  datasets, followed by an evaluation of the immune landscape in DN.

Preparation of sulfur-doped porous carbon from polyphenylene sulfide waste for photothermal conversion materials to achieve solar-driven water evaporation.

In recent years, solar-driven photothermal water evaporation technology for seawater desalination and wastewater treatment has developed rapidly, which is of great significance for addressing the issue of freshwater scarcity. However, due to the high costs associated with the manufacturing, maintenance, and operation of such devices, their application remains challenging in remote and resource-scarce regions. Due to its excellent light absorption capability in the near-infrared region, high hydrophilicity, and stable chemical properties, coupled with the low cost of recycling waste carbonized polyphenylene sulfide, this material is an excellent choice as a photothermal material for solar-driven water evaporation devices.

The heart rate on admission was associated with the mortality in elderly patients with hip fractures: a retrospective cohort study from a trauma centre in northwestern China.

Objectives: To evaluate the association between heart rate on admission and mortality in elderly patients with hip fractures.

Design: A retrospective cohort study.

Setting: At a trauma centre in northwestern China.

Prospects for the development of medical professionalism education in the AI perspective: A qualitative study of Chinese postgraduate medical students' written reflections.

Introduction: Medical professionalism education is of paramount importance to the development of medical careers and medical students. Currently, there is a need for more research in China on the integration of artificial intelligence (AI) and medical professionalism education.

Methods: For this study, we collected 44 written reflections from first-year postgraduate students of clinical medicine in China during the spring semester of 2024 on the prospect of applying AI in conjunction with medical professionalism education.

Coordination Equilibrium-Assisted Coprecipitation Synthesis of Atomically Dispersed 3d Metal Catalysts.

As a frontier of heterogeneous catalysis, single-atom catalysts (SACs) have been extensively studied fundamentally. One obstacle that limits the industrial application of SACs is the lack of a synthetic method that can prepare the catalysts on a large scale. Wet-chemistry methods that are conventionally used to prepare nanoparticle-based industrial catalysts might be a solution.

Unraveling the degradation mechanism of multiple pyrethroid insecticides by Pseudomonas aeruginosa and its environmental bioremediation potential.

Extensive use of pyrethroid insecticides poses significant risks to both ecological ecosystems and human beings. Herein, Pseudomonas aeruginosa PAO1 exhibited exceptional degradation capabilities towards a range of pyrethroid family insecticides including etofenprox, bifenthrin, tetramethrin, D-cypermethrin, allethrin, and permethrin, with a degradation efficiency reaching over 84 % within 36 h (50 mg·L). Strain PAO1 demonstrated effective soil bioremediation by removing etofenprox across different concentrations (25-100 mg·kg), with a degradation efficiency over 77 % within 15 days.

Significant differences in knee kinematics of healthy subjects with high and low anterior tibial laxity.

Background: Anterior tibial laxity is considered to be a risk factor for knee injuries, including anterior cruciate ligament ruptures. The anterior cruciate ligament reconstruction also aims to restore anterior tibial laxity. While anterior tibial laxity is considered to be linked to dynamic knee stability, the mechanisms connecting anterior tibial laxity to these stability issues are not fully understood.

U-Shaped Relationship Between MSpO Levels and the Incidence of Frailty in Elderly OSA Patients: Findings from a Multicenter Cohort Study.

Background: Previous studies have demonstrated a significant correlation between obstructive sleep apnea (OSA) and frailty. However, the association of mean pulse oxygen saturation (MSpO) with frailty among OSA patients remains unconfirmed. This study aimed to explore this potential association using data from a multicenter, prospective cohort.

Declining Influenza Vaccination Uptake, Attitudes, and Knowledge Among Healthcare Workers in Chengdu, China, in the Post-COVID-19 Era.

Purpose: Despite the benefits of influenza vaccination, particularly for healthcare workers (HCWs) at higher risk, vaccination coverage among HCWs in China remains low. This study aims to provide updated insights into the knowledge, attitudes, practices, and barriers related to influenza vaccination among HCWs in China post-COVID-19 era, to inform strategies for improving vaccination rates and healthcare safety.

Methods: A cross-sectional survey was conducted between December 2023 and January 2024 at two tertiary hospitals in Chengdu, China.

The mediating effect of psychosomatic symptoms between physical activity and cognitive function among breast cancer patients: A path analysis.

Purpose: Psychosomatic symptoms are frequently observed side effects in breast cancer (BC) patients and significantly influence cognitive function. However, limited research has addressed the role of psychosomatic symptoms in the relationship between physical activity and cognitive function. This study aimed to examine the mediating effect of psychosomatic symptoms on the relationship between physical activity and cognitive function in BC patients.

Inhibition of TOX exerts anti-tumor effects in acute myeloid leukemia by upregulating IRF7 expression.

Thymocyte selection-associated high mobility group box protein (TOX) is regarded as a crucial transcription factor involved in T cell exhaustion in acute myeloid leukemia (AML). Previous studies have identified aberrant TOX expression as a major oncogenic driver in hematologic malignancies, indicating that TOX may potentially be both an immune biomarker and an immunotherapy target. However, due to heterogeneity in the distribution patterns of TOX and its correlation with clinical prognosis, the mechanism underlying TOX-mediated tumor immune responses remains unclear.

Multi-omics insights implicate the remodeling of the intestinal structure and microbiome in aging.

Background: Aging can impair the ability of elderly individuals to fight infections and trigger persistent systemic inflammation, a condition known as inflammaging. However, the mechanisms underlying the development of inflammaging remain unknown.

Methods: We conducted 16S rRNA sequencing of intestinal contents from young and old C57BL/6J mice to elucidate changes in gut microbiota diversity and microbial community composition after aging.

Biopolymeric Ionotronics Based on Biodegradable Wool Keratin.

The advent of ionotronics has revealed significant potential in flexible transistors, energy harvesting, and unconventional circuits. However, most ionotronic devices, often centered around synthetic polymers, involve complex grafting or synthesis that raise legitimate concerns about their environmental sustainability. Herein, a simple yet versatile approach for developing single-composition ionotronic devices using wool keratin (WK), a biodegradable and pH-responsive natural polymer is presented.

Greater environmental risk of shale gas produced water from lacustrine than marine sources in Fuling shale gas field, China: Insights from inorganic compounds, dissolved organic matter, and halogenated organic compounds.

Lacustrine shale gas represents a promising frontier in the future development of shale gas resources. However, research on the characterization of lacustrine shale gas produced water (SGPW) remains scarce. In this study, we characterized the geochemical properties of both marine and lacustrine SGPW (MSGPW and LSGPW) and assessed their dissolved organic matter (DOM) components using fluorescence EEM spectroscopy.

Dual isotope labelling combined with multi-omics analysis revealing the NO source evolution in aerobic biological systems driven by salinity gradient.

Salinity is considered a major factor influencing nitrous oxide (NO) emissions from biochemical treatment of high-salinity wastewater, but its mechanism has not been thoroughly investigated. In this study, we investigated the effects of salinity on NO emissions under aerobic conditions. As salinity rose from 0.

[High stability enhanced ultrasonic microfluidic structure with flexible tip coupled bubbles].

Ultrasonic microfluidic technology is a technique that couples high-frequency ultrasonic excitation to microfluidic chips. To improve the issues of poor disturbance effects with flexible tip structures and the susceptibility of bubbles to thermal deformation, we propose an enhanced ultrasonic microchannel structure that couples flexible tips with bubbles aiming to improve the disturbance effects and the stability duration. Firstly, we used finite element analysis to simulate the flow field distribution characteristics of the flexible tip, the bubble, and the coupling structure and obtained the steady-state distribution characteristics of the velocity field.

Metatranscriptomics provides an in-depth perspective on the resistance and detoxification of anammox bacteria to dissolved oxygen in a pilot CANON process.

In the completely autotrophic nitrogen removal over nitrite (CANON) process, the conflicting oxygen requirements of anammox and ammonium-oxidizing bacteria often lead to retardation in anammox activity. However, our study achieved stable nitrogen removal with a maximum capacity of 1096 g-N/m/d in a 20 m CANON reactor under long-term intensive aeration. The anammox bacteria unusually distributed in the outer layer of the biofilm and demonstrated remarkable oxygen tolerance.