A Predictive Nomogram for Postoperative Hydrocephalus After Intra- and Paraventricular Tumor Resection: A Retrospective Study of 196 Patients.

Background: Hydrocephalus is a common complication of intra- and paraventricular tumors both before and after tumor resection. We investigated the risk factors for postoperative hydrocephalus and established a predictive nomogram to improve surgical planning and adjust the frequency of postoperative clinical and radiographic monitoring.

Methods: A retrospective study of 196 intra- and paraventricular tumor patients with follow-up data was conducted to investigate the risk factors for postoperative hydrocephalus via univariate and multivariate Cox regression analyses.

A pyroptosis-related signature predicts prognosis and indicates immune microenvironment infiltration in glioma.

Background: Glioma, the most common malignant brain tumor, leads to high recurrence rates and disabilities in patients. Pyroptosis is an inflammasomes-induced programmed cell death in response to infection or chemotherapy. However, the role of pyroptosis in glioma has not yet been elucidated.

The Hyperbranched Polyester Reinforced Unsaturated Polyester Resin.

We report a method of reinforcing and toughening unsaturated polyester resin (UPR) with a kind of hyperbranched polyester (HBP-1). Polyethylene glycol with different molecular weight was used as the core molecule of the preparation reaction, and the reaction product of phthalic anhydride and glycerol was used as the branching unit. The esterification reaction of polycondensation occurred, and then the hydroxyl-terminated hyperbranched polyester was prepared.

Identification of Tumor Antigens and Immune Subtypes of Glioblastoma for mRNA Vaccine Development.

The use of vaccines for cancer therapy is a promising immunotherapeutic strategy that has been shown to be effective against various cancers. Vaccines directly target tumors but their efficacy against glioblastoma multiforme (GBM) remains unclear. Immunotyping that classifies tumor samples is considered to be a biomarker for immunotherapy.

A CNN based Handwritten Numeral Recognition Model for Four Arithmetic Operations.

The pandemic of Covid-19 has caused a shift of paradigm of education, from face-to-face to e-learning. E-learning leads to an escalation in digitalization of handwritten documents because it requires submission of homework and assignments through online. To help teachers in checking digitalized handwritten homework, this paper proposes an automatic checking system based on a convolutional neural network (CNN) for handwritten numeral recognition.

An integrated analysis of enhancer RNAs in glioma and a validation of their prognostic values.

Glioma, a highly aggressive neuroepithelial malignant brain tumor, is associated with high disability and recurrence rates. Enhancer RNA (eRNA) plays a significant role in tumor proliferation and metastasis; however, their functions in gliomas need further evaluation. We used the computational pipeline, PreSTIGE, to predict tissue-specific enhancer-derived RNAs and the underlying regulatory genes.

Identification of as the Key Gene Associated with Antivascular Endothelial Growth Factor Therapy in Glioblastoma Multiforme.

Vascular endothelial growth factors (VEGFs) are important for glioblastoma multiforme (GBM) growth and development. However, the effects of VEGF-targeting drugs in primary GBM remain poorly understood. We aimed to explore the key genes correlated with VEGF expression and prognosis and elucidate their potential implications in GBM anti-VEGF therapy.

Validation of the functions and prognostic values of synapse-associated proteins in lower-grade glioma.

Synapse and synapse-associated proteins (SAPs) play critical roles in various neurodegeneration diseases and brain tumors. However, in lower-grade gliomas (LGG), SAPs have not been explored systematically. Herein, we are going to explore SAPs expression profile and its clinicopathological significance in LGG which can offer new insights to glioma therapy.

An Elevated HbA1c Level Is Associated With Short-Term Adverse Outcomes in Patients With Gastrointestinal Cancer and Type 2 Diabetes Mellitus.

Background: Although an elevated hemoglobin A1c (HbAc1) level is an independent predictor of worse survival in patients with both digestive cancer and diabetes mellitus, its relationship to short-term prognosis in these patients has not been addressed. This study assessed this relationship in gastrointestinal cancer (GIC) patients with type 2 diabetes mellitus (T2DM).

Methods: A retrospective review of patients with GIC with or without T2DM from 2004 to 2014 was performed.