[Expression and Clinical Significance of Co-inhibitory Molecules TIGIT/CD155 and PD-1 in Chronic Lymphocytic Leukemia].

Objective: To investigate the expression of co-inhibitory molecules TIGIT/CD155 and PD-1 on CD4T cells and Treg cells in peripheral blood of patients with chronic lymphocytic leukemia (CLL) and analyze their clinical significance.

Methods: The expression of PD-1 and TIGIT on CD4T cells and Treg cells was detected by flow cytometry in 40 CLL patients and 20 healthy controls. Additionally, the expression of CD155 on peripheral blood B cells and DC cells of the enrolled subjects was detected.

Constructing a Dielectric Fluorinated Solid Electrolyte for Practically Operated All-Solid-State Lithium-Metal Batteries.

The operation of all-solid-state lithium-metal batteries is primarily constrained by an inferior solid electrolyte. Here, we employ a porous dielectric fluorinated electrolyte to encapsulate a Li complex, achieving rapid and stable ion conduction throughout cycling. The electrolyte comprises a porous nanofiber (NF) skeleton made of dielectric fluorinated BaTiO (F-BaTiO) and all-trans block copolymer PVDF--PTFE, with an encapsulated poly(ethylene oxide) (PEO)-LiTFSI filler.

High-resolution and high-fidelity diffusion tensor imaging of cervical spinal cord using 3D reduced-FOV multiplexed sensitivity encoding (3D-rFOV-MUSE).

Purpose: To develop a 3D isotropic high-resolution and high-fidelity cervical spinal cord DTI technique for addressing the current challenges existing in 2D cervical spinal cord DTI.

Methods: A 3D multi-shot DWI acquisition and reconstruction technique was developed by combining 3D multiplexed sensitivity encoding (3D-MUSE) with two reduced FOV techniques, termed 3D-rFOV-MUSE, to acquire 3D cervical spinal cord DTI data using a sagittal thin slab. A self-referenced 2D ghost correction method and a 2D navigator-based inter-shot phase correction were integrated into the reconstruction framework to simultaneously eliminate Nyquist ghost and aliasing artifacts.

BIN1 inhibited tumor growth, metastasis and stemness by ALDH1/NOTCH pathway in bladder carcinoma.

Background: Bladder cancer (BLCA) represents one of the most prevalent urological malignancies worldwide. Bridging integrator 1 (BIN1), a well-characterized tumor suppressor that interacts with and inhibits oncogenic Myc transcription factors, has demonstrated crucial roles in various cancer types. However, its specific functions and underlying molecular mechanisms in BLCA development and progression remain poorly understood.

Single-port robot-assisted pyeloplasty versus multiport pyeloplasty: evidence from controlled trials.

This study evaluates and compares the results of single-port (SP-RAP) versus multi-port robot-assisted laparoscopic pyeloplasty (MP-RAP) for the treatment of ureteropelvic junction obstruction (UPJO). A systematic review and meta-analysis were conducted following PRISMA guidelines. Studies comparing SP-RAP and MP-RAP for UPJO treatment were identified from PubMed, Web of Science, and Cochrane Library databases.

CRISPR/Cas9-mediated editing of the melanization gene ebony in the 28-spotted ladybeetle, Henosepilachna vigintioctopunctata.

The melanization process, which is essential for the proper functioning of the cuticle, has been extensively investigated for its enzymatic roles and physiological effects. Henosepilachna vigintioctopunctata, a significant pest species, presents considerable economic threats. However, due to the variable efficiency of RNA interference for genetic manipulation, establishing a CRISPR/Cas9 system is crucial for providing a more precise and reliable method for functional genomics in this non-model insect.

Proteomics and phosphoproteomics analysis of acute pancreatitis alleviated by forsythoside B.

Acute pancreatitis (AP) is a common acute abdominal condition in clinical practice, associated with high morbidity and mortality rates. Forsythia constitutes a component of traditional Chinese medicinal decoctions used for clinical AP treatment; however, the efficacy of its active monomer in treating AP has yet to be completely substantiated. Here, we engineered an AP cell and mouse model by administering a combination of caerulein and LPS.

Identification of marine microplastics by a combined method of principal component analysis and random forest for fluorescence spectrum processing.

The severely overlapped laser-induced fluorescence spectra between different microplastics pose significant challenges on fluorescence-based particle identification and quantification. To address this problem, this paper proposes a combined method of principal component analysis (PCA) and random forest (RF) for fluorescence spectrum processing. The key idea is to identify the overlapped PCA scores of the first three principal components of fluorescence spectra by the random forest method.

PDE4D inhibition ameliorates cardiac hypertrophy and heart failure by activating mitophagy.

Cyclic adenosine monophosphate (cAMP) plays a major role in normal and pathologic signaling in the heart. Phosphodiesterase 4 (PDE4) is a major PDE degrading cAMP in the heart. There are inconsistencies concerning the roles of the PDE4 isoforms 4B and 4D in regulation of cardiac function.

Recent advances in transition metal-mediated/ catalyzed radiofluorination of arenes and heteroarenes for positron emission tomography.

Positron emission tomography (PET) imaging endows the possibility of precise diagnosis and effective treatment of diseases. Aromatic (hetero)cycle is one of the most fundamental groups in pharmaceuticals as well as in the development of PET tracers. In particular, incorporation of F to aromatic (hetero)cycles has accelerated the progress of nuclear medicine tracers.

Integrated Headband for Monitoring Chloride Anions in Sweat Using Developed Flexible Patches.

Flexible wearable potentiometric ion sensors for continuous monitoring of electrolyte cations have made significant advances in bioanalysis for personal healthcare and diagnostics. However, less attention is paid to the most abundant extracellular anion, chloride ion (Cl) as a mark of electrolyte imbalance and an important diagnostic indicator of cystic fibrosis, which has important significance for accurate monitoring in complex biological fluids. An all-solid-state Cl-selective electrode is constructed utilizing oxygen vacancies reinforced vanadium oxide with a nitrogen-doped carbon shield as the solid contact (VO@NC/Cl-ISE).

The connection between depression and frailty among older adults with obstructive sleep apnea: results from a multicenter cohort study.

Background: The rising rates of obstructive sleep apnea (OSA) and frailty among older adults are linked to higher mortality rates. Depression merges as a critical determinant associated with both OSA and frailty. This study investigates the impact of depression on the risk of developing frailty in older adults diagnosed with OSA.

DDX5 Alleviates Temporomandibular Joint Osteoarthritis via TNF-Induced NF-κB Signaling Pathway.

Background: Temporomandibular joint osteoarthritis (TMJOA) is a prevalent musculoskeletal condition characterized by pain, cartilage degeneration, and subchondral bone loss.

Objective: This study sought to identify specific targets for the treatment of TMJOA.

Method: Through high-throughput RNA-seq analysis in condylar chondrocytes (NC vs.

Visible-Light-Induced Sulfonylation Cyclization to Generate Indole-Fused Medium-Sized -Heterocycles in 2-Me-THF.

A novel visible-light-induced sulfonylation cyclization to indole-fused medium-sized -heterocycles was established under room temperature with biomass-derived 2-Me-THF as the solvent. This reaction proceeds in the absence of external photocatalyst, additive, metal salts, and base. Broad substrate scope, good functional group compatibility, and large-scale synthesis and derivatization via iodination, nitration, chlorination, cyanation, and selenylation demonstrate the utility of this protocol.

Factors influencing premature ovarian insufficiency: a systematic review and meta-analysis.

Background: Premature ovarian insufficiency (POI) has multiple contributing factors. This study aims to systematically evaluate these factors and their mechanisms, identify high-risk groups, support early intervention, and provide a basis for future research.

Methods: Following the PRISMA guidelines, a search was conducted across 11 Chinese and English databases, including PubMed, Embase, and the Cochrane Library, up to January 2024.

Size-Dependent, Topology-Regulated, pH-Change-Tolerable, and Reversible Self-Assembly of Ultrasmall Nanoparticles.

The multiscale ordering of colloidal nanoparticles (NPs) endows materials with diverse functions and performances. The controllable and predictable assembly of NPs is essential for the new generation of materials science. This study presents a topology-regulated self-assembly approach in an aqueous environment, utilizing polysorbate 20 (Tween-20) and ultrasmall gold nanoparticles (2, 4, and 8 nm AuNPs).

The role of artificial intelligence in aortic valve stenosis: a bibliometric analysis.

Purpose: To explore the expanding role of artificial intelligence (AI) in managing aortic valve stenosis (AVS) by bibliometric analysis to identify research trends, key contributors, and the impact of AI on enhancing diagnostic and therapeutic strategies for AVS.

Methods: A comprehensive literature review was conducted using the Web of Science database, covering publications from January 1990 to March 2024. Articles were analyzed with bibliometric tools such as CiteSpace and VOSviewer to identify key research trends, core authors, institutions, and research hotspots in AI applications for AVS.

Correlation between lipid metabolism levels and pregnancy outcomes.

Objective: To establish the reference interval for the serum lipid index in pregnant women and to explore the relationship between lipid metabolism levels and pregnancy outcomes.

Design And Methods: Data were derived from 446 pregnancy women and 317 healthy non-pregnant women. Serum levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), lipoprotein (a) [Lp(a)], and hypersensitive C-reactive protein (hs-CRP) were measured in both groups.

Sequential administration of efgartigimod shortened the course of Guillain-Barré syndrome: a case series.

Guillain-Barré syndrome (GBS) is a serious neurological condition with limited treatment options. A recent report demonstrated successful treatment with efgartigimod alone in two patients with GBS, although it did not significantly shorten the disease duration. This case series investigates the effects of sequential efgartigimod administration in patients with different GBS phenotypes and varying levels of disease severity.

Glymphatic system: a self-purification circulation in brain.

The glymphatic system theory introduces a new perspective on fluid flow and homeostasis in the brain. Here, cerebrospinal fluid and interstitial fluid (CSF-ISF) moves from the perivascular spaces (PVS) of arteries to those of veins for drainage. Aquaporin-4 (AQP4) plays a crucial role in driving fluid within the PVS.

2D Metastable-Phase Hafnium Oxide Triggers Hydrogen Spillover for Boosting Hydrogen Production.

Hydrogen (H) manipulation plays a significantly important role in many important applications, in which the occurrence of hydrogen spillover generally shows substrate-dependent behavior. It therefore remains an open question about how to trigger the hydrogen spillover on the substrates that are generally hydrogen spillover forbidden. Here a new metastable-phase 2D edge-sharing oxide: six-hexagonal phase-hafnium oxide (Hex-HfO, space group: P6mc (186)) with the coordination number of six is demonstrated, which serves as an ideal platform for activating efficient hydrogen spillover after loading Ru nanoclusters (Ru/Hex-HfO).

Advanced 3D Food Printing with Simultaneous Cooking and Generative AI Design.

3D food printing is an indispensable technology for emerging food technologies. However, conventional nonconcurrent postprocessing methods limit the final food quality, including the unappealing nature of food ink modification, imperfections in retaining the desired food shape, and the risk of microbial contamination. Here, an artificial intelligence (AI)-enhanced solution is developed to achieve extrusion-based printing with simultaneous infrared heating, enabling in-line and rapid cooking of complex starch-based food.

Compensating K Ions Through an Organic Salt in Electrolytes for Practical K-Ion Batteries.

K-ion batteries face significant challenges due to a severe shortage of active K ions, with cathode materials typically containing less than 70% K ions and first-cycle irreversible reactions consuming up to 20% more. Conventional K-ion compensation methods fail to supply sufficient K ions without compromising cell integrity. To address this, we introduce potassium sulfocyanate (KSCN) as an electrolyte additive capable of delivering up to 100% active K ions.

Effects of a perioperative support program on reducing psychological distress for family caregivers of patients with early-stage lung cancer: a pilot randomised controlled trial.

Background: For family caregivers, lung cancer surgery is an episodic and stressful event. Some family caregivers frequently lack the necessary skills for their roles, and they may experience psychological distress, which reduce their own quality of life whilst affecting the health outcomes of patients. However, research on perioperative support programs that focus on caregivers of patients with early-stage lung cancer is limited.

Psychophysiological effects of music on sadness in participants with and without depressive symptoms.

Background: Sadness can be a harbinger of serious medical conditions and a primary manifestation of depressive symptoms. Music is a promising modality for regulating sadness, although its effect on participants, whether with or without long-term depressive symptoms, remains unknown. In this study, the effect of music on sadness regulation was investigated using psychological and physiological indicators between depressed and non-depressed individuals.