PPI-CoAttNet: A Web Server for Protein-Protein Interaction Tasks Using a Coattention Model.

Predicting protein-protein interactions (PPIs) is crucial for advancing drug discovery. Despite the proposal of numerous advanced computational methods, these approaches often suffer from poor usability for biologists and lack generalization. In this study, we designed a deep learning model based on a coattention mechanism that was capable of both PPI and site prediction and used this model as the foundation for PPI-CoAttNet, a user-friendly, multifunctional web server for PPI prediction.

Comparative study on the reaction mechanism of 5-hydroxymethyl furfural on Pd(111) and Cu(111).

Context: In this work, a comparative study on the catalytic conversion of 5-hydroxymethyl furfural (HMF) to 2,5-bis(hydroxymethyl)furan (BHMF) on precious Pd(111) and nonprecious Cu(111) was systematically performed. On the basis of the calculated activation energy (E) and reaction energy (E), the optimal energy path for the hydrogenation of HMF (F-CHO) into BHMF (F-CHOH) on Pd(111) is as follows: F-CHO + 2H → F-CHOH + H → F-CHOH; the minimum reaction path on Cu(111) is F-CHO + 2H → F-CHO + H → F-CHOH. On Cu(111), the formation of F-CHOH from F-CHO hydrogenation is the rate-determining step because it has the highest reaction energy barrier and the smallest rate constant.

Purification and Value-Added Conversion of NO under Ambient Conditions with Photo-/Electrocatalysis Technology.

As primary air pollutants from fossil fuel combustion, the excess emission of nitric oxides (NO) results in a series of atmospheric environmental issues. Although the selective catalytic reduction technology has been confirmed to be effective for NO removal, green purification and value-added conversion of NO under ambient conditions are still facing great challenges, especially for nitrogen resource recovery. To address that, photo-/electrocatalysis technology offers sustainable routes for efficient NO purification and upcycling under ambient temperature and pressure, which has received considerable attention from scientific communities.

Research progress on digestive disorders following traumatic brain injury.

Traumatic brain injury (TBI) is a prevalent disease that poses a significant threat to global public health. Digestive dysfunction, as a common complication, is of particular importance to understand its pathogenesis, diagnostic criteria, and relevant treatment strategies. TBI can affect digestive function through inflammatory immune responses, the enteric nervous system, and hormonal levels.

Deriving Membrane-Water and Protein-Water Partition Coefficients from In Vitro Experiments for Per- and Polyfluoroalkyl Substances (PFAS).

The phospholipid membrane-water partition coefficients () and equilibrium binding affinities for human serum albumin (HSA) of 60 structurally diverse perfluoroalkyl and polyfluoroalkyl substances (PFAS) were evaluated through laboratory measurements and modeling to enhance our understanding of PFAS distribution in organisms. Per- and polyfluoroalkyl carboxylic acids exhibited a 0.36 ± 0.

Nonenzymatic lysine D-lactylation induced by glyoxalase II substrate SLG dampens inflammatory immune responses.

Immunometabolism is critical in the regulation of immunity and inflammation; however, the mechanism of preventing aberrant activation-induced immunopathology remains largely unclear. Here, we report that glyoxalase II (GLO2) in the glycolysis branching pathway is specifically downregulated by NF-κB signaling during innate immune activation via tristetraprolin (TTP)-mediated mRNA decay. As a result, its substrate S-D-lactoylglutathione (SLG) accumulates in the cytosol and directly induces D-lactyllysine modification of proteins.

[Annual research progress in chronic obstructive pulmonary disease 2024].

Chronic obstructive pulmonary disease (COPD) is a major global public health problem and the burden of disease is estimated to continue to increase. Since 2023, significant progress has been achieved in the early identification, pathogenesis, biomarkers, and personalized treatment of COPD. Early-stage COPD, as defined by varying criteria, has been shown to have distinct epidemiological features that affect disease prognosis, emphasizing the importance of early monitoring and intervention.

[Clinical characteristics and prognostic analysis of concurrent pneumonia in patients with idiopathic inflammatory myopathy].

To describe the clinical characteristics and to explore the prognostic factors of concurrent pneumonia (PJP) in patients with idiopathic inflammatory myopathy (IIM). We retrospectively enrolled consecutive IIM patients diagnosed with PJP at our center between January 2014 and December 2022. Fifty-eight IIM-PJP patients were enrolled in our study, with the age of 26-79 (56.

Development of a sodium hyaluronate-enriched therapeutic formulation with stevia glycoside and mogroside V for the comprehensive management of diabetes and its complications.

Diabetes prevalence continues to increase as a result of people's increasing sugar intake. Diabetes mellitus and its complications (dry skin, constipation, depression, and dental caries), as well as the prohibition of sweets ingestion, seriously affect patients' physical and mental health. Therefore, it is crucial to develop a long-term food for special medical purposes (FSMP) that aids in managing diabetes and its complications.

A respiratory mucosal vaccine based on chitosan/aluminum adjuvant induces both mucosal and systemic immune responses.

The respiratory mucosa serves as a critical barrier against the invasion of pathogens. Effective mucosal vaccines are essential for enhancing local immunity. However, there is an urgent need to develop new mucosal adjuvants.

Utilizing zebrafish models to elucidate mechanisms and develop therapies for skeletal muscle atrophy.

Skeletal muscle atrophy, resulting from an imbalance in muscle protein synthesis and degradation, compromises muscle quality and function, imposing significant burdens on movement and metabolic stability. Animal models are crucial for understanding the mechanisms of skeletal muscle atrophy and developing clinical prevention and treatment strategies. Zebrafish, as small aquatic vertebrates, exhibit high genetic homology with humans and offer advantages such as rapid reproduction, development, and transparent embryos.

Neural correlates of reciprocity bias: social debts modulate unfairness perception of violation during third-party observation.

The phenomenon of beneficiaries ignoring benefactors' violations, ranging from everyday favors to bribes, is widespread yet lacks targeted theoretical and empirical attention. We propose a conceptual framework that includes "social debt" and "reciprocity bias," where "social debt" is defined as information about benefits bestowed by benefactors and "reciprocity bias" as the influence of social debt on beneficiaries' perceptions and decisions in situations involving the benefactor. To investigate this bias in moral perception and its cognitive-neural mechanisms, we manipulated three levels of social debt (none, less, more) by varying the amount of unasked benefits that benefactors bestowed upon participants.

Indoor incense burning and impaired lung function in patients with diabetes.

While recent studies have indicated a potential link between incense burning and respiratory diseases, there is a lack of data specifically focused on diabetic patients. To explore the relationship between indoor incense burning and impaired lung function among Chinese individuals with diabetes, a comprehensive cross-sectional study was undertaken, enrolling 431 adults diagnosed with diabetes. Information on incense burning and characteristics was collected using a structured questionnaire.

Targeting Siglec-E facilitates tumor vaccine-induced antitumor immunity in renal carcinoma.

Background: Siglec-E is an immune checkpoint inhibitory molecule. Expression of Siglec-E on the immune cells has been shown to promote tumor regression. This study aimed to develop an adenovirus (Ad) vaccine targeting Siglec-E and carbonic anhydrase IX (CAIX) (Ad-Siglec-E/CAIX) and to evaluate its potential antitumor effects in several preclinical renal cancer models.

Spatial and single-cell transcriptomics reveal cellular heterogeneity and a novel cancer-promoting Treg cell subset in human clear-cell renal cell carcinoma.

Background: Clear cell renal cell carcinoma (ccRCC) is the most common histologic type of RCC. However, the spatial and functional heterogeneity of immunosuppressive cells and the mechanisms by which their interactions promote immunosuppression in the ccRCC have not been thoroughly investigated.

Methods: To further investigate the cellular and regional heterogeneity of ccRCC, we analyzed single-cell and spatial transcriptome RNA sequencing data from four patients, which were obtained from samples from multiple regions, including the tumor core, tumor-normal interface, and distal normal tissue.

Proteomic analysis of the nonstructural protein 2-host protein interactome reveals a novel regulatory role of SH3 domain-containing kinase-binding protein 1 in porcine reproductive and respiratory syndrome virus replication and apoptosis.

Virus-host protein interaction is critical for successful completion of viral replication cycles. As the largest nonstructural protein (NSP) of porcine reproductive and respiratory syndrome virus (PRRSV), NSP2 plays multiple and critical roles in viral replication, antiviral immunity, cellular tropism and virulence. An interactome of this protein with host proteins would be instrumental in full understanding of these multifunctional roles.

Identification of a functional vitamin D response element in the promoter of goose anti-Müllerian hormone gene.

Anti-Müllerian hormone (AMH) plays an important role in avian ovarian follicle development. The high mRNA expression of AMH in avian ovarian prehierarchical follicles helps prevent premature granulosa cell differentiation. Vitamin D3 was reported to downregulate AMH mRNA expression in granulosa cells of prehierarchical follicles in hens; however, the underlying molecular mechanism remains unknown.

Observing quantum coherent oscillations in a three-level atom via electromagnetically induced transparency by two-dimensional spectroscopy.

Two-dimensional electronic spectroscopy (2DES) has high spectral resolution and is a useful tool for studying atomic dynamics. In this paper, we show a smallest unit of electromagnetically induced transparency (EIT) for 2DES, i.e.

NK Cell Exosomes Alleviate PD-L1 Expression and Facilitate Tumor Immunity by Repressing PI3K-AKT-mTOR Signaling.

Background: Liver cancer (LC) is a deadly malignancy with limited therapeutic options in recent years. Natural killer cell-derived exosomes (NK-exo), as an important bridge of information transmission between cells, also have a certain killing effect on tumor cells. On this basis, this study investigated the specific regulatory mechanism of NK-exo on LC cells.

Associations between class-level factors and student physical activity during physical education lessons in China.

Background: The purpose of this study is to explore the association between class-level factors, such as lesson start time, class size, lesson location, PE content, and PE context, and student engagement in moderate-to-vigorous physical activity (MVPA) during PE lessons in both elementary and middle schools.

Methods: A total of 284 PE lessons from ten schools in Shanghai, Eastern China, were included in the study. Students' MVPA during PE lessons was recorded using accelerometry, and lesson context was evaluated using the System for Observing Fitness Instruction Time (SOFIT).

Prevalence and risk factors of long COVID-19 persisting for 2 years in Hainan Province: a population-based prospective study.

Coronavirus disease 2019 (COVID-19) can lead to persistent symptoms, sequelae, and other medical complications that may last for weeks or months after recovery. The aim of the study is to assess the prevalence and risk factors of long COVID-19 persisting for 2 years in Hainan Province, China, to aid in its recognition, prevention, and treatment. Between July and August 2022, 960 individuals with confirmed SARS-CoV-2 infection in Hainan, China, were recruited.

Fibrosis and inflammatory activity diagnosis of chronic hepatitis C based on extreme learning machine.

The traditional diagnosis of chronic hepatitis C usually relies on liver biopsy. Diagnosing chronic hepatitis C based on serum indices provides a non-invasive way to determine the stage of chronic hepatitis C without liver biopsy. In this paper, we proposed two automatic diagnosis systems for non-invasive diagnosis of chronic hepatitis C based on serum indices, an extreme learning machine (ELM) based auto-diagnosis method and a hybrid method using k-means clustering and ELM.

Hemodynamic evaluation of symptomatic and asymptomatic intracranial atherosclerotic stenosis using cerebral angiographic images: an exploratory study.

Background: Previous studies suggest that it may be inappropriate to determine treatment strategies solely based on the degree of stenosis for patients with intracranial atherosclerotic stenosis (ICAS). In order to better risk stratify patients with ICAS, we developed a novel non-invasive fractional flow (FF) calculation technique based on intracranial angiography (Angio-FF) to assess the hemodynamics for patients with ICAS. This study aims to investigate the difference in FF between symptomatic and asymptomatic patients with ICAS and its potential optimal threshold.