Diagnosis and treatment of a rare bilateral primary thyroid cancer: a case report.

Preoperative ultrasound examination of thyroid nodules is the most economical and effective screening method for diagnosing thyroid nodules. Fine-needle aspiration biopsy (FNAB) cytology guided by ultrasound has high sensitivity and specificity in distinguishing benign and malignant thyroid nodules. However, approximately 25% of thyroid nodules cannot be determined by FNAB, and accurate differentiation of benign and malignant thyroid nodules is critical for patient prognosis.

Neutrophil Depletion Reduced the Relative Abundance of Unsaturated Long-Chain Fatty Acid Synthesis Microbiota and Intestinal Lipid Absorption.

As immune cells, neutrophils serve as the first line of defense against infections; however, the mechanism by which neutrophils regulate lipid metabolism is unknown. The neutrophil depletion group was treated with 100 μg InVivoMAb anti-mouse Ly6G 6 times, whereas the control group mice were intraperitoneally injected with the same quantity of InVivoMAb rat IgG2a. Body fat content, triglycerides (TGs), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) in the jejunum and ileum, as well as 9 long-chain fatty acids (LCFAs) in the intestinal contents were significantly decreased.

Ethanol causes rapid decreases in the hepatic retinoid levels shaping the early steps of alcohol-associated liver disease.

Background: Chronic alcohol drinking causes hepatic vitamin A (retinoids and derivatives) decreases, which correlate with the progression and severity of alcohol-associated liver disease (ALD). However, the effects of short-term ethanol (EtOH) intake on liver retinoids and ALD are still undefined.

Methods: Using high-performance liquid chromatography and high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC, HPLC-MS/MS), and molecular biology techniques in mice and cultured human hepatocytes, we investigated the temporal EtOH effects on retinoids and ALD.

An Analysis of Contraceptive Use in Women with a Previous Live Birth in a Single Tertiary Women's Hospital: A Survey Study.

The use of contraceptives to prevent unintended pregnancies is not widely accepted in developing countries due to social and cultural factors, lack of knowledge, and limited access to contraceptive services. This results in a relatively high incidence of repeat abortions in women with live births. The objective of this study is to understand the awareness of contraceptive use in women with live births women with previous live births who currently underwent an abortion (n = 272) and women who had a recent live birth (n = 323) voluntarily participated in this survey.

A matching design and parameter identification method of hybrid electric propulsion system.

The hybrid electric propulsion system presents significant potential and advantages for the advancement of general electric aviation. Efforts to optimize the parameters of the serial hybrid electric propulsion (S-HEP) system can effectively enhance energy utilization efficiency. This paper proposes an integrated analysis method to address the matching design problem specific to the S-HEP system, tailored for fixed-wing Vertical Take-off and Landing (VTOL) aircraft.

Mesoscale orchestration of collagen-based hierarchical mineralization.

Mesoscale building blocks are instrumental in bridging multilevel hierarchical mineralization, endowing macroscale entities with remarkable functionality and mechanical properties. However, the mechanism orchestrating the homogeneous morphology of mesoscale mineralized motifs in collagen-based hard tissues remains unknown. Here, utilizing avian tendons as a mineralization model, we reveal a robust correlation between the mesoscale mineralized spherules and the presence of phosvitin.

Efficacy of adjunctive systemic or local antibiotic therapy in peri-implantitis: a systematic review and meta-analysis of randomized controlled clinical trials.

This systematic review and meta-analysis considered the results of randomized controlled clinical trials (RCTs) to evaluate the efficacy of systemic or local antibiotic therapy in peri-implantitis. Two independent authors screened publications from three electronic databases to include RCTs meeting all the inclusion and exclusion criteria. A meta-analysis was performed to evaluate the weighted mean differences in survival rate (SR) and changes in pocket probing depth (PPD), bone level (BL), and clinical attachment level (CAL).

CRISPR/Cas9-mediated editing of the melanization gene ebony in the 28-spotted ladybeetle, Henosepilachna vigintioctopunctata.

The melanization process, which is essential for the proper functioning of the cuticle, has been extensively investigated for its enzymatic roles and physiological effects. Henosepilachna vigintioctopunctata, a significant pest species, presents considerable economic threats. However, due to the variable efficiency of RNA interference for genetic manipulation, establishing a CRISPR/Cas9 system is crucial for providing a more precise and reliable method for functional genomics in this non-model insect.

[Scale-invariant feature-enhanced deep learning framework for oral mucosal lesion segmentation].

To develop PixelSIFT-UNet, a novel semantic segmentation model that integrates deep learning with Scale-Invariant Feature Transform (SIFT) algorithm to improve the segmentation accuracy of oral mucosal lesions. This investigation utilized 838 standard clinical white light images of oral mucosal diseases acquired from January 2020 to December 2022 at the Stomatology Hospital Zhejiang University School of Medicine. Randomization was achieved through Python's random.

[Preliminary study on the significance of serum thyroid antibody in the selection of treatment for oral lichen planus].

To investigate the efficacy of different treatment of oral lichen planus (OLP) patients with thyroid antibody positive and its correlation with thyroid antibody, providing more targeted treatment for OLP patients with thyroid antibody positive. Patients who were admitted to department of Oral Medicine, Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine for OLP with serum thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TGAb) from February 2020 to June 2024 were included. Demographic and clinical data were recorded, and qualitative status and quantitative titers of TPOAb/TGAb were collected.

[A humble opinion on the advance of Oral Medicine research in China].

To better reflect the current status and key research trends in oral medicine research of China and to enhance the overall research abilities in this field, this Special Issue on Oral Medicine Research integrates the work of several young academic leaders from oral medicine research centers nationwide. Their work focuses on key areas such as artificial intelligence-assisted diagnosis, the pathogenic mechanisms of intracellular bacteria, the relations between oral mucosal diseases and systemic diseases, as well as the study and reporting of rare and unique cases, aligning with the forefront of biomedical research. Although it does not encompass all the high-level researches conducted in China, it presents a rich and diverse array of academic achievements.

Macrophage-derived CTSS drives the age-dependent disruption of the blood-CSF barrier.

The choroid plexus (CP) serves as the primary source of cerebrospinal fluid (CSF). The blood-CSF barrier, composed of tight junctions among the epithelial cells in the CP, safeguards CSF from unrestricted exposure to bloodborne factors. This barrier is thus indispensable to brain homeostasis and is associated with age-related neural disorders.

Uncovering miRNA-mRNA regulatory modules of cotton in response to cadmium stress.

Cadmium (Cd), a non-essential heavy metal for plant, adversely effects on crop productivity and food safety. Cotton, predominantly cultivated as a non-food crop, offers the advantage of not transferring Cd into the food chain, making it an effective option for remediating Cdcontaminated soils. While previous researches have extensively examined the gene expression responses of cotton to Cd stress, insights at the post-transcriptional level remain limited.

A Novel Biosynthesized Bacterial Cellulose/MoS/TiO Composite Film for Efficient Removal of Dyes and Pathogenic Bacteria from Industrial Wastewater under Sunlight Illumination.

Developing multifunctional water purification materials is of great significance for the elimination of organic pollutants and bacterial pathogens in industrial wastewater. Herein, we report a novel green material, bacterial cellulose/molybdenum disulfide/titanium oxide (BC/MoS/TiO) composite film, through one-step biosynthesis, and its application in industrial wastewater treatment. The systematic physicochemical characterization of BC/MoS/TiO demonstrated that MoS and TiO were effectively incorporated into the BC porous network matrix.

Nitrogen dominates global atmospheric organic aerosol absorption.

Atmospheric organic aerosols (OAs) influence Earth's climate by absorbing sunlight. However, the link between their evolving composition and their absorptive effects is unclear. We demonstrate that brown nitrogen (BrN), the absorptive nitrogenous component of OAs, dominates their global absorption.

Machine Learning-Based Mortality Prediction for Acute Gastrointestinal Bleeding Patients Admitted to Intensive Care Unit.

Objective: The study aimed to develop machine learning (ML) models to predict the mortality of patients with acute gastrointestinal bleeding (AGIB) in the intensive care unit (ICU) and compared their prognostic performance with that of Acute Physiology and Chronic Health Evaluation II (APACHE-II) score.

Methods: A total of 961 AGIB patients admitted to the ICU of Renmin Hospital of Wuhan University from January 2020 to December 2023 were enrolled. Patients were randomly divided into the training cohort (n = 768) and the validation cohort (n = 193).

Design, Synthesis, and Biological Evaluation of Marchantin C-NO Donor Hybrids for Overcoming Pgp-Mediated Drug Resistance by Targeting Lysosome.

A series of marchantin C-NO donor hybrids were designed, synthesized, and evaluated for their antitumor activity and . Notably, MC-furoxan hybrid exhibited the best selective inhibitory activity against MCF-7/ADR (IC = 0.024 μM) with 883 times potency compared with MCF-7 cells (IC = 21.

NETs-CD44-IL-17A Feedback Loop Drives Th17-Mediated Inflammation in Behçet's Uveitis.

Behçet's uveitis (BU) is a severe ocular manifestation of Behçet's disease, typically accompanied by abnormal neutrophil infiltration and hyperactivation. However, the underlying causes of excessive neutrophil extracellular traps (NETs) production and mechanisms by which NETs contribute to the pathogenesis of BU remain incompletely understood. Neutrophils from BU patients exhibit a higher propensity for NETs release compared to healthy controls.

Social environment, low-carbon cognition and low-carbon consumption behaviors of youth groups: evidence from Xizang, China.

Introduction: Global warming has profoundly transformed the natural environment and significantly impacted people's production methods, thereby promoting low-carbon consumption behaviors. While numerous scholars have examined the factors influencing low-carbon consumption behavior, their analyses predominantly rely on classical theoretical frameworks such as planned behavior theory, value-belief-norm theory and The ABC attitude theory. However, there is a notable scarcity of studies investigating the relationship between the social environment and low-carbon behaviors among youth groups.

Long non-coding RNA HOXC-AS1 promotes the malignancy by sponging miR-195-5p with ANLN in esophageal cancer.

Long non-coding RNA HOXC cluster antisense RNA 1 (HOXC-AS1) exhibits elevated expression in gastric and prostate cancers, yet its involvement in esophageal cancer (EC) remains unexplored. This investigation assessed the expression patterns and functional implications of HOXC-AS1 in EC. Quantitative real-time PCR was employed to evaluate HOXC-AS1 expression in EC cell lines, while its impact on cell proliferation, migration, invasion, tumor growth, and metastasis was examined through MTT, EdU, transwell, wound healing assays, and animal models.

Attentive feature interaction based persistent homology-augmented network for esophageal cancer lesion detection.

Background: Detecting lesions in esophageal cancer (EC) is important in guiding subsequent treatment. Deep learning methods based on convolutional neural networks (CNNs) and vision transformer (ViT) have made remarkable strides in the field of medical image analysis due to their powerful representational capabilities. However, without prior knowledge, both traditional CNNs and ViTs are susceptible to disregarding critical anatomical information, including loops and voids.

Gestational age reference from crown-rump length during 11-14 weeks: a population-based multicenter cohort study in China.

Background: This study aimed to develop a new ultrasonographic dating formula to estimate gestational age (GA) based on fetal crown-rump length (CRL) in a Chinese population, evaluate model accuracy and compare its performance with established dating formulas.

Methods: A prospective, multicenter study was conducted across mainland China. Participants included healthy, low-risk women with spontaneously conceived singleton pregnancies and a regular menstrual cycle in the preceding year.

An online game spread model combining key nodes in scale-free networks.

Research indicates that online game addiction can result in health-damaging disorders and propagate via social interactions. This paper presents a GPAE model for online game spread on a scale-free network, incorporating key nodes. The model assesses local impact via node degree distribution and global impact through collective node influence.

KRT7 promotes pancreatic cancer metastasis by remodeling the extracellular matrix niche through FGF2-fibroblast crosstalk.

Pancreatic ductal adenocarcinoma (PDAC) is a devastating cancer with a dismal prognosis due to distant metastasis. Through an analysis of large RNA sequencing and proteomics datasets, we found that high KRT7 expression in PDAC patients was correlated with liver metastasis and poor survival. A functional investigation revealed that the overexpression of KRT7 promoted liver metastasis but did not affect tumor cell proliferation in vivo or in vitro.