A scoping review of human genetic resources management policies and databases in high- and middle-low-income countries.

Background: This review examines global human genetic resources management, focusing on genetic data policies and repositories in high- and middle-low-income countries.

Methods: A comprehensive search strategy was employed across multiple databases, including official government websites and Google, to gather relevant literature on human genetic resources management policies and genetic resource databases. Documents were screened for relevance, focusing on high-income countries (United States, United Kingdom, Japan) and middle-low-income countries (China, India, Kenya).

Effects of psychosocial factors on postpartum depression: a half-longitudinal mediation analysis of cognitive reactivity.

Background: The prevention and treatment of perinatal depression are currently the focus of perinatal health care, with cognitive reactivity confirmed to be an important predictor. However, how cognitive reactivity mediates the relationship between psychosocial factors (e.g.

Exploring the tissue distribution propensity of active alkaloids in normal and stomach heat syndrome rats following oral administration of Zuojin Pill based on pharmacokinetics and mass spectrometry imaging.

Ethnopharmacological Relevance: Zuojin Pill (ZJP) is a traditional Chinese medicine (TCM) formula composed of Coptidis Rhizoma and Euodiae Fructus in a ratio of 6:1 (w/w), which has been widely used for treating gastrointestinal disorders, especially stomach heat syndrome (SHS). However, the active alkaloids in ZJP showed low plasma exposure in rats following oral administration, which failed to explain their potent pharmacological effects, thereby limiting further mechanism studies.

Aim Of The Study: This study aimed to investigate the in vivo exposure and tissue distribution propensities of the active alkaloids in normal and SHS rats following oral administration of ZJP.

The KSR1/MEK/ERK signaling pathway promotes the progression of intrauterine adhesions.

Ras kinase suppressor 1 (KSR1) serves as a scaffold protein within the RAS-RAF pathway and plays a role in tumorigenesis, immune regulation, cell proliferation, and apoptosis. However, the specific role of KSR1 in the formation and progression of fibrotic diseases, such as intrauterine adhesions (IUA), remains unclear. This study aims to investigate KSR1 expression in IUA and the mechanisms underlying its role in promoting IUA progression.

METTL3 suppressing SLC31A1 mA modification regulates trophoblast migration and invasion.

Objective: This article aims to explore the mechanism of METTL3-mediated SLC31A1 N6-methyladenosine (mA) modification affecting trophoblast migration and invasion in preeclampsia (PE).

Methods: The PE model was established using N-nitro-arginine methyl ester induction. Blood pressure was measured on gestation day (GD) 0, 5, 10, 15, and 20, and urine protein concentration on the day before mating and GD 20.

Exploring the mechanism of vitamin C on the co-expressed genes of papillary thyroid carcinoma and Epstein-Barr virus based on bioinformatics, network pharmacology and molecular docking analysis.

Objective: The study aims to evaluate the role and mechanism of action of vitamin C as an anti- Epstein-Barr virus (EBV) and papillary thyroid carcinoma (PTC) therapeutic agent.

Methods: The PTC/EBV-associated genes were obtained by intersection and further screen out hub genes to construct a prognostic model. The relationship between PTC/EBV-related genes and core genes and immune infiltration was analyzed, respectively.

A Single HS-Releasing Nanozyme for Comprehensive Diabetic Wound Healing through Multistep Intervention.

Diabetic wound healing presents a significant medical challenge and requires multistep interventions due to comprehensive wound environments, such as hyperglycemia, bacterial infection, and impaired angiogenesis. However, current multistep interventions are complicated and need on-demand sequential release and synergy of multicomponents. Herein, a HS-releasing cascade nanozyme (FeS@Au), which is composed of ultrasmall gold nanocluster (AuNC) loaded on ferrous sulfide nanoparticle (FeSNP), is developed as a single component to regulate glucose level, eliminate infection, and promote angiogenesis, achieving multistep interventions for comprehensive diabetic wound treatment.

The global, regional, and national burdens of maternal sepsis and other maternal infections and trends from 1990 to 2021 and future trend predictions: results from the Global Burden of Disease study 2021.

Background: Maternal sepsis and other maternal infections (MSMIs) significantly contribute to maternal morbidity and mortality worldwide, posing critical challenges due to their rapid progression and severe outcomes.

Methods: Data from the Global Burden of Disease (GBD) 2021 study, covering 204 countries and territories, were used to evaluate the incidence, death, and disability-adjusted life years (DALYs) of MSMI. Statistical methods included joinpoint regression, age-period-cohort analysis, decomposition analysis, frontier analysis, and ARIMA model forecasting.

Hypothermic Myocardial Preservation: The Freezing Debate.

Background: Storage of hearts in ice for transportation is thought to cause post-transplantation graft dysfunction secondary to freeze injury. We studied the myocardial damage and resulting function in hearts stored at 0 °C, 4 °C and 8 °C for 4 hours.

Methods: Rat hearts were procured under general anesthesia and immediately stored in University of Wisconsin solution at 0 °C, 4 °C and 8 °C for 4 hours (n = 6-8/group).

Combined traditional Chinese medicine and probiotics (TCMP) alleviates lipid accumulation and improves metabolism in high-fat diet mice via the microbiota-gut-liver axis.

Lipid accumulation and metabolic disorders caused by a high-fat diet (HFD) pose significant threats to human health, and place a substantial burden on individuals and society. In this study, a novel combination comprising three traditional Chinese herbs (lotus leaf, hawthorn, and leaf of Chinese holly) and a probiotic (Bifidobacterium lactis BPL-1) (TCMP) was prepared. Then, its effects on growth performance, fat accumulation, hepatic function and gut microbiota in mice fed a high-fat diet were investigated.

Formation and control of heterocyclic amines and advanced glycation end products in traditional Chinese braised pork belly: The role of food additives.

For braised pork belly, a popular traditional Chinese dish, we lack a scientific knowledge to reduce the formation of harmful heterocyclic amines (HAs) and advanced glycation end products (AGEs) while maintaining sensory quality. This study aimed to clarify the factors affecting the formation of free and protein-bound HAs and AGEs during the braised pork belly cooking process using UPLC-MS/MS analysis. The results indicated that soy sauce significantly promoted the formation of HAs, with organic soy sauce exhibiting the strongest promoting effect, increasing HAs by 270.

The derivatives of hirudin-like peptides from the Poecilobdella manillensis exhibit antithrombotic and anti-ischemic stroke effects.

Almost all currently approved anticoagulants interfere with hemostasis and increase the risk of bleeding complications. Thus, there is a critical need for safer anti-thrombotic drugs without bleeding risk. Hirudin has demonstrated potent antithrombotic properties, but is clinically limited due to its high bleeding risk.

Microencapsulation of cornmint oil with octenyl succinate anhydride debranched starch by electrostatic spray drying: Characterization and release kinetics of the aroma components.

In this study, a novel method for the preparation of corn mint oil microcapsules was developed using electrostatic spray drying (ESD) with three octenyl succinate anhydride debranched starch (OSADS) wall materials. It was complexed with gum arabic (GA) and maltodextrin (MD). This study addresses the research gap that traditional methods have low efficiency in encapsulating volatile compounds (such as essential oils).

Stochastic and deterministic mechanisms jointly drive the assembly of microbial communities in cold-rolling wastewater across China.

Microorganisms play a pivotal role in industrial wastewater treatment, serving as a critical barrier to water purification and safeguarding human and environmental health. Despite their importance, the biogeographic distribution and assembly mechanisms of microbial communities in cold-rolling wastewater treatment systems remain poorly understood. This study analyzed 101 microbial samples from nine regions using high-throughput sequencing, revealing rich microbial diversity and distinct regional aggregation patterns.

Measurement of Very-High-Energy Diffuse Gamma-Ray Emissions from the Galactic Plane with LHAASO-WCDA.

The diffuse Galactic gamma-ray emission is a very important tool used to study the propagation and interaction of cosmic rays in the Milky Way. In this Letter, we report the measurements of the diffuse emission from the Galactic plane-covering Galactic longitudes from 15° to 235° and latitudes from -5° to +5°, in an energy range of 1 to 25 TeV-made with the Water Cherenkov Detector Array (WCDA) of the Large High Altitude Air Shower Observatory. After the sky regions of known sources are masked, the diffuse emission is detected with 24.

Phytomelatonin: Biosynthesis, Signaling, and Functions.

Phytomelatonin has attracted significant attention over the years for its roles in promoting plant growth and enhancing stress resistance. The biosynthetic pathway of phytomelatonin is more intricate than that of melatonin in animals, occurring in plants in the endoplasmic reticulum, chloroplasts, mitochondria, and cytoplasm. By compartmentalizing phytomelatonin production within specific organelles and differentially expressing biosynthesis genes, plants may finely tune the levels of this hormone under normal growth conditions, as well as in rapid responses to changing environmental conditions.

A polyvalent vaccine for selectively killing tumor-associated bacteria to prevent cancer metastasis.

Specific bacteria, including , , , and , have been identified as contributors to breast cancer metastasis. Due to limitations such as lack of selectivity, traditional antibiotic therapies face obstacles in eliminating intratumoral bacteria. Herein, this work proposes the use of therapeutic vaccines to selectively target and eliminate harmful bacteria within tumors.

CUR-PDT induces ferroptosis of RA-FLS via the Nrf2/xCT/GPX4 pathway to inhibit proliferation in rheumatoid arthritis.

Objective: Ferroptosis is a non-apoptotic cell death mechanism driven by reactive oxygen species (ROS) and iron. Its significance in inflammatory arthritis is well-established, but its role in rheumatoid arthritis (RA) remains uncertain. This study aimed to clarify the mechanisms through which curcumin-mediated photodynamic therapy (CUR-PDT) triggers ferroptosis in RA fibroblast-like synoviocytes (FLSs).

NADPH oxidase activator 1 (NOXA1) suppresses ferroptosis and radiosensitization in colorectal cancer.

Radiotherapy is one of the main treatments for colorectal cancer (CRC), but due to the intrinsic resistance of cells or resistance caused by long-term radiotherapy, the effectiveness of this treatment is limited for some CRC patients. Consequently, identifying novel sensitization strategies is essential. This study identifies as a marker linked to radiotherapy resistance in CRC, suggesting its potential as a prognostic biomarker for patients with CRC.

Optimization of hemolytic performance of artificial heart pump based on CFD.

Hemolytic performance is the key performance of artificial heart pumps. To reduce the damage to blood during the operation of artificial heart pumps and improve hemolysis performance, this paper investigates the influence of several key parameters of artificial heart pumps (volute type, inlet guide cone, blade wrap angle, tip clearance) on hemolysis performance. Firstly, a fluid domain model of the artificial heart pump was established, and mesh partitioning and fluid simulation parameter settings were carried out.

Social participation patterns and associations with subsequent cognitive function in older adults with cognitive impairment: a latent class analysis.

Background: Social participation (SP) has been associated with cognitive benefits among older adults; however, little is known about SP patterns and their relationships with cognitive function in cognitively impaired populations. This study aimed to identify SP patterns among cognitively impaired older individuals and evaluate their associations with subsequent cognitive function, specifically mental intactness and episodic memory.

Methods: Data were drawn from the China Health and Retirement Longitudinal Study (CHARLS), including 5,673 individuals aged 60 years and older with cognitive impairment from 2015 to 2018.

Catalytic Atroposelective Electrophilic Amination to Access Axially Chiral Diaryl Phenols.

An enantioselective synthesis of axially chiral diaryl phenols containing sulfonamide groups has been achieved involving an electrophilic amination of 1,1'-biaryl-2,6-diols with N-sulfonyl quinone diimines, catalyzed by a chiral phosphoric acid. This atroposelective reaction offers a modular approach to enantiopure diaryl phenols, with good to excellent yields.

Global seafood production practices and trade patterns contribute to disparities in exposure to methylmercury.

Seafood consumption is a major pathway for exposure to methylmercury (MeHg), a globally pervasive neurotoxin. Yet, how upstream processes in the seafood value chain influence MeHg exposure remains poorly understood. Here we quantified MeHg in seafood production, trade and consumption in 2019 around the world.

Groundwater quality evolution across China.

China is facing a severe groundwater quality crisis amid economic development and climate change, yet the extent and trajectory of this crisis remain largely unknown. Here we developed a machine-learning model, incorporating natural and social-economic factors, to construct annual probabilistic maps of poor groundwater quality (PGQ, i.e.