Gate-tunable van der Waals heterostructure for reconfigurable neural network vision sensor.

Early processing of visual information takes place in the human retina. Mimicking neurobiological structures and functionalities of the retina provides a promising pathway to achieving vision sensor with highly efficient image processing. Here, we demonstrate a prototype vision sensor that operates via the gate-tunable positive and negative photoresponses of the van der Waals (vdW) vertical heterostructures.

Drp-1-Dependent Mitochondrial Fragmentation Contributes to Cobalt Chloride-Induced Toxicity in Caenorhabditis elegans.

Excess cobalt may lead to metallosis, characterized by sensorineural hearing loss, visual, and cognitive impairment, and peripheral neuropathy. In the present study, we sought to address the molecular mechanisms of cobalt-induced neurotoxicity, using Caenorhabditis elegans as an experimental model. Exposure to cobalt chloride for 2 h significantly decreased the survival rate and lifespan in nematodes.

Shuxuening injection, derived from leaf, induced pseudo-allergic reactions through hyperactivation of mTOR.

Shuxuening injection (SXNI), derived from the leaf of G L. (Ginkgoaceae), is widely used to treat cardio-cerebral vascular system related disease due to the efficacy of dilating the blood vessels and improving the function of microcirculation. Nevertheless, SXNI induces immediate hypersensitivity reactions in clinics and the molecular mechanisms are unknown.

[Predicting the Recycling Potential and Evaluating the Environmental Benefits of Waste Electrical and Electronic Equipment in Beijing-Tianjin-Hebei].

Waste electrical and electronic equipment (WEEE or e-waste) is a significant urban mine in the Beijing-Tianjin-Hebei region. A comprehensive and systematic assessment of the amount of e-waste generated in the region and the resources and environmental benefits of e-waste recycling can provide scientific basis and methods to support collaborative and accurate management of e-waste in the region to solve resource and environmental problems. Based on the improved ownership coefficient method, material coefficient method, market value method, and pollution coefficient method, this study predicted and evaluated the recycling potential and environmental benefits of e-waste in Beijing-Tianjin-Hebei from 2010 to 2025 by estimating the production, amount of recyclable resources, resource recycling value, and environmental benefits of waste televisions, refrigerators, air conditioners, washing machines, and computers (five major e-wastes).

NaV(PO)/Porous Carbon Skeleton Embellished with ZIF-67 for Sodium-Ion Storage.

Sodium super ionic conductor (NASICON) NaV(PO) (NVP) is a type of promising cathode material for sodium-ion batteries (SIBs) with superior structural integrity, high energy density, and fast diffusion of sodium ions. However, NVP suffers from intrinsically low electrical conductivity, which results in poor rate performance. Herein, we report on the outstanding cathode performance of NaV(PO) (NVP@C-ZIF67) wrapped by the ZIF-67-derived carbon, which was prepared by sol-gel method and solid-phase method.

Potential role of the skin microbiota in Inflammatory skin diseases.

Background: Inflammatory skin diseases include a variety of skin diseases, such as seborrheic dermatitis, acne, atopic dermatitis, psoriasis and so on, which are more common and tend to have a significant impact on patients' quality of life. Inflammatory skin diseases often result in physical or psychological distress; however, the pathogenesis of these diseases have not been clearly elucidated. Many factors are involved in the pathogenesis of inflammatory skin diseases, including heredity, environment, immunity, epidermal barrier, mental disorders, infection and so on.

Design, synthesis and biological evaluation of novel chroman derivatives as non-selective acetyl-CoA carboxylase inhibitors.

Acetyl-CoA carboxylases (ACCs) are the rate-limiting enzymes in the de no lipogenesis, which play an important role in the synthesis and oxidation of fatty acid. Recent research reveals that ACCs are tightly relevant to many kinds of metabolic diseases and cancers. In this study, we synthesized a series of chroman derivatives and evaluated their ACCs inhibitory activities, obtaining compound 4s with IC value of 98.

Attitude Toward Seeking Professional Psychological Help Among Community-Dwelling Population in China.

Objective: To explore the attitudes and factors in seeking professional psychological help among a Chinese community-dwelling population in order to promote positive help-seeking behaviors and better utilization of mental health services.

Methods: Using system and simple random sampling with Kish selection table methods, 912 community-dwelling residents were included in this study and asked about their attitudes toward seeking professional psychological help, depression symptoms, family function, depression literacy, help-seeking intention, and stigma.

Results: Scores on the Attitudes Toward Seeking Professional Psychological Help scale (ATSPPH-SF) indicated a neutral attitude toward openness to seeking treatment for psychological problems and a negative attitude toward the value and need to seek treatment with a negative total score.

Management strategies of autoimmune bullous diseases during the outbreak of 2019 Novel Coronavirus disease (COVID-19).

Since late December 2019, an outbreak of the novel coronavirus disease, which is mainly characterized by pulmonary lesions, has spread quickly worldwide. With the spread of the novel coronavirus, the outpatient lines of hospitals have mostly shut down, which means that routine clinical diagnosis and treatment for autoimmune bullous diseases patients have been disturbed. Due to the serious condition of autoimmune bullous diseases patients, they are prone to immune suppression and circulatory failure, and are more susceptible to infection than healthy individuals.

Development of small-molecule BRD4 degraders based on pyrrolopyridone derivative.

Bromodomain-containing protein 4 (BRD4) plays a crucial role in the epigenetic regulation of gene transcription and some BRD4 inhibitors have been advanced to clinical trials. Nevertheless, the clinical application of BRD4 inhibitors could be limited by drug resistance. As an alternative strategy, the emerging Proteolysis Targeting Chimeras (PROTACs) technology has the potential to overcome the drug resistance of traditional small-molecule drugs.

Tocilizumab treatment in Felty's syndrome.

Felty's syndrome (FS) is a deforming disease, characterized by the triad of rheumatoid arthritis (RA), neutropenia, and splenomegaly. Currently, FS patients are treated mainly with immunosuppressants, such as methotrexate and glucocorticoids, which however are not suitable to some patients and may cause severe side effects. Here we report a clinical FS case that was treated with Tocilizumab (TCZ) successfully.

Atomic imaging of mechanically induced topological transition of ferroelectric vortices.

Ferroelectric vortices formed through complex lattice-charge interactions have great potential in applications for future nanoelectronics such as memories. For practical applications, it is crucial to manipulate these topological states under external stimuli. Here, we apply mechanical loads to locally manipulate the vortices in a PbTiO/SrTiO superlattice via atomically resolved in-situ scanning transmission electron microscopy.

Carnitine palmitoyltransferase 1C contributes to progressive cellular senescence.

Stable transfection manipulation with antibiotic selection and passaging induces progressive cellular senescence phenotypes. However, the underlying mechanisms remain poorly understood. This study demonstrated that stable transfection of the empty vector induced PANC-1 cells into cellular senescence.

T Lymphocytes: A Promising Immunotherapeutic Target for Pancreatitis and Pancreatic Cancer?

Pancreatic disorders cause a broad spectrum of clinical diseases, mainly including acute and chronic pancreatitis and pancreatic cancer, and are associated with high global rates of morbidity and mortality. Unfortunately, the pathogenesis of pancreatic disease remains obscure, and there is a lack of specific treatments. T lymphocytes (T cells) play a vital role in the adaptive immune systems of multicellular organisms.

Clinical Efficacy Evaluation of 1-Year Subcutaneous Immunotherapy for Pollen Allergic Rhinitis by Serum Metabolomics.

Subcutaneous immunotherapy is the only treatment that improves the natural progression of allergic rhinitis and maintains long-term outcomes after discontinuation of the drug. Metabolomics is increasingly applied in the study of allergic diseases, including allergic rhinitis. However, little is known about the discovery of metabolites that can evaluate clinical efficacy and possible mechanisms of pollen subcutaneous immunotherapy.

Enhanced Synergistic Antibacterial Activity through a Smart Platform Based on UiO-66 Combined with Photodynamic Therapy and Chemotherapy.

Harmful bacteria have seriously threatened human health and wealth for a long time. Herein, a multifunctional drug delivery system based on UiO-66 was fabricated, and it showed potent synergistic antibacterial effects when used in conjunction with photodynamic therapy and chemotherapy. First, UiO-66-NH was prepared via a facile solvothermal method.

A Huge Plaque on the Back: A Quiz.

A previously healthy 44-year-old woman presented to our department with a skin lesion on her back. The lesion presented as multiple, variable-sized, skin-coloured to tan-grey, papules, focally coalesced into a huge plaque (15.5×7 cm) with a grouped distribution on her lower back (Fig.

Postoperative thyroid remnants for differentiated thyroid cancer may not affect the outcome of high-dose radioiodine therapy.

Objectives: This study aims to provide a way to estimate the volume of the thyroid remnant and determine its relationship with the outcome of radioiodine (RAI) therapy in depth.

Materials And Methods: A retrospective analysis was performed on patients who underwent initial RAI therapy between January 2010 and January 2016. The patients were divided into five groups based on the thyroid remnant estimated by post-therapy whole-body scan(post-Rx WBS), thyroid scintigraphy and ultrasonography.

Artificial liver treatment improves survival in patients with hepatitis B virus-related acute-on-chronic liver failure: A case-control matched analysis.

Aim: The artificial liver support system (ALSS) is recognized as a bridge to liver transplantation in hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) patients. However, patient survival remains unknown. We aim to assess the effects of ALSS on survival in HBV-ACLF patients.

Rapidly decreased HBV RNA predicts responses of pegylated interferons in HBeAg-positive patients: a longitudinal cohort study.

Background: As an important anti-HBV drug, pegylated interferon α (PegIFNα) offers promising clinical efficacy, but biomarkers that accurately forecast treatment responses are yet to be elucidated. Here, we evaluated whether HBV RNA could act as an early monitor of pegylated interferon responses.

Methods: We analyzed a phase 3, multicenter, randomized cohort of 727 HBeAg-positive non-cirrhotic patients receiving a 48-week treatment of PegIFNα-2a or PegIFNα-2b and a 24-week treatment-free follow-up.

Nanocomposites membranes from cellulose nanofibers, SiO and carboxymethyl cellulose with improved properties.

The binary nanocomposites blended by carboxymethyl cellulose (CMC) and SiO nanoparticles were constructed to prepare the films with superior thermal stability and flame retardant properties. The incorporation of cellulose nanofibers(CNFs) and SiO nanoparticles were followed to prepare ternary nanocomposite films exhibiting excellent mechanical properties. The mechanism and chemical reaction of the thermal decomposition for the CMC/SiO composite membrane were proposed, which showed that the mass residuals were NaCO, SiO and NaSiO, NaCO when the content of the SiO nanoparticles was lowered and higher than 9.

Correlation between the Glasgow-Blatchford score, shock index, and Forrest classification in patients with peptic ulcer bleeding.

Background/aim: To investigate the correlation between the Glasgow-Blatchford score, shock index, and Forrest classification in patients with peptic ulcer bleeding (PUB).

Materials And Methods: A total of 955 patients with PUB were assessed using the Glasgow-Blatchford score and shock index, as well as the Forrest classification based on their gastroscopy results. The correlation between the Glasgow-Blatchford score and shock index was determined using scatter plot analysis, and the correlation between the Glasgow-Blatchford score or shock index and Forrest classification was determined using Spearman’s analysis.

REPORT-Pleural lavage of amphotericin B for treatment of empyema caused by Candida albicans infections: A case report.

Chest fungal infection is a rarely seen lethal disease with rapid progression. Sufficient residence time of antifungal agent with therapeutic concentration in the chest is an essential point during anti-infection therapy, which is hard to achieve via conventional systemic drug delivery. We here by describe a case of successful treatment of fungal Chest infection via local pleural lavage.