Publications by authors named "Chen Ma"

Efficient intracellular delivery of native proteins remains a big challenge, which greatly hinders the development of protein therapy. Here, we report a generalizable peptide vector that can encapsulate and deliver various proteins to achieve efficient intracellular biocatalysis. The peptide was rationally designed to be cationic amphiphilic peptide that consist of four functional fragments, that is, a hydrophobic domain to promote molecular assembly, an enzyme-cleavable fragment to introduce stimuli-responsibility, several cationic arginine (Arg) residues to enhance cell interaction and transmembrane efficiency, and the cystine (Cys) residues with redox sensitivity to adjust the stability of the peptide/protein complexes as needed.

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Objective: The purpose of this in vitro study was to assess and compare the accuracy of three digital impression techniques based on an innovative integrated model.

Materials And Methods: The integrated model was created by incorporating crown, inlay, and long-distance specimens from the American Dental Association (ADA) Standard No. 132.

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Molybdenum diphosphide (MoP), a topological semimetal, possesses distinctive properties and applications in catalysis, energy storage, and condensed matter physics. However, synthesizing high-purity MoP is complex and often results in undesired stoichiometric by-products. Additionally, the intrinsic orthorhombic crystal structure makes it difficult to synthesize MoP in a 2D morphology, which is desirable for device and energy applications.

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Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide, with morbidity and mortality ranking third and second among all cancers, respectively. As a result of a sequence of genetic and DNA methylation alterations that gradually accumulate in the healthy colonic epithelium, colorectal adenomas and invasive adenocarcinomas eventually give rise to CRC. Global hypomethylation and promoter-specific DNA methylation are characteristics of CRC.

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Mineral carbon storage in mafic and ultramafic rock masses has the potential to be an effective and permanent mechanism to reduce anthropogenic CO. Several successful pilot-scale projects have been carried out in basaltic rock (e.g.

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In this paper, we study the problem of predicting optical chaos for semiconductor lasers, where data uncertainty can severely degrade the performance of chaos prediction. We hereby propose a multi-stage extreme learning machine (MSELM) based approach for the continuous prediction of optical chaos, which handles data uncertainty effectively. Rather than relying on pilot signals for conventional reservoir learning, the proposed approach enables the use of predicted optical intensity as virtual training samples for the MSELM model learning, which leads to enhanced prediction performance and low overhead.

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Cocaine is a white crystalline alkaloid extracted from coca leaf. It can block human nerve conduction, produce local anesthetic effect, and has strong addiction. Therefore, the qualitative and quantitative analysis of cocaine is of great significance in forensic toxicology, pharmacy and metabolomics.

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The secretion, accumulation, and composition of extracellular polymeric substances (EPS) are pivotal factors influencing microalgal growth as well as wastewater recycling. Until now, the accumulation and inhibition mechanism of EPS of Chlorella vulgaris during cycling cultivation is not fully understood. The purpose of this study was to explore how different light qualities regulate the secretion, chemical composition, and structure of microalgal EPS, and subsequently influence the recycling of culture wastewater.

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To examine the effects of different solvents on the molecular weight, yield, chemical composition, and bioactivity of pectins, four RG-I type pectins were separately extracted from sweet potato residue (SPR) using hot water extraction (HWSP), sodium hydroxide extraction (SHSP), hydrochloric acid extraction (HASP), and chelating agents (CASP). The results showed that the four pectin samples comprised GalUA, Gal, Rha, Ara, Glc, GlcUA, Man, and Xyl components. Among these components, GalA content was the highest in all four pectins.

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It remains unknown whether the Chinese tree shrew, regarded as the closest sister of primate, has evolved a dorsolateral prefrontal cortex (dlPFC) comparable with primates that is characterized by a fourth layer (L4) enriched with granular cells and reciprocal connections with the mediodorsal nucleus (MD). Here, we reported that following AAV-hSyn-EGFP expression in the MD neurons, the fluorescence micro-optical sectioning tomography revealed their projection trajectories and targeted brain areas, such as the hippocampus, the corpus striatum, and the dlPFC. Cre-dependent transsynaptic viral tracing identified the MD projection terminals that targeted the L4 of the dlPFC, in which the presence of granular cells was confirmed via cytoarchitectural studies by using the Nissl, Golgi, and vGlut2 stainings.

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Understanding the fundamental light-sample interaction process is a crucial step toward the development of vibrational spectroscopy to determine fruit texture (i.e., firmness).

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Article Synopsis
  • The study explores the use of biochar in combination with reduced nitrogen fertilization to enhance saline soil conditions and promote soybean growth in affected agricultural areas.
  • Results indicate that both the application of biochar and its depth significantly improved soil quality and increased soybean yield, particularly under reduced nitrogen levels.
  • Key findings include a notable increase in beneficial nutrients and decreased harmful sodium levels in the soil, demonstrating the effectiveness of biochar in managing saline soils and optimizing nutrient use for better crop production.
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  • A study explored how a clinical oral rehabilitation program affects salivary metabolite changes, salivary flow rate, antimicrobial peptide levels, and oral health-related quality of life (OHRQoL) in dementia patients.
  • The experimental group received oral care intervention alongside standard information, showing significant improvements in salivary flow and OHRQoL compared to the control group at 3 and 6 months.
  • Results indicated that reductions in certain salivary peptide levels and increases in salivary flow were linked to better OHRQoL, suggesting the oral care program's effectiveness in managing oral health for dementia patients.
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Objective: Although guidelines support the efficacy of Modified Qing' E Formula (MQEF) in treating postmenopausal osteoporosis (PMOP), its underlying mechanisms remain incompletely understood. This retrospective investigation aims to elucidate MQEF's impact on serum exosomal miRNA expression in postmenopausal osteoporosis patients and to explore potential therapeutic mechanisms.

Methods: Following ethical approval and registration, postmenopausal osteoporosis patients aged 50-85 years, meeting the diagnostic criteria were randomly selected and received MQEF decoction supplementary therapy.

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We have developed a cryogen-free, low-temperature terahertz scanning tunneling microscope (THz-STM). This system utilizes a continuous-flow cryogen-free cooler to achieve low temperatures of ∼25 K. Meanwhile, an ultra-small ultra-high vacuum chamber results in the reduction of the distance from sample to viewport to only 4 cm.

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  • In vitro embryonic technology for farm animals faces challenges due to poor oocyte quality and limited developmental potential.
  • The study explores how changes in gut microbiota and metabolites impact follicular development by influencing gene expression in granulosa cells.
  • Results showed improved follicle size and oocyte quality in dairy heifers compared to non-lactating cows, linking gut microbiota metabolites to better follicular development through the gut-follicle axis.
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The study of quantum geometry effects in materials has been one of the most important research directions in recent decades. The quantum geometry of a material is characterized by the quantum geometric tensor of the Bloch states. The imaginary part of the quantum geometry tensor gives rise to the Berry curvature while the real part gives rise to the quantum metric.

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  • The ruby lattice is a tight-binding model that features a flat band in its electronic structure, making it promising for applications in spintronics and quantum devices.
  • Researchers successfully created an atomic ruby lattice by fabricating a monolayer of CuCl on a Au(111) substrate, enabling experimental exploration of this model.
  • Scanning tunneling microscopy and density-functional theory calculations confirmed the arrangement of copper atoms in a ruby lattice, along with a notable peak in density of states that aligns with theoretical expectations.
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Although therapeutic targets for colorectal cancer (CRC) treatment have been developed, the treatment outcomes are not ideal and survival rates for CRC patients remain low. It is critical to identify a specific target and develop an effective CRC treatment system. The ZNF334 gene is a newly identified member of Zinc-finger proteins (ZNFs), which is essential for key biological processes associated with tumorigenesis.

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  • Childhood socioeconomic disadvantage can lead to negative health outcomes, but factors promoting resilience, like neighborhood belonging, may help.
  • A study with 245 adolescents explored how neighborhood belonging influences the link between socioeconomic disadvantage and low-grade inflammation, a marker for chronic diseases.
  • Results showed that strong neighborhood belonging reduces the negative health impact of socioeconomic disadvantage, indicating that social connections are crucial for youth health resilience.
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  • Gossypol, a toxic compound in cotton, is harmful to most animals but ruminants like cows tolerate it due to their rumen microorganisms.
  • A study isolated Enterobacter sp. GD5 from rumen fluid to investigate the impact of gossypol on its metabolism and gene expression using techniques like LC-MS.
  • Results showed that gossypol altered 15 metabolites and affected 132 genes, notably increasing those related to oxidative stress, suggesting that this may help explain how Enterobacter sp. GD5 and ruminants tolerate gossypol.
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