A study on the variation of cytokine and electrolyte levels in rhesus macaques, cynomolgus monkeys, and Assamese macaques.

Background: Non-human primates (NPHs), such as rhesus macaques, cynomolgus monkeys, and Assamese macaques, play a crucial role in biomedical research. However, baseline cytokine and electrolyte data for these three species, particularly data stratified by age and sex, are limited. Therefore, the aim of this study was to establish and analyze age- and sex-specific cytokine and electrolyte profiles in these three species.

To live or to stay alive? A thematic and sentiment analysis of public posts on social media during the 2022 Shanghai COVID-19 outbreak.

Objective: The use of social media during the COVID-19 pandemic has been researched extensively since the outbreak. Sina Weibo, as one of most commonly used social media platforms in China, played an important role in public expression for the duration of COVID-19. We investigated the themes that emerged from the posts and examined the sentiments associated with each theme.

Establishment of a rhesus macaque model for coxsackievirus A6 infection: Pilot study to evaluate infection initiated through the respiratory or digestive track.

Coxsackievirus A6 (CVA6) is a primary pathogen associated with hand, foot, and mouth disease (HFMD) and is typified by fever, rashes or herpetic lesions at distinct locations. Although HFMD patients exhibit mild symptoms, a subset of patients may develop severe complications, such as viral encephalitis, myocarditis, pneumonia, and neurological disorders. However, in addition to rodent models, such as the CVA6-infected mouse model, no definitive nonhuman primate animal model or related research or analysis tool is available, which makes the development of suitable nonhuman primate animal models particularly crucial.

A 3-month-old neonatal rhesus macaque HFMD model caused by coxsackievirus B1 infection and viral tissue tropism.

Coxsackievirus B1 (CVB1), an enterovirus with multiple clinical presentations, has been associated with potential long-term consequences, including hand, foot, and mouth disease (HFMD), in some patients. However, the related animal models, transmission dynamics, and long-term tissue tropism of CVB1 have not been systematically characterized. In this study, we established a model of CVB1 respiratory infection in rhesus macaques and evaluated the clinical symptoms, viral load, and immune levels during the acute phase (0-14 days) and long-term recovery phase (15-30 days).

Coxsackievirus B3 HFMD animal models in Syrian hamster and rhesus monkey.

Coxsackievirus B3 (CVB3) is the pathogen causing hand, foot and mouth disease (HFMD), which manifests across a spectrum of clinical severity from mild to severe. However, CVB3-infected mouse models mainly demonstrate viral myocarditis and pancreatitis, failing to replicate human HFMD symptoms. Although several enteroviruses have been evaluated in Syrian hamsters and rhesus monkeys, there is no comprehensive data on CVB3.

Composition of the intestinal microbiota of infant rhesus macaques at different ages before and after weaning.

Background: Rhesus macaques and humans are closely related genetically and share similar physiological and pathological characteristics. Exploring the impact of diet on the early establishment of gut microbiota in non-human primates can provide relevant clinical models for healthy infant growth and development. At present, few writers have focused on the composition and changes of the intestinal microbes of infant rhesus macaques throughout their progression from birth to formula feeding after weaning.

Intestinal microbial diversity in female rhesus () at different physiological periods.

To explore the relationship between the changes in the physiological period and the fecal microbial population of female rhesus monkeys by measuring microbial composition of fecal samples and the serum hormones. Blood and fecal samples were collected from six female adult rhesus monkeys during the menstrual period (MP), ovulation period (OP), and Luteal period (LP). Serum estradiol (E2) and progesterone (P) levels were determined by the chemiluminescence method and the stool samples were subjected to high-throughput 16S rRNA sequencing.

Pathogenic analysis of coxsackievirus A10 in rhesus macaques.

Coxsackievirus A10 (CV-A10) is one of the etiological agents associated with hand, foot and mouth disease (HFMD) and also causes a variety of illnesses in humans, including pneumonia, and myocarditis. Different people, particularly young children, may have different immunological responses to infection. Current CV-A10 infection animal models provide only a rudimentary understanding of the pathogenesis and effects of this virus.

Hematological and biochemical parameters for Chinese rhesus macaque.

Rhesus macaque is an important animal model in biomedical research, especially human disease, developmental, translational, and pre-clinical research. Blood physiological and biochemical parameters are important markers for physiology, pathology, and toxicology research. However, these parameters have not been systematically reported for Chinese rhesus macaques.

A Microfacet-Based Model for Photometric Stereo with General Isotropic Reflectance.

This paper presents a precise, stable, and invertible reflectance model for photometric stereo. This microfacet-based model is applicable to all types of isotropic surface reflectance, covering cases from diffusion to specular reflections. We introduce a single variable to physically quantify the surface smoothness, and by monotonically sliding this variable between 0 and 1, our model enables a versatile representation that can smoothly transform between an ellipsoid of revolution and the equation for Lambertian reflectance.

Relationship of calcitonin gene-related peptide with disease progression and prognosis of patients with severe traumatic brain injury.

Calcitonin gene-related peptide (CGRP) has been implicated in multiple functions across many bioprocesses; however, whether CGRP is associated with severe traumatic brain injury (TBI) remains poorly understood. In this study, 96 adult patients with TBI (enrolled from September 2015 to December 2016) were divided into a mild/moderate TBI group (36 males and 25 females, aged 38 ± 13 years) and severe TBI group (22 males and 13 females, aged 38 ± 11 years) according to Glasgow Coma Scale scores. In addition, 25 healthy individuals were selected as controls (15 males and 10 females, aged 39 ± 13 years).

The effects of dietary soybean isoflavones on growth, innate immune responses, hepatic antioxidant abilities and disease resistance of juvenile golden pompano Trachinotus ovatus.

The present study was conducted to investigate the effects of dietary soybean isoflavones (SI) supplementation on growth performance, innate immune responses, hepatic antioxidant abilities, heat shock protein 70 (HSP70) gene expression and resistance to the pathogen Vibrio harveyi in Trachinotus ovatus. A basal diet was supplemented with SI at 0, 10, 20, 40, 60, 80 mg kg(-1) feed for 8 weeks. Significantly maximum weight gain (WG) and specific growth rate (SGR) were observed in treatment with 40 mg kg(-1) SI supplement (P < 0.

Type 2 diabetes mellitus non-genetic Rhesus monkey model induced by high fat and high sucrose diet.

To build an ideal animal model for studying the mechanism of occurrence, developing and treating of diabetes become a more important issue, facing with the fact that the big threat of diabetes to human health has been worsen. First, we used the normal control diets or the high-fat/high-sucrose diets to feed the adult rhesus monkeys and the macaques induced by the high-fat/high-sucrose diets in the high-fat/high-sucrose group and the type 2 diabetes mellitus (T2DM) group developed the hyperglycemia, hyperinsulinemia at 6 months in accordance with the precious researches that reported that minipigs, rats and mice could develop hyperglycemia, hyperinsulinemia, hyperlipidemia and obesity after being induced with high-fat/high-carbohydrate diets. Second, the rhesus monkeys in T2DM group were injected STZ at a low dosage of 35 mg/kg BW to induce glucose persistent elevation which maintained pretty well after 12 months.

[Fluorescence characteristics of different chlorophyll a concentration in Lake Taihu].

The spectral reflectance and water qualities of 27 stations were acquired in the lake Taihu during the months from May to August, 2008 when blue algal bloomed. Based on the fluorescence characteristics analysis of different chlorophyll a concentration, it was obvious that the position and height of fluorescence peak both have a positive correlation with chlorophyll a concentration, and the correlation coefficients between chlorophyll a concentration and position and half width of fluorescence peak are larger than those of the reference baseline and the normalized height of fluorescence. Estimating of chlorophyll a concentration in case 2 water using fluorescence characteristics is obviously better than the empirical algorithm based on blue to green ratio.

[Study on refining process of Flos Chrysanthemi extract with macroporous resin].

Objective: To determine the parameters of refining process of Flos Chrysanthemi extract with macroporous adsorption resin.

Methods: According to the chlorogenic acid and total flavonoids, to investigate the kind of macoroporous resin, the maximum quantity of physic liquor, and the type and quantity of elution solvent. Then combining with the retention rate of luteolin, to verify the parameters of the process.