Comparison of biomechanical characteristics of the Schneiderian membrane with different transcrestal sinus floor elevation techniques using three-dimensional finite element analysis.

Objective: The aim of this study was to establish a three-dimensional finite element (FE) hydraulic pressure technique model and compare the biomechanical characteristics of the osteotome technique and the hydraulic pressure technique using three-dimensional finite element analysis (FEA).

Methods: Three FE models were created: the hydraulic pressure technique (M1), the osteotome technique with a Ø 1.6-mm osteotome (M2), and the osteotome technique with a Ø 3.

HYQTD Drug-containing Serum Alleviates H2O2-induced Endothelial Oxidative Damage by Increasing Mitochondrial ATP Synthesis and Inhibiting ROS.

Background: Atherosclerosis (AS) is caused by the endothelium injury associated with oxidative stress. Previous studies have shown that the Phlegm-Eliminating and Stasis- Transforming Decoction (Huayu Qutan Decoction, HYQTD) has mitochondrial protective function. The objective of this research was to explore how HYQTD drug-containing serum (HYQTD-DS) could potentially protect mitochondrial energy production in endothelial cells (ECs) from injury caused by hydrogen peroxide (H2O2)-induced oxidative damage in AS through SIRT1/PGC-1α/ Nrf2 pathway.

Crystal Structural Editing: Novel Biaxial MgTeO Crystal as Zero-Order Waveplates.

Waveplates are important optical components to control the polarization of light. Currently, they are often fabricated from uniaxial crystals, and there is no report about waveplates based on the biaxial crystals. In this work, a novel biaxial crystal MgTeO with a structure constructed by 0D TeO groups is designed and grown as waveplate materials for the first time.

In-situ conversion of BiOBr to Br-doped BiOCl nanosheets for "rocking chair" zinc-ion battery.

Developing insertion-type anodes is essential for designing high-performance "rocking chair" zinc-ion batteries. BiOCl shows great potential as an insertion-type anode material for Zn storage due to its high specific capacity and unique layered structure. However, the development of BiOCl has been significantly hampered by its poor stability and kinetics during cycling.

Integrative Transcriptomic and Small RNA Analysis Uncovers Key Genes for Cold Resistance in Rice.

Background/objectives: Cold stress is the main environmental factor that affects the growth and development of rice, leading to a decrease in its yield and quality. However, the molecular mechanism of rice's low-temperature resistance remains incompletely understood.

Methods: In this study, we conducted a joint analysis of miRNA and mRNA expression profiles in the cold-resistant material Yongning red rice and the cold-sensitive material B3 using high-throughput sequencing.

Global Protein Interactome Mapping in Rice Using Barcode-Indexed PCR Coupled with HiFi Long-Read Sequencing.

Establishing the protein-protein interaction network sheds light on functional genomics studies by providing insights from known counterparts. However, the rice interactome has barely been studied due to the lack of massive, reliable, and cost-effective methodologies. Here, the development of a barcode-indexed PCR coupled with HiFi long-read sequencing pipeline (BIP-seq) is reported for high throughput Protein Protein Interaction (PPI)identification.

A novel oncolytic Vaccinia virus armed with IL-12 augments antitumor immune responses leading to durable regression in murine models of lung cancer.

Oncolytic vaccinia viruses (VVs) are potent stimulators of the immune system and induce immune-mediated tumor clearance and long-term surveillance against tumor recurrence. As such they are ideal treatment modalities for solid tumors including lung cancer. Here, we investigated the use of VVL-m12, a next-generation, genetically modified, interleukin-12 (IL-12)-armed VV, as a new therapeutic strategy to treat murine models of lung cancer and as a mechanism of increasing lung cancer sensitivity to antibody against programmed cell death protein 1 (α-PD1) therapy.

Design, Synthesis, and Pharmacodynamic Evaluation of Highly Selective PARP1 Inhibitors with Brain Penetrance.

Selective poly(ADP-ribose) polymerase 1 (PARP1) inhibitors not only exhibit antitumor efficacy but also offer the potential to mitigate the toxicities typically associated with broader PARP inhibition. In this study, we designed and synthesized a series of small molecules targeting highly selective PARP1 inhibitors. Among these, demonstrated excellent selectivity to PARP1 along with the capability to effectively cross the blood-brain barrier (BBB).

Using the Forel-Ule index (FUI) to track the water quality of subsidence water bodies across the life cycle of coal mining in eastern China.

The water quality and associated ecological risks in subsidence water bodies formed by underground coal mining are an increasing global concern. However, long-term water quality changes in these subsidence water bodies, especially across different spatial regions, remain poorly understood. This paper, by mapping the Forel-Ule index (FUI) a key indicator of water color, using Landsat datasets to reveal the dynamic evolution of water quality in 402 subsidence water bodies in the Huang-Huai-Hai Plain of eastern China from 1990 to 2020, covering their life cycle from formation to extinction.

Assessing Insulin Clearance in Mice via In Situ Liver Perfusion.

Hepatic insulin clearance is essential for maintaining glucose homeostasis and is closely linked to metabolic disorders such as obesity, insulin resistance, and diabetes. Accurate measurement of insulin clearance is vital for understanding the underlying mechanisms of these conditions. This protocol presents a straightforward and user-friendly hepatic perfusion procedure in mice, specifically designed to directly evaluate the hepatic insulin clearance rate.

Paroxetine promotes longevity via ser-7-dop-4-IIS axis in Caenorhabditis elegans.

Paroxetine, a selective serotonin reuptake inhibitor, is widely used in the clinical treatment of depression. While several antidepressants show promise as geroprotectors, the role of paroxetine in aging remains unclear. In this study, we evaluated the lifespan extension effect of paroxetine in Caenorhabditis elegans (C.

Effects of Peer Video Feedback Based on Cultural Historical Activity Theory in the Operational Training of New Nurses: A Quasi-Experimental Study.

Background: Previous studies have confirmed the potential effectiveness of peer video feedback in the operational training of health care students. However, an appropriate theoretical framework to support peer video feedback has not been established. The cultural historical activity theory (CHAT) provides a suitable framework.

Photochromic Film Based on a Mixed-Heteroatom-Templated Er-Incorporated Polyoxometalate Used for Inkless Prints and Anti-Counterfeiting.

Photochromic films have attracted increasing attention for their potential in information storage and photoswitchable devices. Developing novel photochromic materials is still a highly challenging topic. In this work, we successfully obtained an unprecedented mixed-heteroatom-templated Er-incorporated polyoxometalate [HN(CH)]NaKH{Er(HO)WO[SeTeWO][B-α-TeWO]}·117HO () by concurrently introducing the [TeO] and [SeO] heteroanion templates into the Er/WO system.

Gliadin/Konjac glucomannan particle-stabilized Pickering emulsion for honokiol encapsulation with enhanced digestion benefits.

Owing to the limited availability of biocompatible, edible and natural emulsifiers, the development of Pickering emulsions applicable to the food industry still confronts challenges. Moreover, Honokiol (HNK), due to its poor stability and susceptibility to oxidation, most of the existing delivery systems are centered on injection administration routes and relatively complex in preparation, posing significant challenges for industrialization. In this research, a Pickering emulsion system stabilized by gliadin and konjac glucomannan composite particles (GKPs) was constructed using the pH cycling method and was employed for the delivery of HNK.

Characterization of MPK family members in the genus Citrus (Rutaceae) and analysis of the function of AbMPK13 in the response to citrus canker in Atalantia buxifolia.

Citrus bacterial canker has deleterious effects on global citrus production. The mitogen-activated protein kinase (MAPK) signaling cascade regulates plant defense against pathogen infection. Here, we identified 11 MAPKs in Atalantia buxifolia, a wild citrus species with high stress tolerance.

A case report of -related hyperphosphatasia with impaired intellectual development syndrome in a Chinese family and literature review.

Recently, mutations have been identified in six genes (, , , , and ) encoding proteins in the Glycosyl phosphatidylinositol(GPI)-anchor-synthesis pathway in individuals with hyperphosphatasia with impaired intellectual development syndrome(HPMRS). Reports involving the rare pathogenic gene, post-GPI attachment to proteins 2 () are quite limited. In this study, we reported two patients with variants related neurodevelopmental disorders from Asian population.

Fluorescent poly(tannic acid)-based nanoprobes for selective and sensitive detection of bismuth ions.

Herein, blue luminescent fluorescent poly(tannic acid) nanoparticles (FPTA NPs) were fabricated through chemical degradation of poly(tannic acid) large particles using HO, and the obtained FPTA NPs exhibited excellent water dispersibility, great fluorescence stability, and relatively high quantum yield. More importantly, based on the dynamic quenching and chelation enhanced quenching effect between FPTA NPs and bismuth ions (Bi), a fluorescence method for the rapid identification and detection of Bi was developed. With the increase of Bi, the fluorescence of FPTA NPs could be quenched gradually; the linear range was 0.

Resin monomers induce apoptosis of the pulp-dentin complex through the mitochondrial pathway.

Numerous studies have confirmed that the apoptosis induced by the methacrylate resin monomers triethyleneglycol-dimethacrylate (TEGDMA), 2-hydroxy ethyl methacrylate (HEMA), etc., in pulp cells and odontoblast-like cells is caused mainly by oxidative stress (OS). Reactive oxygen species (ROS), recognized as the most important risk factor for apoptosis in cells of the pulp-dentin complex, are produced mainly via the mitochondrial respiratory chain.

Effect of sodium hypochlorite and EDTA pretreatment on the resin infiltration efficacy and acid resistance of enamel white spot lesions: an in vitro study.

Background: This in vitro study aimed to evaluate the effect of sodium hypochlorite (NaOCl) and ethylene diamine tetraacetic acid (EDTA) as pretreatments on the resin infiltration efficacy and acid resistance of enamel white spot lesions (WSLs).

Methods: Enamel blocks prepared from the buccal surfaces of sound human premolars were placed in a demineralisation solution for 3 days to establish artificial enamel WSLs. All the blocks with WSLs were randomly divided into four groups (n = 40 per group): RI (Control): resin infiltration only.

Prediction of SHP2-E76K binding sites based on molecular dynamics simulation and Markov algorithm.

SHP2-E76K, a mutant encoded by the PTPN11 gene, was associated with various solid tumors, such as lung cancer, glioblastoma, and intellectual disability. SHP2-E76K has become potential drug targets, while there was no effective inhibitor against the mutant currently. At present, the crystal complex structure of SHP099 with SHP2-E76K has been reported in the RCSB PDB protein data bank, however, the dynamic structure of SHP099 binding to the active center of SHP2-E76K protein was still lacking.

Identification of Active Ingredients in Ginseng Volatile Oil: A Strategy Combining Computer Virtual Screening With Experimental Validation.

Background: Ginseng volatile oil (GVO) is a valuable active ingredient in ginseng (Panax ginseng C. A. Mey.

Quality maintenance and metabolite changes of grape berry treated by high voltage alternating electric field during near-freezing temperature storage.

High Voltage Alternating Electric Field (HVAEF), as an emerging postharvest preservation technology, is environmentally friendly and has garnered significant attention from scholars. This study investigated the effects of HVAEF on the postharvest quality and metabolite changes in 'Shine Muscat' grapes stored at near-freezing temperatures. The results demonstrated that HVAEF halved the weight loss and decay rate, inhibited browning by preserving polyphenol content, and reduced polyphenol oxidase and peroxidase activities, thereby extending the storage time by more than 20 days.