Publications by authors named "Chen LiangWan"

Objective: The objective of this study is to examine the postoperative self-management experiences of patients with aortic dissection (AD) through qualitative interviews, providing a foundation for the standardized management of postoperative home care for these patients.

Methods: Semi-structured interviews were conducted with 18 patients with AD postoperatively, in the cardiac surgery department of a tertiary hospital in Fujian Province between March and May 2020. This qualitative study used phenomenological methods and purposive sampling, with data analyzed using Colaizzi's seven-step approach to extract themes.

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  • Postoperative cognitive dysfunction (POCD) is a complication linked to negative outcomes after cardiac surgery, and this study examines preoperative hypersensitive C-reactive protein (Hs-CRP) as a potential predictor of POCD in patients with valvular heart disease (VHD).
  • Analyzing data from 372 VHD patients, the study found a 27.6% incidence of POCD one month post-surgery, with significant differences in age, education level, Hs-CRP levels, and duration of mechanical ventilation between patients who developed POCD and those who did not.
  • The findings suggest that elevated preoperative Hs-CRP levels are an independent risk factor for POCD,
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Background: The aim of this study is to explore the value of different systemic inflammatory response indicators in the long-term prognosis of type B aortic dissection (TBAD) patients undergoing thoracic endovascular aortic repair (TEVAR).

Methods: This study retrospectively reviewed the case data of 540 patients with TBAD at our center from January 2013 to January 2019. Based on the occurrence of aorta-related adverse events (ARAEs) during follow-up, patients were divided into two groups: the ARAEs group and the non-ARAEs group.

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Objective: This study aims to investigate the association between preoperative serum uric acid to high-density lipoprotein cholesterol ratio (UHR) and the occurrence of postoperative acute kidney injury (AKI) in patients who underwent coronary artery bypass grafting (CABG).

Methods: A prospective observational study was conducted at Fujian Heart Medical Center between May 2022 and December 2023, recruiting patients scheduled for CABG. Participants were categorized into two groups based on AKI occurrence post-surgery.

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Background: Prolonged mechanical ventilation (PMV) is a common complication after cardiac surgery and is considered a risk factor for poor outcomes. However, the incidence and in-hospital mortality of PMV among cardiac surgery patients reported in studies vary widely, and risk factors are controversial.

Methods: We searched four databases (Web of Science, Cochrane Library, PubMed, and EMBASE) for English-language articles from inception to October 2023.

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Background: Enhanced respiratory muscle management is imperative in cardiac surgery patients due to their universal risk of decreased perioperative respiratory muscle strength.

Objectives: Most existing articles primarily examine respiratory muscle exercise during either the preoperative, postoperative, or at-home phases. Consequently, there is a crucial need to consolidate the evidence for respiratory muscle exercise throughout the perioperative period of cardiac surgery.

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Background: Readmission to the intensive care unit (ICU) remains a severe challenge, leading to higher rates of death and a greater financial burden. This study aimed to develop a nomogram-based prediction model for individuals with acute type A aortic dissection (ATAAD).

Methods: A total of 846 ATAAD patients were retrospectively enrolled between May 2014 and October 2021.

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  • Poor sleep quality is linked to worse clinical outcomes in patients with acute aortic dissection, increasing risks like postoperative delirium, in-hospital death, and prolonged mechanical ventilation.
  • Patients with poor sleep quality had significantly higher rates of complications compared to those with good sleep quality, indicating that sleep quality can affect recovery.
  • The study suggests that quickly assessing sleep quality preoperatively could help identify patients at greater risk for adverse outcomes, allowing for better management and care strategies.
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Increasingly, the shared risk factors and pathological processes of atherosclerosis and abdominal aortic aneurysm (AAA) are being recognized. The aim of our study was to identify the hub genes involved in the pathogenesis of atherosclerosis and AAA. The analysis was based on 2 gene expression profiles for atherosclerosis (GSE28829) and AAA (GSE7084), downloaded from the Gene Expression Omnibus database.

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Purpose: Acute Type A aortic dissection (ATAAD) is a rare and life-threatening aortic disease. This study was aimed at the potential of the D-dimer to platelet count ratio (DPR) as a prognostic indicator of ATAAD.

Patients And Methods: This study retrospectively analyzed ATAAD patients who were admitted to the Department of Cardiac Surgery, Fujian Medical University Union Hospital from January 2022 to April 2023.

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Background And Aims: Aortic dissection (AD) is a fatal condition with a complicated pathogenesis. High mobility group protein B2 (HMGB2) is a member of the high mobility group protein family; HMGB2 is involved in innate immunity and inflammatory diseases, but its role in AD remains unclear.

Methods: HMGB2 mice were generated and treated with β-aminopropionitrile and angiotensin II (Ang II) to establish an AD model.

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  • A study investigated the link between the serum calcium-magnesium (Ca/Mg) ratio and clinical outcomes in patients with acute coronary syndrome (ACS), suggesting that lower ratios may indicate worse outcomes.
  • The research analyzed data from 1,775 ACS patients who underwent coronary procedures, dividing them into four groups based on their Ca/Mg ratios to compare clinical characteristics and postoperative outcomes.
  • Results indicated that a higher Ca/Mg ratio correlates with lower risks of major adverse events and in-hospital mortality, emphasizing the potential protective role of magnesium in cardiovascular health.
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Total thoracoscopic valve replacement (TTVR) is a minimally invasive alternative to traditional open-heart surgery. However, some patients undergoing TTVR experience prolonged mechanical ventilation (PMV). Predicting PMV risk is crucial for optimizing perioperative management and improving outcomes.

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Purpose: Many shift nurses experience poor sleep quality, and the effect on nurses' cognitive function remains unclear. The study aims to investigate sleep status and explore its association with cognitive function.

Methods: This descriptive cross-sectional study was conducted in a tertiary care hospital in Fujian, China between March and September 2022.

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  • The study aimed to explore differences in clinical characteristics and hospital outcomes between male and female patients undergoing surgery for acute type A aortic dissection (AAAD).
  • It included 1137 patients from a cardiac surgery department, analyzing data for outcomes like in-hospital mortality and postoperative complications, with findings showing some differences in symptom presentation and complication rates.
  • Ultimately, the in-hospital mortality rates were similar for both sexes, but females had higher rates of postoperative arrhythmia, while males faced more acute kidney injury and gastrointestinal hemorrhage, highlighting the need for sex-specific considerations in treatment approaches.
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Purpose: The Aggregate Index of Systemic Inflammation (AISI) has emerged as a novel marker for inflammation and prognosis, but its role in patients with acute myocardial infarction has not been studied. Therefore, this study aimed to investigate the impact of different AISI levels on the clinical outcomes of patients with acute myocardial infarction.

Patients And Methods: This study was a retrospective study, including 1044 patients with acute myocardial infarction (AMI) who were treated at the Fujian Medical University Affiliated Union Hospital, China from May 2017 to December 2022.

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Background: Ischemic cardiomyopathy (ICM) is a common condition that leads to left ventricular (LV) functional remodeling and poor prognosis. Extracorporeal membrane oxygenation (ECMO) can provide temporary circulatory support and facilitate percutaneous coronary intervention (PCI) in patients with ICM and hemodynamic instability. However, the impact of ECMO-assisted PCI on LV functional remodeling and clinical outcomes in ICM patients is unclear.

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Objective: This study strives to the variation and significance of microRNA-21 () in children with congenital heart disease (CHD)-related pulmonary artery hypertension (PAH).

Methods: Children with CHD ( = 179) were selected as subjects, including 101 children without PAH and 78 children with PAH. All children underwent general data collection, laboratory examination, echocardiography and cardiac catheterization.

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Objectives: To identify independent predictors of late recurrence of atrial fibrillation (AF) after surgical ablation in patients undergoing rheumatic valve surgery.

Methods: A total of 258 patients who underwent surgical ablation for AF with rheumatic heart disease at our hospital between January 2019 and June 2022 were retrospectively included. The patients were followed up for 12 months.

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Introduction: Acute myocardial infarction (AMI) is a serious, deadly disease with a high incidence. However, it remains unclear how necroptosis affects the pathophysiology of AMI. Using bioinformatic analyses, this study investigated necroptosis in AMI.

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This study unveils the pivotal roles of taurine metabolic reprogramming and its implications in the development and progression of Abdominal Aortic Aneurysm (AAA). Leveraging an integrated approach that combines single-cell RNA sequencing (scRNA-seq) and Weighted Gene Co-expression Network Analysis (WGCNA), our research investigates the intricate transcriptional and gene expression dynamics crucial to AAA. Our findings uniquely link metabolic shifts to the integrity of the extracellular matrix (ECM) and the functionality of smooth muscle cells (SMCs), key elements in the pathology of AAA.

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There is still controversial or limited evidence on whether sex differences exist in clinical characteristics, the risk of contrast-induced nephropathy (CIN), and other clinical outcomes of patients who received coronary angiography (CAG) and/or percutaneous coronary intervention (PCI). The aim of this study was to characterize the effect of sex on clinical characteristics and outcomes of patients undergoing CAG and/or PCI. A total of 3,340 consecutive patients undergoing CAG and/or PCI from May 2017 to December 2022 were assessed in this retrospective study.

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  • A study examined the levels of postoperative kinesiophobia (fear of movement) in patients who had surgery for acute type A aortic dissection (AAAD), finding high prevalence among the cohort.
  • Researchers assessed patients treated between January 2019 and December 2021, using a specific scale to measure kinesiophobia and identifying factors that influenced these levels through statistical analyses.
  • Key findings indicated that education, self-efficacy, family support, and coping strategies helped reduce kinesiophobia, whereas avoidance and yielding coping styles worsened it, highlighting the need for medical staff awareness in rehabilitation programs.
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Malnutrition is linked to adverse outcomes in post-cardiac surgery patients. This study investigates the correlation between the Geriatric Nutritional Risk Index (GNRI) and adverse hospital outcomes in patients following cardiac surgery. This retrospective study included elderly patients with heart disease who were admitted to the Department of Cardiology, Fujian Medical University Union Hospital from January 2020 to December 2022.

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Purpose: The inflammatory response of the body is intimately linked to the quick onset and high in-hospital mortality of Acute Type A Aortic Dissection (ATAAD). The purpose of the study was to examine the connection between in-hospital mortality in patients with ATAAD upon admission and the Pan-Immune-Inflammation Value (PIV).

Patients And Methods: 308 patients who were diagnosed with ATAAD between September 2018 and October 2021 at Fujian Provincial Center for Cardiovascular Medicine had their clinical data retrospectively examined.

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