Topical application of Glauber's salt accelerates the absorption of abdominal fluid after pancreatectomy.

Background: Abdominal fluid collection (AFC) is one of the most common complications after pancreatic surgery, yet there are few recommendations on how to manage it. Most cases of AFC only require observation, while others may require more invasive techniques. Unfortunately, there are no drugs that effectively promote the absorption of AFCs.

Safety and efficacy of anatomical tunneling technique for precise lung segment resection in complex anatomical settings.

Background: Thoracoscopic segmentectomy is the main surgical method for the treatment of earlylung cancer. With the promotion of technology and increasingly accurate criteria for lung subsegments, lung nodules with complex positions involving intersegmental and multisegments have become technical bottlenecks. This study aimed to verify whether seeking anatomical conditions for creating a fissure by tunneling techniques with precise resection of lung segments could solve this bottleneck problem.

Biomimetic "Trojan Horse" Fibers Modulate Innate Immunity Cascades for Nerve Regeneration.

Neutrophil membrane vesicles (NMVs) have been successfully applied to control the inflammatory cascade after spinal cord injury (SCI) by acting as an inflammatory factor decoy to front-load the overall inflammation regulatory window; however, the mechanisms by which NMVs regulate macrophage phenotypic shifts as well as their outcomes have rarely been reported. In this study, we demonstrated the "efferocytosis-like" effect of NMVs endocytosed by macrophages, supplementing the TCA cycle intermediate metabolite α-KG by promoting glutamine metabolism, which in turn facilitates oxidative phosphorylation and inhibits the NF-κB signaling pathway to reprogram inflammatory macrophages to the pro-regenerative phenotype. Based on these findings, a "Trojan horse" composite fiber scaffold was constructed; this comprised a carboxylated poly-l-lactic acid shell encapsulated with NMVs and a core loaded with brain-derived neurotrophic factor to spatiotemporally modulate the inflammatory microenvironment by 39.

Efficient Photolysis of Multidrug-Resistant Polymicrobial Biofilms.

Chronic wounds are prone to infections with multidrug-resistant bacteria, forming polymicrobial biofilms that limit treatment options and increase the risk of severe complications. Current cleansing options are insufficient to disrupt and remove tenacious biofilms; antibiotic treatments, on the other hand, often fall short against these biofilm-embedded bacteria. This study explores an non-antibiotic approach that extends beyond conventional porphyrin-based phototherapy by using blue light (BL) in conjunction with ferric ions (Fe(III)) to disrupt and eradicate biofilms.

Baicalin alleviates intestinal inflammation and microbial disturbances by regulating Th17/Treg balance and enhancing Lactobacillus colonization in piglets.

Background: Intestinal inflammation is a common and serious health problem in piglet production, especially enteritis caused by pathogenic Escherichia coli (E. coli). This condition often leads to high mortality, slow weight gain, and significant economic losses.

Sulfur-vacancy engineering of CoS/TiCT-MXene catalyst for efficient oxygen evolution reaction.

Integrating conductive supports and modulating electronic structures are widely recognized as effective strategies for improving the catalytic performance of transition metal sulfides. This study demonstrates the simultaneous integration of CoS with two-dimensional TiCT-MXene and the introduction of sulfur vacancies (S) in CoS through a straightforward sintering process followed by plasma treatment, culminating in the formation of the CoS/TiCT composite. Characterization results demonstrate that the TiCT support significantly improves electrical conductivity and promotes the uniform dispersion of CoS nanoparticles.

[Literature research and discussion on properties of a new oversea-introduced traditional Chinese medicine Malaysian ginseng(Tongkat Ali)].

Tongkat Ali(Eurycoma longifolia Jack.) is a medicinal plant of Simaroubaceae in Southeast Asia, with centuries of medicinal history. Rich clinical and pharmacological research results have been attained for this plant, which demonstrates diverse and definite effects and high safety, showcasing advantages and broad market prospects to be introduced as a new medicinal plant.

Reactive oxygen species switcher via MnO-coated Prussian blue loaded hyaluronic acid methacrylate hydrogel microspheres for local anti-tumor treatment.

ROS-induced therapy can eradicate breast tumors when combined with thermal ablation, but excessive ROS also threatens peritumoral tissue with inflammation. To eradicate tumors and avoid inflammatory sequela, it is necessary to generate ROS in treatment stage and scavenge ROS in prognostic stage. However, it is a great challenge to reverse ROS in different stages.

Refraction difference value variations in children and adolescents with different refractive errors.

Aim: To evaluate the refraction difference value (RDV) variations in children and adolescents with different refractive errors and analyze its correlation with refractive development.

Methods: Participants aged 4-16y with different refractive statuses (hyperopia, emmetropia, myopia) underwent comprehensive eye examinations, including spherical equivalent (SE) refraction, axial length (AL), total RDV (TRDV), and RDVs at various eccentricities (0°-15°, 15°-30°, 30°-45°) and quadrants (inferior, superior, nasal, temporal). Statistical analysis involved one-way ANOVA for group comparisons and Pearson correlation for examining relationships between SE/AL and RDVs.

Investigation of the relationship between lead exposure in heavy metals mixtures and the prevalence of stroke: a cross-sectional study.

Background: The adverse effects of environmental toxic metal exposure on human health are well-documented. However, the specific influence of heavy metal exposure on stroke prevalence remains underexplored.

Methods: This study utilized data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2011 to 2018 to investigate the association between blood metal concentrations and the incidence of stroke.

Exploring PDE5A upregulation in bipolar disorder: insights from single-nucleus RNA sequencing of human basal ganglia.

Basal ganglia is proposed to mediate symptoms underlying bipolar disorder (BD). To understand the cell type-specific gene expression and network changes of BD basal ganglia, we performed single-nucleus RNA sequencing of 30,752 nuclei from caudate, putamen, globus pallidus, and substantia nigra of control human postmortem brain and 24,672 nuclei from BD brain. Differential expression analysis revealed major difference lying in caudate, with BD medium spiny neurons (MSNs) expressing significantly higher PDE5A, a cGMP-specific phosphodiesterase.

SENP1 promotes deacetylation of isocitrate dehydrogenase 2 to inhibit ferroptosis of breast cancer via enhancing SIRT3 stability.

Breast cancer, one of the most prevalent malignant tumors in women worldwide, is characterized by a poor prognosis and high susceptibility to recurrence and metastasis. Ferroptosis, a lipid peroxide-dependent programed cell death pathway, holds significant potential for breast cancer treatment. Therefore, investigating the regulatory targets and associated mechanisms of ferroptosis is crucial.

Thymol Impacts the Progression of Endometriosis by Disrupting Estrogen Signaling Pathways and Inflammatory Responses.

Endometriosis is a chronic inflammatory, estrogenic disorder caused by endometrial tissue growth places other than uterine lumen, resulting in infertility and severe pelvic pain. Thymol, an extract of , processes diverse biological properties, including anti-inflammatory, local anesthetic, decongestant, and antiseptic effects. However, the efficacy of thymol in treating endometriosis has still not been explored.

Transcriptome Analysis Reveals the Molecular Mechanisms of Carrot Adaptation to Alternaria Leaf Blight.

Carrot ( L.) is an important vegetable crop that is rich in carotenoids and is widely cultivated throughout the world. Alternaria leaf blight (ALB), caused by infection with (), is the most serious fungal disease in carrot production.

Factors associating with bone-only metastasis in Chinese breast cancer patients in the absence of anti-HER2 targeted therapy.

Introduction: Bone-only metastasis (BOM) is a distinct clinical phenomenon in which cancer cells disseminate exclusively to the bone, without involvement of other distant organs. We investigated the factors associated with the BOM state vs. other states of metastasis in breast cancer patients with bone metastasis (BM) at their first relapse.

The impact of maternal emotional warmth on adolescents' internalizing problem behaviors: the roles of meaning in life and friendship conflict.

Introduction: Numerous studies suggest that maternal emotional warmth is a critical protective factor against adolescents' internalizing problem behaviors. However, the underlying mechanisms linking these variables remain unclear. Grounded in ecological systems theory, this study explores the impact mechanisms of social support (maternal emotional warmth), individual resource (meaning in life), and environmental factor (friendship conflict) on adolescents' internalizing problem behaviors.

Molecular Insights into the Regulation of GNPTAB by TMEM251.

In vertebrates, newly synthesized lysosomal enzymes traffick to lysosomes through the mannose-6-phosphate (M6P) pathway. The Golgi membrane protein TMEM251 was recently discovered to regulate lysosome biogenesis by controlling the level of GlcNAc-1-phosphotransferase (GNPT). However, its precise function remained unclear.

Decoding the role of in enhancing osmotic stress tolerance in rice through ABA-dependent pathways and ROS scavenging.

Plant Class III peroxidases have diverse roles in controlling root hair growth, anther development, and abiotic and biotic stress responses. However, their abiotic stress response mechanism in rice remains elusive. Here, we identified a peroxidase precursor gene, , and investigated its role in enhancing osmotic stress tolerance in rice.

Improving grain yield and salt tolerance by optimizing plant height with beneficial haplotypes in rice (Oryza sativa).

Introduction: Rice (Oryza sativa L.), a staple food for billions worldwide, is challenged by salt stress. Owing to the limited understanding of the physiological and genetic basis of rice salt tolerance, few genes have been identified as valuable in rice breeding, causing a major bottleneck in the development of high-yield, salt-tolerant rice varieties.

Innovative formaldehyde adsorption with optimized deep eutectic solvents: An experiment and multilevel computational chemistry approach.

Formaldehyde, a hazardous gas that is exposed to everyone every day, has been proven to pose an elevated risk of respiratory problems, allergies, and chronic diseases. Adsorption technologies have proven to be a straightforward and labor-saving method to reduce indoor formaldehyde levels. Currently, extensive research has been conducted utilizing Deep Eutectic Solvents (DES) as adsorbents for harmful gases, yet the adsorption and conversion mechanisms for formaldehyde remain unclear.

Structural characteristics, techno-functionalities, innovation applications and future prospects of soybean β-conglycinin/glycinin: a comprehensive review.

The structural molecules and conformational variations of soybean β-conglycinin/glycinin are crucial in defining the characteristics of protein-based foods. Recently, significant attention has been focused on the characteristics of soybean β-conglycinin/glycinin across various fields, particularly their structure and application. The research contributes to expanding the application fields of soybean protein-related component in food industry.

Revealing the structural characteristics of lignin and recalcitrant components in bamboos of different heights.

Understanding the chemical structural differences of key components at varying bamboo heights enhances knowledge of its biological properties and adaptive mechanisms, promoting its high-value utilization. In this study, lignin and lignin-carbohydrate complexes (LCC) were extracted from the base, middle, and top sections of bamboo culms, and the chemical composition, micro-regional distribution, and structural characteristics of key components were analyzed. Results showed that both lignin and hemicellulose contents followed the trend: top > base > middle.

Effects of soil bulk density and corresponding soil infiltration rate on the migration and transformation of gibberellic acid.

High intensity agricultural activities can lead to a decrease in soil fertility and an increase in soil bulk density, which may significantly impact the migration and transformation of pesticides in soil. As a new widely-used micro-toxic pesticide, gibberellic acid (GA) is more soluble and hydrophilic than most pesticides, which could readily migrate throughout the soil during water infiltration and impact groundwater quality. In this study, the leaching of GA in saturated soils with different bulk densities (1.