Effect of different surface treatments on PEEK-enamel bonds: Bonding durability and mechanism.

Statement Of Problem: Polyetheretherketone (PEEK) has been used in clinical dentistry because of its excellent physical and biological properties. However, achieving an effective and durable bond with enamel is challenging because of its chemical inertness and low surface energy, and data on the effects of different surface treatments on the durability of PEEK-enamel bonds are scarce.

Purpose: The purpose of this in vitro study was to investigate airborne-particle abrasion, sulfuric acid etching, and the combined use of these treatments on the bonding durability of PEEK-enamel bonds and to gain a deeper understanding of their bonding mechanism.

Ecological and environmental effects of global photovoltaic power plants: A meta-analysis.

The construction of photovoltaic power plants (PVPPs) globally not only mitigates climate change but also exerts various impacts on terrestrial ecosystems. A comprehensive exploration of the intensity of PVPPs on the ecological environmental elements of terrestrial ecosystems, as well as their regulatory mechanisms, is an urgent scientific issue that must be addressed within the context of carbon balance. In this study, we conducted a meta-analysis to investigate the soil, climate, and biological effects of PVPPs construction, as well as changes in ecosystem CO fluxes.

Naphpyrones A-H, Antibacterial Aromatic Polyketides Isolated from the A3(2)/ ΔH3.

, a common foodborne pathogen, has a close association with agriculture and food. With the rapid emergence and widespread dissemination of antimicrobial resistance, efforts have been directed toward developing and studying new antimicrobial compounds to inhibit the growth of and other foodborne pathogens, thereby preventing contamination and ensuring food safety. Herein, we reported eight new aromatic polyketides, naphpyrones A-H (-), from the heterologous expression strain A3(2)/ ΔH3.

β-actin function in platelets and red blood cells can be performed by γ-actin and is therefore independent of actin isoform protein sequence.

Actin is an essential component of the cytoskeleton in every eukaryotic cell. Cytoplasmic β-and γ-actin are over 99% identical to each other at the protein level, but are encoded by different genes and play distinct roles in vivo. Blood cells, especially red blood cells (RBC), contain almost exclusively β-actin, and it has been generally assumed that this bias is dictated by unique suitability of β-actin for RBC cytoskeleton function due to its specific amino acid sequence.

Hematopoietic adverse events associated with PARP Inhibitors:A FAERS database study.

Objectives: To identify and analyze hematopoietic adverse drug reaction (ADR) signals associated with Olaparib, Niraparib, Rucaparib, and Talazoparib - poly(ADP-ribose) polymerase (PARP) inhibitors - using data from the U.S. Food and Drug Administration's Adverse Event Reporting System (FAERS) database, providing guidance for rational clinical use.

Effects of remote support courses on parental mental health and child development in autism: A randomized controlled trial.

Background: Sustaining the mental health of autistic children's parents can be demanding.

Aim: To determine the effect of remote support courses on the mental health of parents and the development of autistic children.

Methods: Parents of 140 autistic children were randomly assigned to two groups receiving a 2-week intervention: The control group received caregiver-mediated intervention (CMI); the experimental group received CMI with remote family psychological support courses (R-FPSC).

Investigating the therapeutic effects of Shenzhiling oral liquid on Alzheimer's disease: a network pharmacology and experimental approach.

There is currently no effective treatment for Alzheimer's disease (AD). This research explored Shenzhiling Oral Liquid (SZLD) against AD by pinpointing crucial elements and understanding its molecular mechanisms through network pharmacology and in vitro experiment. First, we used network pharmacology to screen the main targets and mechanisms of SZLD to improve AD.

The EstroGene2.0 database for endocrine therapy response and resistance in breast cancer.

Endocrine therapies targeting the estrogen receptor (ER/ESR1) are the cornerstone to treat ER-positive breast cancers patients, but resistance often limits their effectiveness. Notable progress has been made although the fragmented way data is reported has reduced their potential impact. Here, we introduce EstroGene2.

Prognostic Significance of Preoperative Neutrophil-to-lymphocyte Ratio and Platelet-to-lymphocyte Ratio in Patients with Ruptured Abdominal Aortic Aneurysm Undergoing Endovascular Aneurysm Repair.

Background: Ruptured abdominal aortic aneurysm (RAAA) is a fatal disease. This study aimed to assess the prognostic value of the preoperative neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with RAAA undergoing endovascular aneurysm repair (EVAR).

Materials And Methods: This retrospective study included patients with RAAA who underwent EVAR from 2012 to 2022.

Dietary methionine supplementation promotes mice hematopoiesis after irradiation.

Background: With the increasing risk of nuclear exposure, more attention has been paid to the prevention and treatment of acute radiation syndrome (ARS). Although amino acids are key nutrients involved in hematopoietic regulation, the impacts of amino acids on bone marrow hematopoiesis following irradiation and the associated mechanisms have not been fully elucidated. Hence, it is of paramount importance to study the changes in amino acid metabolism after irradiation and their effects on hematopoiesis as well as the related mechanisms.

[Salidroside alleviates high glucose and ethanol-induced pyroptosis in insulinoma cells].

This study established a pyroptosis injury model by stimulating insulinoma cells(INS-1) of rats with high glucose(HG) and observed the impact of additional ethanol(ET) exposure on cell pyroptosis, as well as the intervention effect of salidroside(SAL). INS-1 cells were cultured and divided into a normal control group(NG), an HG group, an HG + ET(100 mmol·L~(-1)) group, and an HG + ET + SAL(1-100 μmol·L~(-1)) group. After 72 hours of treatment, cell viability was assessed using the cell counting kit-8(CCK-8) assay.

Fluid-Actuated Nano-Micro-Macro Structure Morphing Enables Smart Multispectrum Compatible Stealth.

Modern detection technology has driven camouflage technology toward multispectral compatibility and dynamic regulation. However, developing such stealth technologies is challenging due to different frequency-band principles. Here, this work proposes a design concept for a fluid-actuated multispectral compatible smart stealth device that employs a deformable mechanochromic layer/elastomer with a channeled dielectric layer.

Optimal Environmental Siting of Future Wind Turbines in the North Sea.

Offshore wind energy (OWE) represents a key technology for achieving a sustainable energy transition. However, offshore wind farms (OWFs) can impact the environment via installation, operation, maintenance, and decommissioning activities together with the raw materials and energy required for their manufacturing. This study assesses the material and carbon footprint of potential OWF locations in the North Sea for various possible future technology developments.

Potential for contrast-enhanced intraoperative ultrasonography with the Kupffer phase to improve and guide therapeutic strategies for hepatocellular carcinoma.

Background: Not all malignant tumors, especially in hepatocellular carcinoma (HCC) patients with cirrhosis, can be detected by preoperative imaging methods. Therefore, it is urgently necessary to improve the intraoperative detectability of HCCs. Contrast-enhanced intraoperative ultrasonography (CE-IOUS) is an effective technique for detecting and characterizing occulting HCC lesions.

Signal detection and analysis of adverse events associated with Genvoya based the FAERS database.

Objective: This study aims to evaluate and understand the safety profile of Genvoya by mining and analyzing adverse drug event (ADE, adverse drug event) reports from the FDA Adverse Event Reporting System (FAERS, FDA Adverse Event Reporting System) database, thus providing valuable reference information for individuals infected with HIV.

Methods: Data were obtained from the FAERS database, covering the period from the first quarter of 2015 to the fourth quarter of 2023, focusing on reports where Genvoya was the primary suspected drug. Data import and extraction were conducted using MySQL 8.

Effects of Jintiange on the healing of osteoporotic fractures in aged rats.

Objective: To examine the effects of Jintiange on enhancing the healing of osteoporotic fractures in aged rats.

Methods: An osteoporotic fracture model of femur was established using 70 SD rats (aged > 12 months), which were randomly numbered and divided into an experimental group and a control group, each with an equal sample size (n = 35). The experimental group received Jintiange capsule ingredients via intragastric administration, while the control group received an equal volume of saline via the same method.

Data mining in FAERS: association of newer-generation H1-antihistamines with nervous system disorders.

Background: H1-antihistamines are widely used to treat symptoms depending on histamine release in a variety of conditions. However, neurological adverse events have been reported in post-marketing surveillance studies and there are limited literatures comparing the neurological disorders associated with newer-generation H1-antihistamines from real-world datasets.

Aims: We performed a comparative analysis of nervous system disorders and several newer-generation H1-antihistamines including: cetirizine, loratadine, levocetirizine, desloratadine and fexofenadine.

Physical-medical integration policies and health equity promotion in China: a text analysis based on policy instruments.

Background: In China, although policies promoting physical-medical integration have received widespread national attention, the existence and manifestation of health equity promotion within these policies still require further exploration.

Methods: This study used text analysis to examine 62 policy documents on physical-medical integration issued by various Chinese governmental departments from June 2016 to June 2023, utilizing KH Coder software for qualitative analysis.

Results: The analysis revealed a strong emphasis on public health, promoting health management and disease prevention across all age groups.

Minimizing DNA trapping while maintaining activity inhibition via selective PARP1 degrader.

Poly (ADP-ribose) polymerase 1 (PARP1) catalyzes poly (ADP) ribosylation reaction, one of the essential post-translational modifications of proteins in eukaryotic cells. Given that PARP1 inhibition can lead to synthetic lethality in cells with compromised homologous recombination, this enzyme has been identified as a potent target for anti-cancer therapeutics. However, the clinical application of existing PARP1 inhibitors is restrained by side effects associated with DNA trapping and off-target effects, highlighting the need for improved therapeutic strategies.

Effectiveness and Safety of the TRIO Optimal Health Management Program in Patients with Type 2 Diabetes Mellitus (T2DM) Initiating Basal Insulin Therapy: Real-World Study.

Background: Diabetes, a chronic disease necessitating long-term treatment and self-management, presents significant challenges for patients who spend most of their treatment time outside of hospitals. The potential of digital therapeutics for diabetes has garnered recognition from different organizations. Although some prior studies have demonstrated successful reductions in patients' blood glucose levels and body weight through digital diabetes programs, many studies were limited by including prediabetes patients, patients treated with mostly premixed insulin, or evaluating user engagement outcomes rather than clinical outcomes.

A spinal neural circuit for electroacupuncture that regulates gastric functional disorders.

Objective: Acupuncture therapies are known for their effectiveness in treating a variety of gastric diseases, although the mechanisms underlying these effects are not fully understood. This study tested the effectiveness of electroacupuncture (EA) at acupoints Zhongwan (RN12) and Weishu (BL21) for managing gastric motility disorder (GMD) and investigated the underlying mechanisms involved.

Methods: A GMD model was used to evaluate the impact of EA on various aspects of gastric function including the amplitude of gastric motility, electrogastrogram, food intake, and the rate of gastric emptying.

Identification of potential substrates of LNX1 in chicken cells.

Ubiquitination of proteins is involved in numerous life activities. In poultry, several ubiquitin ligases tightly control the innate immune response, imbalance of which may result in autoimmune diseases and seriously impair poultry growth, development, and productivity. LNX1, an E3 ubiquitin ligase, catalyzes the ubiquitination and subsequent degradation of specific substrate proteins.

A novel cyanine photosensitizer for sequential dual-site GSH depletion and ROS-potentiated cancer photodynamic therapy.

The efficacy of photodynamic therapy (PDT) is often limited by the reductive microenvironment in tumor cells due to the high level of glutathione (GSH) and glutathione peroxidase 4 (GPX4), which maintain redox homeostasis. Therefore, designing a GSH-responsive photosensitizer that depletes intracellular GSH is a promising strategy to enhance PDT selectivity and efficacy. Herein, we present a GSH-selective sequentially responsive theranostic photosensitizer, Cy-Res.

Serum pentraxin-3 as a potential biomarker for diagnosis and prognosis in primary liver cancer: An observational study.

This study aimed to examine serum pentraxin 3 levels in patients with primary liver cancer and to assess its potential as a diagnostic and prognostic biomarker. Serum samples were obtained from 180 patients with primary liver cancer and 180 healthy control subjects. The concentration of PTX3 in these samples was measured using an ELISA kit.