A Phase I Study of the Pharmacokinetics and Safety of Ipatasertib, an Akt Inhibitor in Chinese Patients With Locally Advanced or Metastatic Solid Tumors.

Purpose: Ipatasertib is a selective inhibitor of Akt, a frequently activated protein kinase that plays a critical role in human cancers. The current clinical trial aimed to assess the pharmacokinetic properties, safety, and tolerability of ipatasertib administered to Chinese patients with locally advanced or metastatic solid tumors.

Methods: A Phase I, single-arm, open-label study was performed in Chinese patients with locally advanced or metastatic solid tumors for whom standard therapy either does not exist or has proven ineffective.

Accurate Identification Partial Discharge of Cable Termination for High-Speed Trains Based on S-Transform and Two-Dimensional Convolutional Network Algorithm.

Cable termination is an important part of energy transmission in high-speed trains, and it is also a weak link in the insulation. It is important to determine the insulation status of cable terminals by the detection results of partial discharge signals, but the partial discharge signals in the field test circuit are mixed with a large amount of external corona interference, which affects the detection accuracy. This paper proposes a signal recognition model that incorporates Stockwell transform (ST) and 2DCNN, which in combination with wavelet noise reduction can achieve a high-precision classification effect for partial discharge and corona interference with an accuracy rate of up to 98.

Preparation of a Novel Composite Coating of APP/MMT/APTES on Polyurethane with Improved Flame-Retarding Performance.

An environmentally friendly flame retardant coating for polyurethane composed of ammonium polyphosphate(APP)/montmorillonite(MMT)/(3-aminopropyl)triethoxysilane(APTES) has been prepared by deposition on a polyurethane surface through a one-step immersion, enhancing its flame retardancy. The coating of APP/MMT/APTES on the polyurethane sample surface has been verified from XPS and FTIR analysis. In comparison to untreated polyurethane, the amount of char residue after combustion of the flame-retardant polyurethane increases significantly, with a 50.

Atomic-Scale Tailoring C-N Coupling Sites for Efficient Acetamide Electrosynthesis over Cu-Anchored Boron Nitride Nanosheets.

Electrochemical conversion of carbon and nitrogen sources into valuable chemicals provides a promising strategy for mitigating CO emissions and tackling pollutants. However, efficiently scaling up C-N products beyond basic compounds like urea remains a significant challenge. Herein, we upgrade the C-N coupling for acetamide synthesis through coreducing CO and nitrate (NO) on atomic-scale Cu dispersed on boron nitride (Cu/BN) nanosheets.

Physical-Matched Nanoplatelets Boost Heterogeneous Thrombi Targeting Through Self-Adaptive Deformation for Thrombolysis and Endothelial Repairing.

The heterogeneity of thrombi in terms of composition, structure, and blood rheology parameters presents a challenge for effective thrombus-targeting drug delivery. To address this, a self-adaptive nano-delivery system, termed D-PLT, is developed. It consists of platelet membrane-cloaked deformable mesoporous organic silicon dioxide nanocomposite, enabling it to respond to the challenge of the heterogeneity of thrombi in arteries and veins.

An integrative analysis based on multiple cell death patterns identifies an immunosuppressive subtype and establishes a prognostic signature in lower-grade glioma.

Background: Cell death modulates the biological behaviors of tumors. However, the comprehensive role of the multiple forms of cell death in lower-grade glioma (LGG) is unknown.

Methods: We collected the transcriptional data of LGG patients from public repositories to comprehensively examine six cell death patterns (autophagy, apoptosis, cuproptosis, necroptosis, ferroptosis, and pyroptosis) in LGG samples and systematically correlated these patterns with patient survival, underlying biological processes, and drug sensitivity using serial bioinformatics analysis, clinical sample validation and assays.

Associations of triglyceride-glucose index cumulative exposure and variability with the transitions from normoglycaemia to prediabetes and prediabetes to diabetes: Insights from a cohort study.

Aim: This study aimed to investigate the separate and joint associations of triglyceride-glucose (TyG) index accumulation and variability with prediabetes and diabetes risk.

Methods: Health check-up participants who underwent 3 sequential health examinations during 2012-2016 and were followed up from 2017 to 2021 were enrolled and categorized into two subcohorts: (a) progression from normoglycaemia to prediabetes subcohort (n = 9373) and (b) progression from prediabetes to diabetes subcohort (n = 4563). Cumulative TyG (cumTyG) and TyG variability from Exams 1-3 were the exposures of interest in our study.

A Bio-Inspired Multifunctional Hydrogel Network with Toughly Interfacial Chemistry for Dendrite-Free Flexible Zinc Ion Battery.

Flexible and high-performance aqueous zinc-ion batteries (ZIBs), coupled with low cost and safe, are considered as one of the most promising energy storage candidates for wearable electronics. Hydrogel electrolytes present a compelling alternative to liquid electrolytes due to their remarkable flexibility and clear advantages in mitigating parasitic side reactions. However, hydrogel electrolytes suffer from poor mechanical properties and interfacial chemistry, which limits them to suppressed performance levels in flexible ZIBs, especially under harsh mechanical strains.

The research on fault and structural trap of the Weixinan Sag, Beibuwan Basin, South China Sea.

The Weixinan Sag in Beibuwan Basin is a pilot area of the offshore exploration and development integrated technology. The main oil bearing layers, first member of Liushagang formation and third member of Weizhou formation, develop many fault systems and structural traps. The key factors of the offshore exploration and development integrated technology are"the fault research"and "the effectiveness of structural trap".

Performance-Degradation Analysis of the Planetary Roller Screw Mechanism under Multi-Factor Coupling Effects.

The performance-degradation pattern of the planetary roller screw mechanism (PRSM) is difficult to predict and evaluate due to a variety of factors. Load-carrying capacity, transmission accuracy, and efficiency are the main indicators for evaluating the performance of the PRSM. In this paper, a testing device for the comprehensive performance of the PRSM is designed by taking into account the coupling relationships among temperature rise, vibration, speed, and load.

Boron Neutron Capture Therapy-Derived Extracellular Vesicles via DNA Accumulation Boost Antitumor Dendritic Cell Vaccine Efficacy.

Radiated tumor cell-derived extracellular vesicles (RT-EVs) encapsulate abundant DNA fragments from irradiated tumor cells, in addition to acting as integrators of multiple tumor antigens. Accumulating evidence indicates these DNA fragments from damaged cells are involved in downstream immune responses, but most of them are degraded in cells before incorporation into derived RT-EVs, thus the low abundance of DNA fragments limits immune responses of RT-EVs. Here, this study found that different radiations affected fates of DNA fragments in RT-EVs.

Effectiveness of intra-arterial manometry in guiding femoral popliteal stent implantation: a prospective randomized controlled trial.

Background: Femoropopliteal artery occlusion is a prevalent peripheral arterial disease, and endovascular therapy has become the preferred treatment. Accurate assessment of balloon dilation efficacy is crucial for determining the necessity for subsequent stent implantation. This study aims to investigate the use of interlesion arterial pressure gradients as a novel approach to assess balloon dilation efficacy and guide stent implantation decisions.

D-CyPre: a machine learning-based tool for accurate prediction of human CYP450 enzyme metabolic sites.

The advancement of graph neural networks (GNNs) has made it possible to accurately predict metabolic sites. Despite the combination of GNNs with XGBOOST showing impressive performance, this technology has not yet been applied in the realm of metabolic site prediction. Previous metabolic site prediction tools focused on bonds and atoms, regardless of the overall molecular skeleton.

Boron-Containing Mesoporous Silica Nanoparticles with Effective Delivery and Targeting of Liver Cancer Cells for Boron Neutron Capture Therapy.

Nanocarriers have been researched comprehensively for the development of novel boron-containing agents in boron neutron capture therapy (BNCT). We designed and synthesized a multifunctional mesoporous silica nanoparticle (MSN)-based boron-containing agent. The latter was coated with a lipid bilayer (LB) and decorated with SP94 peptide (SFSIIHTPILPL) on the surface as SP94-LB@BA-MSN.

Hemophagocytic lymphohistiocytosis associated with brucellosis.

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening immune disorder categorized as familial HLH or secondary HLH. Our case report describes a 63-year-old woman with epilepsy whose clinical signs were unremitting fever and altered consciousness. Primary abnormalities consisted of fever, splenomegaly, cytopenia, hypertriglyceridemia, hyperferritinemia and hemophagocytosis in the bone marrow.