The role of Testis-Specific Protein Y-encoded-Like 2 in kidney injury.

Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI). Recent findings suggest that Testis-Specific Protein Y-encoded-Like 2 (TSPYL2) plays a fibrogenic role in diabetes-associated renal injury. However, the role of TSPYL2 in IRI-induced kidney damage is not entirely clear.

Novel non-invasive method for urine mapping: Deep-learning-enabled SERS spectroscopy for the rapid differential detection of kidney allograft injury.

The kidney allograft has been under continuous attack from diverse injuries since the very beginning of organ procurement, leading to a gradual decline in function, chronic fibrosis, and allograft loss. It is vital to routinely and precisely monitor the risk of injuries after renal transplantation, which is difficult to achieve because the traditional laboratory tests lack sensitivity and specificity, and graft biopsies are invasive with the risk of many complications and time-consuming. Herein, a novel method for the diagnosis of graft injury is demonstrated, using deep learning-assisted surface-enhanced Raman spectroscopy (SERS) of the urine analysis.

Research on the Model for the Friction Coefficient of Resin-Based Friction Material and Its Experimental Verification.

Resin-based friction materials have been widely used in the friction braking of automobiles and power machinery. Based on experiments for the variation law of friction and wear morphology, a new model for the friction coefficient of resin-based friction materials was proposed, which includes the effects of both the micro convex body on the surface of the friction material and the frictional film generated during the friction process. This quantitative model of friction coefficient materials was established for the modelling of shear strength, compressive strength, shear strength of the frictional film, contact load and wear morphology.

fruit body polysaccharide alleviates hyperglycemia and hyperlipidemia modulating intestinal microflora in type 2 diabetic mice.

The disease of type 2 diabetes mellitus (T2DM) is principally induced by insufficient insulin secretion and insulin resistance. In the current study, fruit body polysaccharide (SVP) was prepared and structurally characterized. It was shown that the yield of SVP was 1.

mixture ameliorated type 2 diabetes mellitus and altered intestinal microbiota in mice.

Type 2 diabetes mellitus (T2DM) is a chronic disease mainly caused by insufficient insulin secretion and insulin resistance. In addition, T2DM is often accompanied by dysregulation of lipid metabolism and inflammatory response. The effect of oral administration of a mixture (SVM) on T2DM mice was evaluated.

Ameliorating Effect on Glycolipid Metabolism of Functional Formulation Combination from Traditional Chinese Medicine.

Insulin resistance is the major factor involved in the pathogenesis of type 2 diabetes. Although the oral drug metformin (MH) is widely used to reduce hyperglycemia, it is associated with adverse effects. Therefore, there is an urgent need to search for safe and natural foods that do not cause adverse effects as alternatives to commercial drugs.

Use of contrast-enhanced ultrasound to monitor rabbit renal ischemia-reperfusion injury and correlations between time-intensity curve parameters and renal ICAM-1 expression.

Background: Renal ischemia-reperfusion injury (IRI) is common in renal transplantation, shock, and nephrolithotomy.

Objective: To quantitatively assess rabbit renal IRI with contrast-enhanced ultrasound (CEUS) and investigate associations between renal cortical time-intensity curve (TIC) parameters and intracellular adhesion molecule-1 (ICAM-1) expression.

Methods: Eighteen white rabbits were randomly assigned into control and IRI groups (n = 9 each), and CEUS examination was performed 24 h after modeling.