A comprehensive examination and analysis of the effectiveness and safety of finerenone for the treatment of diabetic kidney disease: a systematic review and meta-analysis.

Objectives: The study will evaluate the effectiveness and safety of finerenone in patients diagnosed with diabetic kidney disease (DKD).

Methods: Various databases including PubMed, Sinomed, Web of Science, Embase, Clinical Trials, and Cochrane Library were systematically reviewed for pertinent studies published from the beginning to February 2024.This meta-analysis utilized RevMan 5.

Driving factors of ship-induced nitrogen dioxide concentrations over coastal seas of China: Implications for ship emission management.

Ships generate large amounts of air pollutants, including nitrogen dioxide (NO) that profoundly impacts air quality and poses serious threats to human health. It is crucial to understand the dynamics and drivers of ship-induced NO concentrations in China to support the prevention and control of fine particulate matter (PM) and ozone (O) pollution. This study built Generalized Additive Models (GAMs) to reveal the nonlinear effects of meteorological factors and ship emissions on ship-induced NO concentrations based on the Tropospheric Monitoring Instrument (TROPOMI) satellite data, AIS based emission model and meteorological data.

Long-term outcome in cervical lymph node-positive nasopharyngeal carcinoma following IMRT with one-step cervical nodal CTV delineation by geometric-anatomic expansion from nodal GTV: A double-center experience.

Background: To report long-term results of cervical node-positive (CLN+) nasopharyngeal carcinoma (NPC) patients treated with IMRT with one-step nodal clinical target volume (CTVn) delineation by geometric-anatomic expansion from the nodal gross target volume (GTVn).

Materials: CLN+ NPC treated with the same one-step-CTVn delineation in two Chinese academic centers were pooled for this study. GTVn was prescribed to 70 Gy equivalent, CTVn1 was omitted, CTVn2 was prescribed to 45-55 Gy equivalent and defined as GTVn + 3 mm geometric expansion (5 mm if radiological extranodal extension-positive, rENE+) + elective nodal regions defined by anatomic boundary of cervical nodal levels.

Cross-speed spindle motor bearings fault diagnosis combined with multi-space variable scale adaptive filter and feedforward hybrid strategy.

The vibration signal of the spindle motor contains complicated mixed modulation harmonics and background noise when computer numerical control (CNC) machine tools perform machining tasks. Additionally, frequent changes in the running speed of the spindle motor cause significant variations in the signal feature distribution, making fault diagnosis challenging. The adaptive sinusoidal fusion convolutional neural networks (ASFCNN) is proposed to achieve cross-speed spindle motor bearings fault diagnosis.

Ameliorative effects of Bacillus subtilis C10 on alcoholic liver injury in mice.

Bacillus subtilis has been reported to maintain the homeostasis of intestinal flora. In this study, a mouse model of alcoholic liver injury (ALI) was constructed to study the ameliorative effect of B. subtilis C10 on ALI and to further clarify its mechanism of action.

Heating and ultraviolet irradiation: Gas pressure meter-based analytical system for on-site and rapid monitoring of permanganate index (COD).

Permanganate index (COD) is one of the important indicators of surface water quality measurement. Herein, a portable analytical system was developed for on-site and rapid analysis of COD, organic substances in water were oxidized and transformed into gases, so that COD concentration was converted into a change of gas pressure signal, the pressure signal change was further detected by a gas pressure meter. Heating method and ultraviolet (UV) irradiation method were used as assisting technologies for oxidization of organic substances by acidic KMnO, a linear range of 2-150 mg l and a detectable limit of 2 mg l were obtained.

Split G-Quadruplex Programmed Recyclable AIE-Biosensor for Label-Free Detection of miRNA in Acute Kidney Injury.

We herein rationally designed a target-recyclable AIE-biosensor based on a split G-quadruplex for label-free detection of miRNA in acute kidney injury. Initially, the PG was in an "OFF" state, and the two split segments (G4-a and G4-b) of G4 were tethered at the two terminals of P1 and far away from each other due to the rigid duplex structure formed by the partially complementary intermediate sequences of P2 and P1, bringing MG with quenched fluorescence. In the presence of target, the 5'-PO P2 was displaced from PG probe and competitively hybridized with target, which led to G4-a and G4-b tending to form an intact intermolecular G-quadruplex, providing sites for MG intercalation, thus generating an activated "ON" fluorescence signal due to the restriction of intermolecular motion.

Efficiency evaluation and improvement pathway of sulfur-oxide emissions in European ports based on Context-dependent SBM-DEA model.

Sulfur-oxide (SO) emissions from ports are a crucial environmental concern due to their impact on air quality. European ports, particularly in sulfur emission control areas (ECAs), are under a stringent regulation to reduce SO emissions; thus, evaluating emission efficiencies and identifying improvement pathways for ports are crucial for developing effective environmental strategies. The research employs a Context-dependent Slack-Based Measure Data Envelopment Analysis (SBM-DEA) model to evaluate the SO emissions efficiency of 70 major European ports from 2006 to 2018 through introducing multi-layered efficiency frontiers to categorize these ports into the efficiency levels and identify specific improvement targets.

Causal diagnostic model and governance strategies to reduce pollution from ship accidents in Chinese waters.

Ship transportation is a primary mode for global trade and cargo transport, yet even minor discrepancies can lead to ship accidents, causing severe secondary environmental pollution. Maritime accidents involve complex and numerous factors. Formal Concept Analysis (FCA) can identify the key contributing factors and their impact levels by eliminating homogenization factors in maritime accidents.

Evaluation of dose delivery based on deformed CT using a commercial software for lung cancer.

This study employed a commercial software velocity to perform deformable registration and dose calculation on deformed CT images, aiming to assess the accuracy of dose delivery during the radiotherapy for lung cancers. A total of 20 patients with lung cancer were enrolled in this study. Adaptive CT (ACT) was generated by deformed the planning CT (pCT) to the CBCT of initial radiotherapy fraction, followed by contour propagation and dose recalculation.

Emerging role of HDAC11 in skeletal muscle biology.

HDAC11 is an epigenetic repressor of gene transcription, acting through its deacetylase activity to remove functional acetyl groups from the lysine residues of histones at genomic loci. It has been implicated in the regulation of different immune responses, metabolic activities, as well as cell cycle progression. Recent studies have also shed lights on the impact of HDAC11 on myogenic differentiation and muscle development, indicating that HDAC11 is important for histone deacetylation at the promoters to inhibit transcription of cell cycle related genes, thereby permitting myogenic activation at the onset of myoblast differentiation.

Ingesting yeast extract causes excitation of neurogenic and myogenic colonic motor patterns in the rat.

Fermented foods play a significant role in the human diet for their natural, highly nutritious and healthy attributes. Our aim was to study the effect of yeast extract, a fermented substance extracted from natural yeast, on colonic motility to better understand its potential therapeutic role. A yeast extract was given to rats by gavage for 3 days, and myogenic and neurogenic components of colonic motility were studied using spatiotemporal maps made from video recordings of the whole colon ex vivo.

A machine learning approach for predicting radiation-induced hypothyroidism in patients with nasopharyngeal carcinoma undergoing tomotherapy.

The purpose of this study was to establish an integrated predictive model that combines clinical features, DVH, radiomics, and dosiomics features to predict RIHT in patients receiving tomotherapy for nasopharyngeal carcinoma. Data from 219 patients with nasopharyngeal carcinoma were randomly divided into a training cohort (n = 175) and a test cohort (n = 44) in an 8:2 ratio. RIHT is defined as serum thyroid-stimulating hormone (TSH) greater than 5.

A portable/miniaturized analytical kit for on-site analysis: Chemical vapor generation-visual colorimetric and smartphone RGB dual-mode for detection of sulfide ion in water and food additives.

Chemical vapor generation (CVG) was used as a gaseous sample introduction technique for the visual/smartphone RGB readout colorimetric system, with the advantages of efficient matrix elimination and high vapor generation efficiency, this analytical system exhibits a good selectivity and sensitivity. Sulfide ion (S) in solution was transformed to its volatile form (HS), the generated HS reacted with a silver-containing metal organic framework (Ag-BTC) selectively, AgS was thus generated. Ag-BTC (fabricated on paper sheet) changed from white to dark brown, the color variance was identified by smartphone and naked-eye simultaneously.

Effects of emission control areas on sulfur-oxides concentrations--Evidence from the coastal ports in China.

The setting of Sulfur limitations in Emission Control Areas (ECAs) is a crucial action of marine environmental governance at the international regulatory levels. In this study, the overall and structural impacts of the two rounds of ECA policies on SOx concentrations were quantified using synthetic control method (SCM) based on time-series data from Chinese coastal ports from 2005 to 2020. From the outcomes, the 1st round of ECA policy announced in 2015 intensified the competition between ECA and non-ECA ports and provided strong support for ECA expansion and enhanced regulation in 2019.

Selectively sparing of the supraclavicular area during intensity-modulated radiotherapy in nasopharyngeal carcinoma: A double-center observation study.

Background And Purpose: This study was aimed at evaluating the feasibility of sparing the supraclavicular area, namely levels IVb and Vc, during intensity-modulated radiotherapy (IMRT) in nasopharyngeal carcinoma (NPC) patients with N1-2 disease[except N1 disease with purely restropharyngeal lymph nodes(RPN) involvement], and providing a basis for the revision of International Guideline for the delineation of the clinical target volume (CTV).

Patients And Materials: Patients with NPC (stage TNM) diagnosed pathologically in Fujian Cancer Hospital (Center 1, Only Lin SJ's attending group) from January 2014 to March 2018 and Jiangxi Cancer Hospital(Center 2) from January 2014 to December 2015 were included. According to our principle, the supraclavicular area (levels IVb and Vc) were excluded from the CTVnd.

From Black Boxes to Actionable Insights: A Perspective on Explainable Artificial Intelligence for Scientific Discovery.

The application of Explainable Artificial Intelligence (XAI) in the field of chemistry has garnered growing interest for its potential to justify the prediction of black-box machine learning models and provide actionable insights. We first survey a range of XAI techniques adapted for chemical applications and categorize them based on the technical details of each methodology. We then present a few case studies to illustrate the practical utility of XAI, such as identifying carcinogenic molecules and guiding molecular optimizations, in order to provide chemists with concrete examples of ways to take full advantage of XAI-augmented machine learning for chemistry.

[Spatio-temporal Change in City-level Greenhouse Gas Emissions from Municipal Solid Waste Sector in China During the Last Decade and Its Potential Mitigation].

The waste sector is a significant source of greenhouse gas(GHG) emissions and clarifying its emission trends and characteristics is the premise for formulating GHG emission reduction strategies. Using the IPCC inventory model, the GHG emissions from the municipal solid waste(MSW) sector in China during 2010 to 2020 were estimated. The results showed that GHG emissions increased from 42.

Factor diagnosis and governance strategies of ship oil spill accidents based on formal concept analysis.

Ship oil spill accidents have a prolonged duration, complex consequences, challenging cleaning and repairing efforts, and pose a significant threat to the environment, economy, and society. Eliminating irrelevant information and identifying key factors using traditional methods is challenging due to the complexity of the causes of ship oil spill accidents. To address this, this article sorts out the accident databases of the International Tanker Owners Pollution Federation (ITOPF) and eight national maritime administration agencies, and innovatively constructs a formal concept analysis (FCA) model based on reports of 100-plus ship oil spill accidents.

Association of C-type lectin-like receptor 2 and galectin-1 with portal vein system thrombosis in HBV-related liver cirrhosis.

Background And Aims: Hepatitis B virus (HBV) infection is the most common cause of liver cirrhosis. Portal venous system thrombosis (PVST) is a major complication of liver cirrhosis. Recently, it has been shown that C-type lectin-like receptor 2 (CLEC-2) and galectin-1 participate in the activation and aggregation of platelets, thereby promoting the development of thrombosis.