Ozone Concentration, Physical Activity, and Emotional and Behavioral Problems in Children and Adolescents.

Background: No prior study has examined the mutual association of long-term outdoor ozone (O) concentration and physical activity (PA) with emotional and behavioral problems (EBPs) in children and adolescents. This study aims to investigate the association between long-term outdoor O concentration and the risk of EBPs in children and adolescents and further explore whether increased PA levels modify this association.

Methods: Data were obtained from the 2020 wave follow-up examination of an ongoing prospective cohort study (COHERENCE project) in Guangzhou, China.

Effects of intermittent visual feedback on EEG characteristics during motor preparation and execution in a goal-directed task.

Introduction: Visual feedback plays a crucial role in goal-directed tasks, facilitating movement preparation and execution by allowing individuals to adjust and optimize their movements. Enhanced movement preparation and execution help to increase neural activity in the brain. However, our understanding of the neurophysiological mechanisms underlying different types of visual feedback during task preparation and execution remains limited.

Study on the effect of occupational exposure on hypertension of steelworkers based on Lasso-Logistic regression model.

Objectives: This study aimed to use a stable and predictive method: Lasso regression model to analyze hypertension's influencing factors and explore the interactions between occupational exposures.

Study Design: This has been a nested case-control study.

Methods: The case group consisted of 959 patients with high blood pressure found during the study.

Genomic and virulent characterization of a duck-associated Salmonella serovar Potsdam from China.

Salmonella, a common zoonotic pathogen, is a significant concern for public health, particularly when it contaminates animal-borne products. The potential for Salmonella to infect duck embryos and disrupt their normal development not only causes substantial economic losses for the industry but also poses a severe threat to public health. However, there is a lack of understanding about the prevalence of Salmonella in duck embryos and their potential public health implications.

Mediating effect of physical activity on the relationship between high dietary live microbe intake and obesity among U.S adolescents, finding from NHANES 1999-2018.

Background And Aims: The impact of dietary live microbe intake on adolescent obesity is still not fully understood. This study aims to investigate the potential relationship between dietary live microbe intake and obesity among U.S adolescents, and to explore the mediating role of physical activity (PA).

Regulation of Shade Avoidance Under Low-Blue-Light by MTA in Soybean.

Under low blue light (LBL) conditions, soybean exhibits classic shade avoidance syndrome (SAS) with exaggerated stem elongation (ESE), leading to lodging and yield reduction in dense farming. Recently, mRNA modification by N6-methyladenosine (m6A) has emerged as a crucial epigenetic mechanism regulating plant biological processes; however, its impact on shade avoidance remains unexplored. In this study, the double mutants, gmmtas, that are impaired in two mA writer genes, GmMTAa and GmMTAb that encode mA methyltransferases or mA writers are generated.

Efficient removal of copper ions through photothermal enhanced flow-electrode capacitive deionization.

Removing Cu from wastewater through capacitive deionization at low temperatures is a great challenge. Herein, a new strategy for enhancing the performance was developed using photothermal carbon nanospheres as the electrodes. Upon irradiating with sunlight, the Cu removal rate and Cu/Na selectivity were increased by 74% and 43%, respectively.

Research on X-ray nondestructive defect detection method of tire based on dynamic Snake Convolution YOLO model.

Tire X-ray nondestructive testing before leaving the factory is crucial for driving safety. Given the complexity of tire structures and the diversity of defect types, traditional manual visual inspections and machine learning methods face significant challenges in terms of accuracy and efficiency. This study proposes an innovative tire X-ray image nondestructive testing technique based on the YOLOv5 model, incorporating several advanced technologies to enhance detection performance.

Health effects of synthetic additives and the substitution potential of plant-based additives.

The growth of the world population and the rapid industrialization of food have led to food producers' increased reliance on food additives. While food additives offer numerous conveniences and advantages in food applications, the potential risks associated with synthetic additives remain a significant concern. This report examines the current status of safety assessment and toxicity studies of common synthetic additives, including flavorings (sweeteners and flavor enhancers), colorants, preservatives (antimicrobials and antioxidants), and emulsifiers.

The second adult case of NUTM1 fusion-positive B-cell lymphoblastic leukemia: A recurring pattern of poor prognosis.

This manuscript reports a rare case of CUX1::NUTM1-positive B-cell lymphoblastic leukemia (B-ALL) in a 25-year-old female patient who experienced early relapse and a poor clinical outcome. Given the rarity of NUTM1 fusion-positive B-ALL in adults, this case contributes to the growing evidence that such cases may present with a more aggressive clinical course compared to the pediatric population. Our findings suggest the need for a re-evaluation of therapeutic strategies in adult patients with this subtype of B-ALL.

Nanobody-based Naturally Selected CD7-Targeted CAR-T Therapy for Acute Myeloid Leukemia.

Approximately 30% of acute myeloid leukemia (AML) patients express CD7 on their myeloblasts. We have previously demonstrated that scFv-based "naturally selected" CD7 CAR-T (NS7CAR-T) therapy shows significant efficacy with a favorable safety profile in T-cell lymphoid malignancies. Here we derived dual nanobody-based dVHH NS7CAR-T cells that have superior CD7 binding specificity, affinity to their scFv-based counterparts and improved proliferative capability.

Prevalence and influencing factors of pulmonary nodules in hospitalized patients with diabetes.

Background: Pulmonary nodules are an early manifestation of many lung cancers, and patients with diabetes are at high risk for lung cancer. However, there is a lack of epidemiological data on pulmonary nodules in patients with diabetes. This study investigated the prevalence rate of pulmonary nodules in hospitalized patients with diabetes and analyzed its influencing factors, with the aim of generating data to inform the management of pulmonary nodules in patients with diabetes.

Pathogen Composition and Fungicide Sensitivity in Rice Spikelet Rot Disease.

Rice spikelet rot disease (RSRD) is an emerging threat to rice crops, with sporadic but severe outbreaks in China in recent years. The composition of its pathogenic fungi has not been consistently identified, and chemical control methods remain unclear. This study aims to characterize the pathogen species responsible for RSRD and develop effective control strategies.

Pretreatment with growth differentiation factor 15 augments cardioprotection by mesenchymal stem cells in myocardial infarction by improving their survival.

Background: The clinical application of mesenchymal stem cells (MSCs) in myocardial infarction (MI) is severely hampered by their poor survival. Pretreatment is a key strategy that has been adopted to promote their therapeutic efficacy. This study aimed to investigate the benefit of growth differentiation factor 15-pretreated MSCs (GDF15-MSCs) in enhancing cardiac repair following MI and to determine the underlying mechanisms.

Study on the Mechanism of Polysaccharide in Reducing Depression-like Behavior in Mice.

Background/objectives: Depression is a prevalent worldwide mental health disorder that inflicts significant harm to individuals and society. is an edible fungus that contains a variety of nutrients, including polysaccharides. This study aims to investigate the monosaccharide composition and molecular weight of the polysaccharide (DDP-B1), followed by an exploration of its antidepressant effects in chronic unpredictable mild stress (CUMS) mice.

A novel conformable embolic for selective transarterial embolization of acute hemorrhages: a technical note.

Background: Obsidio conformable embolic (OCE, Boston Scientific, MA) is a novel, radiopaque and conformable embolic. The purpose of this report is to describe its use for treatment of acute intra-abdominal hemorrhages.

Methods And Results: Three patients presented with acute hemorrhage and were treated with OCE, including post-paracentesis hemorrhage, penetrating trauma to the liver, and blunt trauma in the spleen.

The key metabolite of fruit flavor change in different ripening stages of .

has an unstable ripening period. Herein, five typical periods of fruit ripening of 'LR' were analyzed by non-targeted metabolomics techniques. The results showed that ripening started 73 days after flowering and reached the ripening criterion at 93 days, a total of 451 differential metabolites were identified for the five periods.

Involvement of sphingosine-1-phosphate receptor 1 in pain insensitivity in a BTBR mouse model of autism spectrum disorder.

Background: Abnormal sensory perception, particularly pain insensitivity (PAI), is a typical symptom of autism spectrum disorder (ASD). Despite the role of myelin metabolism in the regulation of pain perception, the mechanisms underlying ASD-related PAI remain unclear.

Methods: The pain-associated gene sphingosine-1-phosphate receptor 1 (S1PR1) was identified in ASD samples through bioinformatics analysis.

[Analysis of Morphologic Classification System for Acute Promyelocytic Leukemia and Its Correlation with Laboratory Tests and Mutation].

Objective: To establish a morphologic classification system for characterizing blast cells in patients with acute promyelocytic leukemia (APL) and analyze the correlation of different APL morphologic characteristics with conventional tests and genetic variants.

Methods: Based on the morphological characteristics of APL blast cells, a classification system of 14 categories was established to characterize the inter- and intra-individual cellular morphological heterogeneity of patients. The classification system was used for the morphological analysis of 40 APL patients, and the classification results were statistically analyzed with the patients' conventional test indexes and gene variant characteristics to analyze the correlation of different APL blast cell morphological features with conventional test indexes and gene variants.

Triterpenoids from the rhizomes and roots of Gentiana scabra Bge. and their cytotoxic activities.

Phytochemical investigation on the rhizomes and roots of Gentiana scabra (Gentianaceae) led to the isolation of five new triterpenoids (1-5), together with seven known ones (6-12). The structures and absolute configurations of the new compounds were elucidated by spectroscopic data interpretation, ECD calculation and X-ray crystallographic analysis. Noticeably, compound 4 was an uncommon 3,4-seco-pentacyclic triterpenoid in natural products.