Ultra-sensitive and accurate multi-ion detection in biofluids via organic electrochemical transistors.

As an emerging ionic sensor with low-voltage operation (<1 V), biocompatibility, and stable operation in aqueous environments, organic electrochemical transistors (OECTs) have attracted significant research interest for various biofluid-related ion detection, where minor ion concentration variations can effectively reflect health or pathology states. However, OECT-based ion sensors are currently limited by restricted device transconductance g and stabilites, which severely hinder their applications in actual ion sensing scenarios. Here, ultra-sensitive multi-ion sensors based on high-performance n-type vertical OECTs (accumulation mode, g = 58 mS) for Na, K, and Ca detection in a practical biofluid (effluent from continuous renal replacement therapy), are demonstrated with high accuracy and stability, which are comparable to conventional Roche method.

Pathogenic variants of TUBB8 cause oocyte spindle defects by disrupting with EB1/CAKP5 interactions and potential treatment targeting microtubule acetylation through HDAC6 inhibition.

Background: Numerous pathogenic variants causing human oocyte maturation arrest have been reported on the primate-specific TUBB8 gene. The main etiology is the dramatic reduction of tubulin α/β dimer, but still large numbers of variants remain unexplained.

Methods: Using microinjection mRNA and genome engineering to reintroduce the conserved pathogenic missense variants into oocytes or in generating TUBB8 variant knock-in mouse models, we investigated that the human deleterious variants alter microtubule nucleation and spindle assembly during meiosis.

Prevalence and associated factors of healthy aging among community-dwelling older adults in Lishui city, China: a cross-sectional study.

Background: Identifying the level of healthy aging and exploring its associated factors are prerequisites in the planning of effective measures among the elderly population. Thus, this study aimed to investigate the prevalence of healthy aging and determine its associated factors among community-dwelling older adults from mountain areas in Lishui, China.

Methods: A multicenter cross-sectional survey was conducted.

Shading stress promotes lignin biosynthesis in soybean seed coat and consequently extends seed longevity.

The macromolecular components of the seed coat, particularly lignin, play a critical role in regulating seed viability. In the maize-soybean intercropping (MSI) system, shading stress was reported to enhance the viability of soybean seeds. However, the specific role of seed coat lignin in this process remains poorly understood.

Nucleus softens during herpesvirus infection.

Mechanical properties of the nucleus are remodeled not only by extracellular forces transmitted to the nucleus but also by internal modifications, such as those induced by viral infections. During herpes simplex virus type 1 infection, the viral regulation of essential nuclear functions and growth of the nuclear viral replication compartments are known to reorganize nuclear structures. However, little is known about how this infection-induced nuclear deformation changes nuclear mechanobiology.

A multicenter, randomized, double-blind, placebo-controlled phase 3 study of Socazolimab or placebo combined with carboplatin and etoposide in the first-line treatment of extensive-stage small cell lung cancer.

This is a randomized, double-blind, placebo-controlled phase 3 clinical trial (ClinicalTrials.gov, NCT04878016) conducted in 54 hospitals in China. Adults who were histologically diagnosed and never treated for extensive-stage small cell lung cancer (ES-SCLC) were enrolled.

An Experimental and Quantum Chemical Calculation Study on the Performance of Different Types of Ester Collectors.

Ester collectors have rapidly developed into the main flotation collectors for copper sulfide minerals since they were developed. In this study, the collecting performance of four collectors, O-isopropyl-N-ethyl thionocarbamate ester (IPETC), 3-pentyl xanthate acrylate ester (PXA), O-isobutyl-N-allyl-thionocarbamate (IBALTC), and O-isobutyl-N-isobutoxycarbonyl-thionocarbamate (IBIBCTC), was investigated through microflotation tests, microcalorimetric measurements, and quantum chemical calculations. The results of the microflotation tests show that IBALTC and IPETC have stronger collecting abilities than IBIBCTC and PXA; the order of collecting ability is IBALTC > IPETC > IBIBCTC > PXA.

An organic electrochemical neuron for a neuromorphic perception system.

Human perception systems are highly refined, relying on an adaptive, plastic, and event-driven network of sensory neurons. Drawing inspiration from Nature, neuromorphic perception systems hold tremendous potential for efficient multisensory signal processing in the physical world; however, the development of an efficient artificial neuron with a widely calibratable spiking range and reduced footprint remains challenging. Here, we report an efficient organic electrochemical neuron (OECN) with reduced footprint (<37 mm) based on high-performance vertical OECT (vOECT) complementary circuitry enabled by an advanced n-type polymer for balanced p-/n-type vOECT performance.

Molecular Design and Mechanism Study of Non-Activated Collectors for Sphalerite (ZnS) Based on Coordination Chemistry Theory and Quantum Chemical Simulation.

Sphalerite flotation is generally achieved by copper activation followed by xanthate collection. This study aims to propose a design idea to find novel collectors from the perspective of molecular design and prove the theoretical feasibility that the collector can effectively recover sphalerite without copper activation. To address this, 30 compounds containing different structures of sulfur atoms and different neighboring atoms were designed based on coordination chemistry.

Comprehensive review on Alzheimer's disease: From the posttranslational modifications of Tau to corresponding treatments.

Alzheimer's disease (AD) is a neurodegenerative disease, which is mainly characterized by the abnormal deposition of β-amyloid peptide (Aβ) and Tau. Since Tau aggregation is more closely associated with synaptic loss, neurodegeneration, and cognitive decline than Aβ, the correlation between Tau and cognitive function in AD has gradually gained attention. The posttranslational modifications (PTMs) of Tau are key factors contributing to its pathological changes, which include phosphorylation, acetylation, ubiquitination, glycosylation, glycation, small ubiquitin-like modifier mediated modification (SUMOylation), methylation, succinylation, etc.

DeepCorr: a novel error correction method for 3GS long reads based on deep learning.

Long reads generated by third-generation sequencing (3GS) technologies are involved in many biological analyses and play a vital role due to their ultra-long read length. However, the high error rate affects the downstream process. DeepCorr, a novel error correction algorithm for data from both PacBio and ONT platforms based on deep learning is proposed.

The landscape of alternative splicing in granulosa cells and a potential novel role of YAP1 in PCOS.

Polycystic ovary syndrome (PCOS) is a prevalent yet complex reproductive endocrine disorder affecting 11-13% of women worldwide. Its main symptoms include elevated androgen levels, irregular menstrual cycles, and long-term metabolic and offspring health implications. Despite the disease's multifaceted nature involving genetic, epigenetic, and environmental factors, the role of alternative splicing in ovarian granulosa cells remains relatively unexplored.

Emergent actin flows explain distinct modes of gliding motility.

During host infection, and related unicellular parasites move using gliding, which differs fundamentally from other known mechanisms of eukaryotic cell motility. Gliding is thought to be powered by a thin layer of flowing filamentous (F)-actin sandwiched between the plasma membrane and a myosin-covered inner membrane complex. How this surface actin layer drives the various gliding modes observed in experiments-helical, circular, twirling and patch, pendulum or rolling-is unclear.

Investigating the action model of the resistance enhancement induced by bacterial volatile organic compounds against in tomato fruit.

Introduction: Inducing natural resistance against pathogen infection in postharvest tomatoes is a sustainable strategy for reducing postharvest losses. The action model underlying the resistance enhancement of tomatoes induced by bacterial volatile organic compounds (VOCs) against , however, have not been explored.

Methods: In this study, RNA-seq, metabolomics and physiological analysis were used to evaluate global change of defense response induced by VOCs in tomatoes.

Significance of the APPLE score and the monocyte-HDL cholesterol ratio in predicting late recurrence of atrial fibrillation following catheter ablation based on a retrospective study.

Objective: Collect the characteristics of patients' baseline data, and explore the predictive factors of late recurrence of atrial fibrillation (AF) after catheter ablation according to whether late recurrence or not. The purpose of this study was to determine the significance of the APPLE score in conjunction with the monocyte-high-density lipoprotein cholesterol ratio (MHR) in predicting the late recurrence of AF after catheter ablation in patients with AF.

Methods: Baseline data were collected to explore the predictors of late recurrence after AF catheter ablation.

Rate adaptive compressed sampling based on region division for wireless sensor networks.

Image acquisition and transmission in wireless sensor networks (WSN) are core issues for some resource-deficient multimedia sensing applications. Reducing sampling rates and data transmission lowers sensor node costs and energy, addressing communication bottlenecks. Block compressed sampling (BCS) can meet the above requirements.

Validation and psychometric properties of the Depression Anxiety Stress Scale for Youth in Chinese adolescents.

Introduction: Depression and anxiety are the most common mental health problems among adolescents. The Depression Anxiety Stress Scales for Youth (DASS-Y) is a newly developed instrument designed to assess these problems in adolescents.

Aim: The present study aims to evaluate the psychometric properties of the DASS-Y among Chinese adolescents.

Male sterility is related to the imbalance of reactive oxygen species homeostasis in Prunus sibirica.

Prunus sibirica is an economically important forest tree with great development prospects. To study the mechanisms of male sterile P. sibirica, we compared the phenotypic, cytological, and physiological characteristics of male sterile clone 1 with those of male fertile clone 60.

Caregiving burden, depression, and anxiety in informal caregivers of people with mental illness in China: a cross-sectional survey.

Background: Caregiving for people with mental illness (PwMI) could be burdensome, especially for informal caregivers. However, there is a scarcity of research investigating caregiving burden among informal caregivers of PwMI in China at the national level. To fill this gap, this study examined the prevalence of caregiving burden, depression, and anxiety, as well as their associated factors, among a cross-sectional sample of informal caregivers of PwMI in China.

Navigating Nutritional Inequality in Schizophrenia: A Comprehensive Exploration of Diet, Genetics, and Holistic Management Across the Life Cycle.

This review explores the understudied topic of nutritional inequality among individuals with schizophrenia, highlighting the complex interplay between diet, genetics, and mental health. Unhealthy dietary patterns, socioeconomic factors, and disordered eating behaviors contribute to malnutrition, increasing the risk of physical health issues and premature mortality. Socioeconomic factors exacerbate nutritional disparities, necessitating targeted interventions.

Association Between FABP7-5-HT Pattern and Anxiety or Depression in Patients With Psoriasis: A Cross-Sectional Study.

Psoriasis exhibits a higher incidence of anxiety and depression. However, the diagnostic process heavily relies on subjective evaluation. Fatty acid-binding protein 7 (FABP7) and serotonin (5-HT) are considered as potential plasma biomarkers.

Genetical effects of sleep traits on postpartum depression: a bidirectional two-sample Mendelian randomization study.

Background: Postpartum depression (PPD) is widely recognized as the most prevalent mental health crisis following childbirth and has been linked to sleep disturbances. However, the potential causal relationships between various sleep traits and PPD remain unclear. This study employs a bidirectional two-sample Mendelian randomization (MR) approach to investigate these associations.