Gas-Water Distribution and Gas Reservoirs Accumulation Properties of Upper Paleozoic Sequence in the Western Yishan Slope, Ordos Basin, NW China.

Gas-water distribution is significant in the determination of hydrocarbon accumulation mechanisms in gas reservoirs, especially for the exploitation of tight sandstone reservoirs. One of such examples are the gas reservoirs in the Yishan Slope in China, where the internal relationship between gas-water distribution is poorly understood. The pattern and controlling factors for gas-water distribution in tight sandstones gas reservoirs in the Yishan Slope have been examined from macro (such as sedimentary and anticlinal structures) and micro (such as pore throat size, heterogeneity) perspectives, using data from rock eval pyrolysis, sedimentary structure, sediment diagenesis, gas migration, mercury injection experiments, and well logs.

Metal-organic frameworks (MOFs): A review of volatile organic compounds (VOCs) detection.

This research presents a systematic review of the application of metal-organic frameworks (MOFs) to detect volatile organic compounds (VOCs). VOCs, compounds with high vapor pressure at ambient temperature and normal pressure, are widely present in a variety of industrial and living environments. VOCs are not only hazardous to the environment but also have a severe impact on human health.

Application of Mendelian randomized research method in oncology research: bibliometric analysis.

Background: Cancer has always been a difficult problem in the medical field, and with the gradual deepening of Genome-wide association studies (GWAS), Mendelian randomization methods have been increasingly used to study cancer pathogenesis. In this study, we examine the literature on Mendelian cancer, summarize the status of the research, and analyze the development trends in the field.

Methods: Publications on "Mendelian Randomization - Cancer" were retrieved and downloaded from the Web of Science Core Collection database.

Efficacy and Safety of Paclitaxel-Based PD-1/PD-L1 Immunotherapies for Triple-Negative Breast Cancer: A Systematic Review and Network Meta-Analysis.

Background: Triple negative breast cancer (TNBC) is a deadly subtype of breast cancer with limited treatment options. Currently, programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) inhibitors have become the first choice for breast cancer immunotherapies. Despite paclitaxel being considered a cornerstone drug in breast cancer treatment, the effectiveness, safety, and optimal drug selection for its combination with PD-1/PD-L1 inhibitors remain uncertain.

Organic photoelectrochemical transistor based on titanium dioxide nanorods for detection of Microcystin-LR.

A more efficient signal amplification strategy is needed to improve the performance of promising photoelectrochemical sensors (PEC). Organic photoelectrochemical transistor (OPECT) sensors are of growing interest in many fields, but their potential has not yet been widely exploited and remains a challenge. In this study, a novel organic photoelectrochemical transistor aptamer (OPECT) biosensor combining photoelectrochemical analysis and organic electrochemical transistor with AgI-TiO (AgI-TNs) as photoreactive material and target-specific DNA chain reaction hybridization as signal amplifier for microcystin-LR detection was developed.

The clinical value of fibrosis indices for predicting the hemorrhagic transformation in patients with acute ischemic stroke after intravenous thrombolysis.

Background: The incidence of stroke in China is approximately 343 per 100,000 people each year, the highest rate worldwide. Hemorrhagic transformation (HT), particularly symptomatic intracerebral hemorrhage (sICH) following acute ischemic stroke (AIS) with or without intravenous thrombolysis (IVT), can lead to rapid neurological deterioration, poor prognosis, and even death. Non-alcoholic fatty liver disease (NAFLD) has been identified as a risk factor for stroke occurrence and associated with poor long-term functional outcomes.

Investigating the causal effect of various metabolites on postherpetic neuralgia: a Mendelian randomization study.

Background: Common side effect of Herpes Zoster, postherpetic neuralgia (PHN), causes persistent pain that seriously affects quality of life. Lack of dependable biomarkers makes the clinical diagnosis and treatment of PHN difficult, so complicating the assessment of therapeutic efficacy. Blood metabolites are becoming more and more well known as significant disease markers.

Organic photoelectrochemical transistor biosensor based on BiVO-ZnInS material for efficient and sensitive detection of MCF-7 cells.

Recently, organic photoelectrochemical transistor (OPECT) has become a very interesting biological measurement method in photoelectrochemical (PEC) bioanalysis and future bio-related applications. OPECT is expected to be a powerful tool for disease detection and early warning. Circulating tumor cells (CTCs) are generally deemed to be the dominant factor of tumor metastasis, and 90 % of cancer patients die from this metastatic disease.

Gut Microbiota's role in lipoma development: evidence from mendelian randomization.

Background: Lipoma, a benign tumor derived from mesenchymal tissue, significantly affects patients' physical and psychological wellbeing. Increasing evidence points to a strong link between the gut microbiome (GM) and lipoma incidence. This study utilizes Mendelian Randomization (MR) to assess the potential causal relationships between the GM and lipoma development.

Association between metabolic dysfunction-associated steatotic liver disease and risk of thyroid cancer: a systematic review and meta-analysis.

Several studies have reported associations between metabolic dysfunction-associated steatotic liver disease (MASLD) and the risk of various cancers. However, studies focusing specifically on the association between MASLD and thyroid cancer are relatively limited, and the conclusions drawn, thus, far remain inconclusive. In response, we conducted a meta-analysis of relevant cohort studies to clarify the association between MASLD and the risk of thyroid cancer.

Development and validation of nomogram models for severe and fatal COVID-19.

Background: The coronavirus disease 2019 (COVID-19) has exhibited escalating contagion and resistance to immunity, resulting in a surge in infections and severe cases. This study endeavors to formulate two nomogram predictive models aimed at discerning patients at heightened risk of severe and fatal outcomes upon hospital admission. The primary objective is to enhance clinical management protocols and mitigate the incidence of severe illness and mortality associated with COVID-19.

Photo-controlled multifunctional hydrogel for photothermal sterilization and microenvironment amelioration of infected diabetic wounds.

Diabetic foot ulcers are linked to a high disability rate, with no effective treatment currently available. Addressing infection, reducing oxidative stress, and safely managing chronic inflammation remain major challenges. In this study, a composite hydrogel dressing was developed using natural substances or clinically approved components (dopamine, D-alpha-tocopheryl polyethylene glycol succinate, and rhein).

Self-focusing morphology of juxtaposed double-ring Airyprime-Gaussian beam arrays.

In this paper, the variation of self-focusing morphology and focusing interval of a juxtaposed double-ring Airyprime-Gaussian beam array (JDAPGBA) is investigated by changing the proportionality coefficient between the transverse displacements of the outer and the inner rings β. When β increases within a certain range, the JDAPGBA will change from a single self-focusing to the first self-focusing from the inner ring and the second self-focusing from the outer ring, accompanied by the gradual increase of the focusing interval. As β increases, the self-focusing ability of the inner ring is initially weaker than that of the outer ring, and then the self-focusing ability of the inner ring increases.

Clinical efficacy of laparoscopic treatment of pediatric inguinal hernia: a meta-analysis.

Objective: To evaluate operative outcomes and postoperative complications of laparoscopic treatment for pediatric inguinal hernia using meta-analysis.

Methods: We conducted a comprehensive search of databases including the Chinese Journal Full-text Database, Wanfang, PubMed, Web of Science, ScienceDirect, VIP Chinese Science, and Technology Journal Database, ProQuest, JSTOR, Wiley, and IEEE Xplore. Relevant randomized controlled trials (RCTs) on laparoscopic surgery for pediatric inguinal hernia were collected, and data were analyzed using Review Manager 5.

The HALP (hemoglobin, albumin, lymphocyte, and platelet) score is associated with hemorrhagic transformation after intravenous thrombolysis in patients with acute ischemic stroke.

Background: Hemorrhagic transformation (HT) after intravenous thrombolysis (IVT) with rt-PA can precipitate rapid neurological deterioration, poor prognosis, and even death. The HALP score (hemoglobin, albumin, lymphocyte, and platelet) is a novel indicator developed to reflect both systemic inflammation and the nutritional status of patients. The goal of this study was to reveal the relationship between the HALP score and the risk of HT after IVT in people with acute ischemic stroke (AIS).

Rumor detection model with weighted GraphSAGE focusing on node location.

While social media platforms promote people's information exchange and dissemination, they also make rumors spread rapidly on online platforms. Therefore, how to detect rumors quickly, timely and accurately has become a hot topic for scholars in related fields. Traditional deep learning models ignore the relationship and topology between nodes in the rumor detection task and use fixed weights or mean aggregation strategies in the feature aggregation process, which fail to capture the complex interactions between nodes and the dynamics of information propagation, limiting the accuracy and robustness of the rumor detection model.

A split organic photophotochemical transistor/vision sensing platform based on MNZ composite and ZIF-67/CuCoO nanospheres for ultra-sensitive detection of CEA.

In this study, a novel organic photophotochemical transistor (OPECT) biosensing platform was proposed for dual-mode detection of CEA. The dual-mode detecting system is achieved benefit from the exceptional photoelectric performance of MIL-53(Fe) -NH@ZnInS (MNZ) and the peroxidase enzyme (POD) activity of ZIF-67/CuCoO (ZIF-67/CuCoO). Ab2- ZIF-67/CuCoO probe was immobilized on a 96-well plate by enzyme-linked immunosorbent assay, which accelerated the oxidation of 3,3,5,5-tetramethylbenzidine (TMB) by hydrogen peroxide and thus successfully realized visual detection of CEA.

The causal effects of lifestyle, circulating, pigment, and metabolic factors on early age-related macular degeneration: a comprehensive Mendelian randomization study.

Purpose: Early detection of lifestyle factors, skin and hair color, circulating parameters, and metabolic comorbidities is crucial for personalized prevention and treatment of early age-related macular degeneration (AMD). This study aimed to assess the relationships between genetically predicted comprehensive risk factors and early AMD.

Methods And Results: Publicly available genome-wide association study (GWAS) data were utilized to identify genetic variants significantly associated with each trait.

3D Z-scheme conjugated polymer/CuO for organic photoelectrochemical transistor bioassay.

Organic photoelectrochemical transistor (OPECT) is an emerging technology studying photo-electric-biological recognition events. Here, this work reports the three-dimensional (3D) Z-scheme poly (1,4-diethynylbenzene) (pDEB)@CuO heterojunction as a high-efficacy photogating module and its application for OPECT bioassay. Specifically, 3D Z-scheme pDEB@CuO heterojunction enabled fast charge transport and ion diffusion in the system, achieving remarkable amplification capability with a current gain as high as ca.

Identification of a newly discovered virus from Culex and Armigeres mosquitoes in China.

Mosquito associated virus have always been a significant threat to global health. Metagenomics offers a straightforward and quantitative means to acquire the information of novel virus and has greatly enriched the content of mosquito associated virus databases. During an entomological surveillance for arthropod-borne viruses in China, we identified a previously unrecognized virus from mosquitoes, temporarily named Huajieling virus.