Risk prediction and early intervention strategies for persistent SARS-CoV-2 infection in patients with non-Hodgkin lymphoma: a retrospective cohort study.

Background: Patients with non-Hodgkin lymphoma (NHL) face heightened mortality and accelerated disease progression when persistently infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This critical situation underscores the urgent need to identify risk factors and establish early intervention strategies tailored to this vulnerable population. The primary aim of this study was to investigate the risk factors associated with persistent SARS-CoV-2 infection in NHL patients during the COVID-19 pandemic.

The serum gamma-glutamyl transpeptidase-to-platelet ratio predicts HELLP syndrome.

Background: HELLP (Hemolysis, elevated liver enzymes, and low platelets) syndrome is a dangerous obstetric condition that is in great need of simple and inexpensive non-invasive early predictors, but it has been poorly studied. This study was conducted to investigate the predictive role of serum gamma-glutamyl transpeptidase to platelet ratio (GPR) during pregnancy in HELLP syndrome and its adverse pregnancy outcomes.

Methods: This was a retrospective study in a tertiary hospital.

Theoretical model and experimental verification of seepage-transition-spontaneous imbibition in water migration of water-injected coal.

Coal seam water injection is widely applied to prevent mine disasters. In the traditional water migration model of water-injected coal, from ignoring capillary force in the seepage stage to generating the capillary dynamic during the spontaneous imbibition state, no transition state exists from 0 to generating capillary force. In this paper, on the basis of theoretical analysis, an equivalent capillary term is introduced to modify the Forchheimer model, and then a seepage-transition-spontaneous imbibition model that is suitable for water migration of water-injected coal is proposed.

Machine learning-based prediction models for renal impairment in Chinese adults with hyperuricaemia: risk factor analysis.

In hyperuricaemic populations, multiple factors may contribute to impaired renal function. This study aimed to establish a machine learning-based model to identify characteristic factors related to renal impairment in hyperuricaemic patients, determine dose‒response relationships, and facilitate early intervention strategies. Data were collected through the big data platform of Nanjing Hospital of Traditional Chinese Medicine, encompassing 2,705 patients with hyperuricaemia (1,577 with renal impairment, 828 without) from June 2019 to June 2022.

General synthesis of covalent organic frameworks under ambient condition within minutes via microplasma electrochemistry approach.

Covalent organic frameworks (COFs) are typically synthesized using solvothermal conditions with high temperature and long reaction time (≥120 °C, >72 h). Herein, we report a general and rapid microplasma electrochemistry strategy to synthesize COFs under ambient conditions. A series of flexible imine-bond COFs with high-crystallinity were prepared in minutes via this method, which showed 1000-fold higher space-time yield than solvothermal method.

Characterization of the Vaginal Microbiota in Women of Childbearing Age with different Nugent Scores.

The present study investigated the richness and diversity of vaginal microbiota among a cohort of 60 childbearing-age women. The samples were classified into three groups: healthy control (HC), bacterial vaginosis (BV), and BV intermediate (BVI). The number of Operational Taxonomic Units (OTUs) per sample ranged from 50 to 212, with three groups having 469 (HC), 482 (BVI), and 456 (BV) OTUs.

Protective Effects and Mechanisms of Lactoferrin and HIF-1α on Dry Eye Syndrome in Mice.

The objective of this study was to investigate the protective effects and related mechanisms of lactoferrin and HIF-1α on dry eye syndrome (DED) in mice. The expression levels of lactoferrin and HIF-1α in tears of DED patients and normal controls were detected. A DED mouse model received lactoferrin (50 mg/kg dissolved in 2 mL PBS) or DMOG (40 mg/kg dissolved in 2 mL PBS) orally daily for 28 days.

Antiviral potential of the arctigenin derivative COA in reducing viral adhesion to the epithelial cell surface against IHNV infection.

Infectious hematopoietic necrosis virus (IHNV) is a major aquaculture threat, highlighting the need for effective antiviral agents. This study evaluates the arctigenin derivative COA for its antiviral potential against IHNV. COA demonstrated no cytotoxicity to EPC cells at concentrations up to 10 μM and inhibited over 90% of IHNV gene expression in vitro.

The rheumatoid arthritis drug Auranofin targets peroxiredoxin 1 and peroxiredoxin 2 to trigger ROS-endoplasmic reticulum stress axis-mediated cell death and cytoprotective autophagy.

Auranofin (AF) is a gold-based compound and it has been used in the treatment of rheumatoid arthritis for over four decades. Recently, it has been demonstrated to show significant antitumor activity across various cancer types and is being repurposed as an anticancer drug. However, the precise mechanisms underlying its antitumor effects, particularly its binding targets, remain poorly understood.

Dietary timing enhances exercise by modulating fat-muscle crosstalk via adipocyte AMPKα2 signaling.

Feeding rhythms regulate exercise performance and muscle energy metabolism. However, the mechanisms regulating adipocyte functions remain unclear. Here, using multi-omics analyses, involving (phospho-)proteomics and lipidomics, we found that day-restricted feeding (DRF) regulates diurnal rhythms of the mitochondrial proteome, neutral lipidome, and nutrient-sensing pathways in mouse gonadal white adipose tissue (GWAT).

Self-training EEG discrimination model with weakly supervised sample construction: An age-based perspective on ASD evaluation.

Deep learning for Electroencephalography (EEG) has become dominant in the tasks of discrimination and evaluation of brain disorders. However, despite its significant successes, this approach has long been facing challenges due to the limited availability of labeled samples and the individuality of subjects, particularly in complex scenarios such as Autism Spectrum Disorders (ASD). To facilitate the efficient optimization of EEG discrimination models in the face of these limitations, this study has developed a framework called STEM (Self-Training EEG Model).

Defect engineering constructs two-dimensional metal sulfoselenide with expanded interlayers for fast and efficient sodium ion storage.

Leveraging abundant natural reserves and lower cost profiles, sodium-ion batteries (SIBs) are poised to supersede lithium-ion batteries (LIBs) within the domain of large-scale energy storage systems. Many achievements have been made in improving the properties of anodes in SIBs from the aspects of nanostructure and surface modification. Recently, the incorporation of anionic species into metal sulfides via defect engineering has emerged as an innovative strategy to boost sodium storage capabilities.

Early-onset Parkinson's disease, regional and national burden, and its attributable risk factors in 204 countries and regions from 1990 to 2021: Results from the global burden of disease study 2021.

Background: Early-Onset Parkinson's Disease (EOPD), defined as diagnosis before age 40, accounts for 5-10 % of Parkinson's cases and is characterized by slower progression and severe motor and non-motor complications. Its global burden has risen significantly, particularly among younger populations, but comprehensive analyses of trends, disparities, and determinants remain scarce.

Methods: EOPD burden was examined in 204 countries from 1990 to 2021 using Global Burden of Disease (GBD) 2021 data.

Droplet digital PCR-based single aptamer selection.

Aptamers are potent alternatives to antibodies in applications including diagnostics and disease treatment. These synthetic molecules are generated from sequences identified through specific targets within an aptamer pool of random sequences, approximately 10 in size, via the Systematic Evolution of Ligands by Exponential Enrichment (SELEX) process. Nevertheless, SELEX encompasses repetitive, time/money-consuming and stochastic methodologies.

Photodynamically activated chlorogenic acid-based antimicrobial packaging films for cherry preservation.

Natural photosensitizers offer promising and sustainable solutions to the challenges of food preservation. This study investigates the potential of chlorogenic acid (CA), a naturally occurring phenolic compound with dual photoactive and antimicrobial properties. Under Xenon lamp irradiation (100 mW/cm), CA at a concentration of 0.

Aberrant expansion of CD177 neutrophils promotes endothelial dysfunction in systemic lupus erythematosus via neutrophil extracellular traps.

Objective: Aberrant neutrophil activation is implicated in the pathogenesis of systemic lupus erythematosus (SLE) and its related comorbidities. We found that CD177 was one of the most highly up-regulated genes at the transcriptional level in purified neutrophils from SLE patients. In this study, we aimed to explore the role of CD177 neutrophils in the pathogenesis of SLE.

The causal effects between autoimmune thyroid disease and urticaria: evidence from a Mendelian randomization study.

Previous studies have suggested a comorbidity between autoimmune thyroid disease (AITD) and urticaria. However, the causal effects between AITD and urticaria remain unclear. This study employed genome-wide association study (GWAS) data to analyze the associations between AITD and urticaria through bidirectional Mendelian randomization (MR), meanwhile, examined the role of 731 immune traits as mediators between the two diseases through mediation analysis.

Mining Highly Active Oleate Hydratases by Structure Clustering, Sequence Clustering, and Ancestral Sequence Reconstruction.

Oleate hydratases (Ohys) catalyze the conversion of oleic acid (OA) to 10-()-hydroxystearic acid (10-HSA), a compound widely used in the chemical industry. However, the limited activity of Ohys has hindered their broader applications. To address this limitation, we propose a novel strategy for mining highly active Ohys through structure clustering, sequence clustering, and ancestral sequence reconstruction (SSA strategy).

A Crystalline Polymer Cathode for Sodium-Organic Batteries.

Sodium-organic batteries (SOBs) are widely recognized as a rising star in large-scale energy storage technology because of their abundant resources, high energy density, and environmental friendliness. However, the poor cyclability and rate performance due to high solubility and poor conductivity with organic electrode materials limit their practical applications. Here, we constructed a new crystalline polymer poly(tetraaminobenzoquione) (PTABQ) featuring a layered structure with conjugated backbone and intermolecular hydrogen bonds.

Evaluation and Comparison of Laboratory Methods in Diagnosing Mycobacterium tuberculosis and Nontuberculous Mycobacteria in 3012 Sputum Samples.

Tuberculosis is a global public health threat as an infectious disease, and effective blocking of transmission relies on timely diagnosis. Although a number of laboratory tests are available in diagnosing Mycobacterium tuberculosis (MTB) and nontuberculous mycobacteria (NTM), it is still of great need to evaluate their diagnostic value in clinical samples. In this study, we evaluated five MTB diagnostic methods (including conventional sputum smear microscopy, sandwich cup sputum smear microscopy, sputum culture, Xpert-MTB/RIF, and CapitalBio TB/NTM kit detection test) in 3012 sputum specimens and compared their diagnostic performance of the single and combined tests.

Treatment Strategies for Refractory Catheter-Related Central Venous Occlusive Disorders: Review.

Background: Catheter-related central vein occlusive disease (CVOD) is a frequent complication in hemodialysis patients and significantly affects their prognosis. Current treatment options for catheter-related CVOD include standard guidewire and catheter techniques, radiofrequency ablation, and sharp recanalization. However, large-scale clinical trials evaluating these techniques are lacking, making CVOD management challenging.

A single-dose, four-cycle, fully repetitive crossover bioequivalence of dabigatran etexilate in Chinese.

Purpose: Among healthy Chinese subjects, two capsules of dabigatran etexilate were tested for bioequivalence.

Method: Fifty healthy subjects were recruited for each of the fasting and postprandial trials in a randomized, two-sequence, open-label, four-cycle, fully replicated trial design of a single 150 mg dose of either the test or the reference formulation of dabigatran etexilate capsules in the fasting and postprandial states. The blood concentration of dabigatran at different time points after administration was determined by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS).

Lenvatinib plus pembrolizumab compared to carboplatin plus paclitaxel for carboplatin and paclitaxel pretreated, recurrent, or advanced endometrial cancer.

Background: Lenvatinib plus pembrolizumab has demonstrated improved survival compared with doxorubicin or paclitaxel monotherapy in patients with advanced or recurrent endometrial cancers (ECs). However, response rates to monotherapy are poor in recurrent settings. Herein, we performed a retrospective analysis using real-world data to compare the outcomes of lenvatinib plus pembrolizumab, carboplatin plus paclitaxel (PT), and doxorubicin for patients with PT-pretreated, advanced, or recurrent ECs.