Publications by authors named "Chen Huiyu"

Purpose: Currently, no relevant studies have reported a relationship between astigmatism and peripheral refraction (PR). We aimed to describe the association between PR and relative peripheral refraction (RPR) with astigmatism in Chinese children with mild to moderate myopia, and to provide new insights into the influence of astigmatism.

Methods: Three-hundred-and-seven children (6-14 years old) from Shanghai were included in this study.

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In recent years, -quinone methides have emerged as indispensable reactive species for enhancing synthetic efficiency in accessing various bioactive natural products. Importantly, the emulation of nature's patterns and strategies has yielded numerous refined synthetic pathways for the construction of intricate molecules. -Quinone methides (-QMs) have demonstrated remarkable versatility in organic synthesis, especially in strategies guided by biomimetic logic.

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Objective: Although previous studies have demonstrated allostatic load (AL) predicts depressive symptoms, few studies have considered the association between AL and trajectories of depressive symptoms. This study aims to systematically examine the associations of abnormal blood biomarkers in the three biological systems with trajectories of depressive symptoms.

Methods: A total of 6251 participants aged 45+ from the China Health and Retirement Longitudinal Study (CHARLS).

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Merbecoviruses comprise four viral species with remarkable genetic diversity: MERS-related coronavirus, Tylonycterisbat coronavirus HKU4, Pipistrellusbat coronavirus HKU5, and Hedgehog coronavirus 1. However, the potential human spillover risk of animal merbecoviruses remains to be investigated. Here, we reported the discovery of HKU5-CoV lineage 2 (HKU5-CoV-2) in bats that efficiently utilize human angiotensin-converting enzyme 2 (ACE2) as a functional receptor and exhibits a broad host tropism.

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Objectives: The American Heart Association defined cardiovascular-kidney-metabolic (CKM) syndrome as a novel multi-stage disorder. We examined the associations of CKM stages with premature mortality and the role of social determinants of health (SDOHs).

Design: A prospective cohort study.

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Background: Group B streptococcus (GBS) causes neonatal invasive disease, mainly sepsis and meningitis. Understanding the clinical characteristics, laboratory tests, and antibiotic resistance patterns of GBS invasive infections provides reliable epidemiological data for preventing and treating GBS infections.

Methods: Clinical characteristics and laboratory test results from 86 patients with neonatal invasive disease (45 cases of early-onset disease [EOD] and 41 cases of late-onset disease [LOD]) recruited from Fujian Maternity and Child Health Hospital between January 2012 and December 2021 were analyzed.

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Background: Colonoscopy is the standard diagnostic method for colorectal cancer. Patients usually receive written and verbal instructions for bowel preparation (BP) before the procedure. Failure to understand the importance of BP can lead to inadequate BP in 25%-30% of patients.

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Background/aim: The CD155/TIGIT axis has recently emerged as a promising immunotherapeutic target in several malignancies. However, its prognostic relevance within the tumor microenvironment (TME) in patients with locally advanced rectal cancer (LARC) who have received neo-adjuvant chemoradiotherapy (neoCRT) remains unclarified.

Materials And Methods: The levels of tumor CD155 and TIGIT T cells in pair-matched pre-neoCRT biopsies and post-neoCRT surgical tissues were evaluated in 110 LARC tissues using immunohistochemistry.

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Article Synopsis
  • Cardiovascular-kidney-metabolic (CKM) syndrome is a common yet complex disorder defined by the American Heart Association, but how its stages vary based on social determinants of health (SDOH) in the U.S. is not well understood.
  • The study aimed to assess the prevalence of different CKM stages in relation to various SDOH factors like income, education, and health insurance, using data from a comprehensive national health survey.
  • Results showed significant disparities in CKM stages across SDOH, with higher prevalence noted in individuals facing unemployment, low family income, and food insecurity, indicating a clear link between social factors and health outcomes.
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Background: There is growing evidence that atrial fibrillation (AF) is a risk factor for cognitive impairment (CI) and dementia in the presence or absence of stroke. The purpose of this study was to explore the mechanism of CI caused by AF.

Methods: Eighteen male canines were randomly divided into a sham group, a pacing group, and a pacing + GW4869 group.

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  • QTXZG is an effective traditional Chinese medicine treatment for chronic glomerulonephritis (CGN), which works by interacting with circStk4 and its N-methyladenosine (mA) modifications.
  • The study aimed to investigate the molecular mechanisms behind QTXZG's effectiveness in CGN through both lab and animal experiments.
  • Results showed that QTXZG reduced METTL3 and circStk4 levels, enhanced apoptosis and autophagy in mouse mesangial cells, and confirmed therapeutic benefits in vivo, highlighting its potential for CGN treatment.
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Objective: Multidisciplinary rehabilitation facilitates post-stroke functional recovery, but is associated with resource and accessibility barriers. This study evaluated the combination of a wearable device-assisted system (WEAR) and conventional therapy for post-stroke rehabilitation.

Methods: This randomized, controlled, parallel group, clinical trial was conducted at two rehabilitation centers.

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Ce-doped lithium alumino-silicate (Li-Al-Si) scintillating glass was prepared using a melting method and crystallized via heat treatment. X-ray diffraction and transmission electron microscopy confirmed the presence of nanocrystals in the materials. Radioluminescence spectra, obtained by X-ray excitation, and luminescence spectra, obtained by 338 nm excitation, showed that the luminescence intensity increased after crystallization.

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Objective: To investigate gray matter volume (GMV) changes in patients with comorbid insomnia and sleep apnea (COMISA) of differing severity and relationships between GMV alterations and clinical measures.

Methods: Thirty-four COMISA patients and 24 healthy controls (HC) were recruited. All patients underwent structural MRI and completed measures related to respiration, sleep, mood, and cognition.

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The first successful copper-catalyzed decarboxylative cyclization reaction of ethynylbenzoxazinones and thiols has been developed. A rarely studied α-addition process to a copper-allenylidene intermediate promoted this reaction. Using this protocol, a range of 2-thiomethylene indole compounds have been obtained.

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Article Synopsis
  • - The development of small molecules that activate in the second near-infrared (NIR-II) window is difficult but important for detection.
  • - A new probe called Z-1065 has been created, which can detect HO (hydroxyl radicals) in real-time.
  • - Z-1065 shows strong sensitivity and selectivity for HO and can successfully track HO production in mouse models of drug-induced liver injury (DILI).
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Background: The relationship between local epicardial adipose tissue (EAT) macrophages and atrial fibrillation (AF) remains unclear. The purpose of this study was to investigate the role of K3.1 in the migration of macrophages from EAT to adjacent atrial tissue during rapid pacing.

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Atherosclerosis (AS) is a chronic inflammatory disorder characterized by arterial intimal lipid plaques. Small interfering ribonucleic acid (siRNA)-based therapies, with their ability to suppress specific genes with high targeting precision and minimal side effects, have shown great potential for AS treatment. However, targets of siRNA therapies based on macrophages for AS treatment are still limited.

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In this work, β-NiS nanoparticles (NPs) were efficiently prepared by a straightforward hydrothermal process. The difference in morphology between these NiS NPs was produced by adding different amounts of thiourea, and the corresponding products were denoted as NiS-15 and NiS-5. Through electrochemical tests, the specific capacity () of NiS-15 was determined to be 638.

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  • Straw is a cost-effective and abundant biomass waste, identified as a promising renewable resource for developing carbon nanosheets.
  • A two-step carbonization method was used to create carbon nanosheets from rice straw, which demonstrated effective adsorption of hydrogen sulfide (HS) with optimal performance at a pyrolysis temperature of 200 °C, achieving a sulfur capacity of 3.1 mg/g.
  • Analysis revealed that these carbon nanosheets possess a highly alkaline surface with various functional groups and radicals that facilitate the conversion and removal of HS, highlighting the potential of straw-based materials in exhaust gas treatment.
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Purpose: To compare corneal biomechanical properties and intraocular pressure (IOP) measurements in patients who underwent Descemet's stripping with endothelial keratoplasty (DSEK) with those of the follow healthy eyes.

Methods: In this retrospective comparative study, a total of 35 eyes of 35 patients who underwent DSEK by a single surgeon from 2015.02 to 2019.

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Colonoscopy is an essential method for diagnosing and treating colorectal cancer, relying on effective bowel preparation to thoroughly examine the large intestinal mucosa. Traditional education involves printed instructions and verbal explanations but does not guarantee clear patient understanding. Poor bowel preparation can obscure mucosal visibility, delaying cancer diagnosis and treatment.

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Article Synopsis
  • Fibroblast-derived exosomes are shown to play a role in regulating heart cell electrical activity, particularly through the intermediate-conductance calcium-activated potassium channel (KCa3.1), which is involved in atrial electrical remodeling.
  • The study involved isolating heart cells from rats and using electrical stimulation to create a model of atrial fibrillation, with experiments designed to see how exosomes from fibroblasts influenced KCa3.1 and related mechanisms.
  • Findings indicated that increased exosome secretion during rapid heart pacing enhanced KCa3.1 expression and altered heart cell action potentials, while blocking KCa3.1 reduced action potential duration and potentially the risk of atrial fibrillation.
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Overcoming tumor apoptosis resistance is a major challenge in enhancing cancer therapy. Pyroptosis, a lytic form of programmed cell death (PCD) involving inflammasomes, Gasdermin family proteins, and cysteine proteases, offers potential in cancer treatment. While photodynamic therapy (PDT) can induce pyroptosis by generating reactive oxygen species (ROS) through the activation of photosensitizers (PSs), many PSs lack specific subcellular targets and are limited to the first near-infrared window, potentially reducing treatment effectiveness.

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Background: Streptococcus agalactiae (GBS) and Escherichia coli (E. coli) are the main pathogenic bacteria in neonatal sepsis. Therefore, the clinical characteristics, nonspecific indicators, and drug susceptibilities of these two bacteria were studied.

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