The potential effective components from Danlou tablet attenuates acute myocardial infarction by restoring ALOX12-mediated perturbed oxylipins.

Ethnopharmacological Relevance: Danlou Tablet (DLP) was developed from the "Gualou-Xiebai-Baijiu decoction", as documented in the "Synopsis of the Golden Chamber" by Dr. Zhongjing Zhang. It is widely used for clinical treatment of different degrees of coronary heart disease (CHD).

Comparison of 3D and 2D area measurement of acute burn wounds with LiDAR technique and deep learning model.

It is generally understood that wound areas appear smaller when calculated using 2D images, but the factors contributing to this discrepancy are not well-defined. With the rise of 3D photography, 3D segmentation, and 3D measurement, more accurate assessments have become possible. We developed an application called the Burn Evaluation Network (B.

A comparative genomic analysis at the chromosomal-level reveals evolutionary patterns of aphid chromosomes.

Genomic rearrangements are primary drivers of evolution, promoting biodiversity. Aphids, an agricultural pest with high species diversity, exhibit rapid chromosomal evolution and diverse karyotypes. These variations have been attributed to their unique holocentric chromosomes and parthenogenesis, though this hypothesis has faced scrutiny.

TRAF3IP3 Induces ER Stress-Mediated Apoptosis with Protective Autophagy to Inhibit Lung Adenocarcinoma Proliferation.

TNF receptor-associated factor 3 interacting protein 3 (TRAF3IP3/T3JAM) exhibits dual roles in cancer progression. While upregulated in most malignancies and critical for immune regulation. However, the specific effects and molecular mechanisms of TRAF3IP3 on the progression of lung adenocarcinoma (LUAD) remains poorly understood.

Accelerometer-Derived "Weekend Warrior" Physical Activity and All-Cause and Cause-Specific Mortality.

Objective: To examine the association of "weekend warrior" (WW) pattern and physical activity distributed throughout the week with mortality risk.

Participants And Methods: In this cohort study of 95,468 participants in the UK Biobank from 2013 through 2015, participants were grouped by accelerometer-derived physical activity levels: inactive (moderate to vigorous physical activity [MVPA] <150 min/wk using World Health Organization guidelines), active WW (≥150 minutes of MVPA per week and ≥50% of total MVPA over 1 to 2 days), and active regular (≥150 minutes of MVPA but not active WW). Cox regression analyzed associations of activity patterns with all-cause mortality and 10 categories of cause-specific mortality and whether the association differed by sedentary time (≤6, 7 to 12, or ≥13 hours) and light physical activity (≤60, 61 to 150, or ≥151 min/d).

Frontiers and Controversies in De Novo Gastrointestinal Tumors After Organ Transplantation: Current Progress and Future Directions.

The increasing success of organ transplantation has significantly improved survival for patients with end-stage diseases, yet it introduces a complex dilemma: the elevated risk for the development of de novo gastrointestinal (GI) tumors. The sustained immunosuppression required to maintain graft function paradoxically undermines the body's natural defenses against cancer, leading to a higher incidence, aggressive progression, and atypical presentations of GI tumors among transplant recipients compared with the general population. This presents a pressing challenge: balancing the dual imperatives of preventing graft rejection and effectively managing malignancies.

Adaptation to invisible motion impairs the understanding of verb phrases.

The question of whether low-level perceptual processes are involved in language comprehension remains unclear. Here, we introduce a promising paradigm in which the role of motion perception in phrase understanding may be causally inferred without interpretational ambiguity. After participants had been adapted to either leftward or rightward drifting motion, resulting in the reduced responsiveness of motion neurons coding for the adapted direction, they were asked to indicate whether a subsequent verb phrase denoted leftward or rightward motion.

BSRF1 modulates IFN-β-mediated antiviral responses by inhibiting NF-κB activity via an IKK-dependent mechanism in Epstein-Barr virus infection.

The Epstein-Barr virus (EBV) encoded tegument protein BSRF1 plays a significant role in the processes of viral maturation and release, however, it's not clear whether BSRF1 is involved in the modulation of host innate immunity. In this study, we demonstrated that BSRF1 can inhibit interferon β (IFN-β) production by downregulating nuclear factor kappa B (NF-κB) activity and subsequently reducing the yield of inflammatory cytokines, thereby facilitating viral replication. Dual luciferase reporter assays indicated that BSRF1 may inhibit NF-κB signaling at the level of IKK or between IKK and p65, while co-immunoprecipitation experiments revealed its association with multiple critical host adaptor proteins.

Dietary polysaccharides from dragon fruit pomace, a co-product of the fruit processing industry, exhibit therapeutic potential in high-fat diet-induced metabolic disorders.

The increasing prevalence of metabolic disorders, often associated with high-fat diets (HFD), highlights the need for new therapeutic approaches, especially from natural sources. Dragon fruit pomace, a by-product of the fruit processing industry, is rich in polysaccharides with potential health benefits. This study investigates the effects of dragon fruit pomace-derived polysaccharides (PDPS) in alleviating HFD-induced metabolic dysfunction.

Direct measurement of fluorocarbon radicals in the thermal destruction of perfluorohexanoic acid using photoionization mass spectrometry.

Thermal destruction is a critical cornerstone of addressing the rampant contamination of natural resources with per- and polyfluoroalkyl substances (PFAS). However, grave concerns associated with stack emissions from incineration exist because mechanistic studies have thus far relied on ex situ analyses of end products and theoretical calculations. Here, we used synchrotron-based vacuum ultraviolet photoionization mass spectrometry to study the pyrolysis of a representative PFAS-perfluorohexanoic acid-and provide direct evidence of fluorocarbon radicals and intermediates.

Balancing Electronic Spin State via Atomically-Dispersed Heteronuclear Fe-Co Pairs for High-Performance Sodium-Sulfur Batteries.

Room-temperature sodium-sulfur (Na-S) batteries are emerging as a promising next-generation energy storage technology, offering high energy densities at low cost and utilizing abundant elements. However, their practical application is hindered by the shuttle effect of sodium-polysulfides and the sluggish kinetics of sulfur redox reactions. In this study, we demonstrate a heteronuclear diatomic catalyst featuring Fe and Co bimetallic sites embedded in nitrogen-doped hollow carbon nanospheres (Fe-Co/NC) as an effective sulfur host at the cathode of Na-S batteries.

Development and evaluation of USCnet: an AI-based model for preoperative prediction of infectious and non-infectious urolithiasis.

Background: Urolithiasis, a prevalent condition characterized by a high rate of incidence and recurrence, necessitates accurate preoperative diagnostic methods to determine stone composition for effective clinical management. Current diagnostic practices, reliant on postoperative specimen analysis, often fail to facilitate timely and precise therapeutic decisions, leading to suboptimal clinical outcomes. This study introduces an artificial intelligence model developed to predict infectious and non-infectious urolithiasis preoperatively using clinical data and CT imaging.

Attentive feature interaction based persistent homology-augmented network for esophageal cancer lesion detection.

Background: Detecting lesions in esophageal cancer (EC) is important in guiding subsequent treatment. Deep learning methods based on convolutional neural networks (CNNs) and vision transformer (ViT) have made remarkable strides in the field of medical image analysis due to their powerful representational capabilities. However, without prior knowledge, both traditional CNNs and ViTs are susceptible to disregarding critical anatomical information, including loops and voids.

Advancements in elucidating the mechanisms of sorafenib resistance in hepatocellular carcinoma.

Primary liver cancer is a major global health challenge, of which hepatocellular carcinoma is the most common. For patients with advanced liver cancer, sorafenib is a first-line targeted drug that occupies a dominant position in clinical applications. Sorafenib is a multi-kinase inhibitor commonly used in clinical practice, which can effectively inhibit tumor cell proliferation, promote cell apoptosis and inhibit angiogenesis.

Stefan-Boltzmann Water Catalyzed Propane Dehydrogenation.

The traditional wisdom of utilizing water in practical olefin synthesis has been viewed as a means to reduce alkane partial pressure and assist in coke removal. However, under such harsh reaction conditions, the potential catalytic role of the water molecule remains unclear. This study explores the intriguing concept that the water molecule, through the selective excitation of molecular vibrations and collisions induced by thermal energy and thermal radiation, could act as a catalyst in homogeneous gaseous propane dehydrogenation.

Association between serum cotinine concentrations on red blood cell folate concentrations in pregnant women and the mediating role of lymphocytes: an NHANES Study.

Background: Folate is essential for DNA synthesis and cell division, particularly during pregnancy, where insufficient levels can lead to adverse outcomes like neural tube defects and preterm birth. Tobacco smoke exposure, indicated by serum cotinine levels, is a known risk factor for reduced folate levels. However, the mechanisms underlying this relationship, especially the role of lymphocytes, are not well understood.

Formation of CH isomers: a combination of experimental and computational investigation.

A propagation mechanism originating from 1,3-cyclopentadienyl, a prearomatic resonantly stabilized radical, makes a significant contribution to the growth of polycyclic aromatic hydrocarbons and soot. 1,3-Cyclopentadiene, as the simplest 5-membered carbon closed-shell molecule that could generate 1,3-cyclopentadienyl photolysis and H-elimination, is attracting attention from astrochemistry and combustion chemistry communities. The reaction of propargyl (˙CH) with ethylene (CH) was investigated in a micro SiC reactor under low-pressure (<100 Torr) conditions coupled with tunable synchrotron radiation photoionization and molecular beam mass spectrometry techniques.

A Comprehensive Quality Evaluation Strategy of Wendan Decoction Based on Qualitative, Fingerprint, and Quantitative Analyses.

Introduction: Wendan decoction (WDD), a classic Chinese medicine formula, has been used for the treatment of insomnia for hundreds of years. However, the current research on the chemical composition and the material basis of the medicinal effect of WDD is not perfect, which limits further research on it.

Objectives: In the present study, we aimed to propose a methodology for the quality control of WDD based on qualitative and quantitative analysis of its components.

A prospective, single-blinded, non-inferiority, randomized controlled study comparing the effectiveness and safety of oral lactulose combined with carbohydrate-containing clear liquids versus 3-L polyethylene glycol electrolyte for colonoscopy bowel preparation.

Background: Polyethylene glycol electrolyte solution (PEG-ELS) is the standard for bowel preparation but often suffers from poor patient compliance and tolerability due to its high-volume requirement. This prospective, single-blinded, non-inferiority, randomized control trial aims to investigate the efficacy and safety of a lactulose-based regimen as an alternative for bowel preparation.

Methods: Two hundred nine patients were randomly allocated to receive either a combination regimen consisting of 133.

Targeting DUSP3 promotes cell senescence by activating the notch1 pathway to treat hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is a malignant tumor of the digestive system, influenced by various factors. Due to its subtle clinical symptoms, it delayed results in poor prognosis and limited treatment options. Cellular senescence, characterized by stable growth arrest, is closely linked to tumor proliferation inhibition, making it a promising therapeutic strategy for HCC.

Metal Doping Activation of Anion-Mediated Electron Transfer in Catalytic Reactions.

Heteroatom-doping has emerged as a transformative approach to producing high-performance catalysts, yet the current trial-and-error approach to optimize these materials remains ineffective. To enable the rational design of more efficient catalysts, models grounded in a deeper understanding of catalytic mechanisms are essential. Existing models, such as -band center theory, fall short in explaining the role of dopants, particularly when these dopants do not directly interact with reactants.

Cardioprotective effects of hUCMSCs-Exosi-EGR1 MN patch in MI/RI by modulating oxidative stress and mitophagy.

In an effort to address the detrimental effects of myocardial ischemia/reperfusion injury (MI/RI), this study introduces a novel therapeutic strategy that involves a microneedle (MN) patch loaded with exosomes derived from human umbilical cord mesenchymal stem cells (hUCMSCs) and carrying small interfering RNA (siRNA) targeting early growth response-1 (EGR1). By delivering hUCMSCs-derived exosomes containing EGR1 siRNA (hUCMSCs-Exosi-EGR1), the MN patch demonstrated promising cardioprotective effects in both and models of MI/RI. The results highlighted the efficacy of Exosi-EGR1 in enhancing cardiomyocyte viability, attenuating oxidative stress levels, and fostering mitophagy regulation.

Real-Time Analysis of CO Reduction Product Distribution by Synchrotron Vacuum Ultraviolet Photoionization Mass Spectrometry.

Understanding the transient physicochemical properties at the cathode/catholyte interface is a prerequisite to shedding light on the complex electrochemical CO reduction reaction (CORR) mechanism as well as to steering the product distribution toward precise CO valorization. Herein, we report a flow-cell-based synchrotron vacuum ultraviolet photoionization mass spectrometric approach to resolve the dynamic interfacial species evolution during Cu-catalyzed CORR. By optimizing the photoionization energy, characteristic molecular ions of 8 volatile reduction products, together with the CO reactant, have been precisely captured for both potential step and linear sweep voltammetric measurements.

Research progress and perspectives on the application of tyramide signal amplification-based multiplex immunohistochemistry/immunofluorescence: a bibliometrics analysis.

Background And Aims: Multiplex immunohistochemistry/immunofluorescence (mIHC/IF), which uses the tyramide signal amplification (TSA) technique, enables sequential staining of multiple targets in formalin-fixed paraffin-embedded (FFPE) samples without worrying about cross-reactivity. This approach has received considerable attention from researchers over the past decades. This article aims to provide a bibliometric analysis of the research progress and perspectives on the application of TSA-based mIHC/IF.

Important role of lymphovascular and perineural invasion in prognosis of colorectal cancer patients with N1c disease.

Background: Lymphovascular invasion (LVI) and perineural invasion (PNI) are associated with decreased survival in colorectal cancer (CRC), but its significance in N1c stage remains to be clearly defined.

Aim: To evaluate LVI and PNI as potential prognostic indicators in N1c CRC.

Methods: We retrospectively identified 107 consecutive patients who had CRC with N1c disease radically resected at our hospital.