Preorthodontic functional long-term trial restoration of a worn dentition for optimizing outcomes: A clinical report.

Orthodontic tooth movement is often required before restorative treatment to maximize the esthetic and functional outcomes. Diagnostic waxing is a crucial step before active treatment to validate the optimal tooth position for future restorations. In this clinical report, a bonded prototype of the diagnostic waxing was used to guide and facilitate orthodontic treatment with the definitive restorations mind.

HMGB2 is associated with pressure loading in chondrocytes of temporomandibular joint: In vitro and in vivo study.

High mobility group protein B2 (HMGB2) is an important protein attributed to tissue function and homeostasis in osteoarthritis (OA), however, its roles in the temporomandibular joint with mechanical pressure are unclear. This study investigated the expression patterns of HMGB2 in chondrocytes of TMJ on OA-related cellular and animal models. The transcriptional level and protein expression of HMGB2 as well as Col- II, MMP-13 and β-catenin were examined in primary cultured chondrocytes from TMJs with hydrostatic pressures (HP).

Food allergy: what it is and what it is not?

Purpose Of Review: Food allergy is defined as an adverse health effect arising from a specific immune response that occurs reproducibly on exposure to a given food. Food intolerance, certain gastrointestinal or systemic diseases are often confused with or mislabeled as food allergy because of symptomatic similarity and general improvement from food avoidance. The differences between these diseases are crucial.

Rapid Palatal Expansion with the Keles Keyless Expander.

Rapid palatal expansion (RPE) is commonly used in orthodontic treatment to correct maxillary transverse deficiency, increase arch length, indirectly widen the mandibular arch in some cases, and move the maxilla downward and forward.(1-5) Maxillary transverse deficiency is usually accompanied by posterior crossbite, unless there is constriction or lingual tipping of the mandibular teeth. Posterior crossbite occurs in about 7.

Investigational new drugs for allergic rhinitis.

Allergic rhinitis (AR) is a multifactorial disease characterized by paroxysmal symptoms of sneezing, rhinorrhea, postnasal drip and nasal congestion. For over a century, subcutaneous allergen immunotherapy (SCIT) has been recognized as the most effective therapy to date that may modify the underlying disease course and provide long-term benefits for individuals refractory to pharmacotherapy. However, over the past 25 years, there has been substantial growth in developing alternative therapies to traditional SCIT.

New insights into an autoimmune mechanism, pharmacological treatment and relationship between multiple sclerosis and inflammatory bowel disease.

Inflammatory bowel disease (IBD) and multiple sclerosis (MS) are autoimmune diseases with a close relationship to their disease pattern and immunologic cascade with considerable morbidity and mortality. This article provides insight of why tumor necrosis factor blockers couldn't work in multiple sclerosis and why interferon-beta doesn't work in inflammatory bowel disease. In this article, we provide a detailed review of the linkage and potential interchangeable medication between IBD and MS in addition to Natalizumab, Trichuris suis egg therapy and vitamin D.

Determination of enantiomerization barrier of thioridazine by dynamic capillary electrophoresis using sulfated cyclodextrins as chiral selectors.

The enantiomerization of thioridazine (THD) using sulfated beta-CDs (S-beta-CDs) as chiral selectors in a citrate buffer at pH 3.0 was investigated by dynamic CE. The enantiomers of THD were well separated with dual CD systems consisting of S-beta-CD and a neutral CD.

Chiral separation of hydroxyflavanones in cyclodextrin-modified capillary zone electrophoresis using sulfated cyclodextrins as chiral selectors.

Chiral separations of three hydroxyflavanone aglycones, including 2'-, 3'-, and 4'-hydroxyflavanone, in capillary zone electrophoresis (CZE) using randomly sulfate-substituted beta-cyclodextrin (S-beta-CD) or dual cyclodextrin (CD) systems consisting of S-beta-CD and a neutral CD at low pH were investigated. The results indicate that S-beta-CD is an excellent chiral selector for enantioseparation of 2'-hydroxyflavanone and is a good chiral selector for 3'-hydroxyflavanone. Depending on the concentration of S-beta-CD ranging from 2.

Enantioseparation of phenothiazines in CD-modified CZE using single isomer sulfated CD as a chiral selector.

Enantioseparations of five chiral phenothiazines in CD-modified CZE using the single isomer sulfate-substituted beta-CD (heptakis(2,3-dihydroxy-6-O-sulfo)-beta-CD, SI-S-beta-CD) and dual CD systems consisting of SI-S-beta-CD and a neutral CD as chiral selectors in a citrate buffer at pH 3.0 were investigated. The results indicate that SI-S-beta-CD is an excellent chiral selector for enantioseparation of promethazine.

Use of beta-cyclodextrin bonded phase with s-triazine moiety in the spacer for separation of aromatic carboxylic acid isomers by high-performance liquid chromatography.

The separation and retention behavior of five aromatic carboxylic acid isomers was investigated by means of high-performance liquid chromatography (HPLC) using a beta-cyclodextrin bonded phase with s-triazine ring in the spacer. The influence of mobile phase pH on the retention was examined. The presence of s-triazine moiety in the spacer enhances greatly the selectivity of the isomers of aromatic carboxylic acids.

Enantioselectivity of basic analytes in CZE enantioseparation under reversed-polarity mode using sulfated beta-cyclodextrins as chiral selectors: An unusual temperature effect.

Temperature effects on the enantioselectivity of basic analytes in CZE enantioseparation were studied under reversed-polarity mode using randomly sulfate-substituted beta-CDs (MI-S-beta-CD) as chiral seletors. Two catecholamines (epinephrine and isoproterenol) and two structurally related compounds (octopamine and norephedrine) were selected as test compounds in an electrophoretic system at low pH. The mobility differences between the (+)-enantiomers and the (-)-enantiomers of the two catecholamines and dopamine at 40 degrees C are greater than those at 25 degrees C with MI-S-beta-CD, even at a concentration as low as 0.

Strategies for enantioseparations of catecholamines and structurally related compounds by capillary zone electrophoresis using sulfated beta-cyclodextrins as chiral selectors.

Strategies for simultaneous enantioseparations of three catecholamines (DL-norepinephrine, DL-epinephrine, and DL-isoproterenol) and three structurally related compounds (DL-octopamine, DL-synephrine, and DL-norephedrine) by CZE using sulfated beta-CDs as chiral selectors were investigated. Four different separation modes were attempted: (I) using randomly sulfate-substituted beta-CD (MI-S-beta-CD) at relatively low concentrations in a high-concentration phosphate buffer at low pH in the normal polarity mode, (II) using MI-S-beta-CD at high concentrations at low pH in the reversed polarity mode, (III) using MI-S-beta-CD at moderately high concentrations in a phosphate buffer at neutral pH in the normal polarity mode, and (IV) using the single isomer heptakis(2,3-dihydroxy-6-O-sulfo)-beta-CD (SI-S-beta-CD) at low to moderately high concentrations in a high-concentration BGE at low pH in the normal polarity mode. Among them, enantioseparation of these cationic solutes was best achieved under the conditions of mode (II).