Potential of traditional Chinese medicine lyophilized powder of in the treatment of hyperuricemia.

Traditional Chinese medicine has a long and illustrious history, and with the development of modern science and technology, the research and application of traditional Chinese medicines have continued to progress significantly. Many traditional Chinese medicinal herbs have undergone scientific validation, reinvigorating with new life and vitality, and contributing unique strengths to the advancement of human health. Recently, the discovery that leech total protein extracted from lyophilized powder reduces blood uric acid (UA) levels by inhibiting the activity of xanthine oxidase to decrease UA synthesis and promotes UA excretion by regulating different UA transporters in the kidney and intestine has undoubtedly injected new vitality and hope into this field of research.

Unlocking Solid-State Sodium-Metal Batteries at -15 °C by Electrolyte Optimization and Interface Regulation.

Beta-AlO-based solid-state sodium metal batteries are some of the best options for large-scale energy storage systems because of their high energy density, high-level safety, and low cost. Nevertheless, their room-/low-temperature operation remains challenging due to low ionic conductivity of Beta-AlO electrolyte and weak solid-solid contact of the Na/Beta-AlO interface. Herein, an integrated strategy was developed via electrolyte optimization and interface regulation, in which Cu as a stabilizing agent was incorporated into Beta-AlO to improve density and ionic conductivity and the InS interface layer was introduced between the Na anode and solid electrolyte to induce the in situ formation of a mixed conductive layer (Na-In alloy and NaS).

Exploring a new chapter in traditional Chinese medicine: The potential of in liver cancer treatment.

In the ongoing quest for new treatments in medicine, traditional Chinese medicine offers unique insights and potential. Recently, studies on the ability of to inhibit M2-type tumour-associated macrophage polarisation by modulating the Wnt/β-catenin signalling pathway to suppress liver cancer have undoubtedly revealed new benefits and hope for this field of research. The purpose of this article is to comment on this study and explore its strengths and weaknesses, thereby providing ideas for the future treatment of liver cancer.

Exercise training alleviates neuronal apoptosis and re-establishes mitochondrial quality control after cerebral ischemia by increasing SIRT3 expression.

Existing evidence indicates that exercise training can enhance neural function by regulating mitochondrial quality control (MQC), which can be impaired by cerebral ischemia, and that sirtuin-3 (SIRT3), a protein localized in mitochondria, is crucial in maintaining mitochondrial functions. However, the relationship among exercise training, SIRT3, and MQC after cerebral ischemia remains obscure. This study attempted to elucidate the relationship among exercise training, SIRT3 and MQC after cerebral ischemia in rats.

Tribological and Heat Transfer Investigation of Graphene Oxide Coatings on Nylon Rotating Bands in an Artillery System.

Exploring ways to improve the performance of rotating bands is of great importance for enhancing the power of modern artillery. This study prepared graphene oxide-coated Nylon (GO-Nylon) and Nylon samples based on nylon rotating bands in artillery systems to investigate the feasibility of introducing GO-coated nylon rotating band materials to enhance their tribological and thermal properties. The friction behavior and thermal effects of these two surfaces were analyzed under different external loads and surface roughness conditions.

Postharvest Immersion in Slightly Acidic Electrolyzed Water Improves Guava Storability by Regulating Phenylpropane Metabolism.

Postharvest guava fruit are at high risk of decay and spoilage, which extremely restrains the further advancement of guava industry in China. Currently, slightly acidic electrolyzed water (SAEW) has been shown to be potent in maintaining the storability of fruits and vegetables. Accordingly, this work was designed to figure out the effectiveness of SAEW on storability maintenance in postharvest guavas via regulating the phenylpropane metabolism.

RSRNeT: a novel multi-modal network framework for named entity recognition and relation extraction.

Named entity recognition (NER) and relation extraction (RE) are two important technologies employed in knowledge extraction for constructing knowledge graphs. Uni-modal NER and RE approaches solely rely on text information for knowledge extraction, leading to various limitations, such as suboptimal performance and low efficiency in recognizing polysemous words. With the development of multi-modal learning, multi-modal named entity recognition (MNER) and multi-modal relation extraction (MRE) have been introduced to improve recognition performance.

Multi-stage anoxic/oxic sequencing batch reactor realizes shortcut nitrogen removal for anaerobically co-digested liquor of municipal sludge and urban organic wastes.

Nitrogen removal from the combined anaerobic digestion dehydration liquor (CADDL) of municipal sludge and urban organic wastes is challenging due to high ammonium concentrations, low C/N ratio, and poor biodegradability. This study proposes a multi-stage anoxic/oxic (A/O) sequencing batch reactor with step feeding to realize partial nitrification and denitrification for shortcut nitrogen removal from the CADDL. We investigated the effects of external carbon source (acetate), dissolved oxygen (DO), A/O duration ratio, and A/O stage number on biological nitrogen removal.

Rebuilding Peripheral F, Cl, Br Footprints on Acceptors Enables Binary Organic Photovoltaic Efficiency Exceeding 19.7 .

Given homomorphic fluorine (F), chlorine (Cl) and bromine (Br) atoms are featured with gradually enlarged polarizability/atomic radius but decreased electronegativity, the rational screen of halogen species and locations on small molecular acceptors (SMAs) is quite essential for acquiring desirable molecular packing to boost efficiency of organic solar cells (OSCs). Herein, three isomeric SMAs (CH-F, CH-C and CH-B) are constructed by delicately rebuilding peripheral F, Cl, Br footprints on both central and end units. Such a re-permutation of peripheral halogens could not only maintain the structural symmetry of SMAs to the maximum, but also acquire extra asymmetric benefits of enhanced dipole moment and intramolecular charge transfer, etc.

IL-18, a therapeutic target for immunotherapy boosting, promotes temozolomide chemoresistance via the PI3K/AKT pathway in glioma.

Interleukin-18, a member of the interleukin - 1 family of cytokines, is upregulated in glioma. However, its effects on glioma remain unclear. This study aimed to explore the role and underlying mechanisms of interleukin-18 expression in glioma.

Effect of brine concentration on the quality of salted large yellow croaker during processing and refrigeration.

Unlabelled: This study aimed to evaluate the effect of brine concentrations (4%, 8%, 12%, 16%) on the quality of salted large yellow croakers. During the wet salting processing, increased salinity inhibited myogenic fibers swelling and extracellular space expansion, and resulted in lower water content and higher salt content of salted large yellow croaker products. During refrigeration of salted large yellow croakers at 4 °C for 24 days, SDS-PAGE patterns showed that high salinity slowed down the degradation of proteins, which was further confirmed by changes in free amino acids (FAAs) and biogenic amine contents.

Integrating respiratory microbiome and host immune response through machine learning for respiratory tract infection diagnosis.

At present, the diagnosis of lower respiratory tract infections (LRTIs) is difficult, and there is an urgent need for better diagnostic methods. This study enrolled 136 patients from 2020 to 2021 and collected bronchoalveolar lavage fluid (BALF) specimens. We used metatranscriptome to analyze the lower respiratory tract microbiome (LRTM) and host immune response.

A vascular endothelial growth factor-loaded chitosanhyaluronic acid hydrogel scaffold enhances the therapeutic effect of adipose-derived stem cells in the context of stroke.

Adipose-derived stem cell, one type of mesenchymal stem cells, is a promising approach in treating ischemia-reperfusion injury caused by occlusion of the middle cerebral artery. However, its application has been limited by the complexities of the ischemic microenvironment. Hydrogel scaffolds, which are composed of hyaluronic acid and chitosan, exhibit excellent biocompatibility and biodegradability, making them promising candidates as cell carriers.

Enhancing lower respiratory tract infection diagnosis: implementation and clinical assessment of multiplex PCR-based and hybrid capture-based targeted next-generation sequencing.

Background: Shotgun metagenomic next-generation sequencing (mNGS) is widely used to detect pathogens in bronchoalveolar lavage fluid (BALF). However, mNGS is complex and expensive. This study explored the feasibility of targeted next-generation sequencing (tNGS) in distinguishing lower respiratory tract infections in clinical practice.

PathoTracker: an online analytical metagenomic platform for Klebsiella pneumoniae feature identification and outbreak alerting.

Clinical metagenomics (CMg) Nanopore sequencing can facilitate infectious disease diagnosis. In China, sub-lineages ST11-KL64 and ST11-KL47 Carbapenem-resistant Klebsiella pneumoniae (CRKP) are widely prevalent. We propose PathoTracker, a specially compiled database and arranged method for strain feature identification in CMg samples and CRKP traceability.

Amine-Borane-Mediated, Nickel/Photoredox-Catalyzed Cross-Electrophile Coupling between Alkyl and Aryl Bromides.

Nickel/photoredox catalysis has emerged as a powerful platform for exploring nontraditional and challenging cross-couplings. Herein, a metallaphotoredox catalytic protocol has been developed on the basis of a tertiary amine-ligated boryl radical-induced halogen atom transfer process under blue-light irradiation. A wide variety of aryl and heteroaryl bromides featuring different functional groups and pharmaceutical moieties were facilely coupled to rapidly install C(sp)-enriched aromatic scaffolds.

The plasma viral communities associate with clinical profiles in a large-scale haematological patients cohort.

Background: Haematological patients exhibit immune system abnormalities that make them susceptible to viral infections. Understanding the relationship between the virome in the blood plasma of haematological patients and their clinical characteristic is crucial for disease management. We aimed to explore the presence of viral pathogens and identify close associations between viral infections and various clinical features.

A case report of the metagenomic next-generation sequencing for timely diagnosis of a traveler with nonspecific febrile Q fever.

Q fever is a worldwide distribution disease caused by （）, an obligate intracellular, Gram-negative acidophilic bacterium belonging to γ-proteobacterium. Most patients present with acute Q-fever accompanied by atypical flu-like symptoms, with only 1%-5% of cases may develop into persistent and focally infected foci, mainly manifest as endocarditis, osteomyelitis and prosthetic arthritis. In this case, the patient experienced an unexplained and uninterrupted fever up to 39.

Clinical Impact of Plasma Metagenomic Next-Generation Sequencing on Infection Diagnosis and Antimicrobial Therapy in Immunocompromised Patients.

Background: Clinical impact of plasma metagenomic next-generation sequencing (mNGS) on infection diagnosis and antimicrobial therapy in immunocompromised patients with suspected infection remains unclear.

Methods: Between March and December 2022, 424 cases with fever, infection history, mechanical ventilation, or imaging abnormalities underwent plasma mNGS testing at a single center. Eleven patients have received solid organ transplantation, and the remaining patients were categorised into febrile neutropenia (FN), non-neutropenia (NN), and non-haematologic disease (NTHD) groups based on immunosuppression severity.