Epitope vaccine design for Toxoplasma gondii based on a genome-wide database of membrane proteins.

Background: There is presently no effective and safe vaccine for Toxoplasma gondii for humans. The study described here was designed to search for a novel group of optimal B cell and T cell epitopes from Toxoplasma membrane proteins using genome-wide comprehensive screening.

Methods: The amino acid sequences of membrane proteins of T.

Bioinformatics analysis of epitope-based vaccine design against the novel SARS-CoV-2.

Background: An outbreak of infection caused by SARS-CoV-2 recently has brought a great challenge to public health. Rapid identification of immune epitopes would be an efficient way to screen the candidates for vaccine development at the time of pandemic. This study aimed to predict the protective epitopes with bioinformatics methods and resources for vaccine development.

Yanghe Huayan decoction inhibits the capability of trans-endothelium and angiogenesis of HER2+ breast cancer via pAkt signaling.

: Yanghe Huayan Decoction (YHD), a traditional Chinese medicine, is one of the most common complementary medicine currently used in the treatment of breast cancer (BC). It has been recently linked to suppress precancerous lesion and tumor development. The current study sought to explore the role of YHD on trans-endothelium and angiogenesis of BC.

STUDY ON THE DIFFERENCES OF MAJOR PHARMACEUTICAL INGREDIENTS IN DIFFERENT PARTS AND PROCESSED MEDICINAL MATERIAL OF EPIMEDIUM BREVICORNU MAXIM IN TAIHANG MOUNTAIN.

The aim of this study is to evaluate the medicinal values of different parts of Epimedium brevicornu Maxim. and the effect of processing on major pharmaceutical ingredients in it. The contents of icariin and epimedin C in different parts and processed medicinal material of E.

[Effect of yanghe huayan decoction on precancerosis of breast cancer, protein and mRNA expression of ki67: an experimental research].

Objective: To explore the effect of Yanghe Huayan Decoction (YHD, a representative recipe for warming yang mass dissipating) in inhibiting precancerosis of breast cancer (PBC) and on the protein and mRNA expression of ki67.

Methods: The PBC rat model was established by dimethylbenzanthracene (DMBA), and 9 weeks later rats were randomly divided into the blank control group, the model group, the YHD group, the Sanjie Huatan Decoction group (SHD), the Pingxiao Tablet group (PT), and the tamoxifen group. Rats in the model group were administered with water by gastrogavage.

[Effects of fertilization level on diurnal variation of gas exchange of young Eucalyptus grandis leaf].

Different levels (0, 90, 180, and 270 g per tree) of compound fertilizer containing 15% N, 15% P2O5, and 15% K2O were applied to young Eucalyptus grandis to study the diurnal variations of its leaf stomatal conductance (Gs), intercellular CO2 concentration (Ci), net photosynthesis rate (Pn), transpiration rate (Tr), water use efficiency (WUE), and vapor pressure deficit on leaf surface (Vpdl) as well as the variation of leaf chlorophyll content, aimed to approach the relationships of E. grandis photosynthesis with fertilization and environmental factors. In all treatments, the diurnal variation of Pn presented a single-peak curve, with the peak at 14:00 and not showing midday depression.