Publications by authors named "Chen Hailin"

Microbes have a profound impact on human health. Identifying disease-associated microbes would provide helpful guidance for drug development and disease treatment. Through an enormous experimental effort, limited disease-associated microbes have been determined.

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The connection between Primary sclerosing cholangitis (PSC) and lymphoma remains uncertain. To address this, Mendelian randomization (MR) was utilized to investigate the potential causal links between PSC and lymphoma. A 2-sample MR analysis was conducted utilizing summary-level data obtained from genome-wide association study datasets.

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Malignant ovarian sex cord-stromal tumors belong to a specific type of ovarian epithelial carcinoma, and their prognosis is related to the kind of pathology. Unlike epithelial ovarian cancer, most malignant ovarian sex cord-stromal tumors are low-grade malignant and have a good prognosis. Still, they have a tendency to recur in the long term, and the mortality rate of patients after recurrence is high.

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Article Synopsis
  • The study investigates the connection between various autoimmune diseases and myelodysplastic syndrome (MDS) using Mendelian randomization (MR) techniques.
  • Researchers identified specific genetic markers (SNPs) related to ten autoimmune diseases by analyzing data from European genome-wide association studies (GWAS).
  • The analysis revealed a genetically predicted increased risk of MDS linked to four autoimmune diseases: rheumatoid arthritis, multiple sclerosis, myasthenia gravis, and Hashimoto thyroiditis, while no significant link was found for the other seven diseases.
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Increasing studies have revealed the critical roles of human microbiome in a wide variety of disorders. Identification of disease-associated microbes might improve our knowledge and understanding of disease pathogenesis and treatment. Computational prediction of microbe-disease associations would provide helpful guidance for further biomedical screening, which has received lots of research interest in bioinformatics.

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Inflammatory bowel disease (IBD) represents a group of recurrent chronic inflammatory disorders associated with autoimmune dysregulation, typically characterized by neutrophil infiltration and mucosal inflammatory lesions. Neutrophils, as the earliest immune cells to arrive at inflamed tissues, play a dual role in the onset and progression of mucosal inflammation in IBD. Most of these cells specifically express CD177, a molecule increasingly recognized for its critical role in the pathogenesis of IBD.

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Spinal cord injury (SCI) is a severe traumatic condition in spinal surgery characterized by nerve damage in and below the injured area. Despite advancements in understanding the pathophysiology of SCI, effective clinical treatments remain elusive. Selenium compounds have become a research hotspot due to their diverse medicinal activities.

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Deep learning methodologies employed for biomass prediction often neglect the intricate relationships between labels and samples, resulting in suboptimal predictive performance. This paper introduces an advanced supervised contrastive learning technique, termed Improved Supervised Contrastive Deep Regression (SCDR), which is adept at effectively capturing the nuanced relationships between samples and labels in the feature space, thereby mitigating this limitation. Simultaneously, we propose the U-like Hierarchical Residual Fusion Network (BioUMixer), a bespoke biomass prediction network tailored for image data.

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Photocatalytic selective oxidation plays an important role in developing green chemistry. However, it is challenging to design an efficient photocatalyst for controlling the selectivity of photocatalytic oxidation reaction and exploring its detailed mechanism. Here, we synthesized three conjugated microporous polymers (CMPs) with D-A structures, named M-SATE-CMPs (MZn, Cu and Co), with different d-band centers based on different metal centers, resulting in the discrepancy in adsorption and activation capacities for the reactants, which produces the selectivity of β-keto esters being catalyzed into α-hydroperoxide β-keto esters (ROOH) or to α-hydroxyl β-keto esters (ROH).

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Wideband microwave absorbers, especially those with high optical transparency, are significantly used in civil and military fields. This paper proposes an ultra-wideband optically transparent metamaterial absorber (MMA) with causal optimal thickness and high angular stability. Based on the equivalent circuits model of the MMA, a genetic algorithm is adopted to identify the best circuit parameters that can realize broadband microwave absorption.

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This study was to investigate the effect of DUSP1 on cervical cancer (CC) cells by targeting the miR-21 regulatory JAK2/STAT3 signaling pathway. For this purpose, fifteen CC patients treated at our hospital from January 2021 to February 2023 were selected. CC tissues and para-cancerous (PC) tissues were collected from the patients, and DUSP1 protein and mRNA expression levels were detected by Western blot and qPCR.

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Hemopressin and related peptides have shown to function as the endogenous ligands or the regulator of cannabinoid receptors. The previous studies demonstrated that the endocannabinoid system played important roles in modulating several physiological functions such as sleep, olfaction, emotion, learning and memory, and reward behaviors. Mouse VD-hemopressin (α) [(m)VD-HPα], an 11-residue peptide derived from the α1 chain of hemoglobin, was recently presumed as a selective agonist of the CB receptor.

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This work aimed to explore the effect of nerve magnetic stimulation based on superparamagnetic Fe3O4 nanoparticle (NP) on bone metabolism during the perimenopausal period. First, the multifunctional water-soluble polymer PTMP-PMAA was utilized as the ligand. PTMP-MAA@ Fe3O4 NP with high magnetization was prepared by the co-precipitation method, and NPX diffraction pattern analysis and in vitro stability analysis were implemented.

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Objective: This study aimed to investigate the molecular mechanism of miR-150-5p regulating the malignant biological behavior of Human Epidermoid cancer cell (HEp-2) by targeting peptidyl-prolyl cis/trans isomerase NIMA-Interacting-1 (PIN1).

Methods: Firstly, qRT-PCR and Western blot were adopted to detect the expression levels of miR-150-5p and PIN1 in cancer tissue and paracancerous tissues of patients with LSCC, and those in human bronchial epithelial cells (16 HBE) and HEp-2. Next, the targeted relationship between miR-150-5p and PIN1 was assessed by bioinformatics website and dual-luciferase reporter assay, followed by their correlation analysis.

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Environmental pollution is an important factor that harms public health, and environmental regulation is the policy instrument to govern pollution, so what impact does environmental regulation have on the public health? What are the mechanisms? To answer these questions, this paper constructs ologit model and uses China General Social Survey data for empirical analysis. The study found first that environmental regulation has a significant effect on improving the health level of residents, and this effect has been increasing with the passage of time. Second, the impact of environmental regulation on residents' health is different among residents with different characteristics.

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This paper took the policy of China' Air Pollution Prevention and Control Action Plan as an exogenous shock to reflect the change in environmental regulation intensity. By matching environmental policies with micro data of listed companies in China, this paper explored the effect and mechanisms of environmental regulation on enterprise green innovation. Through constructing difference-in-difference (DID) and difference-in-difference-in-difference (DDD) models, we found the following to be the case: (1) Environmental regulation had a significant positive effect with the green innovation level of Chinese listed companies.

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The long non-coding RNA LINC02489 has been shown to be significantly downregulated in advanced ovarian cancer (OC). However, the function of LINC02489 remains unknown. This study aims to explain the role and mechanism of LINC02489 in OC.

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In this paper, an enhanced Vernier effect temperature sensor based on two parallel Fabry-Perot interferometers (FPIs) is proposed and demonstrated experimentally. Among them, is composed of a single-mode fiber (SMF), a quartz capillary, and AB glue filled in the capillary. is formed by filling a capillary with polyimide (PI) solution and inserting two-segment SMF from both sides of the capillary.

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Recent studies have shown that the expression of circRNAs would affect drug sensitivity of cells and thus significantly influence the efficacy of drugs. Traditional biomedical experiments to validate such relationships are time-consuming and costly. Therefore, developing effective computational methods to predict potential associations between circRNAs and drug sensitivity is an important and urgent task.

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Increasing studies have proved that microRNAs (miRNAs) are critical biomarkers in the development of human complex diseases. Identifying disease-related miRNAs is beneficial to disease prevention, diagnosis and remedy. Based on the assumption that similar miRNAs tend to associate with similar diseases, various computational methods have been developed to predict novel miRNA-disease associations (MDAs).

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The ontogenetic sleep hypothesis suggested that rapid eye movement (REM) sleep is ontogenetically primitive. Namely, REM sleep plays an imperative role in the maturation of the central nervous system. In coincidence with a rapidly developing brain during the early period of life, a remarkably large amount of REM sleep has been identified in numerous behavioral and polysomnographic studies across species.

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Background: Increasing biomedical studies have shown that the dysfunction of miRNAs is closely related with many human diseases. Identifying disease-associated miRNAs would contribute to the understanding of pathological mechanisms of diseases. Supervised learning-based computational methods have continuously been developed for miRNA-disease association predictions.

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A high sensitivity optical fiber gas pressure sensor based on the enhanced Vernier effect is proposed. The sensor is composed of a fiber Fabry-Perot interferometer (FPI) and Mach-Zehnder interferometer (MZI). Since the interference fringes of FPI and MZI drift in the opposite direction with the change of gas pressure, when their free spectral ranges are similar, the enhanced Vernier effect is formed after their cascading.

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In this paper, a highly sensitive optical fiber gas pressure sensor is proposed and experimentally verified. The sensor is composed of two Fabry-Pérot (F-P) cavities, and two F-P cavities are fabricated by a single-mode fiber and two quartz capillaries with different inner diameters splicing. Among them, the small inner diameter capillary is used as a gas channel connecting the large inner diameter capillary and the external environment.

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Recently, researchers have paid progressively more attention to the study of neural development in infant rats. However, due to the lack of complete intracerebral localization information, such as clear nuclear cluster boundaries, identified main brain structures, and reliable stereotaxic coordinates, it is difficult and restricted to apply technical neuroscience to infant rat's brain. The present study was undertaken to refine the atlas of infant rats.

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