Different temperatures leakage mechanisms of (AlO)(HfO) gate Dielectrics deposited by atomic layer deposition.

(AlO)(HfO) films with varying compositions were deposited on silicon substrates via plasma-enhanced atomic layer deposition (PEALD), and metal-oxide-semiconductor (MOS) capacitors were fabricated. The impact of varying induced Al content on the dielectric properties of HfO was examined through electrical measurements. The results showed that increasing Al content raised the flat-band voltage, reduced the interface state density (D), and significantly lowered the leakage current at a given voltage.

Modulation of TNFR 1-Triggered Inflammation and Apoptosis Signals by Jacaranone in Cancer Cells.

Jacaranone derived from , a traditional Chinese medicine used for centuries, has been documented to exhibit anti-inflammatory and antiproliferative properties in various tumor cell lines. However, the mechanism of action and relationship between inflammation and apoptosis induced by jacaranone remain inadequately elucidated. In this study, the targets of jacaranone and cancer were identified from various databases, while potential targets and pathways were predicted through the analysis of the protein-protein interactions (PPI) network and pathway enrichment.

Using network pharmacology and molecular docking technology, proteomics and experiments were used to verify the effect of Yigu decoction (YGD) on the expression of key genes in osteoporotic mice.

Background: Yigu decoction (YGD) is a traditional Chinese medicine prescription for the treatment of osteoporosis, although many clinical studies have confirmed its anti-OP effect, but the specific mechanism is still not completely clear.

Methods: In this study, through the methods of network pharmacology and molecular docking, the material basis and action target of YGD in preventing and treating OP were analyzed, and the potential target and mechanism of YGD in preventing and treating OP were clarified by TMT quantitative protein and experiment.

Results: Network pharmacology and molecular docking revealed that the active components of YGD were mainly stigmasterol and flavonoids.

Multiple Magnetic Phase Transitions and Giant Refrigerant Capacity in a GdDyHoErTm High-Entropy Alloy.

Magnetocaloric high-entropy alloys (HEAs) have recently garnered significant interest owing to their potential applications in magnetic refrigeration, offering a wide working temperature range and large refrigerant capacity. In this study, we thoroughly investigated the structural, magnetic, and magnetocaloric properties of equiatomic GdDyHoErTm HEAs. The as-cast alloy exhibits a single hexagonal phase, a randomly distributed grain orientation, and complex magnetism.

[Alkaloid compounds in Nelumbinis Folium and their hypolipidemic effect].

Four alkaloid compounds including one new compound and three known ones were isolated and extracted from the 70% ethanol extract of Nelumbinis Folium by silica gel column chromatography, octadecylsilyl(ODS) column chromatography and preparative high-performance liquid chromatography. Their structures were identified by nuclear magnetic resonance spectroscopy, high-resolution mass spectrometry, circular dichroism and other methods. Compound 1 was identified as a new compound and named as lotustine B(1).

Hypersine H, One Undescribed Xanthone From the Hypericum elodeoides Choisy With Anti-Neuroinflammation Activity.

One undescribed xanthone, hypersine H (1), together with three known analogs, 3,7-dihydroxy-1-methoxyxanthone (2), 1,7-dihydroxy-5,6-dimethoxyxanthone (3), and 1,5-dihydroxy-6,7-dimethoxyxanthone (4), were isolated from the whole plant of Hypericum elodeoides Choisy. Their structures, including absolute configurations, were unambiguously elucidated by HR-ESI-MS, extensive NMR spectroscopy, and quantum chemical calculation of electronic circular dichroism (ECD) method. Moreover, the anti-neuroinflammation activities of isolated compounds were evaluated.

Barriers to the Acceptance of Tuberculosis Preventive Treatment: A Multicenter Cross-sectional Study in China.

Objective: We aimed to understand the willingness and barriers to the acceptance of tuberculosis (TB) preventive treatment (TPT) among people with latent TB infection (LTBI) in China.

Methods: A multicenter cross-sectional study was conducted from May 18, 2023 to December 31, 2023 across 10 counties in China. According to a national technical guide, we included healthcare workers, students, teachers, and others occupations aged 15-65 years as our research participants.

A 3D bioprinted adhesive tissue engineering scaffold to repair ischemic heart injury.

Adhesive tissue engineering scaffold (ATES) devices can be secured on tissues by relying on their intrinsic adhesive properties, hence, avoiding the complications such as host tissue/scaffold damage that are associated with conventional scaffold fixation methods like suturing or bioglue. This study introduces a new generation of three-dimensional (3D) bioprinted ATES systems for use as cardiac patches to regenerate the adult human heart. Tyramine-modified methacrylated hyaluronic acid (HAMA-tyr), gelatin methacrylate (GelMA), and gelatin were used to create the hybrid bioink formulation with self-adhesive properties.

Integrated detrital rutile and detrital zircon ages: a new perspective on the tectonic evolution of South China.

Paleogeographic reconstructions are of key importance for understanding the history of continental breakups and amalgamations during Earth's history. A special case is the history of the Asian continent, which, compared to other continents, consists of several large cratons and numerous smaller continental blocks. The history of the assembly of South China remains controversial in terms of the timing, Late Neoproterozoic or Early Paleozoic, and the participating continental blocks, e.

Ultra-Broad Emission Copper Halide Scintillator-Based X-Ray Imager.

Lead-free metal-halide scintillators are gaining considerable attention as more eco-friendly and superior alternatives to their lead-based counterparts. However, novel broad-emission band scintillators like the state-of-the-art CsI: Tl scintillator, which can generate high signals due to its strong compatibility with the spectral responsivity of regular photodiode arrays, are still less investigated. Herein, a TPACuI (TPACI) copper halide scintillator with a unique ultra-broad emission (FWHM > 240 nm) is developed, which shows universal compatibility with the peak response range of commercial photodetector.

Yigu decoction regulates plasma miRNA in postmenopausal osteoporosis patients: a randomized controlled trial.

Background: Postmenopausal osteoporosis (PMOP) is a serious condition that affects elderly individuals. Our previous study revealed that Yigu decoction (YGD) effectively improved bone mineral density (BMD) in elderly individuals, but the mechanism underlying this effect remains unclear. In this study, we investigated the relationships among YGD, microRNAs (miRNAs), and bone metabolism by assessing the effects of YGD on the miRNA levels in patient plasma to provide a scientific basis for treating PMOP with YGD.

C-13 Norisoprenoids and Eudesmanoids from Nelumbo nucifera Gaertn. Regulate the Lipid Metabolism via the AMPK/ACC/SREBP-1c Signaling Pathway.

Lotustine A (1), an undescribed C- norisoprenoid, along with 22 known analogues and two eudesmanoids, were isolated from the aerial parts of Nelumbo nucifera Gaertn. Among them, compounds 2, 15, 17, 21, 22, 24, 25 were isolated from N. nucifera leaves for the first time.

Transcriptome analysis expands underlying mechanisms of quorum sensing mediating heterotrophic nitrification-aerobic denitrification process at low temperature.

Quorum sensing (QS) could regulate the behavior of microbial communities and help them resist adverse low-temperature environments. A newly isolated heterotrophic nitrification-aerobic denitrification (HN-AD) bacterium, strain YB1107, exhibited strong tolerance to harsh cold environments, removing 93.5 % of ammonia within 36 h and achieving a maximum specific growth rate of 0.

Drude2019IDPC polarizable force field reveals structure-function relationship of insulin.

Intrinsically disordered proteins (IDPs) lack stable tertiary structures under physiological conditions, yet play key roles in biological processes and associated with human complex diseases. Their conformational characteristics and high content of charged residues make the use of polarizable force fields an advantageous for simulating IDPs. The Drude2019IDP polarizable force field, previously introduced, has demonstrated comprehensive enhancements and improvements in dipeptides, short peptides, and IDPs, achieving a balanced sampling between IDPs and structured proteins.

"Like an umbrella, protecting me from the rain until I get to my destination": Evaluating the implementation of a tailored primary care model for urban marginalized populations.

Background: Improving health equity and access to the highest possible standard of health care is a key issue of social accountability. Centretown Community Health Centre in Ottawa, Canada has iteratively developed a program to target and serve marginalized and complex populations since 1999. The program implementation was evaluated using a validated implementation framework.

Discovery of N-Benzylpiperidinol derivatives as USP7 inhibitors against Hematology.

USP7 has been recognized as a potential target for the treatment of hematologic malignancies by stabilizing multiple cancer-relevant proteins. Nevertheless, drug-like USP7 inhibitors are still lacking. Herein, compound J21 (USP7 IC: 41.

Facial Action Unit Representation Based on Self-Supervised Learning With Ensembled Priori Constraints.

Facial action units (AUs) focus on a comprehensive set of atomic facial muscle movements for human expression understanding. Based on supervised learning, discriminative AU representation can be achieved from local patches where the AUs are located. Unfortunately, accurate AU localization and characterization are challenged by the tremendous manual annotations, which limits the performance of AU recognition in realistic scenarios.