Neutrophils-mediated accelerated blood clearance phenomenon in beagles and rats based on the cross-injection of non-PEGylated and PEGylated nanoemulsions.

The initial injection of PEGylated nanoparticles can activate antibodies and the complement system, leading to the accelerated blood clearance (ABC) phenomenon, characterized by reduced circulation time and abnormal liver and spleen accumulation upon re-exposure. However, PEGylation is not essential for ABC induction, as non-PEGylated nanoparticles can also trigger the similar ABC phenomenon. In this study, we found non-PEGylated nanoemulsions (CE) could accelerate the blood clearance of subsequent injection of PEGylated nanoemulsions (PE) in beagles and rats, which was independent of antibodies and the complement system, but was associated with an increase in neutrophil numbers and phagocytic activity.

Delayed slipped capital femoral epiphysis with hypothyroidism in children: A case report.

Rationale: Slipped capital femoral epiphysis (SCFE) is a common adolescent hip disorder, but its association with hypothyroidism remains rare and poorly understood. This case highlights the importance of considering endocrine disorders, such as hypothyroidism, as potential risk factors in atypical SCFE presentations, particularly when trauma or other common etiologies are absent.

Patient Concerns: A 14-year-old boy presented with progressive, nontraumatic left hip pain that worsened over 6 weeks, eventually leading to complete immobility.

The alteration of uterine microbiota participated in the activation of the decidual inflammatory response in early spontaneous abortion.

Background: Early spontaneous abortion (ESA) is one of the most common clinically recognized pregnancy complications. While multiple factors such as embryo abnormalities and maternal conditions may contribute to ESA, early identification and screening of maternal risk factors are increasingly important to explore the potential etiologies and improve prevention and treatment strategies for ESA. This study investigates the changes in uterine microbiota and the decidual immune response in ESA patients without embryo abnormalities.

Comprehensive analysis of basement membrane-related genes showed that NELL2 is a new therapeutic target for colorectal cancer.

Background: The basement membrane (BM), an omnipresent extracellular matrix, plays a pivotal role as a physiological element in the process of tumor metastasis. However, given the heterogeneity of colorectal cancer (CRC), prognosis is challengingly predictive. Therefore, we aim to construct a prognostic model using BM-associated genes to assess patient prognosis and clinical drug treatment effects.

Study on the influence of working environment on the insulation of fuel cell.

Fuel cell engines have been widely studied as an efficient energy conversion technology because of their clean and renewable characteristics. The insulation of a fuel cell engine is one of the key factors that ensure its performance and safety. As the core assembly of a vehicle, the fuel cell engine directly affects the efficiency and stability of the vehicle power system.

Associations of MAFLD subtypes and air pollutants with multi-system morbidity and all-cause mortality: A prospective cohort study.

Background: Metabolic dysfunction-associated fatty liver disease (MAFLD) and air pollution are both significant health concerns. However, their combined effects on multi-system morbidity and all-cause mortality remain poorly understood.

Methods: We analyzed data from 434,417 UK Biobank participants, categorizing them into four groups: non-MAFLD, MAFLD-diabetes, MAFLD-lean, and MAFLD-overweight/obesity.

Recent Advances in ZIF Membrane: Fabrication, Separation Ability and Its Application.

With the growth of the population and the development of industry and agriculture, water resources are experiencing contamination by numerous pollutants, posing a threat to the aquatic environment and human health. Zeolitic imidazolate framework (ZIF) membranes, as a solution for water pollutant treatment, not only have the advantages of high efficiency adsorption, good selectivity, stability, and easy recyclability, but they also can be modified or derivatized through surface functionalization, compositing, or structural tuning, which can further endow the membranes with other functions, such as catalysis and degradation. In order to improve the performance of ZIF membranes, it is crucial to select suitable preparation methods to optimize the microstructure of the membranes and to improve the separation performance and stability of the membranes.

Advances of functional nucleic acids based on specific recognition:A review.

Nucleic acids, which are fundamental to living organisms, play a crucial role in carrying and transmitting genetic information. Advances in molecular biology have led to the exploration of functional nucleic acids (FNAs), including aptamers, DNAzymes, and G-quadruplexes, known for specific recognition or catalysis. FNAs with high specificity, sequence programmability, modification ease and biocompatibility, have extensive applications in biosensing, environmental monitoring, drug delivery and cancer diagnosis.

Spectral radiance calibration method for spectroradiometers based on diffraction aberration factors correction.

A spectroradiometer serves as a powerful instrument for measuring the spectral radiance of a target. The spectral radiance calibration function determines the measurement accuracy of the spectroradiometer. However, the general full-field calibration method results in higher spectral radiance values when dealing with targets that only partially fill the field of view (FOV).

Long-term exposure to fine particulate matter constituents and the prognosis of oral cancer patients: A prospective study in Southeastern China.

Evidence on the association of long-term exposure to fine particular matter (PM) and its chemical constituents with the prognosis of oral cancer patients is limited. We identified 1673 oral cancer patients from 2011 to 2021 in Fujian, China. We evaluated annual average concentrations of PM and constituents, including nitrate, sulfate, ammonium, black carbon (BC), and organic matter (OM), using bilinear interpolation based on the patients' residential address.

Identification of a cryptic unbalanced translocation Der(22)t(12;22)(q24.33;q13.33) in a large Chinese family with Phelan-McDermid syndrome by nanopore sequencing.

To explore the genetic cause of a four-generation severe intellectual disability in a Chinese family using nanopore sequencing and to provide genetic counseling and reproductive guidance for family members. Multiple genetic analyses of the proband and family members were performed, including chromosome karyotype analysis, whole exome sequencing, nanopore sequencing, PCR amplification, and Sanger sequencing. The results of G-binding karyotyping, CGG repeats for FMR1, GGC repeats for NOTCH2NCL, and trio-whole-exome sequencing were negative for the proband and his parents.

Unconventional Ferroelectric-Ferroelastic Switching Mediated by Non-Polar Phase in Fluorite Oxides.

HfO/ZrO-based ferroelectrics present tremendous potential for next-generation non-volatile memory due to their high scalability and compatibility with silicon technology. Unlike the continuous polar layers in perovskite ferroelectrics, HfO/ZrO-based ferroelectrics are composed of alternating polar layers with oxygen shifts and non-polar spacers, which leads to a distinct ferroelectric switching mechanism. However, directly observing the switching process has been a big challenge due to the polymorph feature of nanoscale fluorites and the difficulty in in situ imaging on light elements.

Topographic Anatomy and Step-Wised Harvest of Intermuscular Occipital Artery in Far Lateral Approach.

Background: The occipital artery (OA) is an important donor artery for intracranial and extracranial bypass surgery, but its path is tortuous, making it difficult to harvest. Part of the traditional intermuscular OA is not covered by muscle and is easily damaged during surgery. Currently, there are few reports on how to protect this segment of the OA.

Facile synthesis of flower-cluster ZIF nanocarriers: Performance in controlled release of thiamethoxam and insecticidal activity.

At present, it is highly important to develop nanopesticide, which can improve the effect of pesticides and reduce the risks of environmental. Zeolitic imidazolate framework (ZIF) is usually used as a nanocarrier of nanopesticide, which has a porous structure and stimuli-responsive properties. However, the drug loading performance and stability of ZIF are poor.

Interface-engineered non-volatile visible-blind photodetector for in-sensor computing.

Ultraviolet (UV) detection is extensively used in a variety of applications. However, the storage and processing of information after detection require multiple components, resulting in increased energy consumption and data transmission latency. In this paper, a reconfigurable UV photodetector based on CeO/SrTiO heterostructures is demonstrated with in-sensor computing capabilities achieved through interface engineering.

Deciphering ferroptosis in critical care: mechanisms, consequences, and therapeutic opportunities.

Ischemia-reperfusion injuries (IRI) across various organs and tissues, along with sepsis, significantly contribute to the progression of critical illnesses. These conditions disrupt the balance of inflammatory mediators and signaling pathways, resulting in impaired physiological functions in human tissues and organs. Ferroptosis, a distinct form of programmed cell death, plays a pivotal role in regulating tissue damage and modulating inflammatory responses, thereby influencing the onset and progression of severe illnesses.

Automated White Matter Fiber Tract Segmentation for the Brainstem.

This study aimed to develop an automatic segmentation method for brainstem fiber bundles. We utilized the brainstem as a seed region for probabilistic tractography based on multishell, multitissue constrained spherical deconvolution in 40 subjects from the Human Connectome Project (HCP). All tractography data were registered into a common space to construct a brainstem fiber cluster atlas.

Comparative efficacy and safety of metformin, anti-obesity agents, and myoinositol in improving IVF/ICSI outcomes and reducing ovarian hyperstimulation syndrome in women with polycystic ovary syndrome: a systematic review and network meta-analysis.

Purpose: To compare the efficacy and safety of metformin, anti-obesity agents, and inositol with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI).

Methods: A comprehensive search was conducted in PubMed, Web of Science, Embase, Cochrane Library, and ClinicalTrials.gov for studies published in English up to October 26, 2024.

Performance of urinary C-C motif chemokine ligand 14 and the renal resistive index in predicting persistent AKI.

Objectives: The purpose of this study was to evaluate the performance of urinary C-C motif chemokine ligand 14 (CCL14) and the renal resistive index (RI) in predicting persistent AKI in unselected critically ill patients.

Methods: This prospective observational study was conducted in a tertiary hospital's general intensive care unit (ICU). Consecutive adults who were admitted to the ICU were enrolled, with a primary endpoint of AKI lasting 48 h or longer.

Comprehensive assessment of straw returning with organic fertilizer on paddy ecosystems: A study based on greenhouse gas emissions, C/N sequestration, and risk health.

High greenhouse gas emissions and soil deterioration are caused by the overuse of chemical fertilizers. To improve soil quality and crop productivity, it is necessary to utilize fewer chemical fertilizers to achieve sustainable agriculture. Organic substitution is a scientific fertilization strategy that will benefit future agricultural productivity development, little is known about how it affects the heavy metal content and trace gas emissions in rice grains.

A systematic review and meta-analysis comparing robotic-assisted percutaneous screw fixation and conventional surgical techniques for acetabular fractures.

The objective of this comprehensive review and meta-analysis was to evaluate the effectiveness of robot-aided percutaneous screw fixation versus traditional surgical techniques in managing acetabular fractures. We plan to carry out an exhaustive exploration of certain databases (PubMed, CNKI, Embase, and Cochrane Library) to find studies that have been published since the beginning of these databases until August 2024, focusing on patients with acetabular fractures. These studies will compare the efficacy of robot-assisted percutaneous screw fixation with conventional surgical methods.

Confined Magnetization at the Sublattice-Matched Ruthenium Oxide Heterointerface.

Creating a heterostructure by combining two magnetically and structurally distinct ruthenium oxides is a crucial approach for investigating their emergent magnetic states and interactions. Previously, research has predominantly concentrated on the intrinsic properties of the ferromagnet SrRuO and recently discovered altermagnet RuO solely. Here, the study engineers an ultrasharp sublattice-matched heterointerface using pseudo-cubic SrRuO and rutile RuO, conducting an in-depth analysis of their spin interactions.

Spatial and Single-Cell Transcriptomics Unraveled Spatial Evolution of Papillary Thyroid Cancer.

Recurrence and metastasis are the major issues for papillary thyroid cancer (PTC). Current morphological and molecular classification systems are not satisfied for PTC diagnosis due to lacking variant-specific morphological criteria and high signal-to-noise in mutation-based diagnosis, respectively. Importantly, intratumor heterogeneity is largely lost in current molecular classification system, which can be resolved by single cell RNA sequencing (scRNA-seq).

An algorithm for multi-damage size estimation of composite laminates.

Localization and size estimation of composite damage are challenging but essential for composite performance evaluation. This paper proposes a new methodology for the size estimation of multi-damage in composite laminates using Lamb wave technology. The pure A modal of Lamb wave is excited to avoid dispersion and multi-modal effects of Lamb wave.