Publications by authors named "Chen Ende"
: The role of glutathione s-transferase genes (, and ) variants and the GSTP1 expression level on chemotherapy efficacy of gastrointestinal cancer (GIC) patients were inconsistent. : A meta-analysis about , and variants and the GSTP1 expression level on chemotherapy efficacy of GIC patients was performed using data from PubMed, PMC, EMBASE, Web of Science, and Wanfang database. : Our meta-analysis enrolled 50 publications including 6518 patients.
View Article and Find Full Text PDFBackground: Chemoresistance has long been recognized as a major obstacle in cancer therapy. Clarifying the underlying mechanism of chemoresistance would result in novel strategies to improve patient's response to chemotherapeutics.
Methods: lncRNA expression levels in gastric cancer (GC) cells was detected by quantitative real-time PCR (qPCR).
Article Synopsis
- Gastric cancer (GC) has a high incidence and mortality rate globally, and lncRNAs, particularly linc00261, are becoming significant in cancer regulation, although its exact role in GC was previously unclear.
- Research shows that linc00261 is significantly down-regulated in GC tissues, correlating with advanced tumor stages and poor prognoses, while its restoration can inhibit cell invasion and the epithelial-mesenchymal transition (EMT).
- The study identifies Slug as a protein that linc00261 binds to, which leads to instability of Slug proteins, suggesting linc00261 serves as a tumor suppressor in GC by promoting Slug degradation and inhibiting EMT, opening avenues for new therapeutic strategies.
Thyroid cancer is one of the most common carcinomas of the endocrine system with an increasing incidence. A growing number of studies have focused on the diagnostic and prognostic values of dysregulated microRNAs (miRNAs) in thyroid carcinoma. However, differences in the measurement platforms, variations in lab protocols, and small sample sizes can make gene profiling data incomparable.
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