Publications by authors named "Chen Ding"

Background Context: Hybrid surgery (HS), which involves both anterior cervical discectomy and fusion (ACDF) and cervical disc replacement (ACDR), is increasingly used to treat multilevel cervical disc degenerative disease, yielding satisfactory clinical outcomes. Early fusion is critical after anterior cervical fusion surgeries, but there are no studies comparing the rate of early fusion of HS with that of ACDF.

Purpose: The purpose of this study was to compare the rate of early fusion (3-6 months postoperatively) of two-level HS with that of two-level ACDF surgery.

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Quaternary ammonium compounds (QACs) served as broad spectrum antimicrobial agents are widely applied for surface disinfection, skin and mucous disinfection, and mouthwash. The daily applications of QACs have significantly increased, especially during the COVID-19 pandemic. However, the environmental residues of QACs have demonstrated harmful impacts on the environment, leading to an increase in environmental contamination, resistant microbes and disruption of microecology.

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Introduction: The increasing prevalence of systemic fungal infections, especially among immunocompromised individuals, highlights the need for advancements in targeted and effective antifungal treatments. This study presents a novel nanomaterial, CFW-phosphatidylethanolamine conjugate (CFW-PEc), designed to enhance the delivery and efficacy of antifungal agents by targeting fungal cell walls through specific chitin binding. Ethosomes, lipid-based nanocarriers known for their ability to improve drug delivery across skin and cell membranes, were utilized in this study.

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We implement an experiment on a photonic quantum processor establishing efficacy of the elementary quantum system in classical information storage. The advantage is established by considering a class of simple bipartite games played with the communication resource qubit and classical bit (c bit), respectively. Conventional wisdom, supported by the no-go theorems of Holevo and Frenkel-Weiner, suggests that such a quantum advantage is unattainable when the sender and receiver share randomness or classical correlations.

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Rechargeable aqueous zinc-ion batteries (AZIBs) are an attractive alternative to lithium-ion batteries (LIBs) for large-scale energy storage, which offer high ionic conductivity and environmental advantages. However, challenges such as dendrite growth and limited coulombic efficiency (CE) limit electrochemical performance of AZIBs thus hindering their practical application. This study designs a polypyrrole (PPy)-coated copper selenide composite (CuSe@PPy) that works via Zn insertion/extraction mechanism.

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Benzylisoquinoline alkaloids (BIAs) are a class of natural compounds found in plants of the family, known for their diverse pharmacological activities. However, the extraction yields of BIAs from plants are limited, and the cost of chemical synthesis is prohibitively high. Recent advancements in systems metabolic engineering and genomics have made it feasible to use microbes as bioreactors for BIAs production.

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  • Pancreatic cancer's resistance to T cell immunity limits the effectiveness of immunotherapy, but a study found that the protein MCRS1 can improve this sensitivity in mouse models.
  • MCRS1 works by interacting with the YY1 transcription factor, enhancing the expression of MHC-I genes, which are crucial for T cell recognition of cancer cells.
  • High levels of MCRS1 are linked to better patient outcomes in pancreatic cancer and indicate a positive response to α-PD-1 therapy, suggesting MCRS1 could be a target to improve treatment for solid tumors.
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Purpose: This study aimed to identify the potential influencing factors and construct a prediction model for long COVID in hemodialysis patients.

Methods: We retrospectively reviewed 115 patients undergoing hemodialysis in a tertiary hospital between December 2022 and January 2023. Both univariate and multivariate logistic regression models were applied to identify potential influencing factors, and the prediction model was constructed using an ROC curve.

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  • - Candida albicans is a common fungus that causes oral candidiasis, especially in vulnerable populations like the elderly and those with weakened immune systems, leading to challenges due to drug resistance and side effects of current treatments.
  • - Researchers found that moxidectin, an antiparasitic drug, enhances the effectiveness of existing antifungal drugs called polyenes by activating the ergosterol biosynthesis pathway in Candida albicans, which is crucial for the fungi's survival.
  • - In experiments, moxidectin combined with low doses of polyenes significantly reduced Candida albicans infection and inflammation in a mouse model, indicating its potential as a promising treatment option in clinical practice.
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Mass spectrometry (MS)-based proteomics has become instrumental in comprehensively investigating complex biological systems. Data-independent acquisition (DIA)-MS, utilizing hybrid spectral library search strategies, allows for the simultaneous quantification of thousands of proteins, showing promise in enhancing protein identification and quantification precision. However, low-quality profiles can considerably undermine quantitative precision, resulting in inaccurate protein quantification.

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The coronavirus disease 2019 (COVID-19) pandemic has reminded us of human infections with the H7N9 virus and has raised questions related to the clinical and molecular pathophysiological diversity between the two diseases. Here, we performed a proteomic approach on sera samples from patients with H7N9-virus or SARS-CoV-2-virus infection and healthy controls. Compared to SARS-CoV-2, H7N9-virus infection caused elevated neutrophil concentrations, T cell exhaustion, and increased cytokine/interleukin secretion.

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  • The study investigates how microplastics (MPs) and the pesticide imidacloprid affect nitrogen transformation and microbial communities in agricultural soils over a 28-day incubation period.
  • Findings reveal that while imidacloprid decreases soil pH and disrupts nitrification and denitrification processes, PS-MPs can mitigate some of these negative impacts.
  • The research highlights the complex interactions between these pollutants and emphasizes the need for understanding their combined ecological risks to effectively manage agricultural soil health.
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Introduction: The role of endocytosis in drug-resistance and pathogenicity remains poorly understood, despite its importance as a fundamental component of intracellular trafficking.

Objective: In order to understand the role of endocytosis in cell wall integrity, drug resistance, and virulence.

Methods: Detection of intracellular endocytosis by FM4-64 staining; Scanning electron microscopy is used to detect cell wall components; Spot assay for detecting drug sensitivity; Co-ip is used to detect protein interactions.

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The declining availability of cheap fossil-based resources has sparked growing interest in the sustainable biosynthesis of organic acids. l-Malic acid, a crucial four-carbon dicarboxylic acid, finds extensive applications in the food, chemical, and pharmaceutical industries. Synthetic biology and metabolic engineering have enabled the efficient microbial production of l-malic acid, albeit not in , an important industrial microorganism.

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  • - The study addresses challenges faced by aqueous zinc ion batteries (AZIBs), such as low energy density and slow diffusion, which hinder their widespread use in energy storage systems due to complex cathode material preparation.
  • - A new method using microwave-assisted ball milling is introduced to quickly create vanadium-based nanomaterials, specifically NaVO (NVO) nanorods, in just 40 minutes under aqueous conditions, improving efficiency and reducing high-temperature reactions in anode material preparation.
  • - The synthesized NVO nanorods demonstrate impressive electrochemical performance, with a high specific capacity of 564 mA h g and excellent cycle stability, making them a promising option for enhancing the performance of ZIBs.
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  • Multi-omics studies have enhanced our understanding of breast ductal carcinoma (BRDC) biology and helped develop targeted therapies, but the sequence of key biological events during disease progression remains unclear.
  • A comprehensive analysis of 224 samples from 168 patients revealed that mutations in tumor protein P53 and overexpression of estrogen receptor 1 are critical for transitioning from ductal hyperplasia to ductal carcinoma in situ.
  • The study identifies specific molecular factors and pathways, including AKR1C1 as a potential therapeutic target, and highlights the effectiveness of aspirin and dydrogesterone against tumor cells, paving the way for treatment options throughout different stages of BRDC.
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Due to its exceptionally high theoretical energy density, fluorinated carbon has been recognized as a strong contender for the cathode material in lithium primary batteries particularly valued in aerospace and related industries. However, CF cathode with high F/C ratio, which enables higher energy density, often suffer from inadequate rate capability and are unable to satisfy escalating demand. Furthermore, their intrinsic low discharge voltage imposes constraints on their applicability.

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Aberrant repair underlies the pathogenesis of pulmonary fibrosis while effective strategies to convert fibrosis to normal regeneration are scarce. Here, we found that thyroid hormone is decreased in multiple models of lung injury but is essential for lung regeneration. Moreover, thyroid hormone receptor α (TRα) promotes cell proliferation, while TRβ fuels cell maturation in lung regeneration.

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  • A study was conducted to explore the relationship between Systemic Immune-Infiltration (SII) levels and cataracts in US adults, highlighting a gap in existing research.
  • Using data from the NHANES 1999-2008 cycles, the study analyzed 11,205 adults and found that 15.2% had cataracts, with increased SII levels (over 500 × 10/L) linked to higher cataract risk in women specifically.
  • The findings suggest that managing inflammation could help slow cataract development, emphasizing the need for more research on the impact of SII on eye health, particularly in female patients.
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  • Skull-base chordoma is a rare and aggressive bone cancer known for its high recurrence, and the study aims to understand its molecular characteristics and potential treatments through comprehensive analysis of 187 tumors.
  • The research identifies chromosome instability as a significant predictor of prognosis and a possible target for therapy, particularly highlighting RPRD1B in cases resistant to radiotherapy.
  • The study also characterizes tumor subtypes, revealing an immune cold subtype linked to poorer clinical outcomes, while showing that specific chromosomal gains and mitochondrial functions correlate with increased invasiveness in certain tumors.
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Topological defects are inevitable existence in carbon-based frameworks, but their intrinsic electrocatalytic activity and mechanism remain under-explored. Herein, the hydrogen evolution reaction (HER) of pentagonal carbon-rings is probed by constructing pentagonal ring-rich carbon (PRC), with optimized electronic structures and higher HER activity relative to common hexagonal carbon (HC). Furthermore, to improve the reactivity, we couple Ru clusters with PRC (Ru@PRC) through p-d orbital hybridization between C and Ru atoms, which drives a shortcut transfer of electrons from Ru clusters to pentagonal rings.

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Lung squamous cell carcinoma (LUSC), a subset of non-small cell lung cancer (NSCLC), accounts for about 30% of all lung cancers (LC) and exhibits a dismal response to current therapeutic protocols. Existed studies have indicated that aberrations in fibroblast growth factor receptors (FGFRs) play a pivotal role in the progression of LUSC, rendering them as attractive targets for therapeutic intervention in this cancer type. This study found that Erdafitinib (Erda), a novel pan-FGF receptor tyrosine kinase inhibitor (TKI), exerted a cytotoxic effect on LUSC cells.

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A breakthrough in manufacturing procedures often enables people to obtain the desired functional materials. For the field of energy conversion, designing and constructing catalysts with high cost-effectiveness is urgently needed for commercial requirements. Herein, the molten salt-assisted synthesis (MSAS) strategy is emphasized, which combines the advantages of traditional solid and liquid phase synthesis of catalysts.

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Rational designs of polysaccharide-based hydrogels with organ-like three-dimensional architecture provide a great possibility for addressing the shortages of allograft tissues and organs. However, spatial-temporal control over structure in bulk hydrogel and acquire satisfied mechanical properties remain an intrinsic challenge to achieve. Here, we show how electric-field assisted molecular self-assembly can be coupled to a directional reaction-diffusion (RD) process to produce macroscopic hydrogel in a controllable manner.

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  • Lactic acid (LA) plays a significant role in tumor progression by interacting with the tumor microenvironment (TME), yet the function of long non-coding RNAs (lncRNAs) related to LA metabolism in Wilms tumor (WT) is not well understood.
  • Researchers collected gene and clinical data from WT patients to identify lncRNAs linked to tumor immunity and LA metabolism, leading to a prognostic model called TME-LA-LM that includes six lncRNAs.
  • The study found that specific lncRNAs, particularly UNC5B-AS1, are associated with tumor cell growth and movement, providing important insights into potential immunotherapy and personalized treatment approaches for WT.
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