is positively correlated with in infection and a biomarker for mucosal injury.

Our study previously showed the involvement of Notch1 in Th1 differentiation in -infected patients. However, the role of Notch1 in Th17 or Treg differentiation during infection and the potential diagnostic value of its associated genes remain unclear. Here, we found that was positively correlated with Th17-related genes ( = 0.

Notch Signaling Regulates the Function and Phenotype of Dendritic Cells in Infection.

Notch signaling manipulates the function and phenotype of dendritic cells (DCs), as well as the interaction between DCs and CD4 T cells. However, the role of Notch signaling in () infection remains elusive. Murine bone marrow-derived dendritic cells (BMDCs) were pretreated in the absence or presence of Notch signaling inhibitor DAPT prior to stimulation and the levels of Notch components, cytokines and surface markers as well as the differentiation of CD4 T cells in co-culture were measured using quantitative real-time PCR (qRT-PCR), Western blot, enzyme-linked immunosorbent assay (ELISA) and flow cytometry.

[Notch signaling regulates macrophages during inflammation and infection: An update].

Macrophage as a crucial component of innate immunity, plays an important role in inflammation and infection immunity. Notch signal pathway is a highly conserved pathway, which regulates cellular fate and participates in numerous pathological processes. At present, a lot of literature has confirmed the role of Notch signaling in regulating the differentiation, activation and metabolism of macrophage during inflammation and infection.

Notch Signaling Ligand Jagged1 Enhances Macrophage-Mediated Response to .

() is one of the gram-negative bacteria that mainly colonize the stomach mucosa and cause many gastrointestinal diseases, such as gastritis, peptic ulcer, and gastric cancer. Macrophages play a key role in eradicating . Recent data have shown that Notch signaling could modulate the activation and bactericidal activities of macrophages.

Notch 1 Is Involved in CD4 T Cell Differentiation Into Th1 Subtype During Infection.

infection induces CD4 T differentiation cells into IFN-γ-producing Th1 cells. However, the details of mechanism underlying this process remain unclear. Notch signal pathway has been reported to regulate the differentiation of CD4 T cells into Th1 subtype in many Th1-mediated inflammatory disorders but not yet in infection.