Immunoprognostic analysis of indoleamine 2,3-dioxygenase 1 in patients with cervical cancer.

The incidence of cervical cancer is increasing. Immunotherapies show better patient outcomes than monotherapies; however, the mainstay treatment for cervical cancer remains surgery and chemotherapy. Indoleamine 2,3-dioxygenase 1 (IDO1) acts on multiple tryptophan substrates, exhibiting antitumor, immunomodulatory, and antioxidant activities.

Photo-induced protonation assisted nano primary battery for highly efficient immobilization of diverse heavy metal ions.

Highly-stable heavy metal ions (HMIs) appear long-term damage, while the existing remediation strategies struggle to effectively remove a variety of oppositely charged HMIs without releasing toxic substances. Here we construct an iron-copper primary battery-based nanocomposite, with photo-induced protonation effect, for effectively consolidating broad-spectrum HMIs. In FCPBN, Fe/Cu cell acts as the reaction impetus, and functional graphene oxide modified by carboxyl and UV-induced protonated 2-nitrobenzaldehyde serves as an auxiliary platform.

Global prevalence of anxiety and depression among medical students during the COVID-19 pandemic: a systematic review and meta-analysis.

Purpose: As future physicians, medical students have experienced tremendous pressure during the ongoing COVID-19 pandemic, which is associated with a high risk of depression and anxiety. We aimed to investigate an overview of the prevalence of anxiety and depression among medical students in various countries during the global COVID-19 pandemic, and discuss associated stressors.

Methods: We systematically searched CINAHL, EMBASE, MEDLINE, PubMed, and Web of Science for relevant articles from December 1, 2019 to March 15, 2023.

Spherical Assembly of Halloysite Clay Nanotubes as a General Reservoir of Hydrophobic Pesticides for pH-Responsive Management of Pests and Weeds.

The development of smart systems for pesticidal delivery presents a significant advancement in enhancing the utilization efficiency of pesticides and mitigating environmental risks. Here an acid-responsive pesticidal delivery system using microspheres formed by the self-assembly of halloysite clay nanotubes (HNTs) is proposed. Insecticide avermectin (AVM) and herbicide prometryn (PMT) are used as two models of hydrophobic pesticide and encapsulated within the porous microspheres, followed by a coating of tannic acid/iron (TA/Fe) complex films to generate two controlled-release pesticides, named as HCEAT and HCEPT, resulting in the loading capacity of AVM and PMT being 113.

MSLN induced EMT, cancer stem cell traits and chemotherapy resistance of pancreatic cancer cells.

Chemoresistance is one of the main reasons for poor prognosis of pancreatic cancer. The effects of mesothelin (MSLN) on chemoresistance in pancreatic cancer are still unclear. We aim to investigate potential roles of MSLN in chemoresistance and its relationship with proliferation, epithelial-mesenchymal transition (EMT) and cancer stemness of pancreatic cancer cells.

Assessment of Heart Rate Monitoring During Exercise With Smart Wristbands and a Heart Rhythm Patch: Validation and Comparison Study.

Background: The integration of wearable devices into fitness routines, particularly in military settings, necessitates a rigorous assessment of their accuracy. This study evaluates the precision of heart rate measurements by locally manufactured wristbands, increasingly used in military academies, to inform future device selection for military training activities.

Objective: This research aims to assess the reliability of heart rate monitoring in chest straps versus wearable wristbands.

Four Assessment Tools for Predicting Mortality and Adverse Events in Surgical Patients With Sepsis and Septic Shock: A Comparative Study.

Background: The mortality rate for sepsis and septic shock in surgical patients is approximately 36%, which is higher than that of other medical patients. Predisposition, infection/injury, response, and organ dysfunction (PIRO) is currently the most widely used tool for assessing patients with surgical sepsis. However, it is not a standardized assessment tool for surgical patients in general.

Ecofriendly polysaccharide-based alginate/pluronic F127 semi-IPN hydrogel with magnetic collectability for precise release of pesticides and sustained pest control.

Controlled-release systems are crucial for efficient pesticide utilization and environmental protection in agricultural production. The utilization of polysaccharide-based materials derived from biopolymers as carriers for controlling pesticide release holds significant potential. In this work, a reversible near infrared-responsive polysaccharide-based hydrogel (RNPH) was fabricated by employing a semi-interpenetrating polymer network (alginate-Fe/pluronic F127) as a carrier to encapsulate FeO@polydopamine (FP) and emamectin benzoate (EB)-loaded hollow mesoporous silica.

Transcranial stimulation of alpha oscillations modulates brain state dynamics in sustained attention.

The brain operates an advanced complex system to support mental activities. Cognition is thought to emerge from dynamic states of the complex brain system, which are organized spatially through large-scale neural networks and temporally via neural synchrony. However, specific mechanisms underlying these processes remain obscure.

A primary battery for efficient cadmium contamination remediation and electricity generation.

In this work, two kinds of primary batteries, both of which included a Zn anode, C rod cathode, copper wire and electrolyte composed of Cd-contaminated water or soil, were constructed in the first attempt to both remove Cd and generate electricity. Unlike traditional technologies such as electrokinetic remediation with high energy consumption, this technology could realize Cd migration to aggregation and solidification and generate energy at the same time through simultaneous galvanic reactions. The passive surface of Zn and C was proven via electrochemical measurements to be porous to maintain the relatively active galvanic reactions for continuous Cd precipitation.

K-Rod: An Innovative Method of Personalized Rib Splinting for Expeditious Management of Flail Chest in Acute Care Settings.

Flail chest is a severe type of multiple rib fracture that can cause ventilation problems and respiratory complications. Historically, flail chest has been mainly managed through pain control and ventilatory support as needed. Operative fixation has recently become popular for the condition, and some studies have revealed its potentially positive effects on the outcomes of patients with flail chest.

Parental Educational Intervention to Facilitate Informed Consent for Pediatric Procedural Sedation in the Emergency Department: A Parallel-Group Randomized Controlled Trial.

Obtaining valid parental informed consent for pediatric procedures in the emergency department (ED) is challenging. We compared a video-assisted informed consent intervention with conventional discussion to inform parents about pediatric procedural sedation in the ED. We conducted a prospective randomized controlled trial using a convenience sample including the parents of children in the ED in whom procedural sedation for facial laceration was recommended.

Synthesis of Iron-Based Carbon Microspheres with Tobacco Waste Liquid and Waste Iron Residue for Cd(II) Removal from Water and Soil.

Herein, a novel magnetic iron-based carbon microsphere was prepared by cohydrothermal treatment of tobacco waste liquid (TWL) and waste iron residue (WIR) to form WIR@TWL. After that, WIR@TWL was coated with sodium polyacrylate (S.P.

Picomolar thrombin detection by orchestration of triple signal amplification strategy with hierarchically porous TiCT MXene electrode material-catalytic hairpin assembly reaction-metallic nanoprobes.

Signal amplification strategies are essential to boost the sensitivity of detecting targeted ions or molecules with important biological functions, while few studies take advantage of signal amplification strategies more than two. As a "proof-of-concept" demonstration, we present the ultrasensitive electrochemical aptasensor for picomolar thrombin detection by synchronous coordination of triple signal amplification strategy. The porous MXene framework (PMXF) with secondary pores is constructed as carrier to increase electrons transfer channels, and thionine (as redox indicator) labelled Au nanorod (AuNR) and hollow Cu-Pt alloy (HCuPtA) are synthesized as the electrical signal amplifiers to enhance the response signals.

Chitosan-based organic/inorganic composite engineered for UV light-controlled smart pH-responsive pesticide through in situ photo-induced generation of acid.

Background: Confined by the volatile property, pesticides are overused and lost significantly during and after spraying, weakening the ecological microbalance among different species of lives. Acid-responsive pesticide is a type of smartly engineered pesticides that contribute to the improvement of utilization efficiency of pesticidal active ingredients in acid-controlled manner, whilst the implementation of acidic solutions may disturb the balance of microenvironment surrounding targeted plants or cause secondary pollution, underscoring the input of acid in a more precise strategy.

Results: Chitosan was chemically modified with a photoacid generator (2-nitrobenzaldehyde) serving as a light-maneuvered acid self-supplier, based on which a smart pesticide was formulated by the integration of attapulgite and organophosphate insecticide chlorpyrifos.

Chronic Venous Disease in Pregnant Women Causes an Increase in ILK in the Placental Villi Associated with a Decrease in E-Cadherin.

Chronic venous disease (CVD) is a multifactorial vascular disorder frequently manifested in lower limbs in the form of varicose veins (VVs). Women are a vulnerable population for suffering from CVD, especially during pregnancy, when a plethora of changes occur in their cardiovascular system. Previous studies have indicated a worrisome association between CVD in pregnancy with the placental structure and function.

Fabrication of magnetic-responsive controlled-release herbicide by a palygorskite-based nanocomposite.

In this work, a type of magnetic-responsive controlled-release herbicide (MCRH) was developed using a nanocomposite including palygorskite (Pal), ferroferric oxide (FeO), glyphosate (Gly), and amino silicon oil (ASO). In this system, Pal with the structure of micro/nanonetworks can bind a large quantity of Gly and FeO. The movement of FeO particles can be driven by a magnetic field to ensure the controlled release of pesticides.

Understanding Chronic Venous Disease: A Critical Overview of Its Pathophysiology and Medical Management.

Chronic venous disease (CVD) is a multifactorial condition affecting an important percentage of the global population. It ranges from mild clinical signs, such as telangiectasias or reticular veins, to severe manifestations, such as venous ulcerations. However, varicose veins (VVs) are the most common manifestation of CVD.

Association Between Lower Extremity Venous Insufficiency and Intrapartum Fetal Compromise: A Nationwide Cross-Sectional Study.

Chronic venous disorder (CVeD) has a high prevalence, being commonly diagnosed by the presence of varicose veins. In fact, the development of varicose veins in lower extremities and/or pelvic venous insufficiency (LEPVI) is frequent. However, its potential impact on fetal health has not been investigated.

Infrared-Light-Responsive Controlled-Release Pesticide Using Hollow Carbon Microspheres@Polyethylene Glycol/α-Cyclodextrin Gel.

Controlled release of pesticides by light regulation is one of the most viable strategies recently developed for the highly efficient utilization of agrochemicals. Herein, we report an infrared-light-responsive pesticide delivery system for the controlled release of imidacloprid (IMI) by preparation of functional hollow carbon microspheres (HCMs). After IMI loading and surface functionalization with polyethylene glycol (PEG) and α-cyclodextrin (α-CD), IMI was sequestered in the pesticide system (denoted as HCMs/IMI/PEG/α-CD) as a result of the formation of a PEG/α-CD gel network.

Fabrication of Fe3O4/ZIF-8 nanocomposite for simultaneous removal of copper and arsenic from water/soil/swine urine.

In this study, a magnetic nanocomposite (denoted as FZ) was fabricated using FeOand zeolitic imidazolate framework-8 (ZIF-8), based on a coprecipitation method. FZ could efficiently remove Cu(Cu(II)) and AsO (As(III)) ions simultaneously from water, soil, and swine urine samples through hydrogen bonding and electrostatic interactions. The Cu(II) and As(III) removal efficiencies of the optimal FZ sample increased gradually with time and reached 99.

A Technology Acceptance Model for Deploying Masks to Combat the COVID-19 Pandemic in Taiwan (My Health Bank): Web-Based Cross-sectional Survey Study.

Background: The successful completion of medical practices often relies on information collection and analysis. Government agencies and medical institutions have encouraged people to use medical information technology (MIT) to manage their conditions and promote personal health. In 2014, Taiwan established the first electronic personal health record (PHR) platform, My Health Bank (MHB), which allows people to access and manage their PHRs at any time.

Simultaneously removal of Cr(VI) and Cd(II) from water using a flower-like primary battery nanosystem.

In this study, a new flower-like primary battery nanosystem termed "Zn/CCP/ZIF-8" was prepared by depositing conductive carbon paint (CCP) and zeolitic imidazolate framework-8 (ZIF-8) on a zinc plate (Zn). Therein, CCP had good conductivity performance and adhesiveness, ZIF-8 and Zn/CCP/ZIF-8 possessed BET specific surface areas of 1909.5 and 1265.

Systematic Review and Meta-Analysis of Incidence and Prevalence of Endometriosis.

There is still much controversy regarding the epidemiology of endometriosis. The objective of this work is to conduct a systematic review, and if possible, proceed with a meta-analysis of studies that have analyzed the incidence and prevalence of this condition among women in the general population. The inclusion criteria were papers published after 1997 that had reported data of the incidence or prevalence of endometriosis.