Interaction between the liver transcriptome and gut microbiota in mice during Toxoplasma gondii infection as identified by integrated transcriptomic and microbiome analysis.

Background: Toxoplasma gondii is a single-cell parasite capable of infecting both humans and a variety of animal species. Although T. gondii infection is known to adversely affect the liver and gut microbiota, the precise interplay between the gut microbiome and the liver transcriptome in infected mice remains largely unknown.

Influence of processing points on the flavor of meat balls braised with brown sauce.

In this study, electronic nose, electronic tongue and solid-phase microextraction coupled with gas chromatography-olfactometry-mass spectrometry (SPME-GC-O-MS) were used to investigate the volatile flavor characteristics and the changing pattern of meat balls braised with brown sauce in prepared dishes during processing. A total of 13 volatile compounds were detected by combining the results of the OAVs and GC-O analyses using both methods. The detected volatile compounds were benzaldehyde, nonanal, (E)-2-octenal, citral, 6-methyl-5-hepten-2-one, 1-octen-3-ol, eucalyptol, linalool, ethyl acetate, eugenol, d-limonene, anethole, and estragole.

X-rays and gamma rays do not differ in their effectiveness for sterilizing pupae and adults of the mosquito Aedes aegypti (Diptera: Culicidae).

The sterile insect technique (SIT) is increasingly used as an alternative or supplemental tool in the integrated mosquito management toolbox to protect human health worldwide. SIT programs targeting mosquitoes such as Aedes aegypti (L.) have generally used high-activity isotopes of 60Cobalt or 137Caesium to sterilize males, however, these gamma irradiators pose substantial security challenges and are becoming more difficult and expensive to obtain and maintain.

Sodium Iodate-Induced Ferroptosis in Photoreceptor-Derived 661W Cells Through the Depletion of GSH.

Oxidative stress-induced photoreceptor cell death is closely associated with the etiology of age-related macular degeneration (AMD), and sodium iodate (SI) has been widely used as an oxidant stimulus in AMD models to induce retinal pigment epithelium (RPE) and photoreceptor cell death. However, the mechanism underlying SI-induced photoreceptor cell death remains controversial and unclear. In this study, we elucidate that ferroptosis is a critical form of cell death induced by SI in photoreceptor-derived 661W cells.

A dynamic transcriptional cell atlas of testes development after birth in Hu sheep.

Background: Testes development is a fundamental process in sexual development and reproduction. The testes undergo dramatic structural changes during development, including the proliferation and differentiation of somatic cells such as Sertoli cells, Leydig cells, and myoid cells, as well as the maturation of spermatogonia. However, little is known about the onset of spermatogenesis and cell proliferation and maturation in the spermatogonial niche in large animals.

Identifying Heat Adaptability QTLs and Candidate Genes for Grain Appearance Quality at the Flowering Stage in Rice.

High temperature significantly impacts grain appearance quality, yet few studies have focused on identifying new quantitative trait loci (QTLs)/genes related to these traits under heat stress during the flowering stage in rice. In this study, a natural population of 525 rice accessions was used to identify QTLs and candidate genes associated with grain appearance quality using a Genome-Wide Association Study under heat stress. We identified 25 QTLs associated with grain length (GL), grain width (GW), and grain chalkiness (GC) under heat stress across 10 chromosomes in the three rice populations (full, indica, and japonica).

A Comprehensive Review of Traditional Chinese Medicine in the Management of Ulcerative Colitis.

Ulcerative colitis (UC) is a chronic, nonspecific inflammatory disorder characterized by symptoms such as abdominal pain, diarrhea, hematochezia, and urgency during defecation. While the primary site of involvement is the colon, UC can extend to encompass the entire rectum and colon. The causes and development mechanisms of UC are still not well understood; nonetheless, it is currently held that factors including environmental influences, genetic predispositions, intestinal mucosal integrity, gut microbiota composition, and immune dysregulation contribute to its development.

Core muscle strength and stability-oriented breathing training reduces inter-recti distance in postpartum women.

Objective: The aim of this study was to examine the impact of stability-focused core muscle strength training coupled with respiratory techniques on diminishing the inter-recti distance (IRD) among postpartum women.

Methods: A total of 106 women diagnosed with diastasis recti abdominis within 42 days following delivery were 1:1 randomly allocated into a control group ( = 53) and an intervention group ( = 53). Both groups underwent standard postpartum follow-up care and independently pursued self-directed rehabilitation exercises.

Solvent-free fabrication of an NiP/UiO-66 catalyst for the hydrogenation of furfural to cyclopentanone.

Dispersing metal phosphides on supports with large surface areas is a feasible way to boost the catalytic hydrogenation performance. However, metal-organic frameworks (MOFs), which are very promising porous materials, have rarely been used to load metal phosphides owing to the harsh synthesis conditions of metal phosphides. This work demonstrated a facile and solvent-free method to construct a highly dispersed NiP/UiO-66 catalyst (the particle size of NiP was 2.

Isocyanic acid-mediated NLRP3 carbamoylation reduces NLRP3-NEK7 interaction and limits inflammasome activation.

Isocyanic acid, as a reactive metabolite synthesized by the enzyme LACC1, can carbamoylate the ε-amino group of lysine residues in proteins. However, the role of isocyanic acid in inflammatory response remains elusive. Herein, we reveal that lipopolysaccharide stimulation increases LACC1-dependent isocyanic acid production, which attenuates inflammation by limiting the NLRP3 inflammasome activation in macrophages primed with lipopolysaccharide for 8 hours.

Investigating the controversy surrounding statin therapy and Achilles tendinopathy using Mendelian randomization analysis.

Background: The relationship between statin therapy and tendon injuries, particularly Achilles tendinopathy, which is the body's largest and strongest tendon, remains controversial.

Aim: This study employed Mendelian Randomization (MR) analysis to explore the causal link between statin therapy and Achilles tendinopathy (ATP).

Method: Summary statistics were obtained from genome-wide association studies on statin medication and four specific statin drugs from public databases, as well as data related to two ATP phenotypes, namely Achilles tendinitis and Achilles tendon injury.

The miRNA-275 Targeting RpABCG23L is Involved in Pyrethroid Resistance in the Bird Cherry-Oat Aphid, a Serious Agricultural Pest.

is a global agricultural pest which had developed resistance to different insecticides. The ATP-binding cassette (ABC) transporter plays an important role in insecticide resistance. However, ABC transporters' role and regulatory mechanism in mediating 's response to pyrethroids are unclear.

Impact of POU3F4 mutation on cochlear development and auditory function.

Background: Hearing loss, a major public health issue, affects 1.33 per 1,000 live births worldwide. Genetic factors contribute to over half of congenital cases, with X-linked inheritance accounting for 1-5%.

Long term gait postural characteristics of children with general foot pain using smartphone connected wearable sensors.

Whether children's general foot pain related to specific foot posture remains unknown. The aim of the study was to determine long-term dynamic foot posture characteristics in children with general foot pain using smartphone-connected wearable sensors. Over a 30-day period, 94 children (37 girls and 57 boys, mean age 9.

Enhanced electrooxidation of 5-hydroxymethylfurfural over a ZIF-67@β-Ni(OH)/NF heterostructure catalyst: Synergistic effects and mechanistic insights.

The electrooxidation of 5-hydroxymethylfurfural (HMF) to 2,5-furandicarboxylic acid (FDCA) is a crucial step in biomass valorization. While Ni(OH) exhibits promise as an electrocatalyst due to its dynamic Ni/Ni redox transitions, its limited HMF adsorption capacity and high onset potential hinder its widespread application. Herein, we report the design and synthesis of a ZIF-67@β-Ni(OH)/NF heterostructure electrocatalyst featuring a non-homogeneous interface, resulting in an advanced onset-potential of the HMF oxidation reaction (HMFOR), a higher current density than β-Ni(OH) and significantly enhances HMF adsorption.

Construction of Hierarchically Porous Metal-Organic Frameworks via A Novel Metal Ion-Modulation Approach: A Complementary Approach to Linker-Modulation.

Hierarchically porous metal-organic frameworks (HP-MOFs) always present novel and advanced performances in many applications. Herein, we demonstrated a novel mechanochemical metal modulation strategy to construct the HP-MOFs. The metal modulator bearing different coordination ability from the parent metal was incorporated into the parent metal precursor via ball milling.

Characterizing the microbial community constructure and the metabolites among different colour Moutai .

There are three types of produced during the fermentation of Moutai , which are named as white, yellow and black . However, in-depth studies for them are lacking. Herein, the high-throughput sequencing and metabolomics techniques were used to analyze the differences in Moutai The findings indicated that the predominant microorganisms in yellow and white were and , while and emerged as the primary microorganisms in black .

Multimodal single-cell analyses reveal molecular markers of neuronal senescence in human drug-resistant epilepsy.

The histopathological neurons in the brain tissue of drug-resistant epilepsy exhibit aberrant cytoarchitecture and imbalanced synaptic circuit function. However, the gene expression changes of these neurons remain unknown, making it difficult to determine the diagnosis or to dissect the mechanism of drug-resistant epilepsy. By integrating whole-cell patch clamp recording and single-cell RNA-seq approaches, we identified a transcriptionally distinct subset of cortical pyramidal neurons.

Penta-1,4-dien-3-one and quinoxaline conjugates as potential anticancer agents via inhibiting EphB3/SRC/AKT axis.

Overexpression of EphB3 has been documented across various cancers and essential for cell proliferation, survive and metastasis, making it a valuable therapeutic target. In this study, a series of novel penta-1,4-dien-3-one and quinoxaline conjugates were designed and synthesized using pharmacophore fusion strategies to explore potential EphB3 inhibitors. CCK-8 experiments revealed significant anti-cancer activity of most newly synthesized compounds against hepatocellular carcinoma (HCC).

Thermally Triggered In Situ Template-Escape Strategy for Controlled Construction of Hollow MOFs.

Hollow spherical structures can endow metal-organic framework (MOF) materials with new capabilities. However, devising an uncomplicated synthesis method for hollow MOF spheres remains a formidable challenge. Here, the green hydrothermal method is employed to drive the polymer template, inducing a thermal transition (viscous flow state) that facilitates escape and enables the construction of a series of hollow MOF spheres.

A deep learning-based psi CT network effectively predicts early recurrence after hepatectomy in HCC patients.

Background: Hepatocellular carcinoma (HCC) exhibits a high recurrence rate, and early recurrence significantly jeopardizes patient prognosis, necessitating reliable methods for early recurrence prediction.

Methods: Utilizing multi-institutional data and integrating deep learning (DL) techniques, we established a neural network based on DenseNet capable of concurrently processing patients' triphasic enhanced CT scans. By incorporating an attention mechanism, the model automatically focuses on regions that significantly impact patient survival.

Servo Collision Detection Control System Based on Robot Dynamics.

Collision detection and inspection of industrial robots have become essential functions in modern industrial automation. Sensor-based detection methods are commonly employed in research to achieve collision detection, including high-precision force sensors, ultrasonic ranging sensors, electronic skins, and others. While collision detection using force sensors or electronic skin sensors offers very high accuracy, the inclusion of these sensors increases the overall cost.

Manipulation of Oxygen Vacancies and Charge Transfer for Enhancing Visible-Near-Infrared Photodegradation.

Photocatalytic degradation technology has drawn extensive attention due to its ability to utilize light energy for pollutant degradation. However, the generation of superoxide and hydroxyl radicals under broad-spectrum light confronts significant challenges. Herein, N-GQDs/TiO was rationally designed by adjusting oxygen vacancies (O) densities and constructing interfacial charge transfer channels.

Amyloid-Templated Ceria Nanozyme Reinforced Microneedle for Diabetic Wound Treatments.

Amyloid fibrils have emerged as excellent templates and building blocks for the development of ordered functional materials with considerable potential in biomedical applications. Here, lysozyme amyloid fibrils (Lys-AFs) are employed as templates for the in situ synthesis of ceria nanozymes (Lys-AFs-Ceria) with ultrafine dimensions, an optimized Ce/Ce ratio, and uniform distribution on the fibril surface, addressing the challenges of low catalytic efficiency and high susceptibility to aggregation typical of traditional methods. As a proof of concept, it is further applied Lys-AFs-Ceria to develop hydrogel/microneedle for treating bacteria-infected diabetic wounds via non-covalent interactions between polyphenols and amyloid fibrils incorporating glucose oxidase (GOX).

Integrated learning framework for enhanced specific surface area, pore size, and pore volume prediction of biochar.

Specific surface area, pore size, and pore volume are essential biochar properties. Optimization typically reduces yield by focusing on per gram of biochar. This work introduces new indicators and an integrated model to balance quality and quantity, emphasizing overall adsorption potential per gram of raw biomass.