A One Stone Three Birds Paradigm of Photon-Driven Pyroptosis Dye for Amplifying Tumor Immunotherapy.

Activating the pyroptosis pathway of tumor cells by photodynamic therapy (PDT) for immunogenic cell death (ICD) is considered a valid strategy in pursuit of antitumor immunotherapy, but it remains a huge challenge due to the lack of reliable design guidelines. Moreover, it is often overlooked that conventional PDT can exacerbate the development of tumor immunosuppressive microenvironment, which is apparently unfavorable to clinical immunotherapy. The endoplasmic reticulum's (ER) pivotal role in cellular homeostasis and its emerging link to pyroptosis have galvanized interest in ER-centric imaging and therapeutics.

Ionomic and metabolomic analyses reveal association between nutritional value and aleurone layer thickness in rice.

The fortification of aleurone cells represents a promising avenue for enhancing the nutritional quality of cereal. This study investigated dorsal aleurone thickness (DAT) in a rice diversity panel comprising 180 varieties, revealing that DAT of the Geng subspecies is typically greater than that of the Xian subspecies. The minerals and primary metabolites accumulated in the brown grains of ten rice varieties exhibiting distinct DAT were subjected to analysis using spectrometry-based technologies.

A Game Model and Fault Recovery Algorithm for SDN Multi-Domain.

Software-defined networking (SDN) offers an effective solution for flexible management of Wireless Sensor Networks (WSNs) by separating control logic from sensor nodes. This paper tackles the challenge of timely recovery from SDN controller failures and proposes a game theoretic model for multi-domain controllers. A game-enhanced autonomous fault recovery algorithm for SDN controllers is proposed, which boasts fast fault recovery and low migration costs.

Preparation of Novel Slow-Release Acid Materials for Oilfield Development via Encapsulation.

Acid-fracturing technology has been applied to form pathways between deep oil/gas resources and oil production pipelines. The acid fracturing fluid is required to have special slow-release performance, with no acidity at low temperatures, while steadily generating acid at high temperatures underground. At present, commercial acid systems in oilfields present problems such as the uncontrollable release effect, high costs, and significant pollution.

Evaluating the Accumulation of Grain Mercury in Engineered Rice Lines Containing and Genes Under an Organic Mercury-Enriched Condition.

Rice is a critical crop for human sustenance worldwide. Food security has increasingly attracted public concerns, particularly due to heavy metal pollution, which adversely impacts crop yield and quality, with cadmium and mercury being the primary culprits. Excessive soil mercury not only hampers rice's growth and development but also leads to a substantial accumulation in grains, posing a significant threat to human health.

Mapping the chromothripsis landscape in urothelial carcinoma unravels great intratumoral and intertumoral heterogeneity.

Chromothripsis, a hallmark of cancer, is characterized by extensive and localized DNA rearrangements involving one or a few chromosomes. However, its genome-wide frequency and characteristics in urothelial carcinoma (UC) remain largely unknown. Here, by analyzing single-regional and multi-regional whole-genome sequencing (WGS), we present the chromothripsis blueprint in 488 UC patients.

The predictive value of anti-IFI16 antibodies for the development or persistence of digital ulcers in systemic sclerosis.

To evaluate the association of anti-IFI16 antibodies with peripheral vasculopathy and the predictive value of anti-IFI16 antibodies for the development or persistence of digital ulcers (DPDU) in SSc. A total of 42 SSc patients and 42 age- and sex-matched healthy controls were enrolled. Anti-IFI16 antibodies were examined by ELISA.

Integrated healthy lifestyle even in late-life mitigates cognitive decline risk across varied genetic susceptibility.

It remains unclear whether the benefits of adhering to a healthy lifestyle outweigh the effects of high genetic risk on cognitive decline. We examined the association of combined lifestyle factors and genetic risk with changes in cognitive function and six specific dimensions of cognition among older adults from the Chinese Longitudinal Healthy Longevity Survey (1998-2018, n = 18,811, a subset of 6301 participants with genetic information). Compared to participants with an unfavorable lifestyle, those with a favorable lifestyle showed a 46.

Antimicrobial Silicon Rubber Crosslinked with Bornyl-Siloxane.

Silicone rubber (SiR) has a wide range of medical applications, but it lacks antimicrobial properties, leading to potential infection issues with related implants or medical devices. Most studies focus on adding anti-bacterial agents or surface modification, which usually result in composites with anti-bacterial properties, rather than synthesizing SiR with intrinsically antimicrobial performances. To tackle this issue, a double substituted bornyl-siloxane crosslinker (BC) is designed.

Knowledge discovery from database: MRI radiomic features to assess recurrence risk in high-grade meningiomas.

Purpose: We used knowledge discovery from radiomics of T2-weighted imaging (T2WI) and contrast-enhanced T1-weighted imaging (T1C) for assessing relapse risk in patients with high-grade meningiomas (HGMs).

Methods: 279 features were extracted from each ROI including 9 histogram features, 220 Gy-level co-occurrence matrix features, 20 Gy-level run-length matrix features, 5 auto-regressive model features, 20 wavelets transform features and 5 absolute gradient statistics features. The datasets were randomly divided into two groups, the training set (~ 70%) and the test set (~ 30%).

Effects of oil pollution on the growth and rhizosphere microbial community of Calamagrostis epigejos.

Bacteria, fungi, archaea, and viruses are reflective organisms that indicate soil health. Investigating the impact of crude oil pollution on the community structure and interactions among bacteria, fungi, archaea, and viruses in Calamagrostis epigejos soil can provide theoretical support for remediating crude oil pollution in Calamagrostis epigejos ecosystems. In this study, Calamagrostis epigejos was selected as the research subject and subjected to different levels of crude oil addition (0 kg/hm, 10 kg/hm, 40 kg/hm).

Meta-analysis reveals global variations in plant diversity effects on productivity.

Positive effects of plant diversity on productivity have been globally demonstrated and explained by two main effects: complementarity effects and selection effects. However, plant diversity experiments have shown substantial variation in these effects, with driving factors poorly understood. On the basis of a meta-analysis of 452 experiments across the globe, we show that productivity increases on average by 15.

A novel SIRT1 activator attenuates neuropathic pain by inhibiting spinal neuronal activation via the SIRT1-mGluR1/5 pathway.

Neuropathic pain is a type of pain caused by an injury or disease of the somatosensory nervous system. Currently, there is still absence of effective therapeutic drugs for neuropathic pain, so developing new therapeutic drugs is urgently needed. In the present study, we observed the effect of Comp 6d, a novel silent information regulator 1 (SIRT1) activator synthesized in our laboratory, on neuropathic pain and investigated the mechanisms involved.

Mechanistic Insights into the interaction between aldehyde aroma compounds and β-Casein through Multi-Spectroscopy and molecular dynamics.

The interaction between proteins and aroma compounds significantly impacts cheese flavor retention during processing. However, it is still unknown how cheese proteins and the aldehyde aroma compounds (AACs) interact. This study aims to clarify the interaction mechanisms between the AACs (benzaldehyde, 2-methylpropanal, 2-methylbutanal and 3-methylbutanal) and β-casein (β-CN) using SPME-GC/MS, multi-spectroscopy techniques, and molecular dynamics simulations.

Effects of physical multimorbidity on cognitive decline trajectories among adults aged 50 years and older with different wealth status: a 17-year population-based cohort study.

This study aimed to investigate the effects of physical multimorbidity on the trajectory of cognitive decline over 17 years and whether vary across wealth status. The study was conducted in 9035 respondents aged 50+ at baseline from nine waves (2002-2019) of the English Longitudinal Study of Aging. A latent class analysis was used to identify patterns of physical multimorbidity, and mixed multilevel models were performed to determine the association between physical multimorbidity and trajectories of cognitive decline.

Synergistically Halogenated and Methoxylated Thiophene Additive Enables High-Performance Organic Solar Cells.

Morphology control plays a key role for improving efficiency and stability of bulk heterojunctions (BHJ) organic solar cells (OSCs). Halogenation and methoxylation are two separate ways successfully adopted in additives for morphology optimization. In this work, these two strategies are combined together.

Simultaneous measurement of liquid level and R.I. sensor using POF based on twisted structure.

In this paper, a dual-parameter liquid level and refractive index (R.I.) sensor is fabricated using three pieces of bare polymer optical fibers (POFs), which can independently and simultaneously sense the liquid level and R.

The effect of NLRP3 inflammasome on cardiovascular prognosis in patients with acute coronary syndrome.

The NOD‑like receptor protein domain associated protein 3 (NLRP3) inflammasome is critical in inflammatory responses and may be a valuable prognostic biomarker in acute coronary syndrome (ACS). We aimed to investigate the association between NLRP3 inflammasome levels and short-term outcomes in patients with ACS. We enrolled 295 patients with ACS who were monitored for 6 months for major adverse cardiovascular events (MACEs).

Sex Differences in Participation Restriction in Social Activities Among Older Stroke Survivors: A Nationwide Study.

Background: Women experience more poststroke physical activity limitations, but sex differences in social activity participation, an important patient-reported outcome for stroke recovery, remain uncertain.

Methods: Incident stroke survivors aged ≥65 years were identified from the US NHATS (National Health and Aging Trends Study), 2011-2022. Participants were asked to report restricted participation in the past month in 2 formal activities (religious services and clubs/classes) and 2 informal activities (visiting friends/family and going out for enjoyment) in the year of stroke onset.

Phytochemistry, Pharmacology, and Traditional Medicine Applications of L.: A Comprehensive Overview.

L., a species within the genus, is broadly distributed across Southern Europe and Central Asia. In China, its berries, branches, and leaves are traditionally employed in Uyghur medicine to address conditions such as rheumatoid arthritis, itchy skin, tinnitus, deafness, and urinary discomfort.

Influence of Freeze-Thaw Cycles and Sustained Load on the Durability and Bearing Capacity of Reinforced Concrete Columns.

The deterioration of concrete structures is mainly due to the combined action of the environment and external load. In this study, 32 reinforced concrete columns were prepared to evaluate the coupling actions on the properties of reinforced concrete structures. The durability, bearing capacity, and failure mode of reinforced concrete columns were investigated under the combined action of freeze-thaw (F-T) cycles, sustained load, and salt corrosion (water or composite salt solution).

Genome-Wide Identification and Characterization of Gene Family in (Cucurbitaceae).

is a traditional Chinese medicinal plant of considerable application value and commercial potential, primarily due to its production of various bioactive compounds, particularly dammarane-type triterpenoid saponins that are structurally analogous to ginsenosides. Oxidosqualene cyclase (OSC), a pivotal enzyme in the biosynthesis of triterpenoid metabolites in plants, catalyzes the conversion of oxidosqualene into triterpenoid precursors, which are essential components of the secondary metabolites found in . To elucidate the role of gene family members in the synthesis of gypenosides within , this study undertook a comprehensive genome-wide identification and characterization of genes within and compared their expression levels across populations distributed over different geographical regions by both transcriptome sequencing and qRT-PCR experimental validation.