Publications by authors named "Chen C"

Background: Postoperative and ongoing treatment of breast cancer is traumatic to women with breast cancer and may lead to positive and negative psychological diseases, which can affect the prognosis of patients with breast cancer. Positive affect (PA) and negative affect (NA) significantly impact the prognosis of postoperative breast cancer patients. However, the effects of specific emotions on patient prognosis and the relationships between them are still unclear.

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Background: Complications following kidney transplantation elevate the risks of readmission and mortality. The aim of this study was to assess the association between the age-adjusted Charlson Comorbidity Index (ACCI) and postoperative complications among kidney transplant (KT) recipients.

Methods: Between January 2015 and March 2021, a study involving 886 kidney transplant recipients at the Third Affiliated Hospital of Sun Yat-sen University was conducted.

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Purpose: Exploring the computed tomography (CT), magnetic resonance imaging (MRI), and fluorodeoxyglucose positron emission tomography (FDG-PET)/CT Multimodal Imaging Characteristics of Desmoplastic Small Round Cell Tumor (DSRCT) to enhance the diagnostic proficiency of this condition.

Methods: A retrospective analysis was performed on clinical data and multimodal imaging manifestations (CT, MRI, FDG-PET/CT) of eight cases of DSRCT. These findings were systematically compared with pathological results to succinctly summarize imaging features and elucidate their associations with both clinical and pathological characteristics.

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Background: Cryptococcosis is an opportunistic fungal infection in immunocompromised patients. The major species include Cryptococcus grubii, Cryptococcus neoformans, and rarely, Cryptococcus gattii. Here we present a disseminated Cryptococcus gattii infection in a patient with elevated granulocyte-macrophage colony-stimulating-factor autoantibody which was successfully treated with antifungal therapy.

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Article Synopsis
  • The study focuses on identifying salivary proteins as potential biomarkers for primary Sjögren's disease (pSjD) to create a non-invasive prediction model.
  • Liquid chromatography-tandem mass spectrometry was used on saliva samples to find proteins associated with immune processes, highlighting specific proteins such as CFB, CLU, and NE as independent predictors of pSjD.
  • The proposed model combining these biomarkers with serum autoantibodies and Schirmer's test showed high accuracy, with a sensitivity of 84.85% and specificity of 92.45%, suggesting it could serve as a valuable non-invasive tool for pSjD classification.
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Diamond is an exceptional material with great potential across various fields owing to its interesting properties. However, despite extensive efforts over the past decades, producing large quantities of desired ultrathin diamond membranes for widespread use remains challenging. Here we demonstrate that edge-exposed exfoliation using sticky tape is a simple, scalable and reliable method for producing ultrathin and transferable polycrystalline diamond membranes.

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  • MACC1 is a newly identified factor in lung cancer that promotes the transition of non-cancer stem cells (non-CSCs) to cancer stem cells (CSCs), which play a key role in tumor growth.
  • High levels of MACC1 are found in stemness-enriched lung cancer cells, and reducing MACC1 expression through shRNA effectively halts this transition.
  • The study suggests that MACC1 stabilizes KLF4 mRNA by inhibiting microRNA-25, and understanding this relationship could lead to targeted therapies for cancer stem cells.
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Bladder cancer (BC) is the second most prevalent genitourinary malignancy worldwide. Despite recent approvals of immune checkpoint inhibitors and targeted therapy for muscle invasive or recurrent BC, options remain limited for patients with non-muscle invasive BC (NMIBC) refractory to Bacillus Calmette-Guérin (BCG) and chemotherapy. NMIBC is more frequently classified as a luminal subtype, in which increased PPARγ activity is a key feature in promoting tumor growth and evasion of immunosurveillance.

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Background: Effective management strategies against tick infestations are necessary because tickborne diseases represent serious hazards to the health of humans and animals worldwide. The aim of this study was to examine the larvicidal and ovicidal properties of Xanthium strumarium extract against a notorious tick species, Rhipicephalus microplus.

Methodology: The maceration method was used to prepare the ethanolic extract of X.

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Article Synopsis
  • The journal mandates authors to categorize their articles according to a specific level of evidence.
  • Level V indicates the lowest strength of evidence in their rating system.
  • For more details on the Evidence-Based Medicine ratings, authors should consult the Table of Contents or the online Instructions to Authors on the publisher's website.
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Objective: To explore the difference in effectiveness between a dynamic rehabilitation protocol and a traditional static rehabilitation protocol after the treatment of acute Achilles tendon rupture with channel assisted minimally invasive repair (CAMIR) technique through a prospective comparative trial, aiming to provide a reference for clinically selecting a feasible treatment regimen.

Methods: Patients with acute Achilles tendon rupture admitted between June 2021 and June 2022 were included in the study, with 60 patients meeting the selection criteria. They were randomly divided into a dynamic rehabilitation group ( =30) and a static rehabilitation group ( =30) using a computer-generated random number method.

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Purpose: This prospective study aimed to validate the translated Chinese versions of the Ocular Surface Disease Index (OSDI), 5-Item Dry Eye (DEQ-5), and Contact Lens Dry Eye Questionnaire-8 (CLDEQ-8) questionnaires and test their repeatability.

Methods: From August 2022 to July 2023, online (qualtrics.com) English and Chinese versions of OSDI, DEQ-5, and CLDEQ-8 questionnaires were distributed to residents of Hong Kong, mainland China, Taiwan, and Singapore ≥ 18 years old who could understand both written Chinese and English.

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Article Synopsis
  • The study focuses on the genus Daphne, specifically Daphne pseudomezereum, which has not been previously researched for its anti-HIV diterpenoids.
  • Three new compounds, onishibarins A-C, were discovered alongside seven known ones from the plant's fruits.
  • The new compounds showed significant anti-HIV activity, with some having low effective concentrations and minimal cytotoxicity.
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Objective: The aim of this study was to evaluate a novel respiratory frequency-modulated continuous-wave radar-trigger (FT) technique for multiple -b-value diffusion-weighted imaging (DWI) of liver and compare it with conventional free breathing (FB) DWI technique.

Material And Methods: 39 patients with focal liver lesions underwent both frequency-modulated continuous-wave radar-trigger (FT) and conventional free-breathing (FB) multi-b-value diffusion-weighted imaging (DWI,b = 0,50,400,800 s/mm. Two abdominal radiologists independently assessed the quality of liver DWI images obtained using both techniques, measured and compared liver signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) at different b-values, as well as apparent diffusion coefficient (ADC) values calculated from all b-values.

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Exposure to airborne bacteria poses significant risks to human health, highlighting the need for on-site sampling and detection to facilitate control and early warning. Commercial dissolvable gelatin filters are efficient samplers but can only dissolve in warm water. This study developed nanofiber gelatin filters that can rapidly dissolve in room-temperature water, facilitating on-site sampling and detecting of airborne bacteria when combined with adenosine triphosphate (ATP) analysis.

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Article Synopsis
  • The study examines the presence and seasonal changes of endocrine-disrupting compounds (EDCs), specifically phthalate esters (PAE) and alkyl phenols (AP), in marine microplankton over different seasons (Summer 2022, Autumn 2022, Spring 2023) in a polluted area.
  • Sample analysis showed a wide range of concentrations of various EDCs, primarily di-isononyl phthalate (DiNP), di-(2-ethylhexyl) phthalate (DEHP), and nonylphenols (NP), with significant variability depending on the season.
  • The research suggests that rivers are key to EDC distribution in microplankton, and factors like eutrophication
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Pork color is crucial for assessing its safety and freshness, and traditional methods of observing through human eyes are inefficient and subjective. In recent years, several methods have been proposed based on computer vision and deep learning have been proposed, which can provide objective and stable evaluations. However, these methods suffer from a lack of standardized data collection methods and large-scale datasets for training, leading to poor model performance and limited generalization capabilities.

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Background: Rice blast caused by Pyricularia oryzae is a major threat to rice production worldwide. Tainung 84 (TNG84) is an elite japonica rice cultivar developed through the traditional pedigree method. It has maintained superior blast resistance since its release in 2010.

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Metastasis is the major cause of hepatocellular carcinoma (HCC) mortality. But the effective biomarkers for HCC metastasis remain underexplored. Here we integrated GEO (Gene Expression Omnibus) and TCGA (The Cancer Genome Atlas) datasets to screen candidate genes for hepatocellular carcinoma metastasis, a consensus metastasis-derived prognostic signature (MDPS) was constructed by machine learning.

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Coherent diffraction microscopy (CDM) is a robust direct imaging method due to its unique 2D/3D phase retrieval capacity. Nonetheless, its resolution faces limitations due to a diminished signal-to-noise ratio (SNR) in high-frequency regions. Addressing this challenge, X-ray ensemble diffraction microscopy (XEDM) emerges as a viable solution, ensuring an adequate SNR in high-frequency regions and effectively surmounting resolution constraints.

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Article Synopsis
  • HIV-1 can integrate into host chromosomes, creating a latent reservoir that makes curing the infection difficult; activating this latency is crucial for eradication.
  • Tannic acid (TA) has been identified as a potential latency-reversing agent, effectively reactivating multiple proviruses and showing synergy with other agents.
  • TA works by degrading a protein called CBX4, which reduces a specific histone modification (H3K27me3) and enhances the transcriptional activity of HIV-1, suggesting a new strategy for targeting HIV-1 latency.
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Over the past decade, lead halide perovskites (LHPs), an emerging class of organic-inorganic ionic-type semiconductors, have drawn worldwide attention, which injects vitality into next-generation optoelectronics. Facilely tunable bandgap is one of the fascinating features of LHPs, enabling them to be widely used in various nano/microscale applications. Notably, wide-bandgap (WBG) LHPs have been considered as promising alternatives to traditional WBG semiconductors owing to the merits of low-cost, solution processability, superior optoelectronic characteristics, and flexibility, which could improve the cost-effectiveness and expand the application scenarios of traditional WBG devices.

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