The DnaJ1 heat shock protein interacts with the flavanone 3-hydroxylase-like protein F3HL to synergistically enhance drought tolerance by scavenging reactive oxygen species in tomato.

The widely distributed heat shock protein DnaJ is renowned for its pivotal role in enhancing thermal tolerance in plants; however, its involvement in drought tolerance remains elusive. In this study, genes encoding DnaJ1 were cloned from drought-resistant wild tomato (Solanum pennellii) and drought-sensitive cultivated tomato (Solanum lycopersicum). SpDnaJ1 and SlDnaJ1 from both tomato species were localized in the chloroplast, and their gene expression was induced by various abiotic stresses.

Lower body mass index is associated with the achievement of target LDL in patients using PCSK9 inhibitors in Taiwan.

Objective: Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors are a standard therapy for patients who respond poorly to or cannot tolerate statins. However, identifying responders to PCSK9 inhibitors remains unclear. This study investigates the characteristics of patients who achieve target LDL-C reduction (< 70 mg/dl) after PCSK9 inhibitor therapy.

Sequential direct bilirubin values in preterm infants.

Objective: We aim to describe sequential direct bilirubin levels in preterm infants and examine the outcomes of subsequent evaluation of direct hyperbilirubinemia.

Study Design: Retrospective electronic chart analysis of preterm infants admitted and surviving the neonatal intensive care unit (NICU) stay was performed.

Result: A total of 127 preterm infants had 665 bilirubin measurements (333 direct bilirubin; 332 total bilirubin) during their first NICU stay.

Research on computing task scheduling method for distributed heterogeneous parallel systems.

With the explosive growth of terminal devices, scheduling massive parallel task streams has become a core challenge for distributed platforms. For computing resource providers, enhancing reliability, shortening response times, and reducing costs are significant challenges, particularly in achieving energy efficiency through scheduling to realize green computing. This paper investigates the heterogeneous parallel task flow scheduling problem to minimize system energy consumption under response time constraints.

Language and motor plasticity in toddlerhood and early preschool as predictors of intelligence in late preschool.

Background: Early language and motor development may influence cognitive function in a cascading manner later in life. This study aimed to explore the impact of language and motor plasticity during toddlerhood and early preschool years on intelligence in late preschool, with an additional consideration of the influence of ASD and ADHD diagnoses.

Methods: We retrospectively collected medical chart from 423 children aged 2-5 years (316 boys and 107 girls; mean age at Time 1: 3.

Causal Relationships Between Inflammatory Cytokines and Sepsis: A Mendelian Randomization Study.

Objective: The complex interplay between inflammatory cytokines and sepsis is not well understood. This study employs Mendelian Randomization (MR) to investigate the causal relationships between various inflammatory cytokines and sepsis, aiming to elucidate the underlying mechanisms and potential therapeutic targets.

Methods: This study employed a bidirectional MR approach to investigate the causal effects of inflammatory cytokines on sepsis and vice versa.

Zinc-Mediated Deacetylation of FXR Activates the ATGL Pathway to Reduce Hepatic Lipid Accumulation and Enhance Lipolysis in Yellow Catfish.

Background: High-fat diets (HFD) can lead to excessive accumulation of lipids in the liver, leading to liver injury. Dietary zinc (Zn) has been shown to reduce high-fat diets-induced lipid accumulation and improve lipid profiles in mammals, yet it remains unclear whether waterborne Zn maintains its lipid-lowering effects in osteichthyes.

Objective: This study aimed to elucidate the regulatory role of Zn in high fat diet-induced hepatic lipid accumulation in yellow catfish (Pelteobagrus fulvidraco) and its potential mechanisms.

Assessing the efficacy and safety of calcium gluconate soaking as a treatment modality for hydrofluoric acid burns.

Introduction: Hydrofluoric acid is extremely toxic and can corrode tissues while reacting with calcium and magnesium, leading to severe tissue damage. The antidote, calcium gluconate, is effective for treating mild to moderate burns. However, our hospital lacks registered calcium gluconate gel, making treatment challenging.

Protocol for mouse carotid artery perfusion for in situ brain tissue fixation and parallel unfixed tissue collection.

As the study of central control of multiple organ function becomes more prominent, there is an increasing need for the collection of fixed brain and unfixed organs and tissues from the same experimental animal. Here, we present a protocol for performing carotid artery cannulation, organ and tissue collection, in situ brain perfusion and fixation, and brain dissection in mice. We describe steps for cannulating the carotid artery, harvesting the heart and other organs, and perfusing, fixing, and dissecting the brain.

Atomically Dispersed Co/Mo Sites Anchored on Mesoporous Carbon Hollow Spheres for Highly Selective Oxygen Reduction to Hydrogen Peroxide in Acidic Media.

Two-electron oxygen reduction reaction (2e ORR) in acidic media is a promising route for the decentralized and on-site hydrogen peroxide (HO) generation. Nevertheless, strong interaction between active sites and OOH intermediates usually induces the O─O bond cleavage to convert 2e pathway into the sluggish 4e ORR. Therefore, it is highly necessary to optimize the electronic structure of 2e ORR electrocatalysts for the regulation of adsorption energy.

A motor unit action potential-based method for surface electromyography decomposition.

Objective: Surface electromyography (EMG) decomposition is crucial for identifying motor neuron activities by analyzing muscle-generated electrical signals. This study aims to develop and validate a novel motor unit action potential (MUAP)-based method for surface EMG decomposition, addressing the limitations of traditional blind source separation (BSS)-based techniques in computation complexity and motor unit (MU) tracking.

Methods: Within the framework of the convolution kernel compensation algorithm, we developed a MUAP-based decomposition algorithm by reconstructing the MU filters from MUAPs and evaluated its performance using both simulated and experimental datasets.

Association of a 7.9 kb Endogenous Retrovirus Insertion in Intron 1 of CD36 with Obesity and Fat Measurements in Sheep.

Background: Endogenous retroviruses (ERVs) enhance genetic diversity in vertebrates, including sheep. This study investigates the role of Ov-ERV-R13-CD36 within CD36 gene and its association with phenotypic traits in sheep. Analyzing 58 sheep genomes revealed that ERVs constitute approximately 6.

Postoperative adjuvant therapy for stage IA-IIA cervical adenocarcinoma (FIGO 2018) with one intermediate-risk factor: a multicentre retrospective cohort study of 63,926 cases.

Objective: To compare the 5-year oncological outcomes of different adjuvant treatment modalities in patients with FIGO 2018 stage IA-IIA cervical adenocarcinoma who underwent open radical hysterectomy and one intermediate-risk pathological factor.

Methods: Based on the Four C database (between 2004 and 2018,n=63,926), patients with FIGO 2018 stage IA-IIA cervical adenocarcinoma and only one intermediate-risk pathological factor underwent open extensive hysterectomy. All patients were divided into three groups, namely, the simple surgery group (radical hysterectomy, RH), postoperative adjuvant chemotherapy group (radical hysterectomy and chemotherapy, RH + CT), and postoperative adjuvant chemoradiotherapy group (radical hysterectomy and radiotherapy/concurrent chemoradiotherapy, RH + RT/CCRT).

Interaction between the liver transcriptome and gut microbiota in mice during Toxoplasma gondii infection as identified by integrated transcriptomic and microbiome analysis.

Background: Toxoplasma gondii is a single-cell parasite capable of infecting both humans and a variety of animal species. Although T. gondii infection is known to adversely affect the liver and gut microbiota, the precise interplay between the gut microbiome and the liver transcriptome in infected mice remains largely unknown.

Association between 91 circulating inflammatory proteins and the risk of glaucoma: A Mendelian randomization study.

Glaucoma is a leading cause of irreversible blindness worldwide, with its pathogenesis incompletely understood. Inflammation, as an important aspect of glaucoma, has attracted increasing attention. In this study, we performed a Mendelian randomization (MR) analysis to investigate the association between 91 circulating inflammatory proteins and glaucoma.

Association of peripheral vestibular disorder with human papillomavirus infections.

Purpose: Emerging research indicates that viral infections may contribute to the development of certain vestibular disorders. This study aimed to explore the association of peripheral vestibular disorders (PVDs) with human papillomavirus (HPV) using a comprehensive population-based dataset from Taiwan's Longitudinal Health Insurance Database 2010.

Methods: We examined a cohort comprising 94,215 patients with a new diagnosis of PVDs and 471,075 propensity-score matched controls, utilizing propensity score matching.

Influence of processing points on the flavor of meat balls braised with brown sauce.

In this study, electronic nose, electronic tongue and solid-phase microextraction coupled with gas chromatography-olfactometry-mass spectrometry (SPME-GC-O-MS) were used to investigate the volatile flavor characteristics and the changing pattern of meat balls braised with brown sauce in prepared dishes during processing. A total of 13 volatile compounds were detected by combining the results of the OAVs and GC-O analyses using both methods. The detected volatile compounds were benzaldehyde, nonanal, (E)-2-octenal, citral, 6-methyl-5-hepten-2-one, 1-octen-3-ol, eucalyptol, linalool, ethyl acetate, eugenol, d-limonene, anethole, and estragole.

Hypoglycemia knowledge assessment tool - Development and validation of the Hypoglycemia Management Knowledge Scale in Taiwan.

Background: Knowledge can guide and support behaviors. With accurate knowledge, patients are better equipped to engage in appropriate self-care behaviors and effectively manage hypoglycemia. However, there is currently a lack of reliable and valid assessment scales specifically designed to measure hypoglycemia knowledge, which could serve as valuable clinical evaluation tools for healthcare professionals.

Comparison of structure-function correlation among IMO visual function analyser and Humphrey field analyser.

Purpose: To compare the structure-function correlations between optical coherence tomography (OCT) thickness parameters and the corresponding sectorial mean sensitivity (MS) values obtained with IMO visual function analyser (IMOvifa) and Humphrey field analyser (HFA) perimeters.

Design: Prospective cross-sectional study.

Methods: Glaucoma suspect, glaucoma and ocular hypertension patients underwent IMOvifa 24-2 Ambient Interactive Zippy Estimated Sequential Testing, HFA 24-2 Swedish Interactive Threshold Algorithm-Standard and OCT tests within 12 weeks.

The influence and mechanisms of exogenous aryl hydrocarbon receptor ligands on the viability of mouse germ cells.

Environmental pollution is a significant contributor to male infertility. Numerous environmental pollutants, such as PCB118, act as exogenous ligands for the aryl hydrocarbon receptor (AhR). However, the role of AhR in mediating the effects of environmental pollutants on male reproductive functions remains inadequately understood.

Clinical predictive model for identifying high-risk factors in pleurisy tuberculoma patients.

Introduction: Pleurisy tuberculoma (PTM) is a neoplastic lesion that primarily affects the pleural wall or internal organs. The majority of PTM cases are observed during the treatment of tuberculous pleural effusion(TPE), and although the precise pathogenesis remains unclear, there is a significant association between these two conditions. To identify high-risk factors for the development of PTM, we developed a clinical predictive model aimed at providing more insightful information for the development of PTM.

Effect of polysaccharides and saponins from Polygonatum kingianum against uranium-induced renal injury in rats.

Uranium poisoning is increasingly recognized as a public health issue. Polygonatum kingianum (PK) is valued for its therapeutic properties and food applications. Original research showed PK aqueous extract (PKAE) and polysaccharides (PKP) could alleviate uranium-induced cytotoxicity in vitro.

Cost analysis and clinical outcomes of enhanced recovery after surgery for head and neck free flap reconstruction.

Head and neck reconstruction is among the most expensive types of surgery, requiring long operation time and hospital stays, with high complication rates. Enhanced recovery after surgery improves the quality of post-operative recovery. In this study, we evaluated and compared the costs and outcomes in patients who underwent free flap reconstruction after head and neck cancer surgery with or without enhanced recovery.

First Determination of the Spin-Parity of Ξ_{c}(3055)^{+,0} Baryons.

The Ξ_{b}^{0(-)}→Ξ_{c}(3055)^{+(0)}(→D^{+(0)}Λ)π^{-} decay chains are observed, and the spin-parity of Ξ_{c}(3055)^{+(0)} baryons is determined for the first time. The measurement is performed using proton-proton collision data at a center-of-mass energy of sqrt[s]=13  TeV, corresponding to an integrated luminosity of 5.4  fb^{-1}, recorded by the LHCb experiment between 2016 and 2018.