Immune Checkpoint Inhibitor Combined with Antiangiogenic Agent Synergistically Improving the Treatment Efficacy for Solid Tumors.

In recent years, the combination of immune checkpoint inhibitors (ICIs) with antiangiogenic agents has led to significant breakthroughs in cancer treatment. Such as programmed cell death 1 (PD-1), programmed cell death ligand 1 (PD-L1), and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4). Antiangiogenic therapy plays a pivotal role in normalizing blood vessels and remodeling the tumor immune microenvironment while ICIs not only enhance the host's antitumor immune response by blocking negative regulatory signals but also promote vascular normalization.

Artificial Intelligence in Medical Metaverse: Applications, Challenges, and Future Prospects.

The medical metaverse is a combination of medicine, computer science, information technology and other cutting-edge technologies. It redefines the method of information interaction about doctor-patient communication, medical education and research through the integration of medical data, knowledge and services in a virtual environment. Artificial intelligence (AI) is a discipline that uses computer technology to study and develop human intelligence.

Effect of Different Doping Concentrations on the Properties of Fe:ZnSe and Fe, Cr:ZnSe Crystals Grown by the Chemical Vapor Transport Method.

The Fe:ZnSe crystal is an important material for 3-5 μm mid-infrared lasers. In this work, we have grown different doping concentrations of Fe:ZnSe and Fe, Cr:ZnSe by the chemical vapor transport method. The doped crystals have the same structure.

Inflammation-Responsive Functional Core-Shell Micro-Hydrogels Promote Rotator Cuff Tendon-To-Bone Healing by Recruiting MSCs and Immuno-Modulating Macrophages in Rats.

Rotator cuff injuries often necessitate surgical intervention, but the outcomes are often unsatisfactory. The underlying reasons can be attributed to multiple factors, with the intricate inflammatory activities and insufficient presence of stem cells being particularly significant. In this study, an innovative inflammation-responsive core-shell micro-hydrogel is designed for independent release of SDF-1 and IL-4 within a single delivery system to promote tendon-to-bone healing by recruiting MSCs and modulating M2 macrophages polarization.

Crystal Growth, Characterization, and Properties of Nonlinear Optical Crystals of LiAgGaTe for Mid-Infrared Applications.

LiGaTe is a promising nonlinear optical crystal with a large figure of merit (/), but it is difficult to grow the LiGaTe single crystal due to its extreme instability. In this work, we used Ag to replace Li and successfully grew a LiAgGaTe crystal by the modified Bridgman method for the first time. We found it has thermal stability below 200 °C in an atmospheric environment, and the thermal expansion coefficient is positive.

GhGRF4/GhARF2-GhGASA24 module regulates fiber cell wall thickness by modulating cellulose biosynthesis in upland cotton (Gossypium hirsutum).

Fiber elongation rate is an essential characteristic of cotton fiber in the textile industry, yet it has been largely overlooked in genetic studies. Gibberellins (GAs) and auxin (IAA) are recognized for their role in directing numerous developmental processes in plants by influencing cell differentiation and elongation. However, the degree to which GA-IAA interaction governs cellular elongation in cotton fiber cells remains to be fully understood.

The genetic basis of leaf hair development in upland cotton (Gossypium hirsutum).

Trichomes, which originate from the epidermal cell of aerial organs, provide plants with defense and secretion functions. Although numerous genes have been implicated in trichome development, the molecular mechanisms underlying trichome cell formation in plants remain incompletely understood. Here, we using genome-wide association study (GWAS) across 1037 diverse accessions in upland cotton (Gossypium hirsutum) to identify three loci associated with leaf pubescence (hair) amount, located on chromosome A06 (LPA1), A08 (LPA2) and A11 (LPA3), respectively.

Excellent luminescent thermal stability of Dy/Sm co-activated multifunctional titanate single-phase phosphors.

Nowadays, the development of phosphors with excellent luminescent thermal stability for various applications has become a research hotspot. Therefore, the Dy/Sm co-activated multifunctional NaYTiO phosphors with excellent comprehensive performance in the field of non-contact optical measurement and white LED solid-state lighting were reported in this paper, and their crystal structure, elemental composition, optical bandgap and photoluminescence properties were systematically studied. Remarkably, the reason why NaYTiO:Dy,Sm phosphors achieved color-controlled emission from yellow to orange-red and even to white at the excitation wavelength of 363 nm was not based on the energy transfer process from Dy to Sm but on co-excitation.

Strigolactone-gibberellin crosstalk mediated by a distant silencer fine-tunes plant height in upland cotton.

Optimal plant height is crucial in modern agriculture, influencing lodging resistance and facilitating mechanized crop production. Upland cotton (Gossypium hirsutum) is the most important fiber crop globally; however, the genetic basis underlying plant height remains largely unexplored. In this study, we conducted a genome-wide association study to identify a major locus controlling plant height (PH1) in upland cotton.

GhMAX2 Contributes to Auxin-Mediated Fiber Elongation in Cotton ().

Strigolactones (SLs) represent a new group of phytohormones that play a pivotal role in the regulation of plant shoot branching and the development of adventitious roots. In cotton (, ), SLs play a crucial role in the regulation of fiber cell elongation and secondary cell wall thickness. However, the underlying molecular mechanisms of SL signaling involved in fiber cell development are largely unknown.

Exploring the regulatory role of non-coding RNAs in fiber development and direct regulation of GhKCR2 in the fatty acid metabolic pathway in upland cotton.

Cotton fiber holds immense importance as the primary raw material for the textile industry. Consequently, comprehending the regulatory mechanisms governing fiber development is pivotal for enhancing fiber quality. Our study aimed to construct a regulatory network of competing endogenous RNAs (ceRNAs) and assess the impact of non-coding RNAs on gene expression throughout fiber development.

Injectable Bioadhesive Photocrosslinkable Hydrogels with Sustained Release of Kartogenin to Promote Chondrogenic Differentiation and Partial-Thickness Cartilage Defects Repair.

Partial-thickness cartilage defect (PTCD) is a common and formidable clinical challenge without effective therapeutic approaches. The inherent anti-adhesive characteristics of the extracellular matrix within cartilage pose a significant impediment to the integration of cells or biomaterials with the native cartilage during cartilage repair. Here, an injectable photocrosslinked bioadhesive hydrogel, consisting of gelatin methacryloyl (GM), acryloyl-6-aminocaproic acid-g-N-hydroxysuccinimide (AN), and poly(lactic-co-glycolic acid) microspheres loaded with kartogenin (KGN) (abbreviated as GM/AN/KGN hydrogel), is designed to enhance interfacial integration and repair of PTCD.

Physiological and transcriptional analyses reveal formation of memory under recurring drought stresses in seedlings of cotton (Gossypium hirsutum).

Plants are frequently subjected to a range of environmental stresses, including drought, salinity, cold, pathogens, and herbivore attacks. To survive in such conditions, plants have evolved a novel adaptive mechanism known as 'stress memory'. The formation of stress memories necessitates coordinated responses at the cellular, genetic/genomic, and epigenetic levels, involving altered physiological responses, gene activation, hyper-induction and chromatin modification.

Multimodal steerable earthworm-inspired soft robot based on vacuum and positive pressure powered pneumatic actuators.

This article presents a multimodal steerable earthworm-inspired soft robot based on vacuum and positive pressure powered pneumatic actuators capable of crawling both inside pipelines and on planar surfaces. The optimized modular vacuum pressure-driven actuator can generate deformation and anchoring motion through a unified structure under low vacuum pressure, giving it significant speed advantages and multi-modal locomotion capabilities. Meanwhile, the positive pressure powered actuator (PPPA) enables the robot to achieve controlled multi-directional and multi-degrees-of-freedom steering, moreover, enhances the consistency of the driving mechanism.

Incidence, Predictors, and Strategies for Retrograde Wire Tracking Failure via Poor Septal Collateral Channels in Chronic Total Occlusion.

Background: Retrograde guidewire (GW) tracking success via a poor septal collateral channel (CC) when an antegrade approach fails is crucial for successful revascularization of coronary chronic total occlusion (CTO) with poor septal CC. However, the incidence, predictors, and management strategies for retrograde GW tracking failure via poor septal CC remain unclear.

Methods: In total, 122 CTO patients who underwent retrograde septal percutaneous coronary intervention (PCI) with poor CC between January 2017 and May 2022 were retrospectively analyzed.

Preoperative small pulmonary nodule localisation using hookwires or coils: strategy selection in adverse events.

Objective: This is a retrospective study of adverse events associated with preoperative computed tomography (CT)-guided hookwire or coil localisation. We analysed the experience and process flaws in resecting ground-glass nodules (GGNs) through video-assisted thoracoscopic surgery (VATS) and determined the remedial strategy.

Methods: Adverse events were evaluated in 40 patients with 45 GGNs who underwent CT-guided hookwire or coil localisation before VATS.

Crystal Growth, Characterization, and Properties of Nonlinear Optical Crystals of LiAgGaSe for Mid-Infrared Applications.

LiAgGaSe is a new series of solid solution crystals that has a large nonlinear optical (NLO) coefficient and laser-induced damage threshold (LIDT). It has great application prospects in mid-infrared laser frequency conversion. In this work, LiAgGaSe ( = 0, 0.

Genome-wide analysis of the serine carboxypeptidase-like protein family reveals Ga09G1039 is involved in fiber elongation in cotton.

The Gossypium is a model genus for understanding polyploidy and the evolutionary pattern of inheritance. This study aimed to investigate the characteristics of SCPLs in different cotton species and their role in fiber development. A total of 891 genes from one typical monocot and ten dicot species were naturally divided into three classes based on phylogenetic analysis.