Publications by authors named "Chen Aijun"
Warts, benign epidermal proliferations, are a direct result of human papillomavirus (HPV) infection, specifically targeting the keratinocytes within the stratum corneum of the skin. The development of warts is the most common clinical manifestation of HPV, with plantar warts, condylomata acuminata, and common warts being the most frequently observed types. These growths can be unsightly and sometimes painful, affecting the quality of life for those afflicted.
View Article and Find Full Text PDFBackground: In clinical practice, psoriasis is a prevalent chronic inflammatory cutaneous disease featured with the development of red plaque with silvery scales, which considerably affects cutaneous health and quality of life of those afflicted.
Objective: This research aimed to examine the association between the body roundness index (BRI) and psoriasis, using data sourced from the National Health and Nutrition Examination Survey (NHANES).
Methods: Our study used a cross-sectional design, including 8,479 adults, of whom 234 were diagnosed with psoriasis.
Maternal mRNAs and proteins are produced during oogenesis by more than 60% of zebrafish genes. They are indispensable for fertilization and early embryogenesis. Generation and analysis of the maternal mutant is the most direct way to characterize the maternal function of the specific gene.
View Article and Find Full Text PDFPemphigus vulgaris (PV) is an autoimmune skin disorder characterized by the loss of cell cohesion, with the histone deacetylase 1 (HDAC1) and lysine demethylase 1A (KDM1A) playing critical roles in its pathogenesis. This study aimed to elucidate the molecular mechanisms behind PV, focusing on the function of HDAC1 and KDM1A in disease onset and progression. Based on in vitro and in vivo PV models, we observed a significant increase in HDAC1 mRNA and protein levels in skin tissues of PV patients.
View Article and Find Full Text PDFArticle Synopsis
- The 1565 nm non-ablative fractional laser is effective for skin rejuvenation, particularly for treating issues like stretch marks and acne scars, but can lead to temporary redness and swelling post-treatment.
- A new method combines this laser with 30% super molecular salicylic acid to minimize side effects such as erythema and pigmentation.
- The treatment involves specific steps, starting with tailored energy settings for the laser, followed by the application of salicylic acid until a frosty reaction indicates it's time to stop, aiming for a safer facial rejuvenation experience for patients.
Article Synopsis
- * A standardized system for collecting and categorizing this data has been developed, including specific recommendations for measurement techniques and equipment based on usage contexts.
- * A multi-center collaboration in China seeks to gather data on various skin conditions, linking it to disease information to better understand skin phenotype influences and improve treatment methods, while also working on non-invasive measurement technologies.
Article Synopsis
- - Vunakizumab, an anti-interleukin-17A antibody, is being tested for its effectiveness in treating moderate-to-severe plaque psoriasis in a phase 3 trial involving 690 participants.
- - The trial found that those receiving vunakizumab showed significantly better improvement in psoriasis severity scores at week 12 compared to the placebo group, with maintained efficacy through week 52.
- - While the treatment showed good results and tolerability, the study was limited to Chinese subjects and didn't include an active comparator for broader context. !*
The relationship between psoriasis and site-specific cancers remains unclear. Here, we aim to investigate whether psoriasis is causally associated with site-specific cancers. We use observational and genetic data from the UK Biobank, obtaining GWAS summary data, eQTL analysis data, TCGA data, and GTEx data from public datasets.
View Article and Find Full Text PDFTo improve the accuracy of in situ measurement of the standard volumes of pipe provers and to shorten the traceability chain, a new method of in situ pipe prover volume measurement was developed alongside a supporting measurement device. This method is based on the geometric dimension approach, which measures the inner diameter and length of a pipe prover to calculate its volume. For inner diameter measurement, a three-probe inner-diameter algorithm model was established.
View Article and Find Full Text PDFSwell-shrink characteristic soils exhibit a high susceptibility to cracking during the drying process, which poses a significant risk of various geological disasters. Among these, the occurrence of drying shrinkage acts as a prerequisite for the cracking phenomenon. Therefore, it is of utmost importance to comprehend the specific characteristics associated with the drying shrinkage mechanism.
View Article and Find Full Text PDFArticle Synopsis
- Psoriasis is an ongoing skin disease linked to immune issues, and macrophages play a crucial role in its inflammation, but how they get activated isn’t fully clear.
- In psoriasis lesions, there’s an increase in neutrophil extracellular traps (NETs), and lacking an enzyme called PAD4 (which helps form NETs) decreased skin inflammation in mouse models.
- The STING signaling pathway, which is elevated in psoriasis, interacts with NETs and macrophages, suggesting that this pathway could be a significant factor in how psoriasis develops.
Background: Limited information exists regarding the impact of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection on psoriasis patients. The objective of this study was to identify clinical factors associated with the prognosis of psoriasis following SARS-CoV-2 infection.
Methods: A retrospective, multicenter study was conducted between March and May 2023.
Article Synopsis
- Psoriasis is a chronic skin disease that often occurs alongside autoimmune conditions like Graves' disease (GD), making treatment complex.
- A 34-year-old woman with both refractory psoriasis and GD experienced worsening skin symptoms after trying various treatments, including adalimumab and secukinumab.
- Ultimately, switching to guselkumab led to significant improvement in her psoriasis, suggesting it could be an effective option for patients with both conditions.
In this study we aimed to investigate the prevalence of SARS-CoV-2 infection in psoriasis patients, and outcomes of SARS-CoV-2 infection and associated risk factors. A cross-sectional survey was conducted from February 2023 to March 2023. Information was obtained with online questionnaire about psoriasis patients on demographic characteristics, clinical characteristics, SARS-CoV-2 infection and outcomes, vaccination, and routine protection against COVID-19.
View Article and Find Full Text PDFIncrease in the incidence of invasive fungal infections due to Volvariella Volvacea.
Eur J Clin Microbiol Infect Dis
May 2024
Purpose: We aimed to show the increasing incidence of invasive fungal infections due to Volvariella Volvacea in patients with immunosuppression.
Methods: We present a case of an invasive fungal infection caused by Volvariella volvacea, and summarize the clinical and pathological features based on this case and a review of the literature.
Results: A total of seven patients with IFIs due to Volvariella Volvacea have been reported in the literature.
Article Synopsis
- Rosacea is a persistent skin condition that affects quality of life, but its underlying causes are not well understood; this study explores the role of facial bacteria in rosacea patients versus healthy individuals.
- Researchers collected and analyzed facial microbial samples from 44 participants (17 with rosacea and 27 healthy controls), revealing a higher alpha diversity in rosacea patients, although this difference wasn't statistically significant.
- Key findings indicate that rosacea patients had significantly lower levels of Cutibacterium acnes and higher levels of Staphylococcus epidermidis compared to healthy controls, suggesting that changes in skin microbiome composition may be linked to rosacea's development.
Prevalence and burden of skin diseases in college students: A nationwide cross-sectional survey in China.
J Eur Acad Dermatol Venereol
September 2024
Article Synopsis
- Toxic epidermal necrolysis (TEN) is a serious skin condition affecting over 30% of the body that poses a high risk of death and can include severe systemic symptoms.
- TNF-α inhibitors like etanercept have shown promise in treating TEN, even in patients with serious infections, as seen in a study of three adults successfully treated despite having conditions like tuberculosis and septicemia.
- While results were positive and no new infections or adverse effects occurred during follow-up, more extensive studies are needed to confirm the effectiveness of TNF-α inhibitors in these cases.
Background: Continuous exposure to UVB is the main extrinsic cause of skin photodamage, which is associated with oxidative stress, DNA damage, apoptosis and degradation of collagen. Rapamycin, a mechanistic target inhibitor of rapamycin complex 1 (mTORC1), has been shown to play a crucial role anti-tumor and aging retardation, but its mechanism of action in UVB-induced photodamage still remains unknown. In this study, we investigated the role of rapamycin and Hspb2 (also known as Hsp27) in UVB-induced photodamage in mice.
View Article and Find Full Text PDFHerpes Zoster Ophthalmicus Clinical Presentation and Risk Factors for Lesion Recovery.
Clin Cosmet Investig Dermatol
December 2023
Article Synopsis
- * A total of 189 patients were analyzed, revealing that common ocular symptoms included eyelid swelling (92.6%) and eye pain (48.7%), while conjunctivitis (78.3%) was a notable ocular sign.
- * Key factors affecting the improvement of skin rash and duration of ocular symptoms included age (≥70), use of glucocorticoids, topical antiviral drugs, and symptoms like tearing, contributing to a better understanding of HZO in a clinical context.
Background: Thoracic aortic dissection (TAD) is a life-threatening disease caused by an intimal tear in the aorta. The histological characteristics differ significantly between the tear area (TA) and the distant area. Previous studies have emphasized that certain specific genes tend to cluster at the TA.
View Article and Find Full Text PDFA Case Report of Adalimumab Successfully Treated a Severe Plaque Psoriasis Patient with Psoriatic End-Stage Renal Disease.
Clin Cosmet Investig Dermatol
October 2023
Article Synopsis
- Psoriasis is a chronic skin condition that can also affect other tissues and organs, and there’s limited knowledge about its link to kidney function issues.
- The concept of psoriatic nephropathy was introduced in 2005, highlighting a potential relationship between psoriasis and kidney disease.
- The report discusses a case of severe psoriasis in a patient with end-stage renal disease treated with adalimumab, a medication that may help improve kidney damage related to psoriasis.
Introduction: Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia, and it significantly increases the risk of cardiovascular complications and morbidity, even with appropriate treatment. Tissue remodeling has been a significant topic, while its systematic transcriptional signature remains unclear in AF.
Objectives: Our study aims to systematically investigate the molecular characteristics of AF at the cellular-level.