Safety of epoprostenol and treprostinil in children less than 12 months of age.

There is a paucity of data on infant intravenous prostacyclin use, the gold standard for therapy for severe pulmonary hypertension (PH). This review aimed to evaluate the safety, tolerability, and outcomes of infant prostacyclin use. A retrospective observational study was performed in a large pediatric hospital with a dedicated pediatric PH program.

Medication absorption considerations in patients with postpyloric enteral feeding tubes.

Purpose: The gastrointestinal absorption sites of medications administered via postpyloric enteral feeding tubes were examined.

Summary: Many issues must be considered when administering medications via the postpyloric route, including interactions with enteral feeds, additional toxicities, and the concern of whether the medication will be absorbed. Despite the potential clinical significance of this information, data regarding the gastrointestinal site of absorption for most medications are lacking.

Physical and chemical stability of high-dose ifosfamide and mesna for prolonged 14-day continuous infusion.

Purpose: Ifosfamide plus mesna have been used recently in a high-dose regimen that allows this chemotherapy to be given to outpatients with less toxicity over 14 days using a portable pump. However, there is a need for published stability information. The aim of this study was to investigate the physicochemical stability of ifosfamide with mesna in normal saline at room temperature over a prolonged period of 14 days.