Publications by authors named "Chelsey Baldwin"
Article Synopsis
- Complete surgical removal of differentiated papillary thyroid cancer (PTC) usually leads to a very good prognosis, but locally invasive cases can have higher rates of complications and death if complete resection isn’t possible.
- Neoadjuvant therapy using dabrafenib and trametinib (DT) has shown effectiveness in helping some patients with unresectable anaplastic thyroid cancer achieve successful surgeries and improved survival outcomes.
- In a specific case involving a patient with BRAF- and RET-mutated PTC, neoadjuvant DT treatment for 5 months made the cancer undetectable on scans, but it quickly returned after stopping the treatment, suggesting DT could be beneficial for similar patients to lessen surgical risks while still enabling effective resection.
Thyroid nodule rupture after radiofrequency ablation: case report and literature review.
Front Endocrinol (Lausanne)
April 2024
Purpose: Radiofrequency ablation (RFA) is an effective and safe modality for the treatment of thyroid nodules. Nodule rupture is a major complication of RFA. There is little known on the natural history of nodule rupture due to a lack of clinical experience and no consensus on its management.
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- A comprehensive genomic analysis was conducted on a large number of thyroid nodules (50,734 FNA samples) to identify molecular alterations and better understand their clinical significance, particularly in Bethesda categories III-VI.
- The results showed that a majority (65.3%) of the samples tested negative for significant alterations, while a smaller proportion (33.9%) tested positive, revealing different mutation patterns in BCIII-IV and BCV-VI nodules, with BCV-VI showing more aggressive genetic changes.
- The findings indicate that 68% of BCIII-IV nodules were negative, highlighting the potential to avoid unnecessary surgery, while BCV-VI nodules had more actionable mutations that could inform treatment decisions for patients.
Minimally Invasive Techniques for the Management of Thyroid Nodules.
Endocrinol Metab Clin North Am
June 2022
Image-guided interventional techniques have emerged as promising treatments for thyroid disease. Percutaneous ethanol ablation, radiofrequency ablation, laser ablation, high intensity focused ultrasound, and microwave ablation have shown efficacy in treating benign thyroid disease. There is increasing evidence that these techniques may effectively treat papillary thyroid microcarcinomas, recurrent and metastatic disease, follicular neoplasms, and parathyroid lesions.
View Article and Find Full Text PDFBackground: Unlike medullary thyroid carcinoma in adults, the vast majority of pediatric medullary thyroid carcinoma is hereditary. Pediatric medullary thyroid carcinoma is known to have different genetic alterations driving tumorigenesis, but it is not known if pediatric medullary thyroid carcinoma has different clinicopathologic features. This study aims to identify which pediatric medullary thyroid carcinoma patients might warrant elective neck dissection.
View Article and Find Full Text PDFContext: Thyroid hormone plays a critical role in cardiovascular function. Severe hypothyroidism can be associated with "myxedema heart" characterized by relative bradycardia and pericardial effusion. Effusions associated with severe hypothyroidism can be large.
View Article and Find Full Text PDFRationale: Successful treatment of cocaine addiction is severely impeded by the propensity of users to relapse. Withdrawal severity may serve as a key predictor of susceptibility to relapse. Therefore, the identification and treatment of cocaine withdrawal symptoms such as anxiety may improve addiction treatment outcome.
View Article and Find Full Text PDFSignificant sex differences have been demonstrated in clinical and preclinical studies of cocaine addiction, with some of the most consistent differences noted in regard to the role of stress and craving. The current study examined stress-induced reinstatement of cocaine seeking in male and female rats in an animal model of relapse using corticotropin-releasing factor (CRF) administration. Both male and female rats demonstrated increased cocaine seeking in response to CRF.
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