Publications by authors named "Chelsey A Skeete"
Article Synopsis
- Dolosigranulum pigrum is a beneficial bacterium linked to health indicators in human nasal microbiota, with potential therapeutic applications due to its positive health associations.
- Research on its genomic structure over 20 years revealed a stable chromosomal organization, closely related strains, and a diverse range of genetic elements that protect it from mobile genetic elements (MGEs).
- The study identified important defense mechanisms against MGEs, underscoring the bacterium's adaptability while maintaining genomic stability, making it a promising candidate for future health treatments.
Prevotella intermedia, a major periodontal pathogen, is increasingly implicated in human respiratory tract and cystic fibrosis lung infections. Nevertheless, the specific mechanisms employed by this pathogen remain only partially characterized and poorly understood, largely due to its total lack of genetic accessibility. Here, using Single Molecule, Real-Time (SMRT) genome and methylome sequencing, bisulfite sequencing, in addition to cloning and restriction analysis, we define the specific genetic barriers to exogenous DNA present in two of the most widespread laboratory strains, P.
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