Publications by authors named "Chelsea Vrana"
Article Synopsis
- Candida species are a leading cause of invasive fungal diseases, particularly affecting children with blood cancers; the study found that non-albicans Candida (NAC), especially C. tropicalis, are linked to worse outcomes in these patients.* -
- Researchers reviewed data from 53 patients over a decade and discovered a high incidence rate of invasive candidiasis (IC) and a significant link between C. tropicalis infections and dissemination to various organs, including the eyes and skin.* -
- The study highlights the importance of eye examinations in patients with IC, revealing that a notable percentage showed evidence of intraocular candidiasis, and emphasizes the need for further research to refine screening strategies for at-risk patients.*
Background: Comprehensive guidelines for the management of iron deficiency anemia (IDA) in adolescents with heavy menstrual bleeding (HMB) presenting to the emergency department (ED) are lacking, leading to variability in care. We aimed to standardize the evaluation and management of these patients through the development and implementation of an evidence-based algorithm using quality improvement methodology.
Methods: Baseline data of the target population identified variability across four key measures of clinical management: therapy choice and administration, laboratory evaluation, hematology service consultation, and patient disposition.
The survival rate of pediatric acute myeloid leukemia (pAML) is currently around 60%. While survival has slowly increased over the past few decades, the development of novel agents likely to further improve survival for this heterogeneous patient population has been limited by gaps in the pAML pre-clinical pipeline. One of the major hurdles in evaluating new agents for pAML is the lack of pAML patient-derived xenograft (PDX) models.
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