Publications by authors named "Chelsea Ruth"
Introduction: The Canadian Institute of Health Information's (CIHI) Discharge Abstract Database (DAD) contains standardised administrative data on all hospitalisations in Canada, excluding Quebec.
Objectives: We aimed to validate preterm birth related perinatal and neonatal data in DAD by assessing its accuracy against the reference standard of the Canadian Neonatal Network (CNN) database.
Methods: We linked birth hospitalization data between the DAD and CNN databases for all neonates born <33 weeks gestational age (GA) admitted to the Neonatal Intensive Care Units in Winnipeg, Canada, between 2010 and 2022.
Article Synopsis
- The study examines the use of antiseizure medications (ASMs) among pregnant individuals in four Canadian provinces over 20 years, focusing on trends and patterns in ASM usage among those with and without epilepsy.
- Results showed that only 0.7% of the pregnant population had epilepsy, with 1.7% exposed to ASMs; notable increases in ASM use were observed among those without epilepsy, especially in Manitoba, Saskatchewan, and Alberta.
- The analysis also revealed shifts in ASM drug classes, with a decline in older medications like carbamazepine and a rise in newer options like lamotrigine, while usage patterns varied by province and trimester.
Bell's palsy is acute facial palsy due to inflammation involving the facial nerve related to infections. Rates have not been noted to differ by ethnicity. We studied the lifetime prevalence in First Nations and all other Manitobans in people with type 2 diabetes mellitus aged 7 and older in 2013-2014 and 2016-2017.
View Article and Find Full Text PDFGastroschisis and septo-optic-pituitary dysplasia: Is there an association?
J Paediatr Child Health
July 2024
Aim: There are several case reports describing patients with both optic nerve hypoplasia/septo-optic-pituitary dysplasia (ONH/SOD) and gastroschisis (GS). Our aim was to investigate whether ONH/SOD is associated with GS.
Methods: A retrospective population-based study was undertaken using the Population Research Data Repository at the Manitoba Center for Health Policy in Manitoba, Canada to investigate if any patient with ONH/SOD also had GS.
Background: To investigate best-corrected visual acuity (BCVA) outcomes in patients with optic nerve hypoplasia (ONH)/septo-optic-pituitary dysplasia (SOD). Our primary hypothesis was that BCVA in patients with ONH/SOD does not change significantly over time.
Methods: A chart review was undertaken in patients with a confirmed diagnosis of ONH/SOD.
Importance: Data on the middle school outcomes of preterm children are limited and have methodologic issues.
Objective: To study the association between preterm birth and grade 7 school performance.
Methods: A retrospective population-based cohort study of children born in Manitoba, Canada between 1994 and 2006 using their grade 7 school performance data.
Aim: To describe the incidence and prevalence of type 2 diabetes in children in Manitoba over a ten-year period.
Methods: Population-based, provincial databases were linked to calculate the incidence and prevalence of type 2 diabetes in children < 18 years of age in Manitoba from 2009-10 to 2017-18. First Nation and all other Manitoban children are described separately.
Risk factors in children with optic nerve hypoplasia and septo-optic dysplasia.
Dev Med Child Neurol
January 2024
Aim: To identify the risk factors for optic nerve hypoplasia (ONH) and septo-optic dysplasia (SOD).
Method: A retrospective, population-based study with case-control design was undertaken using the Population Research Data Repository at the Manitoba Center for Health Policy in Manitoba, Canada. Cases were 111 patients (63 males, 48 females; age range 1-35 years [mean 11 years 6 months, SD 7 years 2 months]) with ONH and SOD diagnosed from 1990 to 2019, matched to 555 unrelated population-based controls (315 males, 240 females; age range 1-35 years [mean 11 years 6 months, SD 7 years 2 months]) on year of birth, sex, and area of residence.
Aims: We aimed to systematically synthesize the current published literature on neonatal growth outcomes associated with antiseizure medication (ASM) use during pregnancy.
Methods: We searched seven databases, from inception to 23 March 2022. We investigated small for gestational age (SGA) and low birth weight (LBW) as primary outcomes and birth weight, birth height, cephalization index and head circumference as secondary outcomes.
Objectives: The prevalence of type 2 diabetes (T2D) is increasing and Indigenous populations are at highest risk. Canadian data are crucial for health planning.
Methods: Population-based, de-identified, linked databases were used to calculate the incidence and prevalence of T2D for registered adult First Nations Manitobans and all other adult Manitobans from 2011-2012 to 2016-2017.
Septo-optic dysplasia (SOD) and optic nerve hypoplasia (ONH) cause congenital visual impairment. Their aetiology is mostly unknown. Our aim was to investigate the prevalence of selected ophthalmological features in patients with these disorders.
View Article and Find Full Text PDFGrade 3 school performance among children born preterm: a population-based cohort study.
Arch Dis Child Fetal Neonatal Ed
May 2023
Objective: To study the association between prematurity and grade 3 school performance in a contemporary cohort of children.
Methods: Population-based retrospective cohort study in Manitoba, Canada. Children born between 1999 and 2011 who had their grade 3 school performance data available were eligible.
Background: Our aim was to examine the association between preterm delivery and incident maternal mental disorders using a population-based cohort of mothers in Canada.
Methods: Retrospective matched cohort study using Manitoba Centre for Health Policy (MCHP) administrative data in Manitoba. Mothers who delivered preterm babies (<37 weeks gestational age) between 1998 and 2013 were matched 1:5 to mothers of term babies using socio-demographic variables.
Article Synopsis
- - First Nation individuals in Canada have a notably higher prevalence of type 2 diabetes during pregnancy, leading to increased risks of adverse outcomes compared to other Manitoban women with the same condition.
- - In a study involving 2181 females, it was found that First Nation mothers had significantly higher rates of stillbirth and perinatal death, as well as increased risks of neonatal complications like congenital malformations.
- - The findings highlight the need for further research to identify factors that contribute to or protect against pregnancy complications among First Nation individuals with type 2 diabetes.
Importance: Children born preterm may experience learning challenges at school. However, there is a paucity of data on the school readiness of these children as they prepare to begin grade 1.
Objective: To examine the association between prematurity and school readiness in a population-based cohort of children.
Objective: To describe the prevalence of mental health comorbidity in children with type 2 diabetes compared to a matched population without diabetes and children with type 1 diabetes.
Research Design And Methods: Population-based cohorts of 528 youth (7-18 years of age) with prevalent type 2 diabetes, 1519 matched children without diabetes and 778 youth with type 1 diabetes were identified from a clinical registry and linked to provincial health care records to assess the prevalence of mental health comorbidity using ICD-9CM, ICD-10CA and ATC codes.
Results: The majority of children with type 2 diabetes were of First Nations heritage.
Objective: To describe hospitalization rates and reasons for hospitalization in children with type 2 diabetes (T2D) and to compare these rates to a matched cohort without diabetes and to children with type 1 diabetes (T1D).
Methods: Population-based cohorts of 528 children (7-18 years of age) with prevalent T2D, 1519 matched control children without diabetes and 778 children with T1D were identified from a clinical registry and linked to health care records to assess hospitalizations and reasons for hospitalizations using ICD-9CM and ICD-10CA codes.
Results: Children with T2D are more likely than their matched controls and children with T1D to be admitted to hospital in the year prior to diagnosis {RR 2.
Evidence from developed countries demonstrates that the use of antiseizure medications (ASMs) has been increasing in the last decade. Pregnant women have a very challenging risk benefit trade-off in terms of ASM utilization, and it is crucial to know if increased utilization is seen among pregnant women. To examine time-trends of utilization of ASM therapies among pregnant women in Manitoba, Canada.
View Article and Find Full Text PDFArticle Synopsis
- Research indicates that obesity raises the risk of peripartum depression (PPD) and may be linked to lower placental lactogen levels, with insulin treatment for gestational diabetes potentially increasing those levels.
- A study analyzed health data from over 250,000 women, categorizing them into lean and obesity groups to assess the risk of PPD post-delivery, adjusting for factors like maternal age and income.
- Results showed that women with obesity had a higher unadjusted risk of PPD without insulin treatment, but insulin treatment in these women equalized the PPD risk when compared to lean women, indicating insulin's potential protective effect.
Article Synopsis
- Maternal DHA supplementation might help prevent bronchopulmonary dysplasia in premature infants, but the evidence is not clear-cut.
- A clinical trial was conducted with mothers of infants born before 29 weeks, providing them either DHA or placebo capsules; it was stopped early due to potential harm concerns.
- The results showed that 54.9% of infants who received DHA survived without bronchopulmonary dysplasia, compared to 61.6% in the placebo group, suggesting no significant benefit from DHA supplementation.
Objectives: To determine if in utero selective serotonin reuptake inhibitor (SSRI) or selective serotonin norepinephrine inhibitor (SNRI) exposure is associated with developmental vulnerability in kindergarten among children whose mothers were diagnosed with prenatal mood or anxiety disorder.
Methods: Linkable administrative data were used to create a population-based cohort of 266 479 mother-child dyads of children born in Manitoba, Canada, between 1996 and 2014, with follow-up through 2015. The sample was restricted to mothers who had a mood or anxiety disorder diagnosis between 90 days before conception ( = 13 818).
Background: Previous studies have reported an intergenerational association between maternal and offspring preterm birth (PTB) but the nature of the association remains unclear. We assessed the association between maternal and offspring preterm birth using a quasi-experimental sibling design and distinguishing between preterm birth types.
Methods: We conducted a retrospective intergenerational cohort study of 39,573 women born singleton in Manitoba, Canada (1980-2002) who gave birth to 79,198 singleton infants (1995-2016).
Objective: Short and long interpregnancy intervals (IPIs) have been associated with various adverse outcomes, and a 2016 American College of Obstetricians and Gynecologists' Committee Opinion recommends an optimal IPI of 18 months to 5 years. Descriptive data on the IPI in Canada are lacking. The objective of this study was to examine IPIs in a Manitoba cohort.
View Article and Find Full Text PDFObjective: Congenital anomalies are a serious public health issue, and relatively few modifiable risk factors have been identified. Our objective was to investigate one such potential risk factor, the interpregnancy interval (IPI).
Methods: We conducted a secondary analysis of data housed at the Manitoba Centre for Health Policy.